microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1225 Gene

Subcategory (RNA class) for MIR1225 Gene


Quality Score for this RNA gene is


Aliases for MIR1225 Gene

  • MicroRNA 1225 2 3 5
  • Hsa-MiR-1225-5p 168 179
  • Hsa-Mir-1225 3
  • MIMAT0005572 53
  • MIMAT0005573 53
  • MI0006311 53
  • MIRN1225 3
  • RF00946 174
  • MIR1225 2

External Ids for MIR1225 Gene

Previous HGNC Symbols for MIR1225 Gene

  • MIRN1225

Previous GeneCards Identifiers for MIR1225 Gene

  • GC16U900905
  • GC16M002082
  • GC16M002140

Summaries for MIR1225 Gene

Entrez Gene Summary for MIR1225 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1225 Gene

MIR1225 (MicroRNA 1225) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR1225 Gene

Additional gene information for MIR1225 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1225 Gene

Genomics for MIR1225 Gene

GeneHancer (GH) Regulatory Elements for MIR1225 Gene

Promoters and enhancers for MIR1225 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002089 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 -0.8 -773 3.7 POLR2A CTCF SCRT2 SMARCA5 RAD21 ZNF143 HIC1 HNF4A SIN3A BACH1 ENSG00000259933 LOC105371049 MIR1225 lnc-NTHL1-3 ENSG00000261123 TSC2 MLST8 PKD1
GH16J002088 Enhancer 0.6 Ensembl dbSUPER 750.6 +1.5 1483 0.4 ZBTB33 ZFHX2 HIC1 GLIS1 ZNF2 MIR1225 ENSG00000261123 ENSG00000259933 TSC2 PKD1
GH16J002081 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 +7.4 7427 2.7 POLR2A MYC MAX RAD21 SP1 RXRA ZBTB33 CTCF GABPA ZFHX2 PKD1 TSC2 ENSG00000261123 MIR1225
GH16J002086 Enhancer 0.6 dbSUPER 0.6 +4.2 4227 2.8 ZIC2 ZNF585B ATF7 SCRT2 PKNOX1 ZFHX2 KLF17 HIC1 ATF2 ZFX IFT140 NME3 FLYWCH2 PKD1 UBE2I ENSG00000260646 CRAMP1 ERVK13-1 SNHG19 TELO2
GH16J002087 Enhancer 0.5 dbSUPER 0.6 +2.1 2078 0.4 SP1 GLIS2 RXRA ZFHX2 ZBTB33 KLF1 TSC2 ENSG00000259933 ENSG00000261123 MIR1225
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1225 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1225 Gene

Genomic Locations for MIR1225 Gene
90 bases
Minus strand
90 bases
Minus strand

Genomic View for MIR1225 Gene

Genes around MIR1225 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1225 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1225 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1225 Gene

Proteins for MIR1225 Gene

Post-translational modifications for MIR1225 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1225 Gene

Domains & Families for MIR1225 Gene

Gene Families for MIR1225 Gene

genes like me logo Genes that share domains with MIR1225: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1225 Gene

Function for MIR1225 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1225 Gene

Localization for MIR1225 Gene

Gene Ontology (GO) - Cellular Components for MIR1225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR1225: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR1225 Gene

Pathways & Interactions for MIR1225 Gene

PathCards logo

SuperPathways for MIR1225 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR1225: view

No data available for Pathways by source and SIGNOR curated interactions for MIR1225 Gene

Drugs & Compounds for MIR1225 Gene

No Compound Related Data Available

Transcripts for MIR1225 Gene

mRNA/cDNA for MIR1225 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(3) miRBase transcripts :
(1) Rfam transcripts :
(1) LncBase transcripts :
(1) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1225 Gene

No ASD Table

Relevant External Links for MIR1225 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR1225 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1225 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1225 Gene:

genes like me logo Genes that share expression patterns with MIR1225: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1225 Gene

Orthologs for MIR1225 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR1225 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-1225 33
  • 100 (a)
(Canis familiaris)
Mammalia -- 33
  • 91 (a)
(Mus musculus)
Mammalia Gm24589 33
  • 89 (a)
(Bos Taurus)
Mammalia bta-mir-1225 33
  • 88 (a)
Species where no ortholog for MIR1225 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1225 Gene

Gene Tree for MIR1225 (if available)
Gene Tree for MIR1225 (if available)

Paralogs for MIR1225 Gene

No data available for Paralogs for MIR1225 Gene

Variants for MIR1225 Gene

Sequence variations from dbSNP and Humsavar for MIR1225 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1045675831 likely-pathogenic, pathogenic, Autosomal recessive polycystic kidney disease, not provided 2,089,927(-) G/A/C downstream_transcript_variant
rs1057518959 likely-pathogenic, Hypertension, Polycystic kidney dysplasia 2,091,794(-) A/G upstream_transcript_variant
rs1060499718 pathogenic, Polycystic kidney disease, adult type 2,090,418(-) ACA/A upstream_transcript_variant
rs10960 benign, not specified, Polycystic kidney disease, adult type, not provided 2,090,679(-) T/C upstream_transcript_variant
rs112387277 likely-benign, benign, not specified, not provided 2,090,911(-) G/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1225 Gene

Variant ID Type Subtype PubMed ID
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
dgv4862n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1052260 CNV gain 25217958
nsv1160329 CNV deletion 26073780
nsv457349 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv471381 CNV gain 19718026
nsv482186 CNV gain 20164927
nsv571190 CNV loss 21841781
nsv952901 CNV deletion 24416366

Additional Variant Information for MIR1225 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1225 Gene

Disorders for MIR1225 Gene

Additional Disease Information for MIR1225

No disorders were found for MIR1225 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1225 Gene

Publications for MIR1225 Gene

  1. Plasma miRNA-122-5p and miRNA-151a-3p identified as potential biomarkers for liver injury among CHB patients with PNALT. (PMID: 29881991) Cheng JL … Li LJ (Hepatology international 2018) 3 56
  2. MicroRNA-1225-5p inhibits proliferation and metastasis of gastric carcinoma through repressing insulin receptor substrate-1 and activation of β-catenin signaling. (PMID: 26684358) Zheng H … Lin X (Oncotarget 2016) 3 56
  3. Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer. (PMID: 26208314) Tokuhisa M … Endo I (PloS one 2015) 3 56
  4. miR-1915 and miR-1225-5p regulate the expression of CD133, PAX2 and TLR2 in adult renal progenitor cells. (PMID: 23861881) Sallustio F … Schena FP (PloS one 2013) 3 56
  5. Mammalian mirtron genes. (PMID: 17964270) Berezikov E … Lai EC (Molecular cell 2007) 3 56

Products for MIR1225 Gene

Sources for MIR1225 Gene