microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1251 Gene

Subcategory (RNA class) for MIR1251 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR1251 Gene

  • MicroRNA 1251 2 3 5
  • Hsa-Mir-1251 2 3 178
  • MIR1251 2 5
  • MIMAT0026741 50
  • MIMAT0005903 50
  • MI0006386 50
  • MIRN1251 3
  • RF01938 168

External Ids for MIR1251 Gene

Previous HGNC Symbols for MIR1251 Gene

  • MIRN1251

Previous GeneCards Identifiers for MIR1251 Gene

  • GC00U923021
  • GC12P096410
  • GC12P097885

Summaries for MIR1251 Gene

Entrez Gene Summary for MIR1251 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1251 Gene

MIR1251 (MicroRNA 1251) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR1251 Gene

Additional gene information for MIR1251 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1251 Gene

Genomics for MIR1251 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1251 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J097464 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 11.6 -26.6 -26599 5.4 POLR2A RAD21 SIN3A CHD1 SMARCA4 TAF1 NANOG GTF2F1 TBP EZH2 MIR1251 RMST lnc-NEDD1-8 NEDD1
GH12J097565 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.2 +77.9 77912 7.8 CEBPG CREB1 GATAD2A ATF7 REST TFE3 SOX13 NFKBIZ RCOR2 TARDBP RMST MIR1251 ENSG00000277081 piR-38562-020 NEDD1 TMPO
GH12J097536 Enhancer 0.7 Ensembl dbSUPER 10.4 +45.7 45701 2.4 CEBPG FOXA1 CTBP1 PKNOX1 ZNF217 MBD2 GATA3 DPF2 JUND SMARCA4 MIR135A2 MIR1251 RMST ENSG00000274819 ENSG00000251844 NEDD1 TMPO
GH12J097595 Enhancer 0.8 Ensembl 9.2 +104.4 104401 2.6 GATAD2A RBFOX2 POLR2A RXRB GABPA CEBPA SOX13 TCF7 FOXA2 TEAD1 MIR135A2 MIR1251 RMST piR-38562-020 ENSG00000277081 NEDD1 TMPO
GH12J097534 Enhancer 0.5 Ensembl dbSUPER 10.6 +42.2 42201 2.2 ZNF316 MAFK ENSG00000274819 RMST MIR135A2 MIR1251 ENSG00000251844 NEDD1 TMPO
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1251 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1251 Gene

Genomic Locations for MIR1251 Gene
chr12:97,491,900-97,491,983
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr12:97,885,678-97,885,761
(GRCh37/hg19)
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR1251 Gene

Genes around MIR1251 on UCSC Golden Path with GeneCards custom track
MIR1251 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR1251 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1251 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1251 Gene

Proteins for MIR1251 Gene

Post-translational modifications for MIR1251 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1251 Gene

Domains & Families for MIR1251 Gene

Gene Families for MIR1251 Gene

HGNC:
genes like me logo Genes that share domains with MIR1251: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1251 Gene

Function for MIR1251 Gene

Phenotypes From GWAS Catalog for MIR1251 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1251 Gene

Localization for MIR1251 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1251 Gene

Pathways & Interactions for MIR1251 Gene

PathCards logo

SuperPathways for MIR1251 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR1251: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1251 Gene

Drugs & Compounds for MIR1251 Gene

No Compound Related Data Available

Transcripts for MIR1251 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1251 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C678_9606 precursor_RNA 70 4

HGNC: 35317,

RefSeq: NR_031653,

Ensembl: ENST00000408552 (view in UCSC) ,

miRBase: MI0006386,

URS0000113463_9606 miRNA 21 3

RefSeq: NR_031653,

miRBase: MIMAT0026741,

MirGeneDB: Hsa-Mir-1251_3p,

URS00002B4E74_9606 miRNA 21 3

RefSeq: NR_031653,

miRBase: MIMAT0005903,

MirGeneDB: Hsa-Mir-1251_5p,

URS00007143EB_9606 precursor_RNA 84 1

Rfam: RF01938,

URS0000EFBEC8_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-1251,

MIR1251 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1251 Gene

No ASD Table

Relevant External Links for MIR1251 Gene

GeneLoc Exon Structure for
MIR1251

No data available for mRNA/cDNA for MIR1251 Gene

Expression for MIR1251 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1251 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1251

genes like me logo Genes that share expression patterns with MIR1251: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1251 Gene

Orthologs for MIR1251 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR1251 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1251 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir1251 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-1251 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 99 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-1251 31
  • 89 (a)
OneToOne
Species where no ortholog for MIR1251 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR1251 Gene

ENSEMBL:
Gene Tree for MIR1251 (if available)
TreeFam:
Gene Tree for MIR1251 (if available)

Paralogs for MIR1251 Gene

No data available for Paralogs for MIR1251 Gene

Variants for MIR1251 Gene

Additional dbSNP identifiers (rs#s) for MIR1251 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1251 Gene

Variant ID Type Subtype PubMed ID
nsv438229 CNV loss 16468122
nsv7234 OTHER inversion 18451855
nsv832495 CNV gain 17160897

Additional Variant Information for MIR1251 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1251

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1251 Gene

Disorders for MIR1251 Gene

No disorders were found for MIR1251 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1251 Gene

Publications for MIR1251 Gene

  1. MicroRNA-1251-5p Promotes Carcinogenesis and Autophagy via Targeting the Tumor Suppressor TBCC in Ovarian Cancer Cells. (PMID: 31278033) Shao Y … Yang G (Molecular therapy : the journal of the American Society of Gene Therapy 2019) 3
  2. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J … Kaessmann H (Genome research 2013) 3
  3. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3
  4. Hidden layers of human small RNAs. (PMID: 18402656) Kawaji H … Hayashizaki Y (BMC genomics 2008) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR1251 Gene

Sources for MIR1251 Gene