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MIR124-2 Gene(RNA Gene)

MicroRNA 124-2

GCID:
GC08P064379
GIFtS:
17
Genes Participants
UDN Logo

Aliases for MIR124-2 Gene

Subcategory (RNA class) for MIR124-2 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR124-2 Gene

  • MicroRNA 124-2 2 3 5
  • MicroRNA 124a-2 2 3
  • Hsa-Mir-124a-2 3
  • Hsa-Mir-124-2 3
  • Mir-124-2 3
  • MIRN124-2 3
  • MIRN124A2 3

External Ids for MIR124-2 Gene

Previous HGNC Symbols for MIR124-2 Gene

  • MIRN124A2
  • MIRN124-2

Previous GeneCards Identifiers for MIR124-2 Gene

  • GC08P065458
  • GC08P065291

Summaries for MIR124-2 Gene

Entrez Gene Summary for MIR124-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-2 Gene

MIR124-2 (MicroRNA 124-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

Additional gene information for MIR124-2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR124-2 Gene

Genomics for MIR124-2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR124-2 Gene

Promoters and enhancers for MIR124-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08I064382 Enhancer 0.7 ENCODE dbSUPER 550.8 -0.9 -870 0.2 POLR2A ZNF143 CTBP2 REST EZH2 MIR124-2 MIR124-2HG
GH08I064380 Enhancer 0.7 ENCODE dbSUPER 550.8 -1.0 -970 0 ZNF143 CTBP2 REST EZH2 MIR124-2 MIR124-2HG
GH08I064377 Enhancer 0.6 ENCODE dbSUPER 550.8 -1.4 -1390 0.2 RING1 POLR2A MIR124-2 MIR124-2HG
GH08I064381 Enhancer 0.6 ENCODE dbSUPER 550.8 -1.9 -1930 0.2 POLR2A CREB1 ATF2 MIR124-2 MIR124-2HG
GH08I064379 Enhancer 0.6 ENCODE dbSUPER 550.8 -1.1 -1140 0.2 RING1 POLR2A EZH2 MIR124-2 MIR124-2HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR124-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR124-2 Gene

Genomic Locations for MIR124-2 Gene
chr8:64,379,149-64,379,257
(GRCh38/hg38)
Size:
109 bases
Orientation:
Plus strand
chr8:65,291,706-65,291,814
(GRCh37/hg19)

Genomic View for MIR124-2 Gene

Genes around MIR124-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR124-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR124-2 Gene

Proteins for MIR124-2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR124-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-2 Gene

Domains & Families for MIR124-2 Gene

Gene Families for MIR124-2 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR124-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR124-2 Gene

Function for MIR124-2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA for MIR124-2 Gene

miRTarBase miRNAs that target MIR124-2

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR124-2 Gene

Localization for MIR124-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR124-2 Gene

Pathways & Interactions for MIR124-2 Gene

genes like me logo Genes that share pathways with MIR124-2: view

Pathways by source for MIR124-2 Gene

1 BioSystems pathway for MIR124-2 Gene
1 KEGG pathway for MIR124-2 Gene

Interacting Proteins for MIR124-2 Gene

Gene Ontology (GO) - Biological Process for MIR124-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 24122720
GO:0010764 negative regulation of fibroblast migration IDA 24122720
GO:0035195 gene silencing by miRNA IDA 24122720
GO:0048147 negative regulation of fibroblast proliferation IDA 24122720
genes like me logo Genes that share ontologies with MIR124-2: view

No data available for SIGNOR curated interactions for MIR124-2 Gene

Drugs & Compounds for MIR124-2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR124-2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR124-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-2 Gene

No ASD Table

Relevant External Links for MIR124-2 Gene

GeneLoc Exon Structure for
MIR124-2
ECgene alternative splicing isoforms for
MIR124-2

Expression for MIR124-2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR124-2 Gene

mRNA expression in normal human tissues for MIR124-2 Gene
mRNA expression by GTEx for MIR124-2 Gene
genes like me logo Genes that share expression patterns with MIR124-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR124-2 Gene

Orthologs for MIR124-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR124-2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia cfa-mir-124-2 34
  • 100 (a)
 OneToMany
cfa-mir-124-3 34
  • 98 (a)
 OneToMany
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-124a 34
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir124a-2 34
  • 98 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-124a-2 34
  • 87 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-124a-2 34
  • 81 (a)
 ManyToMany
cow
(Bos Taurus)
 Mammalia bta-mir-124a-2 34
  • 77 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-mir-124c 34
  • 64 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 100 (a)
 OneToMany
-- 34
  • 98 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-124-5 34
  • 61 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea csa-mir-124-1 34
  • 53 (a)
 ManyToMany
csa-mir-124-2 34
  • 53 (a)
 ManyToMany
Species where no ortholog for MIR124-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR124-2 Gene

ENSEMBL:
Gene Tree for MIR124-2 (if available)
TreeFam:
Gene Tree for MIR124-2 (if available)

Paralogs for MIR124-2 Gene

No data available for Paralogs for MIR124-2 Gene

Variants for MIR124-2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR124-2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000037419 -- 64,377,557(+) G/A/T upstream_transcript_variant
rs1003143006 -- 64,378,478(+) G/A upstream_transcript_variant
rs1003449461 -- 64,379,689(+) C/A downstream_transcript_variant
rs1003653099 -- 64,378,703(+) A/G upstream_transcript_variant
rs1004840270 -- 64,378,081(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR124-2 Gene

Variant ID Type Subtype PubMed ID
nsv523097 CNV loss 19592680

Additional Variant Information for MIR124-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR124-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR124-2 Gene

Disorders for MIR124-2 Gene

Additional Disease Information for MIR124-2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR124-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR124-2 Gene

Publications for MIR124-2 Gene

  1. MicroRNA-124 upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1. (PMID: 27743351) Zhou Y … Jia X (Human cell 2017) 3 58
  2. Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells. (PMID: 27889233) Jin L … Han X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 58
  3. miR-124 suppresses glioblastoma growth and potentiates chemosensitivity by inhibiting AURKA. (PMID: 28242198) Qiao W … Dong B (Biochemical and biophysical research communications 2017) 3 58
  4. A MicroRNA-124 Polymorphism is Associated with Fracture Healing via Modulating BMP6 Expression. (PMID: 28441666) Zou L … Cai J (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  5. MicroRNA-124 controls human vascular smooth muscle cell phenotypic switch via Sp1. (PMID: 28667053) Tang Y … Xu Z (American journal of physiology. Heart and circulatory physiology 2017) 3 58

Products for MIR124-2 Gene

Sources for MIR124-2 Gene

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