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Aliases for MIR106B Gene

Subcategory (RNA class) for MIR106B Gene


Quality Score for this RNA gene is


Aliases for MIR106B Gene

  • MicroRNA 106b 2 3 5
  • Hsa-Mir-106b 3
  • Mir-106b 3
  • MIRN106B 3

External Ids for MIR106B Gene

Previous HGNC Symbols for MIR106B Gene

  • MIRN106B

Previous GeneCards Identifiers for MIR106B Gene

  • GC07M099538
  • GC07M099693
  • GC07M099695
  • GC07M099701
  • GC07M099721
  • GC07M099743
  • GC07M099786
  • GC07M100095
  • GC07M100102
  • GC07M100106
  • GC07M100112
  • GC07M100119
  • GC07M100126
  • GC07M100141

Summaries for MIR106B Gene

Entrez Gene Summary for MIR106B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR106B Gene

MIR106B (MicroRNA 106b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR106B include Polycystic Kidney Disease 2. Among its related pathways are miRNAs involved in DNA damage response and DNA Damage Response.

fRNAdb sequence ontologies for MIR106B Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR106B

Additional gene information for MIR106B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR106B Gene

Genomics for MIR106B Gene

GeneHancer (GH) Regulatory Elements for MIR106B Gene

Promoters and enhancers for MIR106B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I100040 Enhancer 1 ENCODE dbSUPER 11 +52.4 52376 1.6 PKNOX1 FOXA2 RAD21 THRB TCF12 SCRT2 FOS RCOR1 PAF1 RXRA AP4M1 ZSCAN21 ZKSCAN1 COPS6 MIR106B MIR25 MIR93 MCM7 PILRA GC07P100039
GH07I100061 Enhancer 0.8 ENCODE 11.9 +32.2 32245 0.8 HDAC1 HDGF PKNOX1 TAF9B ARNT TCF12 GATA2 NCOA1 MBD2 NFIC COPS6 MIR106B MIR25 MIR93 MCM7 ZKSCAN1 TRIM4 GC07M100100 PIR44616 PIR43713
GH07I100137 Enhancer 0.8 Ensembl ENCODE 10.8 -44.1 -44094 0.8 PKNOX1 CLOCK EBF1 ELF1 FOXA1 GATA3 IKZF1 NFE2 RUNX3 TCF7L2 PVRIG C7orf43 GAL3ST4 GPC2 STAG3 GATS AP4M1 MCM7 MIR106B MIR25
GH07I100044 Enhancer 0.6 ENCODE 11 +49.2 49201 0.2 SMARCA5 CTCF ZNF687 NRF1 MAX SIN3A MNT ELF1 RAD21 GABPA ZKSCAN1 COPS6 MIR106B MIR25 MIR93 MCM7 ZSCAN21 GC07P100039
GH07I100048 Enhancer 0.3 ENCODE 11 +45.2 45151 0 ZNF610 PIR43713 ZSCAN21 ZKSCAN1 COPS6 MIR25 MIR93 MIR106B MCM7 GC07P100039
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR106B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR106B Gene

Genomic Locations for MIR106B Gene
82 bases
Minus strand

Genomic View for MIR106B Gene

Genes around MIR106B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR106B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR106B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR106B Gene

ORGUL Member Location for MIR106B Gene

ORGUL Member Location for MIR106B gene

Proteins for MIR106B Gene

Post-translational modifications for MIR106B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR106B Gene

Domains & Families for MIR106B Gene

Gene Families for MIR106B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR106B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR106B Gene

Function for MIR106B Gene

Gene Ontology (GO) - Molecular Function for MIR106B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18728182
genes like me logo Genes that share ontologies with MIR106B: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR106B Gene

Localization for MIR106B Gene

Gene Ontology (GO) - Cellular Components for MIR106B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR106B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR106B Gene

Pathways & Interactions for MIR106B Gene

genes like me logo Genes that share pathways with MIR106B: view

Pathways by source for MIR106B Gene

1 KEGG pathway for MIR106B Gene

Interacting Proteins for MIR106B Gene

Gene Ontology (GO) - Biological Process for MIR106B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016525 negative regulation of angiogenesis IDA 26956882
GO:0035195 gene silencing by miRNA IDA 18728182
GO:0035278 miRNA mediated inhibition of translation IDA 19153141
GO:2000351 NOT regulation of endothelial cell apoptotic process IDA 26956882
genes like me logo Genes that share ontologies with MIR106B: view

No data available for SIGNOR curated interactions for MIR106B Gene

Drugs & Compounds for MIR106B Gene

No Compound Related Data Available

Transcripts for MIR106B Gene

fRNAdb Secondary structures for MIR106B Gene

  • FR385482
  • FR259064

mRNA/cDNA for MIR106B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR106B Gene

No ASD Table

Relevant External Links for MIR106B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR106B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR106B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR106B Gene:

genes like me logo Genes that share expression patterns with MIR106B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR106B Gene

Orthologs for MIR106B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR106B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-106b 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-106b 34
  • 97 (a)
(Bos Taurus)
Mammalia bta-mir-106b 34
  • 96 (a)
(Mus musculus)
Mammalia Mir106b 34
  • 93 (a)
(Monodelphis domestica)
Mammalia mdo-mir-18a 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
(Gallus gallus)
Aves gga-mir-18a 34
  • 46 (a)
(Anolis carolinensis)
Reptilia aca-mir-18a 34
  • 53 (a)
(Danio rerio)
Actinopterygii dre-mir-18a 34
  • 52 (a)
Species where no ortholog for MIR106B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR106B Gene

Gene Tree for MIR106B (if available)
Gene Tree for MIR106B (if available)

Paralogs for MIR106B Gene

No data available for Paralogs for MIR106B Gene

Variants for MIR106B Gene

Sequence variations from dbSNP and Humsavar for MIR106B Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000404937 -- 100,093,901(-) G/A downstream_transcript_variant
rs1001565564 -- 100,095,549(-) T/A upstream_transcript_variant
rs1001912842 -- 100,095,716(-) C/T upstream_transcript_variant
rs1002645151 -- 100,095,414(-) A/T upstream_transcript_variant
rs1004588213 -- 100,095,649(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR106B Gene

Variant ID Type Subtype PubMed ID
nsv607931 CNV loss 21841781
nsv510966 OTHER complex 20534489
nsv469687 CNV loss 16826518
esv2734888 CNV deletion 23290073

Additional Variant Information for MIR106B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR106B Gene

Disorders for MIR106B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR106B Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
polycystic kidney disease 2
  • pkd2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR106B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR106B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR106B Gene

Publications for MIR106B Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. MicroRNA-106b-5p regulates cisplatin chemosensitivity by targeting polycystic kidney disease-2 in non-small-cell lung cancer. (PMID: 28723865) Yu S … Feng J (Anti-cancer drugs 2017) 3 58
  3. Silencing miR-106b accelerates osteogenesis of mesenchymal stem cells and rescues against glucocorticoid-induced osteoporosis by targeting BMP2. (PMID: 28108317) Liu K … Shi Q (Bone 2017) 3 58
  4. Discordance of MCM7 mRNA and its Intronic MicroRNA Levels Under Hypoxia. (PMID: 28668890) Kondo H … Suzuki A (Anticancer research 2017) 3 58
  5. The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer. (PMID: 28562634) Li F … Zhang R (PloS one 2017) 3 58

Products for MIR106B Gene

Sources for MIR106B Gene

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