microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR125A Gene

Subcategory (RNA class) for MIR125A Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR125A Gene

  • MicroRNA 125a 2 3 5
  • Hsa-MiR-125a-3p 166 177
  • Hsa-MiR-125a-5p 166 177
  • Hsa-Mir-125a 3
  • MIMAT0000443 51
  • MIMAT0004602 51
  • MiRNA125A 3
  • MI0000469 51
  • Mir-125a 3
  • MIRN125A 3
  • MIR125A 2
  • RF00052 172

External Ids for MIR125A Gene

Previous HGNC Symbols for MIR125A Gene

  • MIRN125A

Previous GeneCards Identifiers for MIR125A Gene

  • GC19P056924
  • GC19P056928
  • GC19P052201
  • GC19P052206
  • GC19P052213
  • GC19P052221
  • GC19P051694
  • GC19P051698
  • GC19P051731
  • GC19P051733
  • GC19P051726
  • GC19P051701
  • GC19P051705
  • GC19P051709
  • GC19P051712
  • GC19P051716
  • GC19P051720

Summaries for MIR125A Gene

Entrez Gene Summary for MIR125A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR125A Gene

MIR125A (MicroRNA 125a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR125A include Lung Cancer and Ovarian Cancer. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

Rfam classification for MIR125A Gene

Additional gene information for MIR125A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR125A Gene

Genomics for MIR125A Gene

GeneHancer (GH) Regulatory Elements for MIR125A Gene

Promoters and enhancers for MIR125A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051695 Enhancer 0.6 Ensembl dbSUPER 500.7 +1.8 1847 0.2 RBM25 BCOR ADNP ZMYM3 KDM1A SMARCA5 MIR125A NONHSAG026381.2 SPACA6P-AS FPR3 RPL7P51 SIGLEC14 SIGLEC5 SPACA6 lnc-HAS1-2
GH19J051545 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 10.5 -143.9 -143879 7.2 HNRNPK NRF1 BCLAF1 GTF2E2 PHB2 ZBTB5 ZNF263 ZBTB11 AFF1 TARDBP SIGLEC6 ZNF175 SIGLEC8 SIGLEC14 CEACAM18 SIGLEC12 RPL7P51 SIGLEC5 SPACA6 MIR125A
GH19J051731 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.4 +45.3 45347 16.8 RBM25 CREB1 CTCF TRIM24 NCOR1 PBX2 SPI1 FOSL1 BCOR GABPA FPR1 FPR2 HAS1 FPR3 SIGLEC10 SIGLEC14 MIR125A MIR99B MIRLET7E SPACA6
GH19J051439 Promoter 0.7 Ensembl 9.9 -253.4 -253353 0.6 BCOR ADNP ZNF146 ZMYM3 KDM1A CTCF ZNF24 SIGLEC12 CEACAM18 VSIG10L RPL7P51 SIGLEC14 SIGLEC5 NKG7 ETFB CLDND2 SPACA6
GH19J051438 Enhancer 0.6 ENCODE 9.9 -254.8 -254842 0.1 CTCF TEAD4 REST RAD21 TRIM22 SMC3 YY1 EHMT2 PKNOX1 IKZF1 SIGLEC12 CEACAM18 VSIG10L SIGLEC14 SIGLEC5 RPL7P51 CLDND2 NKG7 ETFB MIR125A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR125A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR125A Gene

Genomic Locations for MIR125A Gene
chr19:51,693,254-51,693,339
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr19:52,196,507-52,196,592
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR125A Gene

Genes around MIR125A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR125A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR125A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR125A Gene

Proteins for MIR125A Gene

Post-translational modifications for MIR125A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR125A Gene

Domains & Families for MIR125A Gene

Gene Families for MIR125A Gene

genes like me logo Genes that share domains with MIR125A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR125A Gene

Function for MIR125A Gene

Phenotypes From GWAS Catalog for MIR125A Gene

Gene Ontology (GO) - Molecular Function for MIR125A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR125A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR125A Gene

Localization for MIR125A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR125A gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR125A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0070062 extracellular exosome IDA 27252357
genes like me logo Genes that share ontologies with MIR125A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR125A Gene

Pathways & Interactions for MIR125A Gene

genes like me logo Genes that share pathways with MIR125A: view

Pathways by source for MIR125A Gene

1 BioSystems pathway for MIR125A Gene
1 KEGG pathway for MIR125A Gene
;

Gene Ontology (GO) - Biological Process for MIR125A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 25116893
GO:0010629 negative regulation of gene expression IDA 25116893
GO:0016525 negative regulation of angiogenesis IMP 25116893
GO:0035195 gene silencing by miRNA IDA 20190813
GO:0072125 negative regulation of glomerular mesangial cell proliferation IDA 26563755
genes like me logo Genes that share ontologies with MIR125A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR125A Gene

Drugs & Compounds for MIR125A Gene

No Compound Related Data Available

Transcripts for MIR125A Gene

mRNA/cDNA for MIR125A Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
6 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR125A Gene

No ASD Table

Relevant External Links for MIR125A Gene

GeneLoc Exon Structure for
MIR125A

Expression for MIR125A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR125A

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR125A Gene

Orthologs for MIR125A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR125A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-125a 31
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-125a 31
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir125a 31
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-125a 31
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-10c 31
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-125a-1 31
  • 76 (a)
OneToMany
dre-mir-125a-2 31
  • 56 (a)
OneToMany
Species where no ortholog for MIR125A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR125A Gene

ENSEMBL:
Gene Tree for MIR125A (if available)
TreeFam:
Gene Tree for MIR125A (if available)

Paralogs for MIR125A Gene

No data available for Paralogs for MIR125A Gene

Variants for MIR125A Gene

Additional dbSNP identifiers (rs#s) for MIR125A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR125A Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv953608 CNV deletion 24416366
nsv9742 CNV gain+loss 18304495

Additional Variant Information for MIR125A Gene

Human Gene Mutation Database (HGMD)
MIR125A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR125A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR125A Gene

Disorders for MIR125A Gene

MalaCards: The human disease database

(113) MalaCards diseases for MIR125A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
ovarian cancer
  • ovarian cancer, somatic
medulloblastoma
  • mdb
breast cancer
  • breast cancer, familial
vascular disease
  • vascular tissue disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR125A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR125A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR125A Gene

Publications for MIR125A Gene

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 41 54
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41 54
  3. MicroRNA 125a-5p Inhibits Cell Proliferation and Induces Apoptosis in Hepatitis B Virus-Related Hepatocellular Carcinoma by Downregulation of ErbB3. (PMID: 28800792) Li G … Huang X (Oncology research 2019) 3 54
  4. IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer. (PMID: 30387833) Yan L … Han XW (International journal of oncology 2019) 3 54
  5. Regulation of IL-6 signaling by miR-125a and let-7e in endothelial cells controls vasculogenic mimicry formation of breast cancer cells. (PMID: 30670152) Park Y … Kim J (BMB reports 2019) 3 54

Products for MIR125A Gene

Sources for MIR125A Gene