microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1224 Gene

Subcategory (RNA class) for MIR1224 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR1224 Gene

  • MicroRNA 1224 2 3 5
  • Hsa-MiR-1224-3p 166 177
  • Hsa-MiR-1224-5p 166 177
  • Hsa-Mir-1224 3
  • MIMAT0005458 51
  • MIMAT0005459 51
  • MI0003764 51
  • Mir-1224 3
  • MIRN1224 3
  • RF00942 172
  • MIR1224 2

External Ids for MIR1224 Gene

Previous HGNC Symbols for MIR1224 Gene

  • MIRN1224

Previous GeneCards Identifiers for MIR1224 Gene

  • GC03U901145
  • GC03P185443
  • GC03P183959

Summaries for MIR1224 Gene

Entrez Gene Summary for MIR1224 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1224 Gene

MIR1224 (MicroRNA 1224) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1224 include Bladder Disease and Intracranial Berry Aneurysm. Among its related pathways are Parkinsons Disease Pathway.

Rfam classification for MIR1224 Gene

Additional gene information for MIR1224 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1224 Gene

Genomics for MIR1224 Gene

GeneHancer (GH) Regulatory Elements for MIR1224 Gene

Promoters and enhancers for MIR1224 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J184240 Promoter/Enhancer 1.3 Ensembl ENCODE 500.7 +0.4 396 0.8 ZNF217 CTCF NRF1 POLR2G ZIC2 GABPA REST ZBTB25 MYC TGIF2 MIR1224 VWA5B2 lnc-CAMK2N2-4
GH03J184171 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -66.2 -66243 8 ZBTB40 ZNF217 NRF1 POLR2G SP1 NCOR1 PHF8 JUND SIX5 TEAD4 AP2M1 VWA5B2 ABCF3 EIF2B5 DVL3 ECE2 ALG3 MIR1224 CAMK2N2 HSALNG0031211
GH03J184184 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -55.3 -55308 3.6 ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 POLR2G USF1 SP1 PHF8 SIX5 ABCF3 HSALNG0031211 POLR2H ALG3 EIF2B5 VWA5B2 DVL3 ENSG00000228205 ECE2 MIR1224
GH03J184154 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -84.8 -84847 4.5 POLR2G SP1 NCOR1 TEAD4 ZFX ZNF639 ZBTB5 REST POLR2A ZBTB10 DVL3 PARL ENSG00000228205 EIF2B5 ABCF3 POLR2H ALG3 ECE2 CAMK2N2 PSMD2
GH03J183883 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.6 -357.2 -357205 3.2 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 MYC PARL ENSG00000283765 RPSAP31 lnc-PARL-1 ALG3 EIF2B5 FAM131A POLR2H ABCC5 ENSG00000228205
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1224 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1224 Gene

Genomic Locations for MIR1224 Gene
chr3:184,241,405-184,241,489
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand
chr3:183,959,193-183,959,277
(GRCh37/hg19)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR1224 Gene

Genes around MIR1224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1224 Gene

Proteins for MIR1224 Gene

Post-translational modifications for MIR1224 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1224 Gene

Domains & Families for MIR1224 Gene

Gene Families for MIR1224 Gene

HGNC:
genes like me logo Genes that share domains with MIR1224: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1224 Gene

Function for MIR1224 Gene

Phenotypes From GWAS Catalog for MIR1224 Gene

Gene Ontology (GO) - Molecular Function for MIR1224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28717225
genes like me logo Genes that share ontologies with MIR1224: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1224 Gene

Localization for MIR1224 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1224 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1224 Gene

Pathways & Interactions for MIR1224 Gene

PathCards logo

SuperPathways for MIR1224 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR1224: view

Pathways by source for MIR1224 Gene

1 BioSystems pathway for MIR1224 Gene
;

Gene Ontology (GO) - Biological Process for MIR1224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IDA 28717225
GO:0035195 gene silencing by miRNA IDA 28717225
GO:0045746 negative regulation of Notch signaling pathway IDA 28717225
GO:1903672 positive regulation of sprouting angiogenesis IDA 28717225
genes like me logo Genes that share ontologies with MIR1224: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1224 Gene

Drugs & Compounds for MIR1224 Gene

No Compound Related Data Available

Transcripts for MIR1224 Gene

mRNA/cDNA for MIR1224 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
4 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1224 Gene

No ASD Table

Relevant External Links for MIR1224 Gene

GeneLoc Exon Structure for
MIR1224

Expression for MIR1224 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1224 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1224

genes like me logo Genes that share expression patterns with MIR1224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1224 Gene

Orthologs for MIR1224 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR1224 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1224 31
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-1224 31
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir1224 31
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 73 (a)
OneToOne
Species where no ortholog for MIR1224 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1224 Gene

ENSEMBL:
Gene Tree for MIR1224 (if available)
TreeFam:
Gene Tree for MIR1224 (if available)

Paralogs for MIR1224 Gene

No data available for Paralogs for MIR1224 Gene

Variants for MIR1224 Gene

Additional dbSNP identifiers (rs#s) for MIR1224 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1224 Gene

Variant ID Type Subtype PubMed ID
nsv528639 CNV loss 19592680
nsv592666 CNV loss 21841781
nsv829812 CNV loss 17160897

Additional Variant Information for MIR1224 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1224 Gene

Disorders for MIR1224 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR1224 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bladder disease
  • urinary bladder disease
intracranial berry aneurysm
  • aneurysm, intracranial berry, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1224

genes like me logo Genes that share disorders with MIR1224: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1224 Gene

Publications for MIR1224 Gene

  1. Linc00460 promotes osteosarcoma progression via miR-1224-5p/FADS1 axis. (PMID: 31419446) Lian H … Zhang C (Life sciences 2019) 3 54
  2. The effects of microRNA-1224-5p on hepatocellular carcinoma tumor endothelial cells. (PMID: 30964106) Hu C … Shen SQ (Journal of cancer research and therapeutics 2019) 3 54
  3. Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-β1/Smad3 signaling pathway. (PMID: 29050938) Yao X … Zhao T (Biochemical and biophysical research communications 2018) 3 54
  4. miR-1224 Expression Is Increased in Human Macrophages after Infection with Bacillus Calmette-Guérin (BCG). (PMID: 29908542) Alipoor SD … Adcock IM (Iranian journal of allergy, asthma, and immunology 2018) 3 54
  5. miR-1224-5p Enhances Hepatic Lipogenesis by Targeting Adenosine Monophosphate-Activated Protein Kinase α1 in Male Mice. (PMID: 29474539) Chen T … Yin W (Endocrinology 2018) 3 54

Products for MIR1224 Gene

Sources for MIR1224 Gene