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Aliases for MIR1224 Gene

Subcategory (RNA class) for MIR1224 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1224 Gene

  • MicroRNA 1224 2 3 5
  • Hsa-Mir-1224 3
  • Mir-1224 3
  • MIRN1224 3

External Ids for MIR1224 Gene

Previous HGNC Symbols for MIR1224 Gene

  • MIRN1224

Previous GeneCards Identifiers for MIR1224 Gene

  • GC03U901145
  • GC03P185443
  • GC03P183959

Summaries for MIR1224 Gene

Entrez Gene Summary for MIR1224 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1224 Gene

MIR1224 (MicroRNA 1224) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway.

Additional gene information for MIR1224 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1224 Gene

Genomics for MIR1224 Gene

GeneHancer (GH) Regulatory Elements for MIR1224 Gene

Promoters and enhancers for MIR1224 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I184240 Enhancer 1.2 Ensembl ENCODE 550.8 -0.1 -70 1.9 PKNOX1 ARID4B SIN3A ZNF48 TCF12 SLC30A9 POLR2B E2F8 ARID2 ZNF143 MIR1224 VWA5B2
GH03I184171 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.4 -66.2 -66243 8 HDGF ARID4B NEUROD1 SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF143 FOS AP2M1 VWA5B2 ABCF3 EIF2B5 DVL3 EEF1AKMT4 EEF1AKMT4-ECE2 ECE2 ALG3 MIR1224
GH03I184184 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 -55.3 -55308 3.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B ZNF766 ABCF3 VWA5B2 POLR2H EIF2B5 ALG3 EEF1AKMT4-ECE2 EEF1AKMT4 ECE2 MIR1224 CAMK2N2
GH03I184154 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.4 -85.0 -85008 4.2 HDGF FOXA2 ARID4B SIN3A DMAP1 SLC30A9 ZNF121 GLIS2 ELK1 ZNF143 DVL3 EIF2B5 RPS3P3 POLR2H ALG3 ECE2 EEF1AKMT4 EEF1AKMT4-ECE2 ABCF3 CAMK2N2
GH03I184160 Enhancer 1 Ensembl ENCODE dbSUPER 10.4 -80.5 -80547 1.6 FOXA2 JUNB BATF GLIS1 ZBTB33 FOS RUNX3 IKZF2 EIF2B5 ABCF3 CAMK2N2 ECE2 EEF1AKMT4 EEF1AKMT4-ECE2 ALG3 VWA5B2 MIR1224 EIF4G1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR1224 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1224 Gene

Genomic Locations for MIR1224 Gene
chr3:184,241,405-184,241,489
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand
chr3:183,959,193-183,959,277
(GRCh37/hg19)

Genomic View for MIR1224 Gene

Genes around MIR1224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1224 Gene

Proteins for MIR1224 Gene

Post-translational modifications for MIR1224 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1224 Gene

Domains & Families for MIR1224 Gene

Gene Families for MIR1224 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1224: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1224 Gene

Function for MIR1224 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1224 Gene

Localization for MIR1224 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1224 Gene

Pathways & Interactions for MIR1224 Gene

SuperPathways for MIR1224 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR1224: view

Pathways by source for MIR1224 Gene

1 BioSystems pathway for MIR1224 Gene

Interacting Proteins for MIR1224 Gene

Gene Ontology (GO) - Biological Process for MIR1224 Gene

None

No data available for SIGNOR curated interactions for MIR1224 Gene

Drugs & Compounds for MIR1224 Gene

No Compound Related Data Available

Transcripts for MIR1224 Gene

mRNA/cDNA for MIR1224 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1224 Gene

No ASD Table

Relevant External Links for MIR1224 Gene

GeneLoc Exon Structure for
MIR1224
ECgene alternative splicing isoforms for
MIR1224

Expression for MIR1224 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1224 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1224 Gene:

MIR1224
genes like me logo Genes that share expression patterns with MIR1224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1224 Gene

Orthologs for MIR1224 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR1224 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1224 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-1224 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir1224 34
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 73 (a)
OneToOne
Species where no ortholog for MIR1224 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1224 Gene

ENSEMBL:
Gene Tree for MIR1224 (if available)
TreeFam:
Gene Tree for MIR1224 (if available)

Paralogs for MIR1224 Gene

No data available for Paralogs for MIR1224 Gene

Variants for MIR1224 Gene

Sequence variations from dbSNP and Humsavar for MIR1224 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1001347533 -- 184,240,050(+) G/A upstream_transcript_variant
rs1001777404 -- 184,239,869(+) T/G upstream_transcript_variant
rs1002741465 -- 184,239,544(+) G/A upstream_transcript_variant
rs1003424367 -- 184,241,504(+) G/A downstream_transcript_variant
rs1005769492 -- 184,241,177(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1224 Gene

Variant ID Type Subtype PubMed ID
nsv829812 CNV loss 17160897
nsv592666 CNV loss 21841781
nsv528639 CNV loss 19592680

Additional Variant Information for MIR1224 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1224 Gene

Disorders for MIR1224 Gene

Additional Disease Information for MIR1224

No disorders were found for MIR1224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1224 Gene

Publications for MIR1224 Gene

  1. Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-β1/Smad3 signaling pathway. (PMID: 29050938) Yao X … Zhao T (Biochemical and biophysical research communications 2018) 3 58
  2. MiR-1224-5p acts as a tumor suppressor by targeting CREB1 in malignant gliomas. (PMID: 25648114) Qian J … You YP (Molecular and cellular biochemistry 2015) 3 58
  3. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium … Sullivan PF (Molecular psychiatry 2013) 3 58
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  5. Mammalian mirtron genes. (PMID: 17964270) Berezikov E … Lai EC (Molecular cell 2007) 3 58

Products for MIR1224 Gene

Sources for MIR1224 Gene

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