microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1231 Gene

Subcategory (RNA class) for MIR1231 Gene

miRNA

Quality Score for this RNA gene is

15

Aliases for MIR1231 Gene

  • MicroRNA 1231 2 3 5
  • Hsa-MiR-1231 168 179
  • Hsa-Mir-1231 3
  • MIMAT0005586 53
  • MI0006321 53
  • MIRN1231 3
  • MIR1231 2

External Ids for MIR1231 Gene

Previous HGNC Symbols for MIR1231 Gene

  • MIRN1231

Previous GeneCards Identifiers for MIR1231 Gene

  • GC00U923126
  • GC01P200046

Summaries for MIR1231 Gene

Entrez Gene Summary for MIR1231 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1231 Gene

MIR1231 (MicroRNA 1231) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1231 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1231 Gene

Genomics for MIR1231 Gene

GeneHancer (GH) Regulatory Elements for MIR1231 Gene

Promoters and enhancers for MIR1231 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1231 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1231 Gene

Genomic Locations for MIR1231 Gene
chr1:201,808,611-201,808,702
(GRCh38/hg38)
Size:
92 bases
Orientation:
Plus strand
chr1:201,777,739-201,777,830
(GRCh37/hg19)
Size:
92 bases
Orientation:
Plus strand

Genomic View for MIR1231 Gene

Genes around MIR1231 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1231 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1231 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1231 Gene

Proteins for MIR1231 Gene

Post-translational modifications for MIR1231 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1231 Gene

Domains & Families for MIR1231 Gene

Gene Families for MIR1231 Gene

HGNC:
genes like me logo Genes that share domains with MIR1231: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1231 Gene

Function for MIR1231 Gene

Phenotypes From GWAS Catalog for MIR1231 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1231 Gene

Localization for MIR1231 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1231 Gene

Pathways & Interactions for MIR1231 Gene

PathCards logo

SuperPathways for MIR1231 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1231 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1231 Gene

Drugs & Compounds for MIR1231 Gene

No Compound Related Data Available

Transcripts for MIR1231 Gene

mRNA/cDNA for MIR1231 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(2) miRBase transcripts :
(1) LncBase transcripts :
(1) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1231 Gene

No ASD Table

Relevant External Links for MIR1231 Gene

GeneLoc Exon Structure for
MIR1231
ECgene alternative splicing isoforms for
MIR1231

Expression for MIR1231 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1231 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1231 Gene:

MIR1231
genes like me logo Genes that share expression patterns with MIR1231: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1231 Gene

Orthologs for MIR1231 Gene

Evolution for MIR1231 Gene

ENSEMBL:
Gene Tree for MIR1231 (if available)
TreeFam:
Gene Tree for MIR1231 (if available)

No data available for Orthologs for MIR1231 Gene

Paralogs for MIR1231 Gene

No data available for Paralogs for MIR1231 Gene

Variants for MIR1231 Gene

Sequence variations from dbSNP and Humsavar for MIR1231 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000735841 -- 201,806,852(+) C/T upstream_transcript_variant
rs1001104281 -- 201,807,178(+) A/G upstream_transcript_variant
rs1002225110 -- 201,807,822(+) T/C upstream_transcript_variant
rs1002277450 -- 201,808,106(+) A/C upstream_transcript_variant
rs1003743072 -- 201,806,625(+) G/A/C upstream_transcript_variant

Additional Variant Information for MIR1231 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1231

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR1231 Gene

Disorders for MIR1231 Gene

Additional Disease Information for MIR1231

No disorders were found for MIR1231 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1231 Gene

Publications for MIR1231 Gene

  1. [Clinical significance of exosomal miR-1231 in pancreatic cancer]. (PMID: 30678416) Chen SL … Zuo CH (Zhonghua zhong liu za zhi [Chinese journal of oncology] 2019) 3 56
  2. MicroRNA-1231 exerts a tumor suppressor role through regulating the EGFR/PI3K/AKT axis in glioma. (PMID: 29774498) Zhang J … Lu X (Journal of neuro-oncology 2018) 3 56
  3. Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA. (PMID: 24835118) Kohno T … Chayama K (Journal of viral hepatitis 2014) 3 56
  4. A miR-1231 binding site polymorphism in the 3'UTR of IFNAR1 is associated with hepatocellular carcinoma susceptibility. (PMID: 22824466) Zhou C … Zhang J (Gene 2012) 3 56
  5. Mammalian mirtron genes. (PMID: 17964270) Berezikov E … Lai EC (Molecular cell 2007) 3 56

Products for MIR1231 Gene

Sources for MIR1231 Gene