microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR124-3 Gene

Subcategory (RNA class) for MIR124-3 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR124-3 Gene

  • MicroRNA 124-3 2 3 5
  • MicroRNA 124a-3 2 3
  • Hsa-Mir-124a-3 2 3
  • Hsa-MiR-124-3p 163 173
  • Hsa-MiR-124-5p 163 173
  • Hsa-Mir-124-3 2 3
  • MIR124-3 2 5
  • Hsa-Mir-124-P3-V2 178
  • Hsa-Mir-124-P3-V1 178
  • MIMAT0004591 50
  • MIMAT0000422 50
  • MIRN124-3 3
  • MIRN124A3 3
  • Mir-124-3 3
  • MI0000445 50
  • RF00239 168

External Ids for MIR124-3 Gene

Previous HGNC Symbols for MIR124-3 Gene

  • MIRN124A3
  • MIRN124-3

Previous GeneCards Identifiers for MIR124-3 Gene

  • GC20P061284
  • GC20P061812
  • GC20P063179

Summaries for MIR124-3 Gene

Entrez Gene Summary for MIR124-3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-3 Gene

MIR124-3 (MicroRNA 124-3) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR124-3 include Breast Cancer and Pediatric Ependymoma. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR124-3 Gene

  • mir-124 microRNA precursor family

Additional gene information for MIR124-3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR124-3 Gene

Genomics for MIR124-3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR124-3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J063177 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 600.7 -0.1 -69 2.6 CREB1 CTCF ATF7 TEAD4 PRDM10 ZNF692 BACH1 TARDBP LARP7 ZNF143 MIR124-3 RF00239-001 ARFRP1 TNFRSF6B BIRC7 CHRNA4 ENSG00000231977 RTEL1 KCNQ2 ZBTB46
GH20J063180 Promoter 0.6 Ensembl 600.7 +1.4 1401 0.2 CTCF ZBTB17 HIC1 ZNF366 ENSG00000231977 MIR124-3 RF00239-001 YTHDF1 BHLHE23
GH20J063179 Enhancer 0.5 ENCODE 600.7 +1.3 1264 0 CTCF RAD21 ZBTB17 HIC1 ZNF366 ENSG00000231977 MIR124-3 RF00239-001 YTHDF1 BHLHE23
GH20J063252 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 11.4 +75.7 75668 2.3 EZH2 ZNF600 ZBTB20 SP2 CTCF ZBTB26 POLR2A ZNF143 SMARCA4 ATF2 NKAIN4 FLJ16779 BIRC7 COL20A1 RNU6-994P ENSG00000231977 MIR124-3
GH20J063260 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 11.4 +82.9 82900 3.6 GATAD2A ZIC2 CEBPA TCF7 ZBTB17 MBD1 ZFHX2 SAP130 POLR2A SMAD4 BIRC7 DIDO1 MIR647 UCKL1 NKAIN4 ENSG00000237371 COL20A1 RNU6-994P ENSG00000231977 MIR124-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR124-3 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR124-3 Gene

Genomic Locations for MIR124-3 Gene
chr20:63,178,500-63,178,586
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr20:61,809,852-61,809,938
(GRCh37/hg19)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR124-3 Gene

Genes around MIR124-3 on UCSC Golden Path with GeneCards custom track
MIR124-3 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR124-3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-3 Gene

Proteins for MIR124-3 Gene

Post-translational modifications for MIR124-3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-3 Gene

Domains & Families for MIR124-3 Gene

Gene Families for MIR124-3 Gene

genes like me logo Genes that share domains with MIR124-3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR124-3 Gene

Function for MIR124-3 Gene

Phenotypes From GWAS Catalog for MIR124-3 Gene

Gene Ontology (GO) - Molecular Function for MIR124-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008035 high-density lipoprotein particle binding ISS --
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIR124-3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR124-3 Gene

