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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR1253 (MicroRNA 1253) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J002749 | Promoter/Enhancer | 1.3 | Ensembl ENCODE | 750.6 | -1.4 | -1419 | 1.6 | SIN3A RBPJ MIXL1 HLF MAX MNT SP1 ELF3 AHR TFE3 | CCDC92B ENSG00000272920 MIR1253 lnc-RAP1GAP2-2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016442 | RISC complex | IEA | -- |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-1253 33 |
|
OneToOne |
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000194223 | -- | 2,747,951(-) | T/C | downstream_transcript_variant | |
rs1000203930 | -- | 2,749,271(-) | G/A/T | upstream_transcript_variant | |
rs1002283114 | -- | 2,749,310(-) | C/T | upstream_transcript_variant | |
rs1002335656 | -- | 2,749,084(-) | G/C/T | upstream_transcript_variant | |
rs1004386661 | -- | 2,749,600(-) | GGGGGG/GGGGG | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660206 | CNV | deletion | 23128226 |
nsv1065489 | CNV | gain | 25217958 |
nsv574225 | CNV | loss | 21841781 |
nsv833339 | CNV | loss | 17160897 |
nsv833340 | CNV | gain+loss | 17160897 |
No disorders were found for MIR1253 Gene.