microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1181 Gene

Data sources for MIR1181 Gene:

RNA type for MIR1181 Gene

miRNA

Aliases for MIR1181 Gene

External Ids for MIR1181 Gene

Previous HGNC Symbols for MIR1181 Gene

  • MIRN1181

Previous GeneCards Identifiers for MIR1181 Gene

  • GC00U923040
  • GC19M010376
  • GC19M010514

Summaries for MIR1181 Gene

Entrez Gene Summary for MIR1181 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1181 Gene

MIR1181 (MicroRNA 1181) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Signaling by GPCR.

Additional gene information for MIR1181 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1181 Gene

Genomics for MIR1181 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1181 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010400 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 250.7 -0.7 -679 6.5 BCLAF1 SP1 ZNF207 MYC IKZF1 ZNF654 ZNF600 JUND ZNF580 ATF2 PDE4A MIR1181 lnc-PDE4A-4-001 lnc-PDE4A-4-002 CDC37 ICAM1 KANK2 MRPL4 ICAM5 ICAM4
GH19J010399 Enhancer 0.6 Ensembl ENCODE 0.7 +4.9 4909 1.3 ZNF316 NFE2 DPF2 BCOR EMSY CDC37 ICAM1 MRPL4 ICAM5 ICAM4 RAVER1 TYK2 MIR1181 lnc-TIMM29-1 PDE4A
GH19J010388 Enhancer 1 Ensembl ENCODE 0.4 +14.5 14537 1.2 BCLAF1 ZNF207 ZNF654 IKZF1 SSRP1 POLR2A CEBPB CTCF REST DEK ICAM1 ZGLP1 ICAM5 MRPL4 ICAM4 EIF3G TMEM205 TYK2 lnc-TIMM29-1 MIR1181
GH19J010390 Enhancer 0.9 Ensembl ENCODE 0.4 +13.0 12961 0.8 ZNF654 IKZF1 POLR2A CTCF REST DEK TRIM22 SIN3A RAD21 SMC3 ZGLP1 ICAM5 ICAM1 MRPL4 ICAM4 EIF3G lnc-TIMM29-1 TYK2 MIR1181 PDE4A
GH19J010386 Enhancer 0.9 Ensembl ENCODE 0.4 +17.1 17137 0.8 BCLAF1 BCL11A ZNF592 EBF1 SMARCA5 BHLHE40 IKZF1 HDGF CHD4 ZNF217 lnc-TIMM29-1 TYK2 MIR1181 PDE4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1181 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1181 Gene

Latest Assembly
chr19:10,403,458-10,403,538
(GRCh38/hg38)
Size:
81 bases
Orientation:
Minus strand

Previous Assembly
chr19:10,514,134-10,514,214
(GRCh37/hg19 by Entrez Gene)
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR1181 Gene

Genes around MIR1181 on UCSC Golden Path with GeneCards custom track
MIR1181 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR1181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1181 Gene

Proteins for MIR1181 Gene

Post-translational modifications for MIR1181 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1181 Gene

Domains & Families for MIR1181 Gene

Gene Families for MIR1181 Gene

HGNC:
genes like me logo Genes that share domains with MIR1181: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1181 Gene

Function for MIR1181 Gene

Phenotypes From GWAS Catalog for MIR1181 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1181 Gene

Localization for MIR1181 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1181 Gene

Pathways & Interactions for MIR1181 Gene

genes like me logo Genes that share pathways with MIR1181: view

Gene Ontology (GO) - Biological Process for MIR1181 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1181 Gene

Drugs & Compounds for MIR1181 Gene

No Compound Related Data Available

Transcripts for MIR1181 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1181 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075EF45_9606 pre_miRNA 81 3

RefSeq: NR_031592,

Ensembl: ENST00000408639 (view in UCSC) ,

miRBase: MI0006274,

URS000075CF96_9606 miRNA 21 2

RefSeq: NR_031592,

miRBase: MIMAT0005826,

MIR1181 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1181 Gene

No ASD Table

Relevant External Links for MIR1181 Gene

GeneLoc Exon Structure for
MIR1181

No data available for mRNA/cDNA for MIR1181 Gene

Expression for MIR1181 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1181 Gene

genes like me logo Genes that share expression patterns with MIR1181: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1181 Gene

Orthologs for MIR1181 Gene

Evolution for MIR1181 Gene

ENSEMBL:
Gene Tree for MIR1181 (if available)
TreeFam:
Gene Tree for MIR1181 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR1181

No data available for Orthologs for MIR1181 Gene

Paralogs for MIR1181 Gene

No data available for Paralogs for MIR1181 Gene

Variants for MIR1181 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR1181 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR1181 Gene

Variant ID Type Subtype PubMed ID
nsv518008 CNV gain 19592680

Additional Variant Information for MIR1181 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1181
Leiden Open Variation Database (LOVD)
MIR1181

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1181 Gene

Disorders for MIR1181 Gene

Additional Disease Information for MIR1181

No disorders were found for MIR1181 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1181 Gene

Publications for MIR1181 Gene

  1. MicroRNA-1181 supports the growth of hepatocellular carcinoma by repressing AXIN1. (PMID: 31514071) Song Z … Liu Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  2. Down-regulation of miR-1181 indicates a dismal prognosis for nasopharyngeal carcinoma and promoted cell proliferation and metastasis by modulating Wnt/β-catenin signaling. (PMID: 30779075) Hua X … Fan KC (European review for medical and pharmacological sciences 2019) 3
  3. Serum miR-1181 and miR-4314 associated with ovarian cancer: MiRNA microarray data analysis for a pilot study. (PMID: 29353130) Ruan L … Chen X (European journal of obstetrics, gynecology, and reproductive biology 2018) 3
  4. PDGFBB promotes proliferation and migration via regulating miR-1181/STAT3 axis in human pulmonary arterial smooth muscle cells. (PMID: 30211651) Qian Z … Gou D (American journal of physiology. Lung cellular and molecular physiology 2018) 3
  5. miR-1181 inhibits invasion and proliferation via STAT3 in pancreatic cancer. (PMID: 28321160) Wang J … Jiang JX (World journal of gastroenterology 2017) 3

Products for MIR1181 Gene

Sources for MIR1181 Gene