microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1237 Gene

Data sources for MIR1237 Gene:

Subcategory (RNA class) for MIR1237 Gene

miRNA

Aliases for MIR1237 Gene

External Ids for MIR1237 Gene

Previous HGNC Symbols for MIR1237 Gene

  • MIRN1237

Previous GeneCards Identifiers for MIR1237 Gene

  • GC00U922958
  • GC11P063894
  • GC11P064136

Summaries for MIR1237 Gene

Entrez Gene Summary for MIR1237 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1237 Gene

MIR1237 (MicroRNA 1237) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1237 include Spinal Chordoma and Chordoma.

Rfam classification for MIR1237 Gene

Additional gene information for MIR1237 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1237 Gene

Genomics for MIR1237 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1237 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1237 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1237 Gene

Latest Assembly
chr11:64,368,602-64,368,703
(GRCh38/hg38)
Size:
102 bases
Orientation:
Plus strand

Previous Assembly
chr11:64,136,074-64,136,175
(GRCh37/hg19 by Entrez Gene)
Size:
102 bases
Orientation:
Plus strand

chr11:64,136,074-64,136,175
(GRCh37/hg19 by Ensembl)
Size:
102 bases
Orientation:
Plus strand

Genomic View for MIR1237 Gene

Genes around MIR1237 on UCSC Golden Path with GeneCards custom track
MIR1237 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR1237 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1237 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1237 Gene

Proteins for MIR1237 Gene

Post-translational modifications for MIR1237 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1237 Gene

Domains & Families for MIR1237 Gene

Gene Families for MIR1237 Gene

HGNC:
genes like me logo Genes that share domains with MIR1237: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1237 Gene

Function for MIR1237 Gene

Phenotypes From GWAS Catalog for MIR1237 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1237 Gene

Localization for MIR1237 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1237 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1237 Gene

Pathways & Interactions for MIR1237 Gene

PathCards logo

SuperPathways for MIR1237 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1237 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR1237: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1237 Gene

Drugs & Compounds for MIR1237 Gene

No Compound Related Data Available

Transcripts for MIR1237 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1237 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000063ACDB_9606 precursor_RNA 102 4

RefSeq: NR_031602,

Ensembl: ENST00000408346 (view in UCSC) ,

miRBase: MI0006327,

Rfam: RF02007,

URS000075A763_9606 miRNA 21 3

RefSeq: NR_031602,

miRBase: MIMAT0005592,

TarBase: hsa-miR-1237-3p,

URS00003E1F0B_9606 miRNA 21 2

RefSeq: NR_031602,

miRBase: MIMAT0022946,

MIR1237 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1237 Gene

No ASD Table

Relevant External Links for MIR1237 Gene

GeneLoc Exon Structure for
MIR1237

No data available for mRNA/cDNA for MIR1237 Gene

Expression for MIR1237 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1237 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1237

genes like me logo Genes that share expression patterns with MIR1237: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1237 Gene

Orthologs for MIR1237 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR1237 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1237 31
  • 100 (a)
OneToOne
Species where no ortholog for MIR1237 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR1237 Gene

ENSEMBL:
Gene Tree for MIR1237 (if available)
TreeFam:
Gene Tree for MIR1237 (if available)

Paralogs for MIR1237 Gene

No data available for Paralogs for MIR1237 Gene

Variants for MIR1237 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR1237 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR1237 Gene

Variant ID Type Subtype PubMed ID
nsv832186 CNV loss 17160897
nsv832187 CNV loss 17160897

Additional Variant Information for MIR1237 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1237

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1237 Gene

Disorders for MIR1237 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR1237 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
spinal chordoma
  • chordoma of spine
chordoma
  • chordoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1237

genes like me logo Genes that share disorders with MIR1237: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1237 Gene

Publications for MIR1237 Gene

  1. RPS6KA4/MIR1237 and AURKC promoter regions are differentially methylated in Wilms' tumor. (PMID: 28930610) Pereira HS … Seuanez HN (Frontiers in bioscience (Elite edition) 2018) 3
  2. Reduced expression of miRNA-1237-3p associated with poor survival of spinal chordoma patients. (PMID: 25850393) Zou MX … Deng YW (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2015) 3
  3. Epigenetically silenced microRNAs in gastric cancer: Functional analysis and identification of their target genes. (PMID: 26043902) Bae JH … Yi JM (Oncology reports 2015) 3
  4. Mammalian mirtron genes. (PMID: 17964270) Berezikov E … Lai EC (Molecular cell 2007) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR1237 Gene

Sources for MIR1237 Gene