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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR107 Gene
RNA type for MIR107 Gene
miRNA
Aliases for MIR107 Gene
- MicroRNA 107 (HGNC, NCBI Entrez Gene, Ensembl)
- Hsa-Mir-107 (HGNC, NCBI Entrez Gene)
- Hsa-MiR-107 (LncBase, TarBase)
- MIMAT0000104 (miRBase)
- MI0000114 (miRBase)
- MIRN107 (NCBI Entrez Gene)
- MiR-107 (NCBI Entrez Gene)
- RF00129 (Rfam)
- MIR107 (Ensembl)
External Ids for MIR107 Gene
- HGNC: 31496
- NCBI Entrez Gene: 406901
- Ensembl: ENSG00000198997
- OMIM®: 613189
- miRBase: hsa-mir-107
Previous HGNC Symbols for MIR107 Gene
- MIRN107
Previous GeneCards Identifiers for MIR107 Gene
- GC10M091345
- GC10M089594
- GC10M089603
- GC10M089604
- GC10M089602
- GC10M089601
- GC10M089595
- GC10M089596
- GC10M089597
- GC10M089598
Summaries for MIR107 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR107 Gene
MIR107 (MicroRNA 107) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR107 include Alzheimer Disease and Leukemia, Chronic Lymphocytic. Among its related pathways are MicroRNAs in cancer and miRNA targets in ECM and membrane receptors.
Rfam classification for MIR107 Gene
-
mir-103/107 microRNA precursor
Additional gene information for MIR107 Gene
- HGNC (31496)
- NCBI Entrez Gene (406901)
- Ensembl (ENSG00000198997)
- OMIM® (613189)
- Open Targets Platform(ENSG00000198997)
- Alliance of Genome Resources
- Search for MIR107 at DataMed
- Search for MIR107 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR107 Gene
Genomics for MIR107 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR107 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR107 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR107 Gene
Latest Assembly
- chr10:89,592,747-89,592,827
- (GRCh38/hg38)
- Size:
- 81 bases
- Orientation:
- Minus strand
Previous Assembly
- chr10:91,352,504-91,352,584
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 81 bases
- Orientation:
- Minus strand
Genomic View for MIR107 Gene
Genes around MIR107 on UCSC Golden Path with GeneCards custom track
MIR107 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 10q23.31 by HGNC
- 10q23.31 by Entrez Gene
- 10q23.31 by Ensembl
MIR107 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR107 Gene
Proteins for MIR107 Gene
Post-translational modifications for MIR107 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR107 Gene
Domains & Families for MIR107 Gene
Gene Families for MIR107 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR107 Gene
Function for MIR107 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IGI | 30089260 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR107 - Starting at $85 >
- * MIR107 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR107 - Starting at $45 >
- * MIR107 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR107 Gene
Localization for MIR107 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
| GO:0043025 | neuronal cell body | IDA | 18234899 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR107 Gene
Pathways & Interactions for MIR107 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | miRNA targets in ECM and membrane receptors | ||
Pathways by source for MIR107 Gene
1 BioSystems pathway for MIR107 Gene
1 KEGG pathway for MIR107 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032869 | cellular response to insulin stimulus | ISS | 24000013 |
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:0035278 | miRNA mediated inhibition of translation | IDA,IGI | 30089260 |
| GO:0045599 | negative regulation of fat cell differentiation | ISS | 24000013 |
| GO:0045722 | positive regulation of gluconeogenesis | ISS | 24000013 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR107 Gene
Transcripts for MIR107 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR107 Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00005743AE_9606 | miRNA | 23 | 6 |
RefSeq: NR_029524, LncBase: hsa-miR-107, miRBase: MIMAT0000104, MirGeneDB: Hsa-Mir-103-P3_3p, TarBase: hsa-miR-107, ENA: AF480505.1:1..23:ncRNA, LM378791.1:1..23:ncRNA, LM608197.1:50..72:ncRNA, |
| URS000008F0CF_9606 | pre_miRNA | 81 | 4 |
RefSeq: NR_029524, Ensembl: ENST00000362127 (view in UCSC) , miRBase: MI0000114, ENA: AF480550.1:1..81:misc_RNA, LM608197.1:1..81:precursor_RNA, |
| URS00006BE46D_9606 | pre_miRNA | 78 | 1 |
Rfam: RF00129, |
| URS0001BC0964_9606 | pre_miRNA | 78 | 1 |
Rfam: RF00129, |
| URS0000EFC162_9606 | pre_miRNA | 61 | 1 |
MirGeneDB: Hsa-Mir-103-P3, |
MIR107 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR107 Gene
- 4 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR107 - Starting at $85 >
- * MIR107 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR107 - Starting at $45 >
- * MIR107 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR107 Gene
- GeneLoc Exon Structure for
- MIR107
Expression for MIR107 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR107
Primer products for research
-
OriGene qPCR primer pairs for MIR107
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR107 Gene
Orthologs for MIR107 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | cfa-mir-107 30 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-107 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-mir-107 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir107 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-107 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-107 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | gga-mir-107 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-107 30 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-107a 30 |
|
OneToMany | |
| dre-mir-107b 30 |
|
OneToMany |
- Species where no ortholog for MIR107 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MIR107 Gene
- ENSEMBL:
- Gene Tree for MIR107 (if available)
- TreeFam:
- Gene Tree for MIR107 (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR107
Paralogs for MIR107 Gene
No data available for Paralogs for MIR107 Gene
Variants for MIR107 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR107 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR107 Gene
Disorders for MIR107 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alzheimer disease |
|
|
| leukemia, chronic lymphocytic |
|
|
| lung cancer |
|
|
| non-alcoholic fatty liver disease |
|
|
| esophageal cancer |
|
Search MIR107 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR107
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR107 Gene
Publications for MIR107 Gene
- MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. (PMID: 20413881) Nelson PT … Wang WX (Journal of Alzheimer's disease : JAD 2010) 3 72
- miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia. (PMID: 19692702) Pallasch CP … Wendtner CM (Blood 2009) 3 72
- MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines. (PMID: 19688090) Takahashi Y … Yasuda J (PloS one 2009) 3 72
- MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39. (PMID: 31919406) Liang Y … Meng X (British journal of cancer 2020) 3
- miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity. (PMID: 32527986) Zhuang Y … Sun P (Aging 2020) 3
ExternalLinks
Products for MIR107 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR107
- Origene Custom Protein Services for MIR107
- Browse OriGene Inhibitory RNA Products For MIR107
- OriGene qPCR primer pairs for MIR107
- Browse CRISPR knockouts for MIR107
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR107
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR107
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR107
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR107
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR107
Sources for MIR107 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources