microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR106B Gene

Subcategory (RNA class) for MIR106B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR106B Gene

  • MicroRNA 106b 2 3 5
  • Hsa-MiR-106b-5p 163 173
  • Hsa-MiR-106b-3p 163 173
  • Hsa-Mir-106b 2 3
  • MIR106B 2 5
  • Hsa-Mir-17-P3c 178
  • MIMAT0004672 50
  • MIMAT0000680 50
  • MI0000734 50
  • MIRN106B 3
  • Mir-106b 3
  • RF00051 168

External Ids for MIR106B Gene

Previous HGNC Symbols for MIR106B Gene

  • MIRN106B

Previous GeneCards Identifiers for MIR106B Gene

  • GC07M099538
  • GC07M099693
  • GC07M099695
  • GC07M099701
  • GC07M099721
  • GC07M099743
  • GC07M099786
  • GC07M100095
  • GC07M100102
  • GC07M100186
  • GC07M100199
  • GC07M100210
  • GC07M100247
  • GC07M100106
  • GC07M100112
  • GC07M100119
  • GC07M100126
  • GC07M100141
  • GC07M100150
  • GC07M100163
  • GC07M100178

Summaries for MIR106B Gene

Entrez Gene Summary for MIR106B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR106B Gene

MIR106B (MicroRNA 106b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR106B include Alzheimer Disease and Leukemia, Chronic Lymphocytic. Among its related pathways are DNA Damage Response and MicroRNAs in cancer.

Rfam classification for MIR106B Gene

  • mir-17 microRNA precursor family

Additional gene information for MIR106B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR106B Gene

Genomics for MIR106B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR106B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100093 Promoter 0.7 EPDnew 600.7 +0.3 281 0.1 ZIC2 ZNF501 POLR2A ZNF316 SUPT5H ZNF660 EMSY MAFK MIR106B MIR25 MIR93 piR-36984 piR-47148 AZGP1 COPS6 AP4M1 MCM7
GH07J100094 Enhancer 0.4 Ensembl 600.7 +0.8 774 0.2 POLR2A SMAD5 SUPT5H PML MIR106B MIR25 MIR93 piR-36984 piR-47148 MBLAC1 COPS6 AP4M1 MCM7
GH07J100040 Enhancer 1.1 Ensembl ENCODE dbSUPER 11 +52.6 52615 2.1 IKZF1 PKNOX1 RXRB SCRT2 CTBP1 FOXA2 CTCF ESRRA BCOR DPF2 lnc-ZSCAN21-2 AP4M1 ZSCAN21 ZKSCAN1 MCM7 COPS6 MIR106B MIR25 MIR93 PILRA
GH07J100061 Enhancer 1 Ensembl ENCODE 11.9 +32.3 32274 1.2 IKZF1 PKNOX1 NR2C1 DPF2 ZNF600 SOX6 TCF12 EP300 CBX3 NKRF COPS6 MIR106B MIR25 MIR93 MCM7 ZKSCAN1 TRIM4 piR-32504 piR-50617 ZSCAN21
GH07J100044 Enhancer 0.6 ENCODE 11 +49.2 49202 0.2 CTCF NRF1 SMARCA5 GABPA SIN3A ELF1 RAD21 ZNF687 HNF4A EGR1 ZKSCAN1 COPS6 MIR106B MIR25 MIR93 MCM7 ZSCAN21 lnc-ZSCAN21-2 RF00017-6476
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR106B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR106B Gene

Genomic Locations for MIR106B Gene
chr7:100,093,992-100,094,075
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand
chr7:99,691,616-99,691,697
(GRCh37/hg19)
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR106B Gene

Genes around MIR106B on UCSC Golden Path with GeneCards custom track
MIR106B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR106B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR106B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR106B Gene

Proteins for MIR106B Gene

Post-translational modifications for MIR106B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR106B Gene

Domains & Families for MIR106B Gene

Gene Families for MIR106B Gene

genes like me logo Genes that share domains with MIR106B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR106B Gene

Function for MIR106B Gene

Gene Ontology (GO) - Molecular Function for MIR106B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 22556343
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 17205120
genes like me logo Genes that share ontologies with MIR106B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR106B Gene

Localization for MIR106B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR106B gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR106B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR106B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR106B Gene

