microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1224 Gene

Data sources for MIR1224 Gene:

RNA type for MIR1224 Gene

miRNA

Aliases for MIR1224 Gene

External Ids for MIR1224 Gene

Previous HGNC Symbols for MIR1224 Gene

  • MIRN1224

Previous GeneCards Identifiers for MIR1224 Gene

  • GC03U901145
  • GC03P185443
  • GC03P183959

Summaries for MIR1224 Gene

Entrez Gene Summary for MIR1224 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1224 Gene

MIR1224 (MicroRNA 1224) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1224 include Intracranial Berry Aneurysm. Among its related pathways are Parkinsons Disease Pathway.

Rfam classification for MIR1224 Gene

Additional gene information for MIR1224 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1224 Gene

Genomics for MIR1224 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1224 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1224 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1224 Gene

Latest Assembly
chr3:184,241,405-184,241,489
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand

Previous Assembly
chr3:183,959,193-183,959,277
(GRCh37/hg19 by Entrez Gene)
Size:
85 bases
Orientation:
Plus strand

chr3:183,959,193-183,959,277
(GRCh37/hg19 by Ensembl)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR1224 Gene

Genes around MIR1224 on UCSC Golden Path with GeneCards custom track
MIR1224 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR1224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1224 Gene

Proteins for MIR1224 Gene

Post-translational modifications for MIR1224 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1224 Gene

Domains & Families for MIR1224 Gene

Gene Families for MIR1224 Gene

HGNC:
genes like me logo Genes that share domains with MIR1224: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1224 Gene

Function for MIR1224 Gene

Phenotypes From GWAS Catalog for MIR1224 Gene

Gene Ontology (GO) - Molecular Function for MIR1224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28717225
genes like me logo Genes that share ontologies with MIR1224: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1224 Gene

Localization for MIR1224 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1224 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1224 Gene

Pathways & Interactions for MIR1224 Gene

PathCards logo

SuperPathways for MIR1224 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR1224: view

Pathways by source for MIR1224 Gene

1 BioSystems pathway for MIR1224 Gene

Gene Ontology (GO) - Biological Process for MIR1224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IDA 28717225
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045746 negative regulation of Notch signaling pathway IDA 28717225
GO:1903672 positive regulation of sprouting angiogenesis IDA 28717225
genes like me logo Genes that share ontologies with MIR1224: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1224 Gene

Drugs & Compounds for MIR1224 Gene

No Compound Related Data Available

Transcripts for MIR1224 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1224 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00006378D3_9606 pre_miRNA 85 5

RefSeq: NR_030410,

Ensembl: ENST00000408193 (view in UCSC) ,

miRBase: MI0003764,

Rfam: RF00942,

ENA: LM609622.1:1..85:precursor_RNA,

URS000075C165_9606 miRNA 21 5

RefSeq: NR_030410,

LncBase: hsa-miR-1224-3p,

miRBase: MIMAT0005459,

TarBase: hsa-miR-1224-3p,

ENA: LM609622.1:65..85:ncRNA,

URS0000435A77_9606 miRNA 19 5

RefSeq: NR_030410,

LncBase: hsa-miR-1224-5p,

miRBase: MIMAT0005458,

TarBase: hsa-miR-1224-5p,

ENA: LM380566.1:1..19:ncRNA, LM609622.1:1..19:ncRNA,

URS0001BC7E04_9606 pre_miRNA 85 1

Rfam: RF00942,

MIR1224 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR1224 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1224 Gene

No ASD Table

Relevant External Links for MIR1224 Gene

GeneLoc Exon Structure for
MIR1224

Expression for MIR1224 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1224 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1224

genes like me logo Genes that share expression patterns with MIR1224: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1224 Gene

Orthologs for MIR1224 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR1224 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1224 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-1224 30
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir1224 30
  • 81 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 73 (a)
OneToOne
Species where no ortholog for MIR1224 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR1224 Gene

ENSEMBL:
Gene Tree for MIR1224 (if available)
TreeFam:
Gene Tree for MIR1224 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR1224

Paralogs for MIR1224 Gene

No data available for Paralogs for MIR1224 Gene

Variants for MIR1224 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR1224 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR1224 Gene

Variant ID Type Subtype PubMed ID
nsv528639 CNV loss 19592680
nsv592666 CNV loss 21841781
nsv829812 CNV loss 17160897

Additional Variant Information for MIR1224 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1224
Leiden Open Variation Database (LOVD)
MIR1224

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1224 Gene

Disorders for MIR1224 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR1224 Gene - From: COP

Disorder Aliases PubMed IDs
intracranial berry aneurysm
  • familial aneurysmal subarachnoid hemorrhage
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1224

genes like me logo Genes that share disorders with MIR1224: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1224 Gene

Publications for MIR1224 Gene

  1. OGFOD1 negatively regulated by miR-1224-5p promotes proliferation in human papillomavirus-infected laryngeal papillomas. (PMID: 32002629) Yin D … Liu J (Molecular genetics and genomics : MGG 2020) 3
  2. Linc00460 promotes osteosarcoma progression via miR-1224-5p/FADS1 axis. (PMID: 31419446) Lian H … Zhang C (Life sciences 2019) 3
  3. LncRNA NEAT1/miR-1224/KLF3 contributes to cell proliferation, apoptosis and invasion in lung cancer. (PMID: 31646570) Yu PF … Zhao YJ (European review for medical and pharmacological sciences 2019) 3
  4. The effects of microRNA-1224-5p on hepatocellular carcinoma tumor endothelial cells. (PMID: 30964106) Hu C … Shen SQ (Journal of cancer research and therapeutics 2019) 3
  5. Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-β1/Smad3 signaling pathway. (PMID: 29050938) Yao X … Zhao T (Biochemical and biophysical research communications 2018) 3

Products for MIR1224 Gene

Sources for MIR1224 Gene