MIR10A Gene (RNA Gene)

MicroRNA 10a

GC17M048579
GIFtS:
21
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR10A Gene

Subcategory (RNA class) for MIR10A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR10A Gene

  • MicroRNA 10a 2 3 5
  • Hsa-MiR-10a-3p 163 173
  • Hsa-MiR-10a-5p 163 173
  • Hsa-Mir-10a 2 3
  • MIR10A 2 5
  • Hsa-Mir-10-P1a-V1 178
  • Hsa-Mir-10-P1a-V2 178
  • MIMAT0004555 50
  • MIMAT0000253 50
  • MI0000266 50
  • MiRNA10A 3
  • MIRN10A 3
  • Mir-10a 3
  • RF00104 168

External Ids for MIR10A Gene

Previous HGNC Symbols for MIR10A Gene

  • MIRN10A

Previous GeneCards Identifiers for MIR10A Gene

  • GC17M044015
  • GC17M046657
  • GC17M046665

Summaries for MIR10A Gene

Entrez Gene Summary for MIR10A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR10A Gene

MIR10A (MicroRNA 10a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR10A include Leukemia, Chronic Myeloid and Pancreatic Cancer. Among its related pathways are Proteoglycans in cancer and Parkinsons Disease Pathway.

Rfam classification for MIR10A Gene

  • mir-10 microRNA precursor family

Additional gene information for MIR10A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR10A Gene

Genomics for MIR10A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MIR10A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR10A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR10A Gene

Genomic Locations for MIR10A Gene
chr17:48,579,838-48,579,947
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr17:46,656,992-46,659,621
(GRCh37/hg19)
Size:
2,630 bases
Orientation:
Minus strand

Genomic View for MIR10A Gene

Genes around MIR10A on UCSC Golden Path with GeneCards custom track
MIR10A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR10A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR10A Gene

Proteins for MIR10A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR10A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR10A Gene

Domains & Families for MIR10A Gene

Gene Families for MIR10A Gene

HGNC:
genes like me logo Genes that share domains with MIR10A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR10A Gene

Function for MIR10A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR10A Gene

Gene Ontology (GO) - Molecular Function for MIR10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22955733
genes like me logo Genes that share ontologies with MIR10A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR10A Gene

Localization for MIR10A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR10A gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for MIR10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR10A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR10A Gene

Pathways & Interactions for MIR10A Gene

genes like me logo Genes that share pathways with MIR10A: view

Pathways by source for MIR10A Gene

2 BioSystems pathways for MIR10A Gene

Gene Ontology (GO) - Biological Process for MIR10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016525 negative regulation of angiogenesis ISS --
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IGI 22955733
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0043537 negative regulation of blood vessel endothelial cell migration ISS --
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IGI 22955733
genes like me logo Genes that share ontologies with MIR10A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR10A Gene

Drugs & Compounds for MIR10A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR10A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR10A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000048795E_9606 precursor_RNA 110 5

HGNC: 31497,

RefSeq: NR_029608,

Ensembl: ENST00000385043 (view in UCSC) ,

miRBase: MI0000266,

ENA: LM608340.1:1..110:precursor_RNA,

URS000016D2D4_9606 miRNA 23 5

RefSeq: NR_029608,

LncBase: hsa-miR-10a-5p,

miRBase: MIMAT0000253,

TarBase: hsa-miR-10a-5p,

ENA: LM378894.1:1..23:ncRNA, LM608340.1:22..44:ncRNA,

URS00002F4762_9606 miRNA 22 5

RefSeq: NR_029608,

LncBase: hsa-miR-10a-3p,

miRBase: MIMAT0004555,

TarBase: hsa-miR-10a-3p,

ENA: LM380234.1:1..22:ncRNA, LM608340.1:63..84:ncRNA,

URS0000538196_9606 precursor_RNA 76 1

Rfam: RF00104,

URS0000EFE822_9606 precursor_RNA 64 1

MirGeneDB: Hsa-Mir-10-P1a-v1,

MIR10A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR10A Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR10A Gene

No ASD Table

Relevant External Links for MIR10A Gene

GeneLoc Exon Structure for
MIR10A

Expression for MIR10A Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR10A Gene

mRNA expression in normal human tissues for MIR10A Gene
mRNA expression by GTEx for MIR10A Gene

mRNA differential expression in normal tissues according to GTEx for MIR10A Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x7.4), Esophagus - Muscularis (x5.2), and Colon - Sigmoid (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR10A

Evidence on tissue expression from TISSUES for MIR10A Gene

  • Blood(2.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with MIR10A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR10A Gene

Orthologs for MIR10A Gene

Evolution for MIR10A Gene

ENSEMBL:
Gene Tree for MIR10A (if available)
TreeFam:
Gene Tree for MIR10A (if available)

No data available for Orthologs for MIR10A Gene

Paralogs for MIR10A Gene

No data available for Paralogs for MIR10A Gene

Variants for MIR10A Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for MIR10A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR10A Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv2758694 CNV gain 17122850
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897

Additional Variant Information for MIR10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR10A Gene

Disorders for MIR10A Gene

MalaCards: The human disease database

(44) MalaCards diseases for MIR10A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leukemia, chronic myeloid
  • cml
pancreatic cancer
  • pancreatic carcinoma
myelodysplastic syndrome
  • mds
cardiovascular system disease
  • disease of subdivision of hemolymphoid system
leiomyoma, uterine
  • ul
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR10A

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR10A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR10A Gene

Publications for MIR10A Gene

  1. A potential risk factor of essential hypertension in case-control study: MicroRNAs miR-10a-5p. (PMID: 30706734) Luo Y … Zhang L (Clinical and experimental hypertension (New York, N.Y. : 1993) 2020) 3
  2. MiR-10a functions as a tumor suppressor in prostate cancer via targeting KDM4A. (PMID: 30302800) Mu H … Yu K (Journal of cellular biochemistry 2019) 3
  3. Microarray Profiling of Circular RNA Identifies hsa_circ_0126991 as a Potential Risk Factor for Essential Hypertension. (PMID: 31108493) Liu L … Zhang L (Cytogenetic and genome research 2019) 3
  4. Long non-coding RNA ZFAS1 promotes proliferation and metastasis of clear cell renal cell carcinoma via targeting miR-10a/SKA1 pathway. (PMID: 30841471) Dong D … Zhao C (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  5. LncRNA MIR22HG inhibits growth, migration and invasion through regulating the miR-10a-5p/NCOR2 axis in hepatocellular carcinoma cells. (PMID: 30680848) Wu Y … Liang L (Cancer science 2019) 3

ExternalLinks

View latest publications for MIR10A gene in Mastermind

Products for MIR10A Gene

Sources for MIR10A Gene