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Aliases for MIR1258 Gene

Subcategory (RNA class) for MIR1258 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1258 Gene

  • MicroRNA 1258 2 3 5
  • Hsa-Mir-1258 3
  • Mir-1258 3
  • MIRN1258 3

External Ids for MIR1258 Gene

Previous HGNC Symbols for MIR1258 Gene

  • MIRN1258

Previous GeneCards Identifiers for MIR1258 Gene

  • GC00U923048
  • GC02M180434
  • GC02M180725

Summaries for MIR1258 Gene

Entrez Gene Summary for MIR1258 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1258 Gene

MIR1258 (MicroRNA 1258) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1258 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1258 Gene

Genomics for MIR1258 Gene

GeneHancer (GH) Regulatory Elements for MIR1258 Gene

Promoters and enhancers for MIR1258 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I179860 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 -0.3 -314 0.8 KLF1 ZNF449 ZIC2 ZNF2 ZNF335 E2F1 ZFHX2 GLIS2 POLR2A ZNF366 ZNF385B MIR1258
GH02I179861 Promoter 1 Ensembl 550.8 -1.0 -993 0.2 ZIC2 ZNF2 ZNF335 GLIS2 PATZ1 PRDM10 ZBTB20 EZH2 L3MBTL2 ZNF501 ZNF385B MIR1258
GH02I179862 Enhancer 0.8 FANTOM5 550.8 +0.6 571 0.4 MZF1 ZNF335 ZNF324 ZFHX2 ZNF366 ZBTB48 PATZ1 SCRT2 PRDM10 ZNF600 ZNF385B MIR1258 LOC100131482
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR1258 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1258 Gene

Genomic Locations for MIR1258 Gene
chr2:179,860,836-179,860,908
(GRCh38/hg38)
Size:
73 bases
Orientation:
Minus strand
chr2:180,725,563-180,725,635
(GRCh37/hg19)

Genomic View for MIR1258 Gene

Genes around MIR1258 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1258 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1258 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1258 Gene

Proteins for MIR1258 Gene

Post-translational modifications for MIR1258 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1258 Gene

Domains & Families for MIR1258 Gene

Gene Families for MIR1258 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1258: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1258 Gene

Function for MIR1258 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1258 Gene

Localization for MIR1258 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1258 Gene

Pathways & Interactions for MIR1258 Gene

SuperPathways for MIR1258 Gene

No Data Available

Interacting Proteins for MIR1258 Gene

Gene Ontology (GO) - Biological Process for MIR1258 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1258 Gene

Drugs & Compounds for MIR1258 Gene

No Compound Related Data Available

Transcripts for MIR1258 Gene

mRNA/cDNA for MIR1258 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1258 Gene

No ASD Table

Relevant External Links for MIR1258 Gene

GeneLoc Exon Structure for
MIR1258
ECgene alternative splicing isoforms for
MIR1258

Expression for MIR1258 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1258 Gene:

MIR1258
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1258 Gene

Orthologs for MIR1258 Gene

Evolution for MIR1258 Gene

ENSEMBL:
Gene Tree for MIR1258 (if available)
TreeFam:
Gene Tree for MIR1258 (if available)

No data available for Orthologs for MIR1258 Gene

Paralogs for MIR1258 Gene

No data available for Paralogs for MIR1258 Gene

Variants for MIR1258 Gene

Sequence variations from dbSNP and Humsavar for MIR1258 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000724385 -- 179,860,607(-) T/C downstream_transcript_variant
rs1001008898 -- 179,860,969(-) G/C upstream_transcript_variant
rs1002524952 -- 179,861,307(-) G/A upstream_transcript_variant
rs1003119349 -- 179,862,255(-) TTTTTTTTT/TTTTTTTTTT upstream_transcript_variant
rs1004624763 -- 179,862,722(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1258 Gene

Variant ID Type Subtype PubMed ID
nsv3062 CNV insertion 18451855

Additional Variant Information for MIR1258 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1258

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1258 Gene

Disorders for MIR1258 Gene

Additional Disease Information for MIR1258

No disorders were found for MIR1258 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1258 Gene

Publications for MIR1258 Gene

  1. [Novel miRNA genes hypermethylated in breast cancer]. (PMID: 27830681) Loginov VI … Braga EA (Molekuliarnaia biologiia 2016) 3 58
  2. Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CDC28 protein kinase regulatory subunit 1B. (PMID: 27270326) Hu M … Xia H (Oncotarget 2016) 3 58
  3. Inhibition of Kaposi's sarcoma-associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258. (PMID: 24554664) Yan Q … Lu C (Journal of virology 2014) 3 58
  4. The expression and clinical significance of microRNA-1258 and heparanase in human breast cancer. (PMID: 23415719) Tang D … Tian L (Clinical biochemistry 2013) 3 58
  5. The expression of heparanase and microRNA-1258 in human non-small cell lung cancer. (PMID: 22488243) Liu H … Jiang G (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012) 3 58

Products for MIR1258 Gene

Sources for MIR1258 Gene

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