microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR103A2 Gene

Subcategory (RNA class) for MIR103A2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR103A2 Gene

  • MicroRNA 103a-2 2 3 5
  • Hsa-MiR-103a-2-5p 163 173
  • Hsa-MiR-103a-3p 163 173
  • MicroRNA 103-2 2 3
  • Hsa-Mir-103a-2 2 3
  • Hsa-Mir-103-2 2 3
  • MIR103A2 2 5
  • Hsa-Mir-103-P2 178
  • MIMAT0009196 50
  • MIMAT0000101 50
  • Mir-103a-2 3
  • MIRN103-2 3
  • MI0000108 50
  • MIR103-2 3
  • RF00129 168

External Ids for MIR103A2 Gene

Previous HGNC Symbols for MIR103A2 Gene

  • MIRN103-2
  • MIR103-2

Previous GeneCards Identifiers for MIR103A2 Gene

  • GC20P003899
  • GC20P003902
  • GC20P003906

Summaries for MIR103A2 Gene

Entrez Gene Summary for MIR103A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR103A2 Gene

MIR103A2 (MicroRNA 103a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR103A2 include Pituitary Adenoma and Pancreatic Cancer. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

Rfam classification for MIR103A2 Gene

  • mir-103/107 microRNA precursor

Additional gene information for MIR103A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR103A2 Gene

Genomics for MIR103A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR103A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J003870 Enhancer 0.7 Ensembl ENCODE 11.6 -46.1 -46052 1.7 RFX1 BMI1 EP300 RBM22 ZNF664 KLF1 ARID3A CEBPB PANK2-AS1 MIR103A2 CDC25B CENPB AP5S1 SPEF1 RNF24 MAVS piR-57564 PANK2
GH20J003875 Enhancer 0.5 Ensembl 11.6 -42.3 -42277 2.4 PRDM10 ZNF600 RFX1 RBM22 NR2F2 HNRNPH1 SPI1 POLR2A piR-57564 MAVS PANK2-AS1 MIR103A2 CDC25B CENPB AP5S1 SPEF1 RNF24 PANK2
GH20J003827 Enhancer 0.5 Ensembl 11 -88.4 -88393 3.8 CEBPA CEBPB ZBTB33 NR2F6 ZNF362 CEBPG CDC25B HSPA12B CENPB SPEF1 PANK2 PANK2-AS1 MIR103A2 SIGLEC1 AP5S1 lnc-CENPB-2
GH20J003826 Enhancer 0.3 Ensembl 11 -90.9 -90893 0.4 EBF1 CDC25B CENPB SPEF1 PANK2 PANK2-AS1 MIR103A2 HSPA12B SIGLEC1 AP5S1 lnc-CENPB-2
GH20J003831 Enhancer 0.2 Ensembl 11 -85.6 -85593 0.6 CDC25B CENPB SPEF1 PANK2 PANK2-AS1 MIR103A2 HSPA12B SIGLEC1 lnc-CENPB-2 AP5S1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR103A2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR103A2 Gene

Genomic Locations for MIR103A2 Gene
chr20:3,917,494-3,917,571
(GRCh38/hg38)
Size:
78 bases
Orientation:
Plus strand
chr20:3,898,141-3,898,218
(GRCh37/hg19)
Size:
78 bases
Orientation:
Plus strand

Genomic View for MIR103A2 Gene

Genes around MIR103A2 on UCSC Golden Path with GeneCards custom track
MIR103A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR103A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR103A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR103A2 Gene

Proteins for MIR103A2 Gene

Post-translational modifications for MIR103A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR103A2 Gene

Domains & Families for MIR103A2 Gene

Gene Families for MIR103A2 Gene

genes like me logo Genes that share domains with MIR103A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR103A2 Gene

Function for MIR103A2 Gene

Gene Ontology (GO) - Molecular Function for MIR103A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI 30089260
genes like me logo Genes that share ontologies with MIR103A2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR103A2 Gene

Localization for MIR103A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR103A2 gene
Compartment Confidence
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR103A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0005623 cell IEA --
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR103A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR103A2 Gene

Pathways & Interactions for MIR103A2 Gene

PathCards logo

SuperPathways for MIR103A2 Gene

genes like me logo Genes that share pathways with MIR103A2: view

Pathways by source for MIR103A2 Gene

1 BioSystems pathway for MIR103A2 Gene
1 KEGG pathway for MIR103A2 Gene

Gene Ontology (GO) - Biological Process for MIR103A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis ISS 24000013
GO:0010801 negative regulation of peptidyl-threonine phosphorylation IDA 27343180
GO:0032869 cellular response to insulin stimulus ISS 24000013
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA,IGI 30089260
genes like me logo Genes that share ontologies with MIR103A2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR103A2 Gene

