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Aliases for MIR1247 Gene

Subcategory (RNA class) for MIR1247 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1247 Gene

  • MicroRNA 1247 2 3 5
  • Hsa-Mir-1247 3
  • Mir-1247 3
  • MIRN1247 3

External Ids for MIR1247 Gene

Previous HGNC Symbols for MIR1247 Gene

  • MIRN1247

Previous GeneCards Identifiers for MIR1247 Gene

  • GC00U923082
  • GC14M101097
  • GC14M102026

Summaries for MIR1247 Gene

Entrez Gene Summary for MIR1247 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1247 Gene

MIR1247 (MicroRNA 1247) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1247 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1247 Gene

Genomics for MIR1247 Gene

GeneHancer (GH) Regulatory Elements for MIR1247 Gene

Promoters and enhancers for MIR1247 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I101561 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 -1.0 -955 0.2 RING1 MAZ SP3 L3MBTL2 SP2 ZBTB8A ZFHX2 GLIS2 ZBTB48 POLR2A DIO3 DIO3OS GC14P103152 MIR1247 GC14P103292
GH14I101559 Enhancer 0.6 ENCODE 550.8 +0.5 512 1.8 CTCF ZNF449 SUZ12 ZSCAN4 RAD21 ZNF335 NFATC1 EZH2 DIO3 MIR1247 DIO3OS LOC105370674 GC14P103292
GH14I100769 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 9.7 +784.8 784804 12.7 HDGF PKNOX1 SMAD1 ATF1 FOXA2 ARNT ZNF48 NCOA2 TCF12 ZNF766 DLK1 MIR1247 DIO3 EVL MEG3 PIR41786
GH14I101628 Enhancer 1.1 Ensembl ENCODE 10.7 -68.2 -68200 1.2 RB1 SIN3A ZNF2 THRB ZNF48 RAD21 RARA ZNF335 ARID2 ZNF143 MIR1247 DIO3 ENSG00000258919 LOC105370675 LINC02320
GH14I101405 Enhancer 0.7 ENCODE 10.4 +154.8 154783 0.3 FOXA2 NFIB MAX RAD21 ZBTB40 YY1 HNF4G RXRA USF2 CEBPB MIR1247 DIO3 ENSG00000222185 ENSG00000222095 SNORD114-31 MIR493 MIR337 MIR127 MIR136 MIR431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR1247 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1247 Gene

Genomic Locations for MIR1247 Gene
chr14:101,560,287-101,560,422
(GRCh38/hg38)
Size:
136 bases
Orientation:
Minus strand
chr14:102,018,558-102,026,768
(GRCh37/hg19)

Genomic View for MIR1247 Gene

Genes around MIR1247 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1247 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1247 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1247 Gene

Proteins for MIR1247 Gene

Post-translational modifications for MIR1247 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1247 Gene

Domains & Families for MIR1247 Gene

Gene Families for MIR1247 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1247: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1247 Gene

Function for MIR1247 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1247 Gene

Localization for MIR1247 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1247 Gene

Pathways & Interactions for MIR1247 Gene

SuperPathways for MIR1247 Gene

No Data Available

Interacting Proteins for MIR1247 Gene

Gene Ontology (GO) - Biological Process for MIR1247 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1247 Gene

Drugs & Compounds for MIR1247 Gene

No Compound Related Data Available

Transcripts for MIR1247 Gene

mRNA/cDNA for MIR1247 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1247 Gene

No ASD Table

Relevant External Links for MIR1247 Gene

GeneLoc Exon Structure for
MIR1247
ECgene alternative splicing isoforms for
MIR1247

Expression for MIR1247 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1247 Gene:

MIR1247
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1247 Gene

Orthologs for MIR1247 Gene

Evolution for MIR1247 Gene

ENSEMBL:
Gene Tree for MIR1247 (if available)
TreeFam:
Gene Tree for MIR1247 (if available)

No data available for Orthologs for MIR1247 Gene

Paralogs for MIR1247 Gene

No data available for Paralogs for MIR1247 Gene

Variants for MIR1247 Gene

Sequence variations from dbSNP and Humsavar for MIR1247 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001107414 -- 101,560,676(-) G/T upstream_transcript_variant
rs1001117243 -- 101,560,810(-) C/A upstream_transcript_variant
rs1002469076 -- 101,560,554(-) C/A upstream_transcript_variant
rs1002624007 -- 101,560,891(-) A/G upstream_transcript_variant
rs1003043577 -- 101,561,075(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1247 Gene

Variant ID Type Subtype PubMed ID
dgv1978n100 CNV gain 25217958
dgv388n67 CNV gain 20364138
esv29376 CNV loss 19812545
nsv1047869 CNV gain 25217958
nsv565879 CNV loss 21841781
nsv565880 CNV loss 21841781
nsv565881 CNV gain+loss 21841781
nsv565882 CNV loss 21841781
nsv827060 CNV gain 20364138
nsv827061 CNV gain 20364138
nsv952247 CNV deletion 24416366

Additional Variant Information for MIR1247 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1247

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1247 Gene

Disorders for MIR1247 Gene

Additional Disease Information for MIR1247

No disorders were found for MIR1247 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1247 Gene

Publications for MIR1247 Gene

  1. MiRNA profile of osteosarcoma with CD117 and stro-1 expression: miR-1247 functions as an onco-miRNA by targeting MAP3K9. (PMID: 25973030) Zhao F … Chen Y (International journal of clinical and experimental pathology 2015) 3 58
  2. MiR-1247-5p is overexpressed in castration resistant prostate cancer and targets MYCBP2. (PMID: 25731699) Scaravilli M … Visakorpi T (The Prostate 2015) 3 58
  3. Epigenetically regulated MIR941 and MIR1247 target gastric cancer cell growth and migration. (PMID: 24785261) Kim JG … Yi JM (Epigenetics 2014) 3 58
  4. miR-1247 functions by targeting cartilage transcription factor SOX9. (PMID: 24014021) Martinez-Sanchez A … Murphy CL (The Journal of biological chemistry 2013) 3 58
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58

Products for MIR1247 Gene

Sources for MIR1247 Gene

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