microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR10A Gene

RNA type for MIR10A Gene

miRNA

Aliases for MIR10A Gene

External Ids for MIR10A Gene

Previous HGNC Symbols for MIR10A Gene

  • MIRN10A

Previous GeneCards Identifiers for MIR10A Gene

  • GC17M044015
  • GC17M046657
  • GC17M046665

Summaries for MIR10A Gene

Entrez Gene Summary for MIR10A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR10A Gene

MIR10A (MicroRNA 10a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR10A include Leukemia, Chronic Myeloid and Pancreatic Cancer. Among its related pathways are Proteoglycans in cancer and MicroRNAs in cancer.

Rfam classification for MIR10A Gene

  • mir-10 microRNA precursor family

Additional gene information for MIR10A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR10A Gene

Genomics for MIR10A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR10A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR10A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR10A Gene

Latest Assembly
chr17:48,579,838-48,579,947
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand

Previous Assembly
chr17:46,657,200-46,657,309
(GRCh37/hg19 by Entrez Gene)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR10A Gene

Genes around MIR10A on UCSC Golden Path with GeneCards custom track
MIR10A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR10A Gene

Proteins for MIR10A Gene

Post-translational modifications for MIR10A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR10A Gene

Domains & Families for MIR10A Gene

Gene Families for MIR10A Gene

genes like me logo Genes that share domains with MIR10A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR10A Gene

Function for MIR10A Gene

Phenotypes From GWAS Catalog for MIR10A Gene

Gene Ontology (GO) - Molecular Function for MIR10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22955733
genes like me logo Genes that share ontologies with MIR10A: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR10A Gene

Localization for MIR10A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR10A gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for MIR10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR10A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR10A Gene

Pathways & Interactions for MIR10A Gene

genes like me logo Genes that share pathways with MIR10A: view

Pathways by source for MIR10A Gene

Gene Ontology (GO) - Biological Process for MIR10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016525 negative regulation of angiogenesis ISS --
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IGI 22955733
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0043537 negative regulation of blood vessel endothelial cell migration ISS --
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IGI 22955733
genes like me logo Genes that share ontologies with MIR10A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR10A Gene

Drugs & Compounds for MIR10A Gene

No Compound Related Data Available

Transcripts for MIR10A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR10A Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000016D2D4_9606 miRNA 23 5

RefSeq: NR_029608,

LncBase: hsa-miR-10a-5p,

miRBase: MIMAT0000253,

TarBase: hsa-miR-10a-5p,

ENA: LM378894.1:1..23:ncRNA, LM608340.1:22..44:ncRNA,

URS00002F4762_9606 miRNA 22 5

RefSeq: NR_029608,

LncBase: hsa-miR-10a-3p,

miRBase: MIMAT0004555,

TarBase: hsa-miR-10a-3p,

ENA: LM380234.1:1..22:ncRNA, LM608340.1:63..84:ncRNA,

URS000048795E_9606 precursor_RNA 110 4

RefSeq: NR_029608,

Ensembl: ENST00000385043 (view in UCSC) ,

miRBase: MI0000266,

ENA: LM608340.1:1..110:precursor_RNA,

URS0000538196_9606 pre_miRNA 76 1

Rfam: RF00104,

URS0000EFE822_9606 precursor_RNA 64 1

MirGeneDB: Hsa-Mir-10-P1a-v1,

MIR10A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR10A Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR10A Gene

No ASD Table

Relevant External Links for MIR10A Gene

GeneLoc Exon Structure for
MIR10A

Expression for MIR10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR10A Gene

mRNA differential expression in normal tissues according to GTEx for MIR10A Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x7.4), Esophagus - Muscularis (x5.2), and Colon - Sigmoid (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR10A

Evidence on tissue expression from TISSUES for MIR10A Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR10A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR10A Gene

Orthologs for MIR10A Gene

Evolution for MIR10A Gene

ENSEMBL:
Gene Tree for MIR10A (if available)
TreeFam:
Gene Tree for MIR10A (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR10A

No data available for Orthologs for MIR10A Gene

Paralogs for MIR10A Gene

No data available for Paralogs for MIR10A Gene

Variants for MIR10A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR10A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR10A Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv2758694 CNV gain 17122850
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897

Additional Variant Information for MIR10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR10A
Leiden Open Variation Database (LOVD)
MIR10A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR10A Gene

Disorders for MIR10A Gene

MalaCards: The human disease database

(40) MalaCards diseases for MIR10A Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
leukemia, chronic myeloid
  • cml
pancreatic cancer
  • pancreatic carcinoma
myelodysplastic syndrome
  • mds
cardiovascular system disease
  • disease of subdivision of hemolymphoid system
leiomyoma, uterine
  • ul
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR10A

genes like me logo Genes that share disorders with MIR10A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR10A Gene

Publications for MIR10A Gene

  1. Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer. (PMID: 19747919) Weiss FU … Bagowski CP (Gastroenterology 2009) 3 72
  2. Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth. (PMID: 19074828) Agirre X … Prósper F (Molecular cancer research : MCR 2008) 3 72
  3. miR‑10a increases the cisplatin resistance of lung adenocarcinoma circulating tumor cells via targeting PIK3CA in the PI3K/Akt pathway. (PMID: 32186774) Huang T … Wang Z (Oncology reports 2020) 3
  4. Hsa-miR-10a-5p promotes pancreatic cancer growth by BDNF/SEMA4C pathway. (PMID: 32683841) Fei X … Tan XD (Journal of biological regulators and homeostatic agents 2020) 3
  5. Adipose derived mesenchymal stem cell exosomes loaded with miR-10a promote the differentiation of Th17 and Treg from naive CD4+ T cell. (PMID: 32784057) Bolandi Z … Hashemi SM (Life sciences 2020) 3

Products for MIR10A Gene

Sources for MIR10A Gene