microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR124-1 Gene

Subcategory (RNA class) for MIR124-1 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR124-1 Gene

  • MicroRNA 124-1 2 3 5
  • MicroRNA 124a-1 2 3
  • Hsa-MiR-124-3p 166 177
  • Hsa-MiR-124-5p 166 177
  • Hsa-Mir-124a-1 3
  • Hsa-Mir-124-1 3
  • MIMAT0000422 51
  • MIMAT0004591 51
  • Mir-124-1 3
  • MIRN124-1 3
  • MIRN124A1 3
  • MI0000443 51
  • MIR124A1 3
  • MIR124-1 2
  • MIR124A 3
  • RF00239 172

External Ids for MIR124-1 Gene

Additional External Ids for MIR124-1 Gene

Previous HGNC Symbols for MIR124-1 Gene

  • MIRN124A1
  • MIRN124-1

Previous GeneCards Identifiers for MIR124-1 Gene

  • GC08M009803
  • GC08M009760
  • GC08M009904
  • GC08M009901

Summaries for MIR124-1 Gene

Entrez Gene Summary for MIR124-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-1 Gene

MIR124-1 (MicroRNA 124-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR124-1 include Lung Cancer and Cocaine Dependence. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

Rfam classification for MIR124-1 Gene

  • mir-124 microRNA precursor family

Additional gene information for MIR124-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR124-1 Gene

Genomics for MIR124-1 Gene

GeneHancer (GH) Regulatory Elements for MIR124-1 Gene

Promoters and enhancers for MIR124-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J009902 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 500.7 -1.6 -1572 4.9 ZBTB10 ZBTB26 EZH2 ZEB1 HDAC2 MXI1 ZNF341 POLR2A CREB1 SP2 LINC00599 MIR124-1 MSRA RPL10P19
GH08J009903 Enhancer 0.6 ENCODE dbSUPER 500.7 +1.2 1206 0.2 ZNF341 POLR2A SMARCA4 SUZ12 MIR124-1 LINC00599 piR-40110-642
GH08J009901 Enhancer 0.4 dbSUPER 500.7 +1.7 1664 0.7 ZNF341 POLR2A EZH2 MIR124-1 RPL10P19 LINC00599 piR-40110-642
GH08J010279 Enhancer 0.8 Ensembl ENCODE 9.9 -376.4 -376429 1 EP300 JUND FOS ATF2 CEBPG CEBPB ATF4 BHLHE40 ZBTB21 ATF3 ENSG00000285606 MSRA MIR124-1 LINC00599 ENSG00000269918 lnc-PRSS55-4
GH08J010273 Enhancer 0.6 Ensembl 9.9 -370.6 -370601 0.5 CTCF ZNF10 RAD21 MYC TRIM22 DEK SMC3 YY1 TCF12 ELF1 MSRA LINC00599 MIR124-1 ENSG00000285606 piR-57460-625
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR124-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR124-1 Gene

Genomic Locations for MIR124-1 Gene
chr8:9,903,388-9,903,472
(GRCh38/hg38)
Size:
85 bases
Orientation:
Minus strand
chr8:9,757,574-9,762,876
(GRCh37/hg19)
Size:
5,303 bases
Orientation:
Minus strand

Genomic View for MIR124-1 Gene

Genes around MIR124-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR124-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-1 Gene

Proteins for MIR124-1 Gene

Post-translational modifications for MIR124-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-1 Gene

Domains & Families for MIR124-1 Gene

Gene Families for MIR124-1 Gene

genes like me logo Genes that share domains with MIR124-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR124-1 Gene

Function for MIR124-1 Gene

Phenotypes From GWAS Catalog for MIR124-1 Gene

Gene Ontology (GO) - Molecular Function for MIR124-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008035 high-density lipoprotein particle binding ISS --
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIR124-1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR124-1 Gene

Localization for MIR124-1 Gene

Gene Ontology (GO) - Cellular Components for MIR124-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0070062 extracellular exosome ISS --
genes like me logo Genes that share ontologies with MIR124-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR124-1 Gene

Pathways & Interactions for MIR124-1 Gene

genes like me logo Genes that share pathways with MIR124-1: view

Pathways by source for MIR124-1 Gene

1 BioSystems pathway for MIR124-1 Gene
1 KEGG pathway for MIR124-1 Gene
;

Gene Ontology (GO) - Biological Process for MIR124-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA --
GO:0010764 negative regulation of fibroblast migration IDA --
GO:0035195 gene silencing by miRNA IDA --
GO:0035278 miRNA mediated inhibition of translation IDA --
GO:0035308 negative regulation of protein dephosphorylation IDA --
genes like me logo Genes that share ontologies with MIR124-1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR124-1 Gene

Drugs & Compounds for MIR124-1 Gene

No Compound Related Data Available

Transcripts for MIR124-1 Gene

mRNA/cDNA for MIR124-1 Gene

5 RNACentral transcripts :
3 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
9 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-1 Gene

No ASD Table

Relevant External Links for MIR124-1 Gene

GeneLoc Exon Structure for
MIR124-1

Expression for MIR124-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR124-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR124-1

genes like me logo Genes that share expression patterns with MIR124-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR124-1 Gene

Orthologs for MIR124-1 Gene

Evolution for MIR124-1 Gene

ENSEMBL:
Gene Tree for MIR124-1 (if available)
TreeFam:
Gene Tree for MIR124-1 (if available)

No data available for Orthologs for MIR124-1 Gene

Paralogs for MIR124-1 Gene

No data available for Paralogs for MIR124-1 Gene

Variants for MIR124-1 Gene

Additional dbSNP identifiers (rs#s) for MIR124-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR124-1 Gene

Variant ID Type Subtype PubMed ID
nsv951098 CNV deletion 24416366

Additional Variant Information for MIR124-1 Gene

Human Gene Mutation Database (HGMD)
MIR124-1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR124-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR124-1 Gene

Disorders for MIR124-1 Gene

MalaCards: The human disease database

(40) MalaCards diseases for MIR124-1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
cocaine dependence
central nervous system cancer
  • central nervous system tumor
temporal lobe epilepsy
  • epilepsy, temporal lobe
nervous system cancer
  • malignant neoplasm of nervous system
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR124-1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR124-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR124-1 Gene

Publications for MIR124-1 Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 41 54
  2. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 41 54
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 41 54
  4. Targeting EphA2 with miR-124 mediates Erlotinib resistance in K-RAS mutated pancreatic cancer. (PMID: 30604411) Du J … Han Y (The Journal of pharmacy and pharmacology 2019) 3 54
  5. Dynamic changes in miR-124 levels in patients with acute cerebral infarction. (PMID: 30124350) Sun M … Cheng H (The International journal of neuroscience 2019) 3 54

Products for MIR124-1 Gene

Sources for MIR124-1 Gene