microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1250 Gene

Data sources for MIR1250 Gene:

RNA type for MIR1250 Gene

miRNA

Aliases for MIR1250 Gene

External Ids for MIR1250 Gene

Previous HGNC Symbols for MIR1250 Gene

  • MIRN1250

Previous GeneCards Identifiers for MIR1250 Gene

  • GC00U923150
  • GC17M076722
  • GC17M079106

Summaries for MIR1250 Gene

Entrez Gene Summary for MIR1250 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1250 Gene

MIR1250 (MicroRNA 1250) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1250 Gene

Genomics for MIR1250 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1250 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1250 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1250 Gene

Latest Assembly
chr17:81,133,196-81,133,308
(GRCh38/hg38)
Size:
113 bases
Orientation:
Minus strand

Previous Assembly
chr17:79,106,996-79,107,108
(GRCh37/hg19 by Entrez Gene)
Size:
113 bases
Orientation:
Minus strand

chr17:79,106,996-79,107,108
(GRCh37/hg19 by Ensembl)
Size:
113 bases
Orientation:
Minus strand

Genomic View for MIR1250 Gene

Genes around MIR1250 on UCSC Golden Path with GeneCards custom track
MIR1250 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR1250 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1250 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1250 Gene

Proteins for MIR1250 Gene

Post-translational modifications for MIR1250 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1250 Gene

Domains & Families for MIR1250 Gene

Gene Families for MIR1250 Gene

HGNC:
genes like me logo Genes that share domains with MIR1250: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1250 Gene

Function for MIR1250 Gene

Phenotypes From GWAS Catalog for MIR1250 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1250 Gene

Localization for MIR1250 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1250 gene
Compartment Confidence
extracellular 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1250 Gene

Pathways & Interactions for MIR1250 Gene

PathCards logo

SuperPathways for MIR1250 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1250 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1250 Gene

Drugs & Compounds for MIR1250 Gene

No Compound Related Data Available

Transcripts for MIR1250 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1250 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075AF0B_9606 pre_miRNA 113 4

RefSeq: NR_031652,

Ensembl: ENST00000408098 (view in UCSC) ,

miRBase: MI0006385,

ENA: LM610146.1:1..113:precursor_RNA,

URS0000277201_9606 miRNA 21 4

RefSeq: NR_031652,

miRBase: MIMAT0005902,

TarBase: hsa-miR-1250-5p,

ENA: LM380699.1:1..21:ncRNA, LM610146.1:24..44:ncRNA,

URS00007605DA_9606 miRNA 19 3

RefSeq: NR_031652,

miRBase: MIMAT0026740,

ENA: LM610146.1:63..81:ncRNA,

MIR1250 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR1250 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1250 Gene

No ASD Table

Relevant External Links for MIR1250 Gene

GeneLoc Exon Structure for
MIR1250

Expression for MIR1250 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1250 Gene

mRNA differential expression in normal tissues according to GTEx for MIR1250 Gene

This gene is overexpressed in Brain - Cerebellum (x8.9), Whole Blood (x7.9), Brain - Cerebellar Hemisphere (x7.1), and Pituitary (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1250

genes like me logo Genes that share expression patterns with MIR1250: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1250 Gene

Orthologs for MIR1250 Gene

Evolution for MIR1250 Gene

ENSEMBL:
Gene Tree for MIR1250 (if available)
TreeFam:
Gene Tree for MIR1250 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR1250

No data available for Orthologs for MIR1250 Gene

Paralogs for MIR1250 Gene

No data available for Paralogs for MIR1250 Gene

Variants for MIR1250 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR1250 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR1250 Gene

Variant ID Type Subtype PubMed ID
dgv3292n100 CNV gain 25217958
esv26223 CNV gain+loss 19812545
esv3641392 CNV gain 21293372
nsv1065052 CNV gain 25217958
nsv1066947 CNV loss 25217958
nsv470619 CNV loss 18288195
nsv523417 CNV gain 19592680
nsv828128 CNV loss 20364138
nsv833564 CNV loss 17160897
nsv952388 CNV deletion 24416366

Additional Variant Information for MIR1250 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1250
Leiden Open Variation Database (LOVD)
MIR1250

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1250 Gene

Disorders for MIR1250 Gene

Additional Disease Information for MIR1250

No disorders were found for MIR1250 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1250 Gene

Publications for MIR1250 Gene

  1. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J … Kaessmann H (Genome research 2013) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR1250 Gene

Sources for MIR1250 Gene