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Aliases for MIR122 Gene

Subcategory (RNA class) for MIR122 Gene


Quality Score for this RNA gene is


Aliases for MIR122 Gene

  • MicroRNA 122 2 3 5
  • MicroRNA 122a 2 3
  • Hsa-Mir-122a 3
  • Hsa-Mir-122 3
  • MiRNA122A 3
  • MiRNA122 3
  • MIRN122A 3
  • MIR122A 3
  • Mir-122 3
  • MIRN122 3

External Ids for MIR122 Gene

ORGUL Members for MIR122 Gene

Previous HGNC Symbols for MIR122 Gene

  • MIRN122A
  • MIRN122

Previous GeneCards Identifiers for MIR122 Gene

  • GC18P054273
  • GC18P056118

Summaries for MIR122 Gene

Entrez Gene Summary for MIR122 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR122 Gene

MIR122 (MicroRNA 122) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR122 include Nonalcoholic Fatty Liver Disease and Hepatitis C. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR122 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR122 Gene

Genomics for MIR122 Gene

GeneHancer (GH) Regulatory Elements for MIR122 Gene

Promoters and enhancers for MIR122 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J058524 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +76.3 76292 4.8 FOXA2 ARID4B SIN3A IRF4 ZNF48 SLC30A9 RUNX3 RXRA MIER2 REST MALT1 SNORA108 MIR3591 MIR122 ENSG00000199713 ENSG00000267257 NEDD4L ENSG00000274354 ALPK2
GH18J058360 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -87.9 -87868 4.6 FOXA2 TAF1 JUN ZSCAN4 FEZF1 RAD21 YY1 ZFHX2 EGR1 NFE2 MIR122 MIR3591 ENSG00000267504 MALT1 LOC105372143 NEDD4L
GH18J058283 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.8 -163.4 -163412 7.7 PKNOX1 FOXA2 ZFP64 YY1 TCF12 RUNX3 RXRA JUNB PPARG NFIL3 HMGN1P30 MIR122 MIR3591 ENSG00000267504 LOC105372143 NEDD4L
GH18J058230 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.5 -217.0 -216970 8.2 PKNOX1 FOXA2 YY1 ZNF121 GLIS2 FOS RXRA JUNB TSHZ1 REST NEDD4L MIR122 MIR3591 LOC105372143 ENSG00000267504
GH18J058401 Enhancer 1.1 Ensembl ENCODE 10.9 -47.8 -47768 2.8 FOXA2 MLX SIN3A ZNF48 YY1 NFKBIZ PAF1 RXRA SP5 NFYC MIR122 MIR3591 ENSG00000267504 ENSG00000267396 ENSG00000267675
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR122 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR122 Gene

Genomic Locations for MIR122 Gene
85 bases
Plus strand
85 bases
Plus strand

Genomic View for MIR122 Gene

Genes around MIR122 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR122 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR122 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR122 Gene

Proteins for MIR122 Gene

Post-translational modifications for MIR122 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR122 Gene

Domains & Families for MIR122 Gene

Gene Families for MIR122 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR122: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR122 Gene

Function for MIR122 Gene

Phenotypes From GWAS Catalog for MIR122 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR122 Gene

Localization for MIR122 Gene

Gene Ontology (GO) - Cellular Components for MIR122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR122: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR122 Gene

Pathways & Interactions for MIR122 Gene

SuperPathways for MIR122 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR122: view

Pathways by source for MIR122 Gene

1 KEGG pathway for MIR122 Gene

Interacting Proteins for MIR122 Gene

Gene Ontology (GO) - Biological Process for MIR122 Gene


No data available for SIGNOR curated interactions for MIR122 Gene

Drugs & Compounds for MIR122 Gene

No Compound Related Data Available

Transcripts for MIR122 Gene

mRNA/cDNA for MIR122 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR122 Gene

No ASD Table

Relevant External Links for MIR122 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR122 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR122 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR122 Gene:

genes like me logo Genes that share expression patterns with MIR122: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR122 Gene

Orthologs for MIR122 Gene

Evolution for MIR122 Gene

Gene Tree for MIR122 (if available)
Gene Tree for MIR122 (if available)

No data available for Orthologs for MIR122 Gene

Paralogs for MIR122 Gene

No data available for Paralogs for MIR122 Gene

Variants for MIR122 Gene

Sequence variations from dbSNP and Humsavar for MIR122 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000314392 -- 58,451,596(+) C/G downstream_transcript_variant
rs1002935215 -- 58,450,245(+) A/G upstream_transcript_variant
rs1003273699 -- 58,450,539(+) C/T upstream_transcript_variant
rs1005089444 -- 58,450,600(+) C/T upstream_transcript_variant
rs1006091883 -- 58,449,246(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR122 Gene

Variant ID Type Subtype PubMed ID
dgv3364n100 CNV gain 25217958

Additional Variant Information for MIR122 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR122 Gene

Disorders for MIR122 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MIR122 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
nonalcoholic fatty liver disease
  • non-alcoholic fatty liver disease
hepatitis c
  • chronic hepatitis c
3-hydroxyacyl-coa dehydrogenase deficiency
  • hadh deficiency
hepatocellular carcinoma
  • hcc
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR122

genes like me logo Genes that share disorders with MIR122: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR122 Gene

Publications for MIR122 Gene

  1. DCAF1 is involved in HCV replication through regulation of miR-122. (PMID: 29327233) Yan Y … Yang R (Archives of virology 2018) 3 58
  2. MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease. (PMID: 28987423) Satishchandran A … Szabo G (Gastroenterology 2018) 3 58
  3. miR-122 promotes metastasis of clear-cell renal cell carcinoma by downregulating Dicer. (PMID: 28921581) Fan Y … Zhang X (International journal of cancer 2018) 3 58
  4. Knockdown of LncRNA ANRIL suppresses cell proliferation, metastasis, and invasion via regulating miR-122-5p expression in hepatocellular carcinoma. (PMID: 29127494) Ma J … Yuan H (Journal of cancer research and clinical oncology 2018) 3 58
  5. MiR-122 promotes renal cancer cell proliferation by targeting Sprouty2. (PMID: 28231730) Wang Z … Gu M (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58

Products for MIR122 Gene

Sources for MIR122 Gene

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