microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR124-2 Gene

Subcategory (RNA class) for MIR124-2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR124-2 Gene

  • MicroRNA 124-2 2 3 5
  • MicroRNA 124a-2 2 3
  • Hsa-Mir-124a-2 2 3
  • Hsa-MiR-124-3p 163 173
  • Hsa-MiR-124-5p 163 173
  • Hsa-Mir-124-2 2 3
  • MIR124-2 2 5
  • Hsa-Mir-124-P2-V2 178
  • Hsa-Mir-124-P2-V1 178
  • MIMAT0000422 50
  • MIMAT0004591 50
  • MIRN124-2 3
  • MIRN124A2 3
  • Mir-124-2 3
  • MI0000444 50
  • RF00239 168

External Ids for MIR124-2 Gene

Previous HGNC Symbols for MIR124-2 Gene

  • MIRN124A2
  • MIRN124-2

Previous GeneCards Identifiers for MIR124-2 Gene

  • GC08P065458
  • GC08P065291

Summaries for MIR124-2 Gene

Entrez Gene Summary for MIR124-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-2 Gene

MIR124-2 (MicroRNA 124-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR124-2 include Hepatocellular Carcinoma. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR124-2 Gene

  • mir-124 microRNA precursor family

Additional gene information for MIR124-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR124-2 Gene

Genomics for MIR124-2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR124-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J064381 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 600.7 -1.8 -1770 0.5 CREB1 POLR2A RAD21 SIN3A ATF2 EZH2 MIR124-2 MIR124-2HG RF00239-002 BHLHE22
GH08J064377 Promoter/Enhancer 1 Ensembl ENCODE dbSUPER 600.7 -1.1 -1106 0.7 POLR2A EZH2 YY1 ZNF143 SMARCA4 TBP EGR1 MIR124-2 RF00239-002 MIR124-2HG BHLHE22
GH08J064372 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.7 -4.8 -4795 4.1 REST POLR2A EZH2 RAD21 MAFF MAFK YY1 ETS1 SIN3A CBX8 MIR124-2HG BHLHE22 MIR124-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR124-2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR124-2 Gene

Genomic Locations for MIR124-2 Gene
chr8:64,379,149-64,379,257
(GRCh38/hg38)
Size:
109 bases
Orientation:
Plus strand
chr8:65,291,706-65,291,814
(GRCh37/hg19)
Size:
109 bases
Orientation:
Plus strand

Genomic View for MIR124-2 Gene

Genes around MIR124-2 on UCSC Golden Path with GeneCards custom track
MIR124-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR124-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-2 Gene

Proteins for MIR124-2 Gene

Post-translational modifications for MIR124-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-2 Gene

Domains & Families for MIR124-2 Gene

Gene Families for MIR124-2 Gene

genes like me logo Genes that share domains with MIR124-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR124-2 Gene

Function for MIR124-2 Gene

Phenotypes From GWAS Catalog for MIR124-2 Gene

Gene Ontology (GO) - Molecular Function for MIR124-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008035 high-density lipoprotein particle binding ISS --
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIR124-2: view

Animal Model Products

CRISPR Products

miRNA for MIR124-2 Gene

miRTarBase miRNAs that target MIR124-2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR124-2 Gene

Localization for MIR124-2 Gene

Gene Ontology (GO) - Cellular Components for MIR124-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane ISS --
GO:0070062 extracellular exosome ISS --
genes like me logo Genes that share ontologies with MIR124-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR124-2 Gene

Pathways & Interactions for MIR124-2 Gene

PathCards logo

SuperPathways for MIR124-2 Gene

genes like me logo Genes that share pathways with MIR124-2: view

Pathways by source for MIR124-2 Gene

1 BioSystems pathway for MIR124-2 Gene
1 KEGG pathway for MIR124-2 Gene

Gene Ontology (GO) - Biological Process for MIR124-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA --
GO:0010764 negative regulation of fibroblast migration IDA --
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA --
GO:0035308 negative regulation of protein dephosphorylation IDA --
genes like me logo Genes that share ontologies with MIR124-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR124-2 Gene

Drugs & Compounds for MIR124-2 Gene

No Compound Related Data Available

Transcripts for MIR124-2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR124-2 Gene

MIR124-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR124-2 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-2 Gene

No ASD Table

Relevant External Links for MIR124-2 Gene

GeneLoc Exon Structure for
MIR124-2

Expression for MIR124-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR124-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR124-2

genes like me logo Genes that share expression patterns with MIR124-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR124-2 Gene

Orthologs for MIR124-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR124-2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-124a 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-124-2 31
  • 100 (a)
OneToMany
cfa-mir-124-3 31
  • 98 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Mir124a-2 31
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-124a-2 31
  • 87 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-124a-2 31
  • 81 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia bta-mir-124a-2 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-124c 31
  • 64 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 100 (a)
OneToMany
-- 31
  • 98 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-124-5 31
  • 61 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-124-2 31
  • 53 (a)
ManyToMany
csa-mir-124-1 31
  • 53 (a)
ManyToMany
Species where no ortholog for MIR124-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR124-2 Gene

ENSEMBL:
Gene Tree for MIR124-2 (if available)
TreeFam:
Gene Tree for MIR124-2 (if available)

Paralogs for MIR124-2 Gene

No data available for Paralogs for MIR124-2 Gene

Variants for MIR124-2 Gene

Additional dbSNP identifiers (rs#s) for MIR124-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR124-2 Gene

Variant ID Type Subtype PubMed ID
nsv523097 CNV loss 19592680

Additional Variant Information for MIR124-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR124-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR124-2 Gene

Disorders for MIR124-2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR124-2 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR124-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR124-2 Gene

Publications for MIR124-2 Gene

  1. Targeting EphA2 with miR-124 mediates Erlotinib resistance in K-RAS mutated pancreatic cancer. (PMID: 30604411) Du J … Han Y (The Journal of pharmacy and pharmacology 2019) 3
  2. UHRF1 is regulated by miR-124-3p and promotes cell proliferation in intrahepatic cholangiocarcinoma. (PMID: 30989656) Zhu M … Liu B (Journal of cellular physiology 2019) 3
  3. Role of MicroRNA-124 as a Prognostic Factor in Multiple Neoplasms: A Meta-Analysis. (PMID: 31885731) Zhou Z … Li P (Disease markers 2019) 3
  4. Mutual inhibitions between epidermal growth factor receptor signaling and miR-124a control pancreatic progenitor proliferation. (PMID: 30537082) Zhang Z … Teng CB (Journal of cellular physiology 2019) 3
  5. NEAT1/miR‑124/STAT3 feedback loop promotes breast cancer progression. (PMID: 31322202) Pang Y … Yang G (International journal of oncology 2019) 3

Products for MIR124-2 Gene

Sources for MIR124-2 Gene