microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR10B Gene

Subcategory (RNA class) for MIR10B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR10B Gene

  • MicroRNA 10b 2 3 5
  • Hsa-MiR-10b-5p 163 173
  • Hsa-MiR-10b-3p 163 173
  • Hsa-Mir-10b 2 3
  • MIR10B 2 5
  • Hsa-Mir-10-P1b-V1 178
  • Hsa-Mir-10-P1b-V2 178
  • MIMAT0000254 50
  • MIMAT0004556 50
  • MI0000267 50
  • MiRNA10B 3
  • MIRN10B 3
  • Mir-10b 3
  • RF00104 168

External Ids for MIR10B Gene

Previous HGNC Symbols for MIR10B Gene

  • MIRN10B

Previous GeneCards Identifiers for MIR10B Gene

  • GC02P176725
  • GC02P177015

Summaries for MIR10B Gene

Entrez Gene Summary for MIR10B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR10B Gene

MIR10B (MicroRNA 10b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR10B include Non-Alcoholic Fatty Liver Disease and Bladder Cancer. Among its related pathways are Proteoglycans in cancer and MicroRNAs in cancer.

Rfam classification for MIR10B Gene

  • mir-10 microRNA precursor family

Additional gene information for MIR10B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR10B Gene

Genomics for MIR10B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR10B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J176152 Promoter 1 EPDnew Ensembl 600.7 +1.5 1498 0.8 EZH2 USF1 CBX8 RAD51 USF2 HOXD4 MIR10B RF00104-019 piR-57249 HOXD1 ENSG00000272729 HOXD3
GH02J176151 Promoter 0.5 EPDnew 600.7 +1.0 971 0.1 HNRNPL EZH2 HOXD4 MIR10B RF00104-019 piR-57249 HOXD8 HOXD3 ENSG00000272729 HOXD1
GH02J176153 Promoter 0.4 EPDnew 600.7 +2.0 1959 0.1 EZH2 HOXD4 MIR10B RF00104-019 piR-57249 ENSG00000272729 HOXD3 HOXD1
GH02J176552 Promoter/Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas 10.5 +403.4 403388 3 CTCF KDM1A PRDM1 ZNF143 ZSCAN4 POLR2A MTA1 PATZ1 REST RAD21 lnc-MTX2-5 HNRNPA3 HOXD4 HOXD3 HOXD-AS2 MIR10B HAGLR HOXD1 HOXD13 lnc-EVX2-12
GH02J176177 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 10.4 +27.9 27865 1.7 RBFOX2 EZH2 NRF1 KLF9 CTBP1 USF1 ZBTB26 ZBTB17 ZFHX2 ZNF777 HAGLR HAGLROS HOXD1 HOXD4 HOXD3 HOXD-AS2 MIR10B HOXD11 HOXD12 HOXD10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR10B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR10B Gene

Genomic Locations for MIR10B Gene
chr2:176,150,303-176,150,412
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr2:177,015,031-177,015,140
(GRCh37/hg19)
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR10B Gene

Genes around MIR10B on UCSC Golden Path with GeneCards custom track
MIR10B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR10B Gene

Proteins for MIR10B Gene

Post-translational modifications for MIR10B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR10B Gene

Domains & Families for MIR10B Gene

Gene Families for MIR10B Gene

genes like me logo Genes that share domains with MIR10B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR10B Gene

Function for MIR10B Gene

Phenotypes From GWAS Catalog for MIR10B Gene

Gene Ontology (GO) - Molecular Function for MIR10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22955733
genes like me logo Genes that share ontologies with MIR10B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR10B Gene

Localization for MIR10B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR10B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR10B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR10B Gene

Pathways & Interactions for MIR10B Gene

PathCards logo

SuperPathways for MIR10B Gene

genes like me logo Genes that share pathways with MIR10B: view

Pathways by source for MIR10B Gene

2 KEGG pathways for MIR10B Gene

Gene Ontology (GO) - Biological Process for MIR10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IGI 22955733
GO:0035195 gene silencing by miRNA IGI 24804980
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IGI 22955733
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI 22955733
genes like me logo Genes that share ontologies with MIR10B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR10B Gene

