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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR125A Gene
Subcategory (RNA class) for MIR125A Gene
miRNA
Aliases for MIR125A Gene
- MIMAT0000443 (miRBase)
- MiRNA125A (NCBI Entrez Gene)
- MI0000469 (miRBase)
- MIRN125A (NCBI Entrez Gene)
- Mir-125a (NCBI Entrez Gene)
- MIR125A (Ensembl)
- RF00052 (Rfam)
External Ids for MIR125A Gene
- HGNC: 31505
- NCBI Entrez Gene: 406910
- Ensembl: ENSG00000208008
- OMIM®: 611191
- miRBase: hsa-mir-125a
Previous HGNC Symbols for MIR125A Gene
- MIRN125A
Previous GeneCards Identifiers for MIR125A Gene
- GC19P056924
- GC19P056928
- GC19P052201
- GC19P052206
- GC19P052213
- GC19P052221
- GC19P051694
- GC19P051698
- GC19P051731
- GC19P051733
- GC19P051726
- GC19P051723
- GC19P051701
- GC19P051705
- GC19P051709
- GC19P051712
- GC19P051716
Summaries for MIR125A Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR125A Gene
MIR125A (MicroRNA 125a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR125A include Medulloblastoma and Lung Cancer. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.
Rfam classification for MIR125A Gene
-
lin-4 microRNA precursor
Additional gene information for MIR125A Gene
- HGNC (31505)
- NCBI Entrez Gene (406910)
- Ensembl (ENSG00000208008)
- OMIM® (611191)
- Open Targets Platform(ENSG00000208008)
- Monarch Initiative
- Search for MIR125A at DataMed
- Search for MIR125A at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR125A Gene
Genomics for MIR125A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR125A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR125A on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR125A Gene
Latest Assembly
- chr19:51,693,254-51,693,339
- (GRCh38/hg38)
- Size:
- 86 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:52,196,507-52,196,592
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 86 bases
- Orientation:
- Plus strand
- chr19:52,196,507-52,196,592
- (GRCh37/hg19 by Ensembl)
- Size:
- 86 bases
- Orientation:
- Plus strand
Genomic View for MIR125A Gene
Genes around MIR125A on UCSC Golden Path with GeneCards custom track
MIR125A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 19q13.41 by HGNC
- 19q13.41 by Entrez Gene
- 19q13.41 by Ensembl
MIR125A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR125A Gene
Proteins for MIR125A Gene
Post-translational modifications for MIR125A Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR125A Gene
Domains & Families for MIR125A Gene
Gene Families for MIR125A Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR125A Gene
Function for MIR125A Gene
Phenotypes From GWAS Catalog for MIR125A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000993 | RNA polymerase II complex binding | IDA | 25336585 |
| GO:0003730 | mRNA 3'-UTR binding | IDA | 30089723 |
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20190813 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR125A - Starting at $85 >
- * MIR125A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR125A - Starting at $45 >
- * MIR125A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR125A Gene
Localization for MIR125A Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| nucleus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
| GO:0070062 | extracellular exosome | IDA | 27252357 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR125A Gene
Pathways & Interactions for MIR125A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Alzheimers Disease | ||
Pathways by source for MIR125A Gene
1 BioSystems pathway for MIR125A Gene
1 KEGG pathway for MIR125A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001960 | negative regulation of cytokine-mediated signaling pathway | ISS | 30089723 |
| GO:0010628 | positive regulation of gene expression | IDA | 25116893 |
| GO:0010629 | negative regulation of gene expression | IDA | 25116893 |
| GO:0016525 | negative regulation of angiogenesis | IMP | 25116893 |
| GO:0032699 | negative regulation of interleukin-16 production | IDA | 30089723 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR125A Gene
Transcripts for MIR125A Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR125A Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00005A4DCF_9606 | miRNA | 24 | 6 |
RefSeq: NR_029693, LncBase: hsa-miR-125a-5p, miRBase: MIMAT0000443, MirGeneDB: Hsa-Mir-10-P3b_5p, TarBase: hsa-miR-125a-5p, ENA: HB859642.1:1..24:misc_RNA, LM379061.1:1..24:ncRNA, LM608509.1:15..38:ncRNA, |
| URS00001F0C23_9606 | miRNA | 22 | 6 |
RefSeq: NR_029693, LncBase: hsa-miR-125a-3p, miRBase: MIMAT0004602, MirGeneDB: Hsa-Mir-10-P3b_3p, TarBase: hsa-miR-125a-3p, |
| URS000075D168_9606 | precursor_RNA | 86 | 4 |
RefSeq: NR_029693, Ensembl: ENST00000385273 (view in UCSC) , miRBase: MI0000469, |
| URS000063D7EB_9606 | precursor_RNA | 69 | 1 |
Rfam: RF00052, |
| URS0001BC760F_9606 | pre_miRNA | 69 | 1 |
Rfam: RF00052, |
MIR125A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR125A Gene
- 1 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR125A - Starting at $85 >
- * MIR125A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR125A - Starting at $45 >
- * MIR125A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR125A Gene
- GeneLoc Exon Structure for
- MIR125A
Expression for MIR125A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR125A
Evidence on tissue expression from TISSUES for MIR125A Gene
- Blood(2.1)
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for MIR125A
Gene Expression Assays for research
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR125A Gene
Orthologs for MIR125A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-125a 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | cfa-mir-125a 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir125a 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-mir-125a 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-10c 31 |
|
ManyToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-125a-1 31 |
|
OneToMany | |
| dre-mir-125a-2 31 |
|
OneToMany |
- Species where no ortholog for MIR125A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for MIR125A Gene
No data available for Paralogs for MIR125A Gene
Variants for MIR125A Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758767 | CNV | gain+loss | 17122850 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv953608 | CNV | deletion | 24416366 |
| nsv9742 | CNV | gain+loss | 18304495 |
Additional Variant Information for MIR125A Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR125A Gene
Disorders for MIR125A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| medulloblastoma |
|
|
| lung cancer |
|
|
| breast cancer |
|
|
| ovarian cancer |
|
|
| vascular disease |
|
Search MIR125A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR125A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR125A Gene
Publications for MIR125A Gene
- Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 41
- The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells. (PMID: 19881956) Cowden Dahl KD … Hudson LG (Neoplasia (New York, N.Y.) 2009) 3 74
- Epidermal growth factor receptor-regulated miR-125a-5p--a metastatic inhibitor of lung cancer. (PMID: 19702827) Wang G … Ye J (The FEBS journal 2009) 3 74
- Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41
- MicroRNA-125a/VDR axis impaired autophagic flux and contributed to fibrosis in a CCL4-induced mouse model and patients with liver cirrhosis. (PMID: 33130085) He W … Fan Z (Life sciences 2021) 3
ExternalLinks
Products for MIR125A Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR125A
- Origene Custom Protein Services for MIR125A
- Browse OriGene Inhibitory RNA Products For MIR125A
- OriGene qPCR primer pairs for MIR125A
- Browse CRISPR knockouts for MIR125A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR125A
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR125A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR125A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR125A
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR125A
Sources for MIR125A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB