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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR124-2 (MicroRNA 124-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR124-2 include Hepatocellular Carcinoma. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08J064381 | Promoter/Enhancer | 1.3 | EPDnew Ensembl ENCODE dbSUPER | 600.7 | -1.8 | -1770 | 0.5 | CREB1 POLR2A RAD21 SIN3A ATF2 EZH2 | MIR124-2 MIR124-2HG RF00239-002 BHLHE22 | |
GH08J064377 | Promoter/Enhancer | 1 | Ensembl ENCODE dbSUPER | 600.7 | -1.1 | -1106 | 0.7 | POLR2A EZH2 YY1 ZNF143 SMARCA4 TBP EGR1 | MIR124-2 RF00239-002 MIR124-2HG BHLHE22 | |
GH08J064372 | Promoter/Enhancer | 1.6 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 0.7 | -4.8 | -4795 | 4.1 | REST POLR2A EZH2 RAD21 MAFF MAFK YY1 ETS1 SIN3A CBX8 | MIR124-2HG BHLHE22 MIR124-2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008035 | high-density lipoprotein particle binding | ISS | -- |
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | ISS | -- |
GO:0005886 | plasma membrane | ISS | -- |
GO:0070062 | extracellular exosome | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Alzheimers Disease |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010629 | negative regulation of gene expression | IDA | -- |
GO:0010764 | negative regulation of fibroblast migration | IDA | -- |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0035278 | miRNA mediated inhibition of translation | IDA | -- |
GO:0035308 | negative regulation of protein dephosphorylation | IDA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00003AA409_9606 | miRNA | 22 | 6 |
RefSeq: NR_029668, NR_029669, NR_029670, LncBase: hsa-miR-124-5p, miRBase: MIMAT0004591, MirGeneDB: Hsa-Mir-124-P1-v1_5p, Hsa-Mir-124-P2-v1_5p, Hsa-Mir-124-P3-v1_5p, TarBase: hsa-miR-124-5p, ENA: AY940852.1:1..22:ncRNA, LM608483.1:14..35:ncRNA, LM608484.1:25..46:ncRNA, LM608485.1:15..36:ncRNA, |
URS000023AB58_9606 | precursor_RNA | 109 | 5 |
HGNC: 31503, RefSeq: NR_029669, Ensembl: ENST00000385081 (view in UCSC) , miRBase: MI0000444, |
URS00000ADB79_9606 | miRNA | 22 | 3 |
RefSeq: NR_029668, NR_029669, NR_029670, miRBase: MIMAT0000422, MirGeneDB: Hsa-Mir-124-P1-v1_3p, Hsa-Mir-124-P2-v1_3p, Hsa-Mir-124-P3-v1_3p, |
URS000020BE6A_9606 | miRNA | 20 | 3 |
LncBase: hsa-miR-124-3p, TarBase: hsa-miR-124-3p, ENA: LM379040.1:1..20:ncRNA, LM608483.1:53..72:ncRNA, LM608484.1:62..81:ncRNA, LM608485.1:53..72:ncRNA, |
URS00006A7236_9606 | precursor_RNA | 80 | 1 |
Rfam: RF00239, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-124a 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-124-2 31 |
|
OneToMany | |
cfa-mir-124-3 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Mir124a-2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-124a-2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-124a-2 31 |
|
ManyToMany | |
Cow (Bos Taurus) |
Mammalia | bta-mir-124a-2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-124c 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-124-5 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-mir-124-2 31 |
|
ManyToMany | |
csa-mir-124-1 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatocellular carcinoma |
|