Pathways & Interactions for MIR106B Gene

genes like me logo Genes that share pathways with MIR106B: view

Pathways by source for MIR106B Gene

1 KEGG pathway for MIR106B Gene

Gene Ontology (GO) - Biological Process for MIR106B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 22556343
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0016525 negative regulation of angiogenesis IDA 26956882
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 19153141
genes like me logo Genes that share ontologies with MIR106B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR106B Gene

Drugs & Compounds for MIR106B Gene

No Compound Related Data Available

Transcripts for MIR106B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR106B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004449AE_9606 miRNA 21 6

RefSeq: NR_029831,

LncBase: hsa-miR-106b-5p,

miRBase: MIMAT0000680,

MirGeneDB: Hsa-Mir-17-P3c_5p,

TarBase: hsa-miR-106b-5p,

ENA: LM379200.1:1..21:ncRNA, LM608661.1:12..32:ncRNA,

URS00000600E6_9606 precursor_RNA 82 5

HGNC: 31495,

RefSeq: NR_029831,

Ensembl: ENST00000385301 (view in UCSC) ,

miRBase: MI0000734,

ENA: LM608661.1:1..82:precursor_RNA,

URS0000384021_9606 miRNA 22 5

RefSeq: NR_029831,

LncBase: hsa-miR-106b-3p,

miRBase: MIMAT0004672,

TarBase: hsa-miR-106b-3p,

ENA: LM380336.1:1..22:ncRNA, LM608661.1:52..73:ncRNA,

URS00006CDA34_9606 precursor_RNA 84 1

Rfam: RF00051,

URS0000EFCD54_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-17-P3c,

MIR106B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR106B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR106B Gene

No ASD Table

Relevant External Links for MIR106B Gene

GeneLoc Exon Structure for
MIR106B

Expression for MIR106B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR106B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR106B

Evidence on tissue expression from TISSUES for MIR106B Gene

  • Blood(2.4)
  • Nervous system(2.2)
  • Liver(2.1)
  • Intestine(2.1)
  • Heart(2)
  • Skin(2)
  • Muscle(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with MIR106B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR106B Gene

Orthologs for MIR106B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR106B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-106b 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-106b 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-106b 31
  • 96 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir106b 31
  • 93 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-18a 31
  • 47 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 46 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves gga-mir-18a 31
  • 46 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia aca-mir-18a 31
  • 53 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-18a 31
  • 52 (a)
ManyToMany
Species where no ortholog for MIR106B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR106B Gene

ENSEMBL:
Gene Tree for MIR106B (if available)
TreeFam:
Gene Tree for MIR106B (if available)

Paralogs for MIR106B Gene

No data available for Paralogs for MIR106B Gene

Variants for MIR106B Gene

Additional dbSNP identifiers (rs#s) for MIR106B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR106B Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv469687 CNV loss 16826518
nsv510966 OTHER complex 20534489
nsv607931 CNV loss 21841781

Additional Variant Information for MIR106B Gene

Human Gene Mutation Database (HGMD)
MIR106B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR106B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR106B Gene

Disorders for MIR106B Gene

MalaCards: The human disease database

(54) MalaCards diseases for MIR106B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
leukemia, chronic lymphocytic
  • cll
myeloma, multiple
  • multiple myeloma, susceptibility to
gastric cancer
  • gastric cancer, somatic
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR106B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR106B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR106B Gene

Publications for MIR106B Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. LGP2 virus sensor enhances apoptosis by upregulating apoptosis regulatory genes through TRBP-bound miRNAs during viral infection. (PMID: 31799626) Takahashi T … Ui-Tei K (Nucleic acids research 2020) 3
  3. Exosomal miR-106b serves as a novel marker for lung cancer and promotes cancer metastasis via targeting PTEN. (PMID: 31954745) Sun S … Deng Z (Life sciences 2020) 3
  4. miR-106b Promotes Metastasis of Early Gastric Cancer by Targeting ALEX1 in Vitro and in Vivo. (PMID: 30907988) Zhu Z … Zhu Z (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2019) 3
  5. E2F7, EREG, miR-451a and miR-106b-5p are associated with the cervical cancer development. (PMID: 30607582) Zong S … Yue Y (Archives of gynecology and obstetrics 2019) 3

Products for MIR106B Gene

Sources for MIR106B Gene