microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR103A1 Gene

Subcategory (RNA class) for MIR103A1 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR103A1 Gene

  • MicroRNA 103a-1 2 3 5
  • Hsa-MiR-103a-3p 168 179
  • MicroRNA 103-1 2 3
  • Hsa-Mir-103a-1 3
  • Hsa-Mir-103-1 3
  • MIMAT0000101 53
  • MIMAT0037306 53
  • Mir-103a-1 3
  • MIRN103-1 3
  • MI0000109 53
  • MIR103-1 3
  • MIR103A1 2
  • RF00129 174

External Ids for MIR103A1 Gene

Previous HGNC Symbols for MIR103A1 Gene

  • MIRN103-1
  • MIR103-1

Previous GeneCards Identifiers for MIR103A1 Gene

  • GC05M167988

Summaries for MIR103A1 Gene

Entrez Gene Summary for MIR103A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR103A1 Gene

MIR103A1 (MicroRNA 103a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR103A1 include Bladder Cancer and Scleral Staphyloma. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.

Rfam classification for MIR103A1 Gene

  • mir-103/107 microRNA precursor

Additional gene information for MIR103A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR103A1 Gene

Genomics for MIR103A1 Gene

GeneHancer (GH) Regulatory Elements for MIR103A1 Gene

Promoters and enhancers for MIR103A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J168583 Enhancer 0.7 Ensembl ENCODE 11.2 -23.4 -23407 2 ZNF652 IKZF1 POLR2A IKZF2 NFE2 DPF2 RUNX3 JUNB RCOR1 BATF FBLL1 MIR103A1 RARS1 ENSG00000254192 PANK3 HSALNG0046447 RPL10P9
GH05J168531 Enhancer 0.3 Ensembl 11.2 +28.7 28672 1.4 ZIC2 POLR2A FBLL1 PANK3 MIR103A1 RARS1 lnc-PANK3-23 lnc-PANK3-13-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR103A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR103A1 Gene

Genomic Locations for MIR103A1 Gene
chr5:168,560,896-168,560,973
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand
chr5:167,987,897-167,987,982
(GRCh37/hg19)
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR103A1 Gene

Genes around MIR103A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR103A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR103A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR103A1 Gene

Proteins for MIR103A1 Gene

Post-translational modifications for MIR103A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR103A1 Gene

Domains & Families for MIR103A1 Gene

Gene Families for MIR103A1 Gene

genes like me logo Genes that share domains with MIR103A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR103A1 Gene

Function for MIR103A1 Gene

Gene Ontology (GO) - Molecular Function for MIR103A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR103A1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR103A1 Gene

Localization for MIR103A1 Gene

Gene Ontology (GO) - Cellular Components for MIR103A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0005623 cell IEA --
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR103A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR103A1 Gene

Pathways & Interactions for MIR103A1 Gene

PathCards logo

SuperPathways for MIR103A1 Gene

genes like me logo Genes that share pathways with MIR103A1: view

Pathways by source for MIR103A1 Gene

1 BioSystems pathway for MIR103A1 Gene
1 KEGG pathway for MIR103A1 Gene

Gene Ontology (GO) - Biological Process for MIR103A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis ISS 24000013
GO:0010801 negative regulation of peptidyl-threonine phosphorylation IDA 27343180
GO:0032869 cellular response to insulin stimulus ISS 24000013
GO:0035195 gene silencing by miRNA IEA,IDA --
GO:0035278 miRNA mediated inhibition of translation IDA 22723340
genes like me logo Genes that share ontologies with MIR103A1: view

No data available for SIGNOR curated interactions for MIR103A1 Gene

Drugs & Compounds for MIR103A1 Gene

No Compound Related Data Available

Transcripts for MIR103A1 Gene

mRNA/cDNA for MIR103A1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(5) RNACentral transcripts :
(8) ENA transcripts :
(1) LncBase transcripts :
(1) TarBase transcripts :
(1) Rfam transcripts :
(3) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR103A1 Gene

No ASD Table

Relevant External Links for MIR103A1 Gene

GeneLoc Exon Structure for
MIR103A1
ECgene alternative splicing isoforms for
MIR103A1

Expression for MIR103A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR103A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR103A1 Gene:

MIR103A1
genes like me logo Genes that share expression patterns with MIR103A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR103A1 Gene

Orthologs for MIR103A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR103A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-103-1 33
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir103-1 33
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-103-1 33
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-103-1 33
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-103-1 33
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-103-1 33
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-103 33
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-103 33
  • 72 (a)
ManyToMany
Species where no ortholog for MIR103A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR103A1 Gene

ENSEMBL:
Gene Tree for MIR103A1 (if available)
TreeFam:
Gene Tree for MIR103A1 (if available)

Paralogs for MIR103A1 Gene

No data available for Paralogs for MIR103A1 Gene

Variants for MIR103A1 Gene

Sequence variations from dbSNP and Humsavar for MIR103A1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1002908307 -- 168,561,039(-) T/C upstream_transcript_variant
rs1003313499 -- 168,562,850(-) A/C upstream_transcript_variant
rs1003365809 -- 168,562,603(-) C/G upstream_transcript_variant
rs1003495276 -- 168,562,546(-) G/A upstream_transcript_variant
rs1003963661 -- 168,562,182(-) C/T upstream_transcript_variant

Additional Variant Information for MIR103A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR103A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR103A1 Gene

Disorders for MIR103A1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR103A1 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
bladder cancer
  • bladder cancer, somatic
scleral staphyloma
  • scleral ectasia
bladder disease
  • urinary bladder disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR103A1

genes like me logo Genes that share disorders with MIR103A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR103A1 Gene

Publications for MIR103A1 Gene

  1. The risk variant rs884225 within EGFR impairs miR-103a-3p's anti-tumourigenic function in non-small cell lung cancer. (PMID: 30470824) Fan Z … Jiao S (Oncogene 2019) 3 56
  2. Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-κB/p65 regulatory axis. (PMID: 31086184) Lu Q … Zou MH (Nature communications 2019) 3 56
  3. MicroRNA-103 suppresses glioma cell proliferation and invasion by targeting the brain-derived neurotrophic factor. (PMID: 29257320) Wang L … Song J (Molecular medicine reports 2018) 3 56
  4. MicroRNA-103 Promotes Proliferation and Inhibits Apoptosis in Spinal Osteosarcoma Cells by Targeting p57. (PMID: 29295723) Wang X … Zhang X (Oncology research 2018) 3 56
  5. miR-103 promotes the metastasis and EMT of hepatocellular carcinoma by directly inhibiting LATS2. (PMID: 30272278) Han LL … Zhang SQ (International journal of oncology 2018) 3 56

Products for MIR103A1 Gene

Sources for MIR103A1 Gene