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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR10A Gene
RNA type for MIR10A Gene
miRNA
Aliases for MIR10A Gene
- MIMAT0000253 (miRBase)
- MI0000266 (miRBase)
- MiRNA10A (NCBI Entrez Gene)
- MIRN10A (NCBI Entrez Gene)
- Mir-10a (NCBI Entrez Gene)
- RF00104 (Rfam)
- MIR10A (Ensembl)
External Ids for MIR10A Gene
- HGNC: 31497
- NCBI Entrez Gene: 406902
- Ensembl: ENSG00000284038
- OMIM®: 610173
- miRBase: hsa-mir-10a
Previous HGNC Symbols for MIR10A Gene
- MIRN10A
Previous GeneCards Identifiers for MIR10A Gene
- GC17M044015
- GC17M046657
- GC17M046665
Summaries for MIR10A Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR10A Gene
MIR10A (MicroRNA 10a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR10A include Leukemia, Chronic Myeloid and Pancreatic Cancer. Among its related pathways are Proteoglycans in cancer and MicroRNAs in cancer.
Rfam classification for MIR10A Gene
-
mir-10 microRNA precursor family
Additional gene information for MIR10A Gene
- Alliance of Genome Resources
- Search for MIR10A at DataMed
- Search for MIR10A at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR10A Gene
Genomics for MIR10A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR10A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR10A on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR10A Gene
Latest Assembly
- chr17:48,579,838-48,579,947
- (GRCh38/hg38)
- Size:
- 110 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:46,657,200-46,657,309
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 110 bases
- Orientation:
- Minus strand
Genomic View for MIR10A Gene
Genes around MIR10A on UCSC Golden Path with GeneCards custom track
MIR10A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 17q21.32 by HGNC
- 17q21.32 by Entrez Gene
- 17q21.32 by Ensembl
MIR10A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR10A Gene
Proteins for MIR10A Gene
Post-translational modifications for MIR10A Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR10A Gene
Domains & Families for MIR10A Gene
Gene Families for MIR10A Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR10A Gene
Function for MIR10A Gene
Phenotypes From GWAS Catalog for MIR10A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 22955733 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR10A - Starting at $85 >
- * MIR10A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR10A - Starting at $45 >
- * MIR10A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR10A Gene
Localization for MIR10A Gene
| Compartment | Confidence |
|---|---|
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR10A Gene
Pathways & Interactions for MIR10A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fluid shear stress and atherosclerosis | ||
| 2 | MicroRNAs in cancer | ||
| 3 | Proteoglycans in cancer | ||
| 4 | Alzheimers Disease | ||
| 5 | Parkinsons Disease Pathway | ||
Pathways by source for MIR10A Gene
2 BioSystems pathways for MIR10A Gene
3 KEGG pathways for MIR10A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016525 | negative regulation of angiogenesis | ISS | -- |
| GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | IGI | 22955733 |
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:0043537 | negative regulation of blood vessel endothelial cell migration | ISS | -- |
| GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | IGI | 22955733 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR10A Gene
Transcripts for MIR10A Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR10A Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000016D2D4_9606 | miRNA | 23 | 5 |
RefSeq: NR_029608, LncBase: hsa-miR-10a-5p, miRBase: MIMAT0000253, TarBase: hsa-miR-10a-5p, |
| URS00002F4762_9606 | miRNA | 22 | 5 |
RefSeq: NR_029608, LncBase: hsa-miR-10a-3p, miRBase: MIMAT0004555, TarBase: hsa-miR-10a-3p, |
| URS000048795E_9606 | precursor_RNA | 110 | 4 |
RefSeq: NR_029608, Ensembl: ENST00000385043 (view in UCSC) , miRBase: MI0000266, |
| URS0000538196_9606 | pre_miRNA | 76 | 1 |
Rfam: RF00104, |
| URS0000EFE822_9606 | precursor_RNA | 64 | 1 |
MirGeneDB: Hsa-Mir-10-P1a-v1, |
MIR10A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR10A Gene
- 2 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR10A - Starting at $85 >
- * MIR10A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR10A - Starting at $45 >
- * MIR10A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR10A Gene
- GeneLoc Exon Structure for
- MIR10A
Expression for MIR10A Gene
mRNA differential expression in normal tissues according to GTEx for MIR10A Gene
This gene is overexpressed in Esophagus - Gastroesophageal Junction (x7.4), Esophagus - Muscularis (x5.2), and Colon - Sigmoid (x4.5).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR10A
Evidence on tissue expression from TISSUES for MIR10A Gene
- Blood(2.1)
Primer products for research
-
OriGene qPCR primer pairs for MIR10A
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR10A Gene
Orthologs for MIR10A Gene
Evolution for MIR10A Gene
- ENSEMBL:
- Gene Tree for MIR10A (if available)
- TreeFam:
- Gene Tree for MIR10A (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR10A
No data available for Orthologs for MIR10A Gene
Paralogs for MIR10A Gene
No data available for Paralogs for MIR10A Gene
Variants for MIR10A Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv369n27 | CNV | loss | 19166990 |
| dgv5676n54 | CNV | loss | 21841781 |
| esv2758694 | CNV | gain | 17122850 |
| nsv833469 | CNV | loss | 17160897 |
| nsv833471 | CNV | gain | 17160897 |
Additional Variant Information for MIR10A Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR10A Gene
Disorders for MIR10A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukemia, chronic myeloid |
|
|
| pancreatic cancer |
|
|
| myelodysplastic syndrome |
|
|
| cardiovascular system disease |
|
|
| leiomyoma, uterine |
|
Search MIR10A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR10A
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR10A Gene
Publications for MIR10A Gene
- Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer. (PMID: 19747919) Weiss FU … Bagowski CP (Gastroenterology 2009) 3 72
- Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth. (PMID: 19074828) Agirre X … Prósper F (Molecular cancer research : MCR 2008) 3 72
- miR‑10a increases the cisplatin resistance of lung adenocarcinoma circulating tumor cells via targeting PIK3CA in the PI3K/Akt pathway. (PMID: 32186774) Huang T … Wang Z (Oncology reports 2020) 3
- Hsa-miR-10a-5p promotes pancreatic cancer growth by BDNF/SEMA4C pathway. (PMID: 32683841) Fei X … Tan XD (Journal of biological regulators and homeostatic agents 2020) 3
- Adipose derived mesenchymal stem cell exosomes loaded with miR-10a promote the differentiation of Th17 and Treg from naive CD4+ T cell. (PMID: 32784057) Bolandi Z … Hashemi SM (Life sciences 2020) 3
ExternalLinks
Products for MIR10A Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR10A
- Origene Custom Protein Services for MIR10A
- Browse OriGene Inhibitory RNA Products For MIR10A
- OriGene qPCR primer pairs for MIR10A
- Browse CRISPR knockouts for MIR10A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR10A
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR10A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR10A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR10A
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR10A
Sources for MIR10A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources