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Aliases for MIR10B Gene

Subcategory (RNA class) for MIR10B Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR10B Gene

  • MicroRNA 10b 2 3 5
  • Hsa-Mir-10b 3
  • MiRNA10B 3
  • Mir-10b 3
  • MIRN10B 3

External Ids for MIR10B Gene

ORGUL Members for MIR10B Gene

Previous HGNC Symbols for MIR10B Gene

  • MIRN10B

Previous GeneCards Identifiers for MIR10B Gene

  • GC02P176725
  • GC02P177015

Summaries for MIR10B Gene

Entrez Gene Summary for MIR10B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR10B Gene

MIR10B (MicroRNA 10b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR10B include Nonalcoholic Fatty Liver Disease and Bladder Cancer. Among its related pathways are MicroRNAs in cancer and Proteoglycans in cancer.

Additional gene information for MIR10B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR10B Gene

Genomics for MIR10B Gene

GeneHancer (GH) Regulatory Elements for MIR10B Gene

Promoters and enhancers for MIR10B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J176151 Promoter 0.7 EPDnew 650.7 +1.0 971 0.1 SUZ12 EZH2 ENSG00000278500 GC02P176170 GC02P176171 PIR51248 MIR10B HOXD4 HOXD8 HOXD3 ENSG00000272729
GH02J176152 Promoter 0.7 EPDnew 650.7 +1.2 1228 0.1 USF1 USF2 EZH2 ENSG00000278500 GC02P176170 GC02P176171 HOXD4 PIR51248 MIR10B HOXD3 ENSG00000272729
GH02J176153 Promoter 0.7 EPDnew 650.7 +2.0 1959 0.1 SUZ12 EZH2 ENSG00000278500 GC02P176170 GC02P176171 HOXD4 MIR10B PIR51248 ENSG00000272729 HOXD3
GH02J176552 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.5 +403.4 403388 3 ARNT FEZF1 ZNF2 ZBTB7B YY1 ZNF280A E2F8 ZNF143 ATF7 RUNX3 HNRNPA3 HOXD4 HOXD3 HOXD-AS2 MIR10B HAGLR HOXD1 HOXD13 ENSG00000236231 GC02P176590
GH02J176581 Enhancer 1 Ensembl ENCODE 10 +432.9 432906 3.3 INSM2 KLF17 ZNF2 GLIS2 ZNF366 SCRT2 RCOR1 FOS ZNF362 RXRA HOXD3 HOXD4 MIR10B GC02P176590 ENSG00000236231
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR10B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR10B Gene

Genomic Locations for MIR10B Gene
chr2:176,150,303-176,150,412
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr2:177,015,031-177,015,140
(GRCh37/hg19)
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR10B Gene

Genes around MIR10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR10B Gene

Proteins for MIR10B Gene

Post-translational modifications for MIR10B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR10B Gene

Domains & Families for MIR10B Gene

Gene Families for MIR10B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR10B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR10B Gene

Function for MIR10B Gene

Phenotypes From GWAS Catalog for MIR10B Gene

Gene Ontology (GO) - Molecular Function for MIR10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22955733
genes like me logo Genes that share ontologies with MIR10B: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR10B Gene

Localization for MIR10B Gene

Gene Ontology (GO) - Cellular Components for MIR10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR10B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR10B Gene

Pathways & Interactions for MIR10B Gene

genes like me logo Genes that share pathways with MIR10B: view

Pathways by source for MIR10B Gene

2 KEGG pathways for MIR10B Gene

Interacting Proteins for MIR10B Gene

Gene Ontology (GO) - Biological Process for MIR10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IGI 22955733
GO:0035195 gene silencing by miRNA IGI 24804980
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IGI 22955733
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI 22955733
genes like me logo Genes that share ontologies with MIR10B: view

No data available for SIGNOR curated interactions for MIR10B Gene

Drugs & Compounds for MIR10B Gene

No Compound Related Data Available

Transcripts for MIR10B Gene

mRNA/cDNA for MIR10B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR10B Gene

No ASD Table

Relevant External Links for MIR10B Gene

GeneLoc Exon Structure for
MIR10B
ECgene alternative splicing isoforms for
MIR10B

Expression for MIR10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR10B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR10B Gene:

MIR10B
genes like me logo Genes that share expression patterns with MIR10B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR10B Gene

Orthologs for MIR10B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-10b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-10b 34
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir10b 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-10b 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-10b 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-10b 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-10b 34
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-10b 34
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-10b-1 34
  • 87 (a)
OneToMany
dre-mir-10b-2 34
  • 72 (a)
OneToMany
dre-mir-10c 34
  • 71 (a)
OneToMany
Species where no ortholog for MIR10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR10B Gene

ENSEMBL:
Gene Tree for MIR10B (if available)
TreeFam:
Gene Tree for MIR10B (if available)

Paralogs for MIR10B Gene

No data available for Paralogs for MIR10B Gene

Variants for MIR10B Gene

Sequence variations from dbSNP and Humsavar for MIR10B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000334284 -- 176,150,841(+) T/A downstream_transcript_variant
rs1000430812 -- 176,150,499(+) A/T downstream_transcript_variant
rs1000607670 -- 176,148,630(+) G/A upstream_transcript_variant
rs1007565042 -- 176,150,901(+) C/A downstream_transcript_variant
rs1008418719 -- 176,148,721(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR10B Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV gain 20364138

Additional Variant Information for MIR10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR10B Gene

Disorders for MIR10B Gene

MalaCards: The human disease database

(12) MalaCards diseases for MIR10B Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
nonalcoholic fatty liver disease
  • non-alcoholic fatty liver disease
bladder cancer
  • bladder cancer, somatic
breast cancer
  • breast cancer, familial
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
pancreatitis, hereditary
  • pctt
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR10B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR10B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR10B Gene

Publications for MIR10B Gene

  1. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. (PMID: 17898713) Ma L … Weinberg RA (Nature 2007) 3 22 58
  2. MicroRNA-10b expression in breast cancer and its clinical association. (PMID: 29408861) Zhang J … Zhang P (PloS one 2018) 3 58
  3. miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis. (PMID: 28039186) Chen L … Bowness P (Annals of the rheumatic diseases 2017) 3 58
  4. Overexpression of miR-10b in colorectal cancer patients: Correlation with TWIST-1 and E-cadherin expression. (PMID: 28345456) Abdelmaksoud-Dammak R … Mokdad-Gargouri R (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  5. Evaluation of MiR-21 and MiR-10b Expression of Human Breast Cancer in West Sumatera. (PMID: 29023075) Yanwirasti … Arisanty D (Pakistan journal of biological sciences : PJBS 2017) 3 58

Products for MIR10B Gene

Sources for MIR10B Gene

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