Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR107 (MicroRNA 107) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR107 include Alzheimer Disease and Leukemia, Chronic Lymphocytic. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J089590 | Enhancer | 0.8 | Ensembl ENCODE | 600.7 | +1.0 | 982 | 2.7 | REST SP1 SCRT2 NFE2 FOXA2 ZNF316 MAFF YY1 MAFK ZBTB33 | MIR107 PANK1 SLC16A12 | |
GH10J089632 | Enhancer | 0.9 | Ensembl ENCODE | 10.2 | -40.8 | -40809 | 1.9 | GATAD2A ZNF629 ZNF692 RXRB SP1 CEBPA CEBPB JUN ATF3 FOS | ENSG00000240996 KIF20B MIR107 ENSG00000235100 PANK1 lnc-SLC16A12-1 hsa-miR-5095-048 SLC16A12 | |
GH10J089466 | Enhancer | 0.8 | Ensembl ENCODE | 9.3 | +126.0 | 126026 | 2 | CREB1 CTCF PRDM10 FOXA1 ZSCAN4 RAD21 JUND JUN SMC3 PKNOX1 | IFIT5 LIPA ENSG00000235100 KIF20B MIR107 SLC16A12-AS1 SLC16A12 | |
GH10J089562 | Enhancer | 0.7 | Ensembl ENCODE | 10.5 | +30.1 | 30126 | 2.2 | CTCF CEBPA HMBOX1 ZBTB26 CEBPG NFIL3 HLF | MIR107 SLC16A12-AS1 SLC16A12 PANK1 | |
GH10J089564 | Enhancer | 0.6 | ENCODE | 10.5 | +28.7 | 28748 | 0.1 | CTCF RAD21 HMBOX1 CEBPB SMC3 TEAD1 CEBPG ZNF654 ARID3A TRIM22 | MIR107 SLC16A12-AS1 SLC16A12 PANK1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IGI | 30089260 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:0043025 | neuronal cell body | IDA | 18234899 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | miRNA targets in ECM and membrane receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0032869 | cellular response to insulin stimulus | ISS | 24000013 |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0035278 | miRNA mediated inhibition of translation | IDA,IGI | 30089260 |
GO:0045599 | negative regulation of fat cell differentiation | ISS | 24000013 |
GO:0045722 | positive regulation of gluconeogenesis | ISS | 24000013 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00005743AE_9606 | miRNA | 23 | 6 |
RefSeq: NR_029524, LncBase: hsa-miR-107, miRBase: MIMAT0000104, MirGeneDB: Hsa-Mir-103-P3_3p, TarBase: hsa-miR-107, ENA: AF480505.1:1..23:ncRNA, LM378791.1:1..23:ncRNA, LM608197.1:50..72:ncRNA, |
URS000008F0CF_9606 | precursor_RNA | 81 | 5 |
HGNC: 31496, RefSeq: NR_029524, Ensembl: ENST00000362127 (view in UCSC) , miRBase: MI0000114, ENA: AF480550.1:1..81:misc_RNA, LM608197.1:1..81:precursor_RNA, |
URS00006BE46D_9606 | precursor_RNA | 78 | 1 |
Rfam: RF00129, |
URS0000EFC162_9606 | precursor_RNA | 61 | 1 |
MirGeneDB: Hsa-Mir-103-P3, |
URS0000035FEE_9606 | miRNA | 23 | 1 |
MirGeneDB: Hsa-Mir-103-P3_5p, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | cfa-mir-107 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-107 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-107 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir107 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-107 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-107 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-107 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-107 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-107a 31 |
|
OneToMany | |
dre-mir-107b 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
alzheimer disease |
|
|
leukemia, chronic lymphocytic |
|
|
lung cancer |
|
|
non-alcoholic fatty liver disease |
|
|
schizophrenia |
|