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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR125A (MicroRNA 125a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR125A include Medulloblastoma and Lung Cancer. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000993 | RNA polymerase II complex binding | IDA | 25336585 |
GO:0003730 | mRNA 3'-UTR binding | IDA | 30089723 |
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20190813 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:0070062 | extracellular exosome | IDA | 27252357 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Alzheimers Disease |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001960 | negative regulation of cytokine-mediated signaling pathway | ISS | 30089723 |
GO:0010628 | positive regulation of gene expression | IDA | 25116893 |
GO:0010629 | negative regulation of gene expression | IDA | 25116893 |
GO:0016525 | negative regulation of angiogenesis | IMP | 25116893 |
GO:0032699 | negative regulation of interleukin-16 production | IDA | 30089723 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00005A4DCF_9606 | miRNA | 24 | 6 |
RefSeq: NR_029693, LncBase: hsa-miR-125a-5p, miRBase: MIMAT0000443, MirGeneDB: Hsa-Mir-10-P3b_5p, TarBase: hsa-miR-125a-5p, ENA: HB859642.1:1..24:misc_RNA, LM379061.1:1..24:ncRNA, LM608509.1:15..38:ncRNA, |
URS00001F0C23_9606 | miRNA | 22 | 6 |
RefSeq: NR_029693, LncBase: hsa-miR-125a-3p, miRBase: MIMAT0004602, MirGeneDB: Hsa-Mir-10-P3b_3p, TarBase: hsa-miR-125a-3p, |
URS000075D168_9606 | precursor_RNA | 86 | 4 |
RefSeq: NR_029693, Ensembl: ENST00000385273 (view in UCSC) , miRBase: MI0000469, |
URS000063D7EB_9606 | precursor_RNA | 69 | 1 |
Rfam: RF00052, |
URS0001BC760F_9606 | pre_miRNA | 69 | 1 |
Rfam: RF00052, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-125a 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-125a 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir125a 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-125a 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-10c 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-125a-1 31 |
|
OneToMany | |
dre-mir-125a-2 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758767 | CNV | gain+loss | 17122850 |
nsv1140251 | OTHER | inversion | 24896259 |
nsv953608 | CNV | deletion | 24416366 |
nsv9742 | CNV | gain+loss | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
medulloblastoma |
|
|
lung cancer |
|
|
breast cancer |
|
|
ovarian cancer |
|
|
vascular disease |
|