Drugs & Compounds for MIR103A2 Gene

No Compound Related Data Available

Transcripts for MIR103A2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR103A2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000302909_9606 precursor_RNA 78 6

HGNC: 31491,

RefSeq: NR_029519,

Ensembl: ENST00000362154 (view in UCSC) ,

miRBase: MI0000108,

Rfam: RF00129,

ENA: HI454491.1:1..78:misc_RNA, LM608192.1:1..78:precursor_RNA,

URS0000476BE1_9606 miRNA 23 6

RefSeq: NR_029519, NR_029520,

LncBase: hsa-miR-103a-3p,

miRBase: MIMAT0000101,

MirGeneDB: Hsa-Mir-103-P1_3p, Hsa-Mir-103-P2_3p,

TarBase: hsa-miR-103a-3p,

ENA: AF480501.1:1..23:ncRNA, LM378788.1:1..23:ncRNA, LM608192.1:48..70:ncRNA, LM608193.1:48..70:ncRNA,

URS000060A0B0_9606 miRNA 23 5

RefSeq: NR_029519,

LncBase: hsa-miR-103a-2-5p,

miRBase: MIMAT0009196,

TarBase: hsa-miR-103a-2-5p,

ENA: FM956498.1:1..23:ncRNA, LM381139.1:1..23:ncRNA, LM608192.1:11..33:ncRNA,

URS0000255FE6_9606 precursor_RNA 78 2

Rfam: RF00129,

ENA: AF480544.1:1..78:misc_RNA,

URS000031E300_9606 miRNA 24 2

MirGeneDB: Hsa-Mir-103-P2_5p,

ENA: AB372801.1:1..24:ncRNA,

MIR103A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR103A2 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR103A2 Gene

No ASD Table

Relevant External Links for MIR103A2 Gene

GeneLoc Exon Structure for
MIR103A2

Expression for MIR103A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR103A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR103A2

genes like me logo Genes that share expression patterns with MIR103A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR103A2 Gene

Orthologs for MIR103A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR103A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-103-2 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-103-2 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-103-2 31
  • 95 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir103-2 31
  • 90 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-103-2 31
  • 88 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-103-2 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-103-2 31
  • 87 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CT573279.1 31
  • 72 (a)
ManyToMany
Species where no ortholog for MIR103A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR103A2 Gene

ENSEMBL:
Gene Tree for MIR103A2 (if available)
TreeFam:
Gene Tree for MIR103A2 (if available)

Paralogs for MIR103A2 Gene

No data available for Paralogs for MIR103A2 Gene

Variants for MIR103A2 Gene

Additional dbSNP identifiers (rs#s) for MIR103A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR103A2 Gene

Variant ID Type Subtype PubMed ID
esv3645053 CNV loss 21293372
esv3645054 CNV gain 21293372
nsv828673 CNV gain 20364138

Additional Variant Information for MIR103A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR103A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR103A2 Gene

Disorders for MIR103A2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIR103A2 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
pancreatic cancer
  • pancreatic carcinoma
hepatocellular carcinoma
  • hcc
crohn's colitis
  • crohn disease
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR103A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR103A2 Gene

Publications for MIR103A2 Gene

  1. microRNA-103 promotes LPS-induced inflammatory injury by targeting c-Myc in HK-2 cells. (PMID: 31284776) Zhang W … Wang Y (Artificial cells, nanomedicine, and biotechnology 2019) 3
  2. MicroRNA-103a regulates sodium-dependent vitamin C transporter-1 expression in intestinal epithelial cells. (PMID: 30616065) Subramanian VS … Said HM (The Journal of nutritional biochemistry 2019) 3
  3. Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-κB/p65 regulatory axis. (PMID: 31086184) Lu Q … Zou MH (Nature communications 2019) 3
  4. High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2. (PMID: 29955039) Cappella M … Martelli F (Cell death & disease 2018) 3
  5. miR-103 promotes the metastasis and EMT of hepatocellular carcinoma by directly inhibiting LATS2. (PMID: 30272278) Han LL … Zhang SQ (International journal of oncology 2018) 3

Products for MIR103A2 Gene

Sources for MIR103A2 Gene