microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR122 Gene

Subcategory (RNA class) for MIR122 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR122 Gene

  • MicroRNA 122 2 3 5
  • Hsa-MiR-122-3p 168 179
  • Hsa-MiR-122-5p 168 179
  • MicroRNA 122a 2 3
  • Hsa-Mir-122a 3
  • MIMAT0004590 53
  • MIMAT0000421 53
  • Hsa-Mir-122 3
  • MiRNA122A 3
  • MI0000442 53
  • MiRNA122 3
  • MIRN122A 3
  • MIR122A 3
  • Mir-122 3
  • MIRN122 3
  • RF00684 174
  • MIR122 2

External Ids for MIR122 Gene

Previous HGNC Symbols for MIR122 Gene

  • MIRN122A
  • MIRN122

Previous GeneCards Identifiers for MIR122 Gene

  • GC18P054273
  • GC18P056118

Summaries for MIR122 Gene

Entrez Gene Summary for MIR122 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR122 Gene

MIR122 (MicroRNA 122) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR122 include Non-Alcoholic Fatty Liver Disease and Hepatitis C. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR122 Gene

  • mir-122 microRNA precursor

Additional gene information for MIR122 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR122 Gene

Genomics for MIR122 Gene

GeneHancer (GH) Regulatory Elements for MIR122 Gene

Promoters and enhancers for MIR122 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J058449 Enhancer 0.3 Ensembl 750.6 -1.2 -1173 0.2 SP1 TAF1 5KI6_B MIR122 MIR3591 MIR122HG
GH18J058524 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +76.3 76327 5.6 CTCF LCORL NR2F1 NR2F6 CREB1 MIXL1 ETV6 RAD21 ELF3 POLR2A MALT1 SNORA108 MIR122 MIR3591 ENSG00000199713 ENSG00000267257 NEDD4L ENSG00000274354 ALPK2
GH18J058534 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.1 +89.4 89427 12.6 ZNF24 SP1 ATF1 CREB1 MIXL1 JUND NFYC ETV6 RELA HLF ENSG00000267257 SNORA108 MIR122 MIR3591 MALT1 ALPK2 piR-52294-062 lnc-RAX-6
GH18J058400 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 11.1 -48.7 -48698 4.6 CTCF MLX RBPJ NR2F1 NR2F6 MIXL1 NFYC RAD21 NFIB ELF3 MIR122 MIR3591 ENSG00000267504 ENSG00000267396 lnc-ALPK2-3 NEDD4L
GH18J058358 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -89.1 -89074 8 FOXA1 SP1 MAFK RXRA ZSCAN4 FOXA2 NFE2 ZXDB JUND ZNF580 MIR122 MIR3591 ENSG00000267504 MALT1 piR-34822-147 NEDD4L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR122 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR122 Gene

Genomic Locations for MIR122 Gene
chr18:58,451,074-58,451,158
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand
chr18:56,118,306-56,118,390
(GRCh37/hg19)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR122 Gene

Genes around MIR122 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR122 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR122 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR122 Gene

Proteins for MIR122 Gene

Post-translational modifications for MIR122 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR122 Gene

Domains & Families for MIR122 Gene

Gene Families for MIR122 Gene

HGNC:
genes like me logo Genes that share domains with MIR122: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR122 Gene

Function for MIR122 Gene

Phenotypes From GWAS Catalog for MIR122 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR122 Gene

Localization for MIR122 Gene

Gene Ontology (GO) - Cellular Components for MIR122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0016442 RISC complex IEA --
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR122: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR122 Gene

Pathways & Interactions for MIR122 Gene

PathCards logo

SuperPathways for MIR122 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR122: view

Pathways by source for MIR122 Gene

1 KEGG pathway for MIR122 Gene

Gene Ontology (GO) - Biological Process for MIR122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR122: view

No data available for SIGNOR curated interactions for MIR122 Gene

Drugs & Compounds for MIR122 Gene

No Compound Related Data Available

Transcripts for MIR122 Gene

mRNA/cDNA for MIR122 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(6) RNACentral transcripts :
(2) TarBase transcripts :
(2) LncBase transcripts :
(6) ENA transcripts :
(3) miRBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR122 Gene

No ASD Table

Relevant External Links for MIR122 Gene

GeneLoc Exon Structure for
MIR122
ECgene alternative splicing isoforms for
MIR122

Expression for MIR122 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR122 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR122 Gene:

MIR122

Evidence on tissue expression from TISSUES for MIR122 Gene

  • Liver(3)
genes like me logo Genes that share expression patterns with MIR122: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR122 Gene

Orthologs for MIR122 Gene

Evolution for MIR122 Gene

ENSEMBL:
Gene Tree for MIR122 (if available)
TreeFam:
Gene Tree for MIR122 (if available)

No data available for Orthologs for MIR122 Gene

Paralogs for MIR122 Gene

No data available for Paralogs for MIR122 Gene

Variants for MIR122 Gene

Sequence variations from dbSNP and Humsavar for MIR122 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000314392 -- 58,451,596(+) C/G downstream_transcript_variant
rs1002935215 -- 58,450,245(+) A/G upstream_transcript_variant
rs1003273699 -- 58,450,539(+) C/T upstream_transcript_variant
rs1005089444 -- 58,450,600(+) C/T upstream_transcript_variant
rs1006091883 -- 58,449,246(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR122 Gene

Variant ID Type Subtype PubMed ID
dgv3364n100 CNV gain 25217958

Additional Variant Information for MIR122 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR122

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR122 Gene

Disorders for MIR122 Gene

MalaCards: The human disease database

(13) MalaCards diseases for MIR122 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR122

genes like me logo Genes that share disorders with MIR122: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR122 Gene

Publications for MIR122 Gene

  1. miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. (PMID: 17179747) Chang J … Taylor JM (RNA biology 2004) 2 3 56
  2. LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p/BRCC3 axis. (PMID: 30347231) Hu J … Dong J (Biochimie 2019) 3 56
  3. Inhibition of apoptosis by miR‑122‑5p in α‑fetoprotein‑producing gastric cancer. (PMID: 30816512) Maruyama S … Ichikawa D (Oncology reports 2019) 3 56
  4. miR‑122 promotes proliferation and invasion of clear cell renal cell carcinoma by suppressing Forkhead box O3. (PMID: 30483771) Nie W … Zhang X (International journal of oncology 2019) 3 56
  5. miR‑122 and miR‑199 synergistically promote autophagy in oral lichen planus by targeting the Akt/mTOR pathway. (PMID: 30664152) Wang L … Cai Y (International journal of molecular medicine 2019) 3 56

Products for MIR122 Gene

Sources for MIR122 Gene