MIR103A1 Gene (RNA Gene)

MicroRNA 103a-1

GC05M168560
GIFtS:
18
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR103A1 Gene

Subcategory (RNA class) for MIR103A1 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR103A1 Gene

  • MicroRNA 103a-1 2 3 5
  • Hsa-MiR-103a-3p 166 177
  • MicroRNA 103-1 2 3
  • Hsa-Mir-103a-1 3
  • Hsa-Mir-103-1 3
  • MIMAT0037306 51
  • MIMAT0000101 51
  • Mir-103a-1 3
  • MIRN103-1 3
  • MI0000109 51
  • MIR103-1 3
  • MIR103A1 2
  • RF00129 172

External Ids for MIR103A1 Gene

Previous HGNC Symbols for MIR103A1 Gene

  • MIRN103-1
  • MIR103-1

Previous GeneCards Identifiers for MIR103A1 Gene

  • GC05M167988

Summaries for MIR103A1 Gene

Entrez Gene Summary for MIR103A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR103A1 Gene

MIR103A1 (MicroRNA 103a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR103A1 include Bladder Cancer and Neurodegeneration With Brain Iron Accumulation 1. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

Rfam classification for MIR103A1 Gene

  • mir-103/107 microRNA precursor

Additional gene information for MIR103A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR103A1 Gene

Genomics for MIR103A1 Gene

GeneHancer (GH) Regulatory Elements for MIR103A1 Gene

Promoters and enhancers for MIR103A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05J168583 Enhancer 0.8 Ensembl ENCODE 11.2 -23.4 -23407 2 MXI1 SPI1 NFE2 BATF EBF1 IKZF1 RCOR1 JUNB NFIC TBL1XR1 FBLL1 MIR103A1 RARS1 ENSG00000254192 PANK3 HSALNG0046447 RPL10P9
GH05J168531 Enhancer 0.4 Ensembl 11.2 +28.7 28672 1.4 ZIC2 POLR2A SMARCA4 FBLL1 PANK3 MIR103A1 RARS1 lnc-PANK3-13-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR103A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR103A1 Gene

Genomic Locations for MIR103A1 Gene
chr5:168,560,896-168,560,973
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand
chr5:167,987,897-167,987,982
(GRCh37/hg19)
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR103A1 Gene

Genes around MIR103A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR103A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR103A1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR103A1 Gene

Proteins for MIR103A1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR103A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR103A1 Gene

Domains & Families for MIR103A1 Gene

Gene Families for MIR103A1 Gene

HGNC:
genes like me logo Genes that share domains with MIR103A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR103A1 Gene

Function for MIR103A1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR103A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI 30089260
genes like me logo Genes that share ontologies with MIR103A1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR103A1 Gene

Localization for MIR103A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR103A1 gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR103A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with MIR103A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR103A1 Gene

Pathways & Interactions for MIR103A1 Gene

PathCards logo

SuperPathways for MIR103A1 Gene

genes like me logo Genes that share pathways with MIR103A1: view

Pathways by source for MIR103A1 Gene

1 BioSystems pathway for MIR103A1 Gene
1 KEGG pathway for MIR103A1 Gene
;

Gene Ontology (GO) - Biological Process for MIR103A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis ISS 24000013
GO:0010801 negative regulation of peptidyl-threonine phosphorylation IDA 27343180
GO:0032869 cellular response to insulin stimulus ISS 24000013
GO:0035195 gene silencing by miRNA IDA 15131085
GO:0035278 miRNA mediated inhibition of translation IGI 30089260
genes like me logo Genes that share ontologies with MIR103A1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR103A1 Gene

Drugs & Compounds for MIR103A1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR103A1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR103A1 Gene

5 RNACentral transcripts :
2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
8 ENA transcripts :
1 LncBase transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR103A1 Gene

No ASD Table

Relevant External Links for MIR103A1 Gene

GeneLoc Exon Structure for
MIR103A1

Expression for MIR103A1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR103A1 Gene

mRNA expression in normal human tissues for MIR103A1 Gene
mRNA expression by GTEx for MIR103A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR103A1

genes like me logo Genes that share expression patterns with MIR103A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR103A1 Gene

Orthologs for MIR103A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR103A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia bta-mir-103-1 31
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-103-1 31
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir103-1 31
  • 100 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-103-1 31
  • 95 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-103-1 31
  • 65 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-mir-103-1 31
  • 96 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-103 31
  • 68 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-103 31
  • 72 (a)
 ManyToMany
Species where no ortholog for MIR103A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR103A1 Gene

ENSEMBL:
Gene Tree for MIR103A1 (if available)
TreeFam:
Gene Tree for MIR103A1 (if available)

Paralogs for MIR103A1 Gene

No data available for Paralogs for MIR103A1 Gene

Variants for MIR103A1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for MIR103A1 Gene

Additional Variant Information for MIR103A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR103A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR103A1 Gene

Disorders for MIR103A1 Gene

MalaCards: The human disease database

(43) MalaCards diseases for MIR103A1 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
bladder cancer
  • bladder cancer, somatic
neurodegeneration with brain iron accumulation 1
  • hss
differentiating neuroblastoma
bladder disease
  • urinary bladder disease
overnutrition
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR103A1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR103A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR103A1 Gene

Publications for MIR103A1 Gene

  1. The risk variant rs884225 within EGFR impairs miR-103a-3p's anti-tumourigenic function in non-small cell lung cancer. (PMID: 30470824) Fan Z … Jiao S (Oncogene 2019) 3 54
  2. microRNA-103 promotes LPS-induced inflammatory injury by targeting c-Myc in HK-2 cells. (PMID: 31284776) Zhang W … Wang Y (Artificial cells, nanomedicine, and biotechnology 2019) 3 54
  3. Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-κB/p65 regulatory axis. (PMID: 31086184) Lu Q … Zou MH (Nature communications 2019) 3 54
  4. MicroRNA-103 suppresses glioma cell proliferation and invasion by targeting the brain-derived neurotrophic factor. (PMID: 29257320) Wang L … Song J (Molecular medicine reports 2018) 3 54
  5. MicroRNA-103 Promotes Proliferation and Inhibits Apoptosis in Spinal Osteosarcoma Cells by Targeting p57. (PMID: 29295723) Wang X … Zhang X (Oncology research 2018) 3 54

ExternalLinks

View latest publications for MIