microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR125B2 Gene

Subcategory (RNA class) for MIR125B2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR125B2 Gene

  • MicroRNA 125b-2 2 3 5
  • Hsa-MiR-125b-2-3p 163 173
  • Hsa-MiR-125b-5p 163 173
  • Hsa-Mir-125b-2 2 3
  • MIR125B2 2 5
  • Hsa-Mir-10-P3c 178
  • MIMAT0000423 50
  • MIMAT0004603 50
  • Mir-125b-2 3
  • MIRN125B2 3
  • MI0000470 50
  • RF00052 168

External Ids for MIR125B2 Gene

Previous HGNC Symbols for MIR125B2 Gene

  • MIRN125B2

Previous GeneCards Identifiers for MIR125B2 Gene

  • GC21P016887
  • GC21P017962

Summaries for MIR125B2 Gene

Entrez Gene Summary for MIR125B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR125B2 Gene

MIR125B2 (MicroRNA 125b-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR125B2 include Pancreatitis, Hereditary and Down Syndrome. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and TFs Regulate miRNAs related to cardiac hypertrophy.

Rfam classification for MIR125B2 Gene

Additional gene information for MIR125B2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR125B2 Gene

Genomics for MIR125B2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR125B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J016554 Enhancer 0.4 Ensembl 12.6 -35.5 -35536 1 NR2F2 GATA3 GATA2 MIR125B2 lnc-USP25-11 lnc-BTG3-10 MIR99AHG USP25 CXADR
GH21J016586 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.5 -2492 3 PRDM10 FOXA1 PRDM1 POLR2A PATZ1 SP1 ZNF341 CEBPA SOX13 CEBPB MIR99AHG MIR99A MIRLET7C MIR125B2 ENSG00000269950 CXADR USP25
GH21J016604 Enhancer 0.6 Ensembl CraniofacialAtlas 0.4 +15.6 15564 2 RFX1 POLR2A RAD21 BMI1 RFX5 CHD2 piR-41525-428 MIR125B2 MIR99AHG CXADR USP25
GH21J016592 Enhancer 0.3 Ensembl dbSUPER 0.7 +2.6 2564 1.2 MIR125B2 piR-41525-428 MIR99AHG CXADR USP25
GH21J016596 Enhancer 0.3 VISTA 0.4 +7.5 7467 2.8 POLR2A PKNOX1 MIR125B2 piR-41525-428 MIR99AHG USP25 CXADR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR125B2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR125B2 Gene

Genomic Locations for MIR125B2 Gene
chr21:16,590,237-16,590,325
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr21:17,962,557-17,962,645
(GRCh37/hg19)
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR125B2 Gene

Genes around MIR125B2 on UCSC Golden Path with GeneCards custom track
MIR125B2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR125B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR125B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR125B2 Gene

Proteins for MIR125B2 Gene

Post-translational modifications for MIR125B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR125B2 Gene

Domains & Families for MIR125B2 Gene

Gene Families for MIR125B2 Gene

genes like me logo Genes that share domains with MIR125B2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR125B2 Gene

Function for MIR125B2 Gene

Gene Ontology (GO) - Molecular Function for MIR125B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19437538
genes like me logo Genes that share ontologies with MIR125B2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR125B2 Gene

Localization for MIR125B2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR125B2 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR125B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR125B2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR125B2 Gene

Pathways & Interactions for MIR125B2 Gene

genes like me logo Genes that share pathways with MIR125B2: view

Pathways by source for MIR125B2 Gene

1 KEGG pathway for MIR125B2 Gene

Gene Ontology (GO) - Biological Process for MIR125B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010839 negative regulation of keratinocyte proliferation IMP 21412257
GO:0016525 negative regulation of angiogenesis IDA 22391569
GO:0032720 negative regulation of tumor necrosis factor production IDA 26435691
GO:0035195 gene silencing by miRNA IMP 20347935
GO:0035278 miRNA mediated inhibition of translation IDA 21412257
genes like me logo Genes that share ontologies with MIR125B2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR125B2 Gene

