microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR125B1 Gene

Subcategory (RNA class) for MIR125B1 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR125B1 Gene

  • MicroRNA 125b-1 2 3 5
  • Hsa-MiR-125b-1-3p 166 177
  • Hsa-MiR-125b-5p 166 177
  • Hsa-Mir-125b-1 3
  • MIMAT0000423 51
  • MIMAT0004592 51
  • Mir-125b-1 3
  • MIRN125B1 3
  • MI0000446 51
  • MIR125B1 2
  • RF00052 172

External Ids for MIR125B1 Gene

Previous HGNC Symbols for MIR125B1 Gene

  • MIRN125B1

Previous GeneCards Identifiers for MIR125B1 Gene

  • GC11M121478
  • GC11M121970

Summaries for MIR125B1 Gene

Entrez Gene Summary for MIR125B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR125B1 Gene

MIR125B1 (MicroRNA 125b-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR125B1 include Pancreatitis, Hereditary and Pancreatic Cancer. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Rfam classification for MIR125B1 Gene

Additional gene information for MIR125B1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR125B1 Gene

Genomics for MIR125B1 Gene

GeneHancer (GH) Regulatory Elements for MIR125B1 Gene

Promoters and enhancers for MIR125B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J122090 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.2 1217 16.5 EP300 USF1 JUND FOS TEAD4 CTCF REST FOXA2 SMC3 MXI1 MIR125B1 lnc-BLID-5 MIR100HG
GH11J122067 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +30.8 30751 4 EP300 RFX1 MXI1 SMC3 GATA3 SPI1 BMI1 RCOR1 TAF1 CTCF MIR125B1 lnc-SORL1-4 ENSG00000286497 MIR100HG
GH11J122043 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +54.1 54132 3.8 JUND FOS EZH2 MAFK TAF1 GATA2 JUN POLR2A BLID MIR100HG MIR125B1 ENSG00000286497 lnc-SORL1-4
GH11J122037 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +60.5 60526 3.3 USF1 TEAD4 JUND JUN TOE1 BHLHE40 POU5F1 NANOG POLR2A USF2 MIR125B1 ENSG00000286497 lnc-SORL1-4 MIR100HG
GH11J122035 Enhancer 1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +63.3 63344 1.8 CEBPB MIR125B1 ENSG00000286497 lnc-SORL1-4 MIR100HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR125B1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR125B1 Gene

Genomic Locations for MIR125B1 Gene
chr11:122,099,757-122,099,844
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand
chr11:121,970,465-121,970,552
(GRCh37/hg19)
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR125B1 Gene

Genes around MIR125B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR125B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR125B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR125B1 Gene

Proteins for MIR125B1 Gene

Post-translational modifications for MIR125B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR125B1 Gene

Domains & Families for MIR125B1 Gene

Gene Families for MIR125B1 Gene

genes like me logo Genes that share domains with MIR125B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR125B1 Gene

Function for MIR125B1 Gene

Phenotypes From GWAS Catalog for MIR125B1 Gene

Gene Ontology (GO) - Molecular Function for MIR125B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19437538
genes like me logo Genes that share ontologies with MIR125B1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR125B1 Gene

Localization for MIR125B1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR125B1 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR125B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR125B1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR125B1 Gene

Pathways & Interactions for MIR125B1 Gene

genes like me logo Genes that share pathways with MIR125B1: view

Pathways by source for MIR125B1 Gene

;

Gene Ontology (GO) - Biological Process for MIR125B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 28947385
GO:0016525 negative regulation of angiogenesis IDA 22391569
GO:0032720 negative regulation of tumor necrosis factor production IDA 26435691
GO:0035195 gene silencing by miRNA IMP 20347935
GO:0035278 miRNA mediated inhibition of translation IDA 22391569
genes like me logo Genes that share ontologies with MIR125B1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR125B1 Gene

Drugs & Compounds for MIR125B1 Gene

No Compound Related Data Available

Transcripts for MIR125B1 Gene

mRNA/cDNA for MIR125B1 Gene

4 RNACentral transcripts :
2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
8 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR125B1 Gene

No ASD Table

Relevant External Links for MIR125B1 Gene

GeneLoc Exon Structure for
MIR125B1

Expression for MIR125B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR125B1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR125B1

genes like me logo Genes that share expression patterns with MIR125B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR125B1 Gene

Orthologs for MIR125B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR125B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-125b-1 31
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir125b-1 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-125b-1 31
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-125b-2 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-125b-1 31
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-125 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-125b-1 31
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-125b-2 31
  • 76 (a)
OneToOne
Species where no ortholog for MIR125B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR125B1 Gene

ENSEMBL:
Gene Tree for MIR125B1 (if available)
TreeFam:
Gene Tree for MIR125B1 (if available)

Paralogs for MIR125B1 Gene

No data available for Paralogs for MIR125B1 Gene

Variants for MIR125B1 Gene

Additional dbSNP identifiers (rs#s) for MIR125B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR125B1 Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV gain 17160897

Additional Variant Information for MIR125B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR125B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR125B1 Gene

Disorders for MIR125B1 Gene

MalaCards: The human disease database

(31) MalaCards diseases for MIR125B1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • cp
pancreatic cancer
  • pancreatic carcinoma
ovarian cancer
  • ovarian cancer, somatic
glioma susceptibility 1
  • glm1
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR125B1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR125B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR125B1 Gene

Publications for MIR125B1 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41 54
  2. Plasma Levels of miR-125b-5p and miR-206 in Acute Ischemic Stroke Patients After Recanalization Treatment: A Prospective Observational Study. (PMID: 30878364) He XW … Liu JR (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019) 3 54
  3. miR‑125b‑mediated regulation of cell proliferation through the Jagged‑1/Notch signaling pathway by inhibiting BRD4 expression in psoriasis. (PMID: 31059052) Pan M … Luo D (Molecular medicine reports 2019) 3 54
  4. Microenvironment Stimuli HGF and Hypoxia Differently Affected miR-125b and Ets-1 Function with Opposite Effects on the Invasiveness of Bone Metastatic Cells: A Comparison with Breast Carcinoma Cells. (PMID: 29337876) Matteucci E … Desiderio MA (International journal of molecular sciences 2018) 3 54
  5. The therapeutic effect of miR-125b is enhanced by the prostaglandin endoperoxide synthase 2/cyclooxygenase 2 blockade and hampers ETS1 in the context of the microenvironment of bone metastasis. (PMID: 29700305) Maroni P … Desiderio MA (Cell death & disease 2018) 3 54

Products for MIR125B1 Gene

Sources for MIR125B1 Gene