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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR1238 (MicroRNA 1238) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19J010551 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 600.7 | +1.8 | 1783 | 5.8 | CTCF POLR2A FOXA1 ZIC2 RBFOX2 PKNOX1 PATZ1 TCF12 ZNF600 ZNF341 | MIR1238 KRI1 CDKN2D SLC44A2 ILF3 AP1M2 RF00066-093 RNU7-140P lnc-CDKN2D-1 ATG4D | |
GH19J010514 | Promoter/Enhancer | 2 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 12 | -34.9 | -34906 | 5.2 | HNRNPL PRDM10 ZNF629 IKZF1 KDM1A ZIC2 ZSCAN4 PATZ1 ZNF501 EZH2 | S1PR5 LOC100419831 ILF3 KRI1 QTRT1 ATG4D ZNF846 CDKN2D SLC44A2 ZNF562 | |
GH19J010515 | Enhancer | 0.6 | ENCODE dbSUPER | 12 | -37.8 | -37802 | 0.2 | CTCF TEAD4 EZH2 ZBTB33 NRF1 POLR2A | lnc-KEAP1-1 ATG4D KRI1 CDKN2D MIR1238 RNU7-140P ILF3 SLC44A2 S1PR5 KEAP1 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075A0EE_9606 | precursor_RNA | 83 | 4 |
HGNC: 33933, RefSeq: NR_031603, Ensembl: ENST00000408483 (view in UCSC) , miRBase: MI0006328, |
URS000075EC66_9606 | miRNA | 23 | 2 |
RefSeq: NR_031603, miRBase: MIMAT0022947, |
URS000075E57E_9606 | miRNA | 20 | 2 |
RefSeq: NR_031603, miRBase: MIMAT0005593, |
No disorders were found for MIR1238 Gene.