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MIR125A Gene(RNA Gene)

MicroRNA 125a

GCID:
GC19P051723
GIFtS:
21
Genes Participants
UDN Logo

Aliases for MIR125A Gene

Subcategory (RNA class) for MIR125A Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR125A Gene

  • MicroRNA 125a 2 3 5
  • Hsa-Mir-125a 3
  • MiRNA125A 3
  • Mir-125a 3
  • MIRN125A 3

External Ids for MIR125A Gene

ORGUL Members for MIR125A Gene

Previous HGNC Symbols for MIR125A Gene

  • MIRN125A

Previous GeneCards Identifiers for MIR125A Gene

  • GC19P056924
  • GC19P056928
  • GC19P052201
  • GC19P052206
  • GC19P052213
  • GC19P052221
  • GC19P051694
  • GC19P051698
  • GC19P051701
  • GC19P051705
  • GC19P051709
  • GC19P051712
  • GC19P051716
  • GC19P051720

Summaries for MIR125A Gene

Entrez Gene Summary for MIR125A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR125A Gene

MIR125A (MicroRNA 125a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR125A include Medulloblastoma and Ovarian Cancer. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

Additional gene information for MIR125A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR125A Gene

Genomics for MIR125A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR125A Gene

Promoters and enhancers for MIR125A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J051545 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -143.5 -143481 8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A IRF4 POLR2B ZNF175 ZNF841 ZNF836 SIGLEC6 ZNF616 ZNF350 ZNF808 CTU1 ZNF613 ZNF766
GH19J051748 Promoter/Enhancer 1.3 EPDnew FANTOM5 Ensembl ENCODE 10.8 +57.2 57247 5 CEBPB FPR1 FPR2 SIGLEC10 FPR3 MIR125A MIR99B MIRLET7E SPACA6 ZNF350 HAS1
GH19J051438 Enhancer 0.6 ENCODE 9.9 -254.8 -254842 0.1 CTCF PKNOX1 TRIM22 SIN3A MIER2 REST RAD21 IKZF1 ZNF143 EHMT2 SIGLEC12 CEACAM18 VSIG10L SIGLEC14 SIGLEC5 RPL7P51 CLDND2 NKG7 ETFB MIR125A
GH19J051687 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.7 -2.8 -2763 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 SPACA6 ZNF137P ZNF841 ZNF808 ZNF616 ZNF766 ZNF836 ZNF577 ENSG00000268970 ENSG00000269825
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR125A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR125A Gene

Genomic Locations for MIR125A Gene
chr19:51,693,254-51,693,339
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr19:52,196,507-52,196,592
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR125A Gene

Genes around MIR125A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR125A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR125A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR125A Gene

Proteins for MIR125A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR125A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR125A Gene

Domains & Families for MIR125A Gene

Gene Families for MIR125A Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR125A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR125A Gene

Function for MIR125A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR125A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR125A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR125A Gene

Localization for MIR125A Gene

Gene Ontology (GO) - Cellular Components for MIR125A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA,HDA 26646931
GO:0070062 extracellular exosome IDA 27252357
genes like me logo Genes that share ontologies with MIR125A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR125A Gene

Pathways & Interactions for MIR125A Gene

genes like me logo Genes that share pathways with MIR125A: view

Pathways by source for MIR125A Gene

1 BioSystems pathway for MIR125A Gene
1 KEGG pathway for MIR125A Gene

Interacting Proteins for MIR125A Gene

Gene Ontology (GO) - Biological Process for MIR125A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 25116893
GO:0010629 negative regulation of gene expression IDA 25116893
GO:0016525 negative regulation of angiogenesis IMP 25116893
GO:0035195 gene silencing by miRNA IDA 20190813
GO:1903672 positive regulation of sprouting angiogenesis IDA 27252357
genes like me logo Genes that share ontologies with MIR125A: view

No data available for SIGNOR curated interactions for MIR125A Gene

Drugs & Compounds for MIR125A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR125A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR125A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR125A Gene

No ASD Table

Relevant External Links for MIR125A Gene

GeneLoc Exon Structure for
MIR125A
ECgene alternative splicing isoforms for
MIR125A

Expression for MIR125A Gene

Products:

  1. Primer
  2. Gene Expression Assay

NURSA nuclear receptor signaling pathways regulating expression of MIR125A Gene:

MIR125A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR125A Gene

Orthologs for MIR125A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR125A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-125a 34
  • 99 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-125a 34
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir125a 34
  • 94 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-125a 34
  • 93 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-10c 34
  • 37 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-125a-1 34
  • 76 (a)
 OneToMany
dre-mir-125a-2 34
  • 56 (a)
 OneToMany
Species where no ortholog for MIR125A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR125A Gene

ENSEMBL:
Gene Tree for MIR125A (if available)
TreeFam:
Gene Tree for MIR125A (if available)

Paralogs for MIR125A Gene

No data available for Paralogs for MIR125A Gene

Variants for MIR125A Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR125A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000530929 -- 51,692,052(+) G/A upstream_transcript_variant
rs1000647040 -- 51,692,365(+) G/A upstream_transcript_variant
rs1003007762 -- 51,691,352(+) G/A upstream_transcript_variant
rs1004203043 -- 51,691,463(+) G/A upstream_transcript_variant
rs1005186365 -- 51,691,694(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR125A Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv953608 CNV deletion 24416366
nsv9742 CNV gain+loss 18304495

Additional Variant Information for MIR125A Gene

Human Gene Mutation Database (HGMD)
MIR125A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR125A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR125A Gene

Disorders for MIR125A Gene

MalaCards: The human disease database

(17) MalaCards diseases for MIR125A Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
medulloblastoma
  • mdb
ovarian cancer
  • ovarian cancer, somatic
breast cancer
  • breast cancer, familial
vascular disease
  • vascular tissue disease
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR125A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR125A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR125A Gene

Publications for MIR125A Gene

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 44 58
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 44 58
  3. MicroRNA-125a-5p alleviates the deleterious effects of ox-LDL on multiple functions of human brain microvessel endothelial cells. (PMID: 27903586) Pan Q … Ma X (American journal of physiology. Cell physiology 2017) 3 58
  4. MicroRNA-125a-5p Is a Downstream Effector of Sorafenib in Its Antiproliferative Activity Toward Human Hepatocellular Carcinoma Cells. (PMID: 27982429) Potenza N … Russo A (Journal of cellular physiology 2017) 3 58
  5. Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p. (PMID: 28695772) Li JF … Song YZ (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58

Products for MIR125A Gene

Sources for MIR125A Gene

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