microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR122 Gene

Subcategory (RNA class) for MIR122 Gene

miRNA

Number of RNA Genes sources:

7 / 17

Aliases for MIR122 Gene

  • MicroRNA 122 2 3 5
  • Hsa-Mir-122 2 3 178
  • Hsa-MiR-122-3p 163 173
  • Hsa-MiR-122-5p 163 173
  • MicroRNA 122a 2 3
  • Hsa-Mir-122a 2 3
  • MIR122 2 5
  • MIMAT0004590 50
  • MIMAT0000421 50
  • MiRNA122A 3
  • MI0000442 50
  • MIRN122A 3
  • MiRNA122 3
  • MIR122A 3
  • MIRN122 3
  • Mir-122 3
  • MiR-122 2
  • RF00684 168
  • 6NIT_D 167
  • 5KI6_B 167
  • 6MFR_D 167
  • 6NIT_C 167
  • 6MDZ_D 167
  • 6MFR_C 167
  • 6N4O_C 167
  • 6MDZ_C 167

External Ids for MIR122 Gene

Previous HGNC Symbols for MIR122 Gene

  • MIRN122A
  • MIRN122

Previous GeneCards Identifiers for MIR122 Gene

  • GC18P054273
  • GC18P056118

Summaries for MIR122 Gene

Entrez Gene Summary for MIR122 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR122 Gene

MIR122 (MicroRNA 122) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR122 include Non-Alcoholic Fatty Liver Disease and Hepatitis C. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR122 Gene

  • mir-122 microRNA precursor

Additional gene information for MIR122 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR122 Gene

Genomics for MIR122 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR122 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR122 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR122 Gene

Genomic Locations for MIR122 Gene
chr18:58,451,074-58,451,158
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand
chr18:56,118,306-56,118,390
(GRCh37/hg19)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR122 Gene

Genes around MIR122 on UCSC Golden Path with GeneCards custom track
MIR122 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR122 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR122 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR122 Gene

Proteins for MIR122 Gene

Post-translational modifications for MIR122 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR122 Gene

Domains & Families for MIR122 Gene

Gene Families for MIR122 Gene

HGNC:
genes like me logo Genes that share domains with MIR122: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR122 Gene

Function for MIR122 Gene

Phenotypes From GWAS Catalog for MIR122 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR122 Gene

Localization for MIR122 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR122 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0070062 extracellular exosome IDA 28159509
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR122: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR122 Gene

Pathways & Interactions for MIR122 Gene

PathCards logo

SuperPathways for MIR122 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR122: view

Pathways by source for MIR122 Gene

1 KEGG pathway for MIR122 Gene

Gene Ontology (GO) - Biological Process for MIR122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR122: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR122 Gene

Drugs & Compounds for MIR122 Gene

No Compound Related Data Available

Transcripts for MIR122 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR122 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00003380CC_9606 miRNA 22 6

RefSeq: NR_029667,

LncBase: hsa-miR-122-5p,

miRBase: MIMAT0000421,

MirGeneDB: Hsa-Mir-122_5p,

TarBase: hsa-miR-122-5p,

ENA: LM379039.1:1..22:ncRNA, LM608482.1:15..36:ncRNA,

URS000075BAE6_9606 miRNA 22 6

RefSeq: NR_029667,

LncBase: hsa-miR-122-3p,

miRBase: MIMAT0004590,

MirGeneDB: Hsa-Mir-122_3p,

TarBase: hsa-miR-122-3p,

ENA: LM608482.1:51..72:ncRNA,

URS000075E935_9606 precursor_RNA 85 5

HGNC: 31501,

RefSeq: NR_029667,

Ensembl: ENST00000385044 (view in UCSC) ,

miRBase: MI0000442,

ENA: LM608482.1:1..85:precursor_RNA,

URS000065381A_9606 precursor_RNA 74 1

Rfam: RF00684,

URS0000EFD118_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-122,

MIR122 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR122 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR122 Gene

No ASD Table

Relevant External Links for MIR122 Gene

GeneLoc Exon Structure for
MIR122

Expression for MIR122 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR122 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR122

Evidence on tissue expression from TISSUES for MIR122 Gene

  • Liver(3.3)
  • Blood(2.8)
  • Heart(2.5)
  • Muscle(2.4)
  • Kidney(2.4)
  • Nervous system(2.3)
  • Intestine(2.3)
  • Skin(2.2)
  • Urine(2.2)
  • Saliva(2.1)
  • Pancreas(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with MIR122: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR122 Gene

Orthologs for MIR122 Gene

Evolution for MIR122 Gene

ENSEMBL:
Gene Tree for MIR122 (if available)
TreeFam:
Gene Tree for MIR122 (if available)

No data available for Orthologs for MIR122 Gene

Paralogs for MIR122 Gene

No data available for Paralogs for MIR122 Gene

Variants for MIR122 Gene

Additional dbSNP identifiers (rs#s) for MIR122 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR122 Gene

Variant ID Type Subtype PubMed ID
dgv3364n100 CNV gain 25217958

Additional Variant Information for MIR122 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR122

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR122 Gene

Disorders for MIR122 Gene

MalaCards: The human disease database

(53) MalaCards diseases for MIR122 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR122

genes like me logo Genes that share disorders with MIR122: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR122 Gene

Publications for MIR122 Gene

  1. miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. (PMID: 17179747) Chang J … Taylor JM (RNA biology 2004) 2 3
  2. MiR-122-5p suppresses the proliferation, migration, and invasion of gastric cancer cells by targeting LYN. (PMID: 31828293) Meng L … Ying S (Acta biochimica et biophysica Sinica 2020) 3
  3. MiR-122-5p and miR-326-3p: Potential novel biomarkers for early detection of cadmium exposure. (PMID: 31626960) Yuan W … Zou F (Gene 2020) 3
  4. Adenosine deaminase acting on RNA-1 (ADAR1) inhibits hepatitis B virus (HBV) replication by enhancing microRNA-122 processing. (PMID: 31366735) Liu G … Li L (The Journal of biological chemistry 2019) 3
  5. miR-122 and Ago interactions with the HCV genome alter the structure of the viral 5' terminus. (PMID: 30941417) Chahal J … Sagan SM (Nucleic acids research 2019) 3

Products for MIR122 Gene

Sources for MIR122 Gene