Drugs & Compounds for MIR10B Gene

No Compound Related Data Available

Transcripts for MIR10B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR10B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004CAC40_9606 precursor_RNA 110 5

HGNC: 31498,

RefSeq: NR_029609,

Ensembl: ENST00000385011 (view in UCSC) ,

miRBase: MI0000267,

ENA: LM608341.1:1..110:precursor_RNA,

URS000058760A_9606 miRNA 23 5

RefSeq: NR_029609,

LncBase: hsa-miR-10b-5p,

miRBase: MIMAT0000254,

TarBase: hsa-miR-10b-5p,

ENA: AJ535830.1:1..23:ncRNA, LM378895.1:1..23:ncRNA, LM608341.1:27..49:ncRNA,

URS00004AC389_9606 miRNA 22 5

RefSeq: NR_029609,

LncBase: hsa-miR-10b-3p,

miRBase: MIMAT0004556,

TarBase: hsa-miR-10b-3p,

ENA: LM380235.1:1..22:ncRNA, LM608341.1:66..87:ncRNA,

URS0000680F44_9606 precursor_RNA 75 1

Rfam: RF00104,

URS0000EFE4D0_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-10-P1b-v1,

MIR10B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR10B Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR10B Gene

No ASD Table

Relevant External Links for MIR10B Gene

GeneLoc Exon Structure for
MIR10B

Expression for MIR10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR10B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR10B

Evidence on tissue expression from TISSUES for MIR10B Gene

  • Blood(2.3)
  • Lymph node(2.2)
  • Liver(2.2)
  • Nervous system(2.1)
  • Intestine(2.1)
  • Saliva(2.1)
genes like me logo Genes that share expression patterns with MIR10B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR10B Gene

Orthologs for MIR10B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR10B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-10b 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-10b 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir10b 31
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-10b 31
  • 95 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-10b 31
  • 92 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-10b 31
  • 90 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-10b 31
  • 92 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-10b 31
  • 89 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-10b-1 31
  • 87 (a)
OneToMany
dre-mir-10b-2 31
  • 72 (a)
OneToMany
dre-mir-10c 31
  • 71 (a)
OneToMany
Species where no ortholog for MIR10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR10B Gene

ENSEMBL:
Gene Tree for MIR10B (if available)
TreeFam:
Gene Tree for MIR10B (if available)

Paralogs for MIR10B Gene

No data available for Paralogs for MIR10B Gene

Variants for MIR10B Gene

Additional dbSNP identifiers (rs#s) for MIR10B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR10B Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV gain 20364138

Additional Variant Information for MIR10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR10B Gene

Disorders for MIR10B Gene

MalaCards: The human disease database

(47) MalaCards diseases for MIR10B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
non-alcoholic fatty liver disease
  • nafld
bladder cancer
  • bladder cancer, somatic
breast cancer
  • breast lobular carcinoma
pancreatitis, hereditary
  • cp
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR10B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR10B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR10B Gene

Publications for MIR10B Gene

  1. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. (PMID: 17898713) Ma L … Weinberg RA (Nature 2007) 3 23
  2. High serum extracellular vesicle miR-10b expression predicts poor prognosis in patients with acute myeloid leukemia. (PMID: 31594209) Fang Z … Liu J (Cancer biomarkers : section A of Disease markers 2020) 3
  3. miR-10b-5p regulates 3T3-L1 cells differentiation by targeting Apol6. (PMID: 30423386) Tan Y … Zhu L (Gene 2019) 3
  4. Critical role of miR-10b in B-RafV600E dependent anchorage independent growth and invasion of melanoma cells. (PMID: 30995246) Datar I … Yeung KC (PloS one 2019) 3
  5. miR-10b promoted melanoma progression through Wnt/β-catenin pathway by repressing ITCH expression. (PMID: 31129246) Wang S … Tang X (Gene 2019) 3

Products for MIR10B Gene

Sources for MIR10B Gene