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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR10A (MicroRNA 10a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR10A include Leukemia, Chronic Myeloid and Pancreatic Cancer. Among its related pathways are Proteoglycans in cancer and Parkinsons Disease Pathway.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 22955733 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Fluid shear stress and atherosclerosis | ||
2 | MicroRNAs in cancer | ||
3 | Proteoglycans in cancer | ||
4 | Alzheimers Disease | ||
5 | Parkinsons Disease Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016525 | negative regulation of angiogenesis | ISS | -- |
GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | IGI | 22955733 |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0043537 | negative regulation of blood vessel endothelial cell migration | ISS | -- |
GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | IGI | 22955733 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000048795E_9606 | precursor_RNA | 110 | 5 |
HGNC: 31497, RefSeq: NR_029608, Ensembl: ENST00000385043 (view in UCSC) , miRBase: MI0000266, |
URS000016D2D4_9606 | miRNA | 23 | 5 |
RefSeq: NR_029608, LncBase: hsa-miR-10a-5p, miRBase: MIMAT0000253, TarBase: hsa-miR-10a-5p, |
URS00002F4762_9606 | miRNA | 22 | 5 |
RefSeq: NR_029608, LncBase: hsa-miR-10a-3p, miRBase: MIMAT0004555, TarBase: hsa-miR-10a-3p, |
URS0000538196_9606 | precursor_RNA | 76 | 1 |
Rfam: RF00104, |
URS0000EFE822_9606 | precursor_RNA | 64 | 1 |
MirGeneDB: Hsa-Mir-10-P1a-v1, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv369n27 | CNV | loss | 19166990 |
dgv5676n54 | CNV | loss | 21841781 |
esv2758694 | CNV | gain | 17122850 |
nsv833469 | CNV | loss | 17160897 |
nsv833471 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
leukemia, chronic myeloid |
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pancreatic cancer |
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myelodysplastic syndrome |
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cardiovascular system disease |
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leiomyoma, uterine |
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