Drugs & Compounds for MIR125B2 Gene

No Compound Related Data Available

Transcripts for MIR125B2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR125B2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000209905_9606 miRNA 22 6

RefSeq: NR_029671, NR_029694,

LncBase: hsa-miR-125b-5p,

miRBase: MIMAT0000423,

MirGeneDB: Hsa-Mir-10-P3a_5p, Hsa-Mir-10-P3c_5p,

TarBase: hsa-miR-125b-5p,

ENA: AB232081.1:351..372:ncRNA, HB859643.1:1..22:misc_RNA, LM379041.1:1..22:ncRNA, LM608486.1:15..36:ncRNA, LM608510.1:17..38:ncRNA,

URS000058997A_9606 precursor_RNA 89 5

HGNC: 31507,

RefSeq: NR_029694,

Ensembl: ENST00000385128 (view in UCSC) ,

miRBase: MI0000470,

ENA: LM608510.1:1..89:precursor_RNA,

URS00001925C1_9606 miRNA 22 5

RefSeq: NR_029694,

LncBase: hsa-miR-125b-2-3p,

miRBase: MIMAT0004603,

TarBase: hsa-miR-125b-2-3p,

ENA: LM380278.1:1..22:ncRNA, LM608510.1:54..75:ncRNA,

URS00004FCB5F_9606 miRNA 22 2

MirGeneDB: Hsa-Mir-10-P3c_3p,

ENA: AY940870.1:1..22:ncRNA,

URS000031D4C0_9606 precursor_RNA 70 1

Rfam: RF00052,

MIR125B2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR125B2 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR125B2 Gene

No ASD Table

Relevant External Links for MIR125B2 Gene

GeneLoc Exon Structure for
MIR125B2

Expression for MIR125B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR125B2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR125B2

genes like me logo Genes that share expression patterns with MIR125B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR125B2 Gene

Orthologs for MIR125B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR125B2 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-125b-2 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-125b-2 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-125b-2 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir125b-2 31
  • 97 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-125b-1 31
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-125b 31
  • 90 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-100 31
  • 44 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-125b-1 31
  • 39 (a)
ManyToMany
Species where no ortholog for MIR125B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR125B2 Gene

ENSEMBL:
Gene Tree for MIR125B2 (if available)
TreeFam:
Gene Tree for MIR125B2 (if available)

Paralogs for MIR125B2 Gene

No data available for Paralogs for MIR125B2 Gene

Variants for MIR125B2 Gene

Additional dbSNP identifiers (rs#s) for MIR125B2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR125B2 Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV deletion 23290073

Additional Variant Information for MIR125B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR125B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR125B2 Gene

Disorders for MIR125B2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR125B2 Gene - From: miR2Disease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR125B2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR125B2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR125B2 Gene

Publications for MIR125B2 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41
  2. MiR-125b-5p and miR-181b-5p inhibit keratinocyte proliferation in skin by targeting Akt3. (PMID: 31518563) Zheng Y … Yin G (European journal of pharmacology 2019) 3
  3. Plasma Levels of miR-125b-5p and miR-206 in Acute Ischemic Stroke Patients After Recanalization Treatment: A Prospective Observational Study. (PMID: 30878364) He XW … Liu JR (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019) 3
  4. miR‑125b‑mediated regulation of cell proliferation through the Jagged‑1/Notch signaling pathway by inhibiting BRD4 expression in psoriasis. (PMID: 31059052) Pan M … Luo D (Molecular medicine reports 2019) 3
  5. Circulating miR-34a and miR-125b as Promising non Invasive Biomarkers in Egyptian Locally Advanced Breast Cancer Patients. (PMID: 31554373) Kassem NM … El-Desouky MA (Asian Pacific journal of cancer prevention : APJCP 2019) 3

Products for MIR125B2 Gene

Sources for MIR125B2 Gene