microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1228 Gene

Subcategory (RNA class) for MIR1228 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR1228 Gene

  • MicroRNA 1228 2 3 5
  • Hsa-MiR-1228-5p 163 173
  • Hsa-Mir-1228 2 3
  • MIR1228 2 5
  • MIMAT0005583 50
  • MIMAT0005582 50
  • MI0006318 50
  • MIRN1228 3
  • Mir-1228 3

External Ids for MIR1228 Gene

Previous HGNC Symbols for MIR1228 Gene

  • MIRN1228

Previous GeneCards Identifiers for MIR1228 Gene

  • GC00U922937
  • GC12P055876
  • GC12P057588

Summaries for MIR1228 Gene

Entrez Gene Summary for MIR1228 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1228 Gene

MIR1228 (MicroRNA 1228) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1228 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1228 Gene

Genomics for MIR1228 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1228 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057194 Enhancer 0.6 dbSUPER 600.7 +1.7 1693 2.5 BRD9 ZNF341 CTCF ZNF316 ZBTB17 CREM ZNF366 MAFK GLIS1 KLF1 MIR1228 ENSG00000224713 NXPH4 STAT6 LRP1
GH12J057229 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.2 +35.1 35134 5.3 CEBPG HNRNPL CREB1 ATF7 PRDM10 ZNF629 REST TFE3 SIX5 POLR2A ENSG00000276727 RF00019-020 SHMT2 MIR1228 STAT6 ENSG00000224713 NDUFA4L2
GH12J057233 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 12.2 +40.9 40911 3.7 HNRNPL ZBTB33 PRDM10 RFX1 ZNF692 PRDM1 ZIC2 RBFOX2 PATZ1 ZNF501 NONHSAG011418.2 NDUFA4L2 EEF1AKMT3 NEMP1 CDK4 BAZ2A RN7SL809P CTDSP2 OS9 MBD6
GH12J057170 Enhancer 0.7 Ensembl ENCODE dbSUPER 12.1 -22.9 -22863 1.5 RBM22 POLR2A RAD21 LRP1 MIR1228 STAT6 NDUFA4L2 GLI1 INHBE NONHSAG011413.2 piR-31416 NXPH4
GH12J057182 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 -10.8 -10802 2.2 ARHGAP35 CTCF PRDM10 IKZF1 BACH1 JUND LARP7 PRDM1 ZNF143 REST BAZ2A RN7SL809P NEMP1 STAT2 CTDSP2 MBD6 CDK4 EEF1AKMT3 PAN2 OS9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1228 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1228 Gene

Genomic Locations for MIR1228 Gene
chr12:57,194,504-57,194,576
(GRCh38/hg38)
Size:
73 bases
Orientation:
Plus strand
chr12:57,588,287-57,588,359
(GRCh37/hg19)
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR1228 Gene

Genes around MIR1228 on UCSC Golden Path with GeneCards custom track
MIR1228 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR1228 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1228 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1228 Gene

Proteins for MIR1228 Gene

Post-translational modifications for MIR1228 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1228 Gene

Domains & Families for MIR1228 Gene

Gene Families for MIR1228 Gene

HGNC:
genes like me logo Genes that share domains with MIR1228: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1228 Gene

Function for MIR1228 Gene

Phenotypes From GWAS Catalog for MIR1228 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1228 Gene

Localization for MIR1228 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1228 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1228 Gene

Pathways & Interactions for MIR1228 Gene

PathCards logo

SuperPathways for MIR1228 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1228 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1228 Gene

Drugs & Compounds for MIR1228 Gene

No Compound Related Data Available

Transcripts for MIR1228 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1228 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D5D5_9606 precursor_RNA 73 5

HGNC: 33928,

RefSeq: NR_031597,

Ensembl: ENST00000408438 (view in UCSC) ,

miRBase: MI0006318,

ENA: LM610107.1:1..73:precursor_RNA,

URS00004F1E01_9606 miRNA 21 5

RefSeq: NR_031597,

LncBase: hsa-miR-1228-5p,

miRBase: MIMAT0005582,

TarBase: hsa-miR-1228-5p,

ENA: LM380631.1:1..21:ncRNA, LM610107.1:1..21:ncRNA,

URS0000100748_9606 miRNA 20 3

RefSeq: NR_031597,

miRBase: MIMAT0005583,

ENA: LM380632.1:1..20:ncRNA, LM610107.1:52..71:ncRNA,

MIR1228 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR1228 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1228 Gene

No ASD Table

Relevant External Links for MIR1228 Gene

GeneLoc Exon Structure for
MIR1228

Expression for MIR1228 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1228

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1228 Gene

Orthologs for MIR1228 Gene

Evolution for MIR1228 Gene

ENSEMBL:
Gene Tree for MIR1228 (if available)
TreeFam:
Gene Tree for MIR1228 (if available)

No data available for Orthologs for MIR1228 Gene

Paralogs for MIR1228 Gene

No data available for Paralogs for MIR1228 Gene

Variants for MIR1228 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR1228 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
733780 Likely Benign: not provided 57,194,568(+) G/A NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR1228 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1228 Gene

Variant ID Type Subtype PubMed ID
dgv96n21 CNV loss 19592680
nsv482992 CNV gain+loss 15286789
nsv519293 CNV loss 19592680
nsv559023 CNV loss 21841781
nsv952189 CNV deletion 24416366

Additional Variant Information for MIR1228 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1228

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1228 Gene

Disorders for MIR1228 Gene

Additional Disease Information for MIR1228

No disorders were found for MIR1228 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1228 Gene

Publications for MIR1228 Gene

  1. Exosomal miR-1228 From Cancer-Associated Fibroblasts Promotes Cell Migration and Invasion of Osteosarcoma by Directly Targeting SCAI. (PMID: 30180920) Wang JW … Jiang XH (Oncology research 2019) 3
  2. CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression. (PMID: 30176158) Chen D … Xie F (Cell cycle (Georgetown, Tex.) 2018) 3
  3. microRNA-1228⁎ impairs the pro-angiogenic activity of gastric cancer cells by targeting macrophage migration inhibitory factor. (PMID: 28465246) Jia L … Zhang L (Life sciences 2017) 3
  4. MicroRNA-1228(*) inhibit apoptosis in A549 cells exposed to fine particulate matter. (PMID: 26867688) Li X … Chen R (Environmental science and pollution research international 2016) 3
  5. MiR-1228 promotes breast cancer cell growth and metastasis through targeting SCAI protein. (PMID: 26261546) Lin L … Liu M (International journal of clinical and experimental pathology 2015) 3

Products for MIR1228 Gene

Sources for MIR1228 Gene