microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1248 Gene

Subcategory (RNA class) for MIR1248 Gene

miRNA

Number of RNA Genes sources:

3 / 14

Aliases for MIR1248 Gene

  • MicroRNA 1248 2 3 5
  • Hsa-Mir-1248 3
  • Hsa-MiR-1248 177
  • MIMAT0005900 51
  • MI0006383 51
  • Mir-1248 3
  • MIRN1248 3
  • MIR1248 2

External Ids for MIR1248 Gene

Previous HGNC Symbols for MIR1248 Gene

  • MIRN1248

Previous GeneCards Identifiers for MIR1248 Gene

  • GC00U922851
  • GC03P188000
  • GC03P186505
  • GC03P186508
  • GC03P186512
  • GC03P186515
  • GC03P186523
  • GC03P186529
  • GC03P186534
  • GC03P186540
  • GC03P186549
  • GC03U902061
  • GC03P186570
  • GC03P186787
  • GC03P186792
  • GC03P186828
  • GC03P186844
  • GC03P186853
  • GC03P186798
  • GC03P186803
  • GC03P186809
  • GC03P186815
  • GC03P186820
  • GC03P186825

Summaries for MIR1248 Gene

Entrez Gene Summary for MIR1248 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1248 Gene

MIR1248 (MicroRNA 1248) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Gene Expression.

Rfam classification for MIR1248 Gene

  • Small nucleolar RNA SNORA81

Additional gene information for MIR1248 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1248 Gene

Genomics for MIR1248 Gene

GeneHancer (GH) Regulatory Elements for MIR1248 Gene

Promoters and enhancers for MIR1248 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J186782 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -1.0 -1026 7.3 ZBTB40 ZNF217 EP300 TCF12 NRF1 POLR2G BCLAF1 GTF2E2 PHF8 TEAD4 SNORA4 SNORA63B SNORA81 EIF4A2 AB372791 ENSG00000263826 NONHSAG036923.2-001 NONHSAG036923.2-002 MIR1248 SNORD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1248 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1248 Gene

Genomic Locations for MIR1248 Gene
chr3:186,786,672-186,786,777
(GRCh38/hg38)
Size:
106 bases
Orientation:
Plus strand
chr3:186,504,461-186,504,566
(GRCh37/hg19)
Size:
106 bases
Orientation:
Plus strand

Genomic View for MIR1248 Gene

Genes around MIR1248 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1248 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1248 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1248 Gene

Proteins for MIR1248 Gene

Post-translational modifications for MIR1248 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1248 Gene

Domains & Families for MIR1248 Gene

Gene Families for MIR1248 Gene

HGNC:
genes like me logo Genes that share domains with MIR1248: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1248 Gene

Function for MIR1248 Gene

Phenotypes From GWAS Catalog for MIR1248 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1248 Gene

Localization for MIR1248 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1248 Gene

Pathways & Interactions for MIR1248 Gene

genes like me logo Genes that share pathways with MIR1248: view
;

Gene Ontology (GO) - Biological Process for MIR1248 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1248 Gene

Drugs & Compounds for MIR1248 Gene

No Compound Related Data Available

Transcripts for MIR1248 Gene

mRNA/cDNA for MIR1248 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
3 ENA transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1248 Gene

No ASD Table

Relevant External Links for MIR1248 Gene

GeneLoc Exon Structure for
MIR1248

Expression for MIR1248 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1248 Gene

genes like me logo Genes that share expression patterns with MIR1248: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1248 Gene

Orthologs for MIR1248 Gene

Evolution for MIR1248 Gene

ENSEMBL:
Gene Tree for MIR1248 (if available)
TreeFam:
Gene Tree for MIR1248 (if available)

No data available for Orthologs for MIR1248 Gene

Paralogs for MIR1248 Gene

No data available for Paralogs for MIR1248 Gene

Variants for MIR1248 Gene

Additional dbSNP identifiers (rs#s) for MIR1248 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1248 Gene

Variant ID Type Subtype PubMed ID
dgv5005n100 CNV gain 25217958
esv2759206 CNV loss 17122850
esv34136 CNV loss 18971310
esv3893839 CNV gain 25118596
nsv1012615 CNV gain 25217958

Additional Variant Information for MIR1248 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1248

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1248 Gene

Disorders for MIR1248 Gene

Additional Disease Information for MIR1248

No disorders were found for MIR1248 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1248 Gene

Publications for MIR1248 Gene

  1. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 54
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 54
  3. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3 54
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR1248 Gene

Sources for MIR1248 Gene