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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR1178 (MicroRNA 1178) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Signaling by GPCR and G13 Signaling Pathway.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12J119678 | Enhancer | 1.3 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 12.3 | +30.3 | 30304 | 9.7 | GATAD2A REST ZNF629 RELA ZIC2 RXRB SP1 EED SOX13 TCF7 | PRKAB1 MIR1178 CIT ENSG00000248636 TMEM233 HSALNG0094474 lnc-RAB35-6 | |
GH12J119715 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 0.7 | -2.9 | -2867 | 2.4 | GATAD2A REST RCOR2 TARDBP JUND FOXA1 RXRB NR2C1 SP1 GABPA | HSALNG0094477 CIT TMEM233 PRKAB1 MIR1178 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by Rho GTPases | ||
2 | Semaphorin interactions | ||
3 | Signaling by GPCR | ||
4 | G13 Signaling Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075AF6E_9606 | precursor_RNA | 91 | 4 |
HGNC: 35259, RefSeq: NR_031589, Ensembl: ENST00000408396 (view in UCSC) , miRBase: MI0006271, |
URS000075AB23_9606 | miRNA | 21 | 2 |
RefSeq: NR_031589, miRBase: MIMAT0005823, |
URS00008E3963_9606 | miRNA | 18 | 2 |
RefSeq: NR_031589, miRBase: MIMAT0022940, |
URS00006BD53C_9606 | precursor_RNA | 111 | 1 |
Rfam: RF02014, |
No disorders were found for MIR1178 Gene.