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MIR1253 Gene(RNA Gene)

MicroRNA 1253

GCID:
GC17M002748
GIFtS:
14
Genes Participants
UDN Logo

Aliases for MIR1253 Gene

Subcategory (RNA class) for MIR1253 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1253 Gene

  • MicroRNA 1253 2 3 5
  • Hsa-Mir-1253 3
  • MIRN1253 3

External Ids for MIR1253 Gene

ORGUL Members for MIR1253 Gene

Previous HGNC Symbols for MIR1253 Gene

  • MIRN1253

Previous GeneCards Identifiers for MIR1253 Gene

  • GC00U922941
  • GC17M002599
  • GC17M002651

Summaries for MIR1253 Gene

Entrez Gene Summary for MIR1253 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1253 Gene

MIR1253 (MicroRNA 1253) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1253 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1253 Gene

Genomics for MIR1253 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR1253 Gene

Promoters and enhancers for MIR1253 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17I002749 Promoter/Enhancer 1.4 Ensembl ENCODE 550.8 -1.7 -1666 0.5 ARID4B SIN3A ZNF48 SLC30A9 ZNF143 KLF7 KLF13 DEK SP3 SP5 CCDC92B ENSG00000272920 MIR1253 GC17P002752
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR1253 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1253 Gene

Genomic Locations for MIR1253 Gene
chr17:2,748,078-2,748,182
(GRCh38/hg38)
Size:
105 bases
Orientation:
Minus strand
chr17:2,651,372-2,651,476
(GRCh37/hg19)

Genomic View for MIR1253 Gene

Genes around MIR1253 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1253 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1253 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR1253 Gene

Proteins for MIR1253 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR1253 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1253 Gene

Domains & Families for MIR1253 Gene

Gene Families for MIR1253 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1253: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1253 Gene

Function for MIR1253 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1253 Gene

Localization for MIR1253 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1253 Gene

Pathways & Interactions for MIR1253 Gene

SuperPathways for MIR1253 Gene

PathCards logo More details on SuperPathways for MIR1253
No Data Available

Interacting Proteins for MIR1253 Gene

Gene Ontology (GO) - Biological Process for MIR1253 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1253 Gene

Drugs & Compounds for MIR1253 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR1253 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR1253 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1253 Gene

No ASD Table

Relevant External Links for MIR1253 Gene

GeneLoc Exon Structure for
MIR1253
ECgene alternative splicing isoforms for
MIR1253

Expression for MIR1253 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1253 Gene

mRNA expression in normal human tissues for MIR1253 Gene
mRNA expression by GTEx for MIR1253 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1253 Gene:

MIR1253
genes like me logo Genes that share expression patterns with MIR1253: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1253 Gene

Orthologs for MIR1253 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR1253 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-1253 34
  • 100 (a)
 OneToOne
Species where no ortholog for MIR1253 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1253 Gene

ENSEMBL:
Gene Tree for MIR1253 (if available)
TreeFam:
Gene Tree for MIR1253 (if available)

Paralogs for MIR1253 Gene

No data available for Paralogs for MIR1253 Gene

Variants for MIR1253 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR1253 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000194223 -- 2,747,951(-) T/C downstream_transcript_variant
rs1000203930 -- 2,749,271(-) G/A/T upstream_transcript_variant
rs1002283114 -- 2,749,310(-) C/T upstream_transcript_variant
rs1002335656 -- 2,749,084(-) G/C upstream_transcript_variant
rs1004386661 -- 2,749,600(-) GGGGGG/GGGGG upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1253 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
nsv1065489 CNV gain 25217958
nsv574225 CNV loss 21841781
nsv833339 CNV loss 17160897
nsv833340 CNV gain+loss 17160897

Additional Variant Information for MIR1253 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1253

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1253 Gene

Disorders for MIR1253 Gene

Additional Disease Information for MIR1253

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR1253 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1253 Gene

Publications for MIR1253 Gene

  1. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR1253 Gene

Sources for MIR1253 Gene

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