Localization for MIR124-3 Gene

Gene Ontology (GO) - Cellular Components for MIR124-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane ISS --
GO:0070062 extracellular exosome ISS --
genes like me logo Genes that share ontologies with MIR124-3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR124-3 Gene

Pathways & Interactions for MIR124-3 Gene

PathCards logo

SuperPathways for MIR124-3 Gene

genes like me logo Genes that share pathways with MIR124-3: view

Pathways by source for MIR124-3 Gene

1 BioSystems pathway for MIR124-3 Gene
1 KEGG pathway for MIR124-3 Gene

Gene Ontology (GO) - Biological Process for MIR124-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA --
GO:0010764 negative regulation of fibroblast migration IDA --
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA --
GO:0035308 negative regulation of protein dephosphorylation IDA --
genes like me logo Genes that share ontologies with MIR124-3: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR124-3 Gene

Drugs & Compounds for MIR124-3 Gene

No Compound Related Data Available

Transcripts for MIR124-3 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR124-3 Gene

MIR124-3 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR124-3 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-3 Gene

No ASD Table

Relevant External Links for MIR124-3 Gene

GeneLoc Exon Structure for
MIR124-3

Expression for MIR124-3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR124-3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR124-3

genes like me logo Genes that share expression patterns with MIR124-3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR124-3 Gene

Orthologs for MIR124-3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR124-3 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia bta-mir-124b 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-124a-3 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir124a-3 31
  • 100 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-124a-2 31
  • 81 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-124a-3 31
  • 79 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-124-2 31
  • 86 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-124-2 31
  • 53 (a)
ManyToMany
csa-mir-124-1 31
  • 48 (a)
ManyToMany
Species where no ortholog for MIR124-3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR124-3 Gene

ENSEMBL:
Gene Tree for MIR124-3 (if available)
TreeFam:
Gene Tree for MIR124-3 (if available)

Paralogs for MIR124-3 Gene

No data available for Paralogs for MIR124-3 Gene

Variants for MIR124-3 Gene

Additional dbSNP identifiers (rs#s) for MIR124-3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR124-3 Gene

Variant ID Type Subtype PubMed ID
dgv519n27 CNV loss 19166990
dgv68n68 CNV loss 17160897
dgv7664n54 CNV loss 21841781
nsv834031 CNV loss 17160897
nsv953306 CNV deletion 24416366
nsv9825 CNV gain 18304495

Additional Variant Information for MIR124-3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR124-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR124-3 Gene

Disorders for MIR124-3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR124-3 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
pediatric ependymoma
  • childhood ependymoma
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR124-3

genes like me logo Genes that share disorders with MIR124-3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR124-3 Gene

Publications for MIR124-3 Gene

  1. Histone deacetylases up-regulate C/EBPα expression through reduction of miR-124-3p and miR-25 in hepatocellular carcinoma. (PMID: 31092334) Hu XX … Lu GD (Biochemical and biophysical research communications 2019) 3
  2. Targeting EphA2 with miR-124 mediates Erlotinib resistance in K-RAS mutated pancreatic cancer. (PMID: 30604411) Du J … Han Y (The Journal of pharmacy and pharmacology 2019) 3
  3. Hypermethylation-mediated inactivation of miR-124 predicts poor prognosis and promotes tumor growth at least partially through targeting EZH2/H3K27me3 in ESCC. (PMID: 31197517) Tian Z … Wang G (Clinical & experimental metastasis 2019) 3
  4. MicroRNA-124-3p suppresses cell migration and invasion by targeting ITGA3 signaling in bladder cancer. (PMID: 30614803) Wang JR … Huang YX (Cancer biomarkers : section A of Disease markers 2019) 3
  5. Long non‑coding RNA MALAT1 sponges miR‑124‑3p.1/KLF5 to promote pulmonary vascular remodeling and cell cycle progression of pulmonary artery hypertension. (PMID: 31257528) Wang D … Chen J (International journal of molecular medicine 2019) 3

Products for MIR124-3 Gene

Sources for MIR124-3 Gene