microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR107 Gene

Subcategory (RNA class) for MIR107 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR107 Gene

  • MicroRNA 107 2 3 5
  • Hsa-Mir-107 2 3
  • Hsa-MiR-107 163 173
  • MIR107 2 5
  • Hsa-Mir-103-P3 178
  • MIMAT0000104 50
  • MI0000114 50
  • MIRN107 3
  • MiR-107 3
  • RF00129 168

External Ids for MIR107 Gene

Previous HGNC Symbols for MIR107 Gene

  • MIRN107

Previous GeneCards Identifiers for MIR107 Gene

  • GC10M091345
  • GC10M089594
  • GC10M089603
  • GC10M089604
  • GC10M089602
  • GC10M089601
  • GC10M089595
  • GC10M089596
  • GC10M089597
  • GC10M089598

Summaries for MIR107 Gene

Entrez Gene Summary for MIR107 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR107 Gene

MIR107 (MicroRNA 107) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR107 include Alzheimer Disease and Leukemia, Chronic Lymphocytic. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.

Rfam classification for MIR107 Gene

  • mir-103/107 microRNA precursor

Additional gene information for MIR107 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR107 Gene

Genomics for MIR107 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR107 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J089590 Enhancer 0.8 Ensembl ENCODE 600.7 +1.0 982 2.7 REST SP1 SCRT2 NFE2 FOXA2 ZNF316 MAFF YY1 MAFK ZBTB33 MIR107 PANK1 SLC16A12
GH10J089632 Enhancer 0.9 Ensembl ENCODE 10.2 -40.8 -40809 1.9 GATAD2A ZNF629 ZNF692 RXRB SP1 CEBPA CEBPB JUN ATF3 FOS ENSG00000240996 KIF20B MIR107 ENSG00000235100 PANK1 lnc-SLC16A12-1 hsa-miR-5095-048 SLC16A12
GH10J089466 Enhancer 0.8 Ensembl ENCODE 9.3 +126.0 126026 2 CREB1 CTCF PRDM10 FOXA1 ZSCAN4 RAD21 JUND JUN SMC3 PKNOX1 IFIT5 LIPA ENSG00000235100 KIF20B MIR107 SLC16A12-AS1 SLC16A12
GH10J089562 Enhancer 0.7 Ensembl ENCODE 10.5 +30.1 30126 2.2 CTCF CEBPA HMBOX1 ZBTB26 CEBPG NFIL3 HLF MIR107 SLC16A12-AS1 SLC16A12 PANK1
GH10J089564 Enhancer 0.6 ENCODE 10.5 +28.7 28748 0.1 CTCF RAD21 HMBOX1 CEBPB SMC3 TEAD1 CEBPG ZNF654 ARID3A TRIM22 MIR107 SLC16A12-AS1 SLC16A12 PANK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR107 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR107 Gene

Genomic Locations for MIR107 Gene
chr10:89,592,747-89,592,827
(GRCh38/hg38)
Size:
81 bases
Orientation:
Minus strand
chr10:91,352,500-91,352,586
(GRCh37/hg19)
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR107 Gene

Genes around MIR107 on UCSC Golden Path with GeneCards custom track
MIR107 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR107 Gene

Proteins for MIR107 Gene

Post-translational modifications for MIR107 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR107 Gene

Domains & Families for MIR107 Gene

Gene Families for MIR107 Gene

genes like me logo Genes that share domains with MIR107: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR107 Gene

Function for MIR107 Gene

Gene Ontology (GO) - Molecular Function for MIR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI 30089260
genes like me logo Genes that share ontologies with MIR107: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR107 Gene

Localization for MIR107 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR107 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0043025 neuronal cell body IDA 18234899
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR107: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR107 Gene

Pathways & Interactions for MIR107 Gene

genes like me logo Genes that share pathways with MIR107: view

Pathways by source for MIR107 Gene

1 BioSystems pathway for MIR107 Gene
1 KEGG pathway for MIR107 Gene

Gene Ontology (GO) - Biological Process for MIR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032869 cellular response to insulin stimulus ISS 24000013
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA,IGI 30089260
GO:0045599 negative regulation of fat cell differentiation ISS 24000013
GO:0045722 positive regulation of gluconeogenesis ISS 24000013
genes like me logo Genes that share ontologies with MIR107: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR107 Gene

Drugs & Compounds for MIR107 Gene

No Compound Related Data Available

Transcripts for MIR107 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR107 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00005743AE_9606 miRNA 23 6

RefSeq: NR_029524,

LncBase: hsa-miR-107,

miRBase: MIMAT0000104,

MirGeneDB: Hsa-Mir-103-P3_3p,

TarBase: hsa-miR-107,

ENA: AF480505.1:1..23:ncRNA, LM378791.1:1..23:ncRNA, LM608197.1:50..72:ncRNA,

URS000008F0CF_9606 precursor_RNA 81 5

HGNC: 31496,

RefSeq: NR_029524,

Ensembl: ENST00000362127 (view in UCSC) ,

miRBase: MI0000114,

ENA: AF480550.1:1..81:misc_RNA, LM608197.1:1..81:precursor_RNA,

URS00006BE46D_9606 precursor_RNA 78 1

Rfam: RF00129,

URS0000EFC162_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-103-P3,

URS0000035FEE_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-103-P3_5p,

MIR107 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR107 Gene

4 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR107 Gene

No ASD Table

Relevant External Links for MIR107 Gene

GeneLoc Exon Structure for
MIR107

Expression for MIR107 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR107 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR107

Evidence on tissue expression from TISSUES for MIR107 Gene

  • Blood(2.2)
  • Nervous system(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with MIR107: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR107 Gene

Orthologs for MIR107 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR107 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-107 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-107 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-107 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir107 31
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-107 31
  • 94 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-107 31
  • 93 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-107 31
  • 96 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-107 31
  • 100 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-107a 31
  • 85 (a)
OneToMany
dre-mir-107b 31
  • 77 (a)
OneToMany
Species where no ortholog for MIR107 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR107 Gene

ENSEMBL:
Gene Tree for MIR107 (if available)
TreeFam:
Gene Tree for MIR107 (if available)

Paralogs for MIR107 Gene

No data available for Paralogs for MIR107 Gene

Variants for MIR107 Gene

Additional dbSNP identifiers (rs#s) for MIR107 Gene

Additional Variant Information for MIR107 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR107 Gene

Disorders for MIR107 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MIR107 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR107

genes like me logo Genes that share disorders with MIR107: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR107 Gene

Publications for MIR107 Gene

  1. MiR-107 overexpression attenuates neurotoxicity induced by 6-hydroxydopamine both in vitro and in vivo. (PMID: 31778666) Sun L … Zhao W (Chemico-biological interactions 2020) 3
  2. APOE genetic variants and apoE, miR-107 and miR-650 levels in Alzheimer's disease. (PMID: 31556571) Prendecki M … Dorszewska J (Folia neuropathologica 2019) 3
  3. miR-107 inhibits CDK6 expression, differentiation, and lipid storage in human adipocytes. (PMID: 30261211) Ahonen MA … Olkkonen VM (Molecular and cellular endocrinology 2019) 3
  4. Long non‑coding RNA nuclear paraspeckle assembly transcript 1 interacts with microRNA‑107 to modulate breast cancer growth and metastasis by targeting carnitine palmitoyltransferase‑1. (PMID: 31485672) Xiong Y … Huang T (International journal of oncology 2019) 3
  5. Knockdown of NEAT1 repressed the malignant progression of glioma through sponging miR-107 and inhibiting CDK14. (PMID: 30480816) Zhen Y … Liu X (Journal of cellular physiology 2019) 3

Products for MIR107 Gene

Sources for MIR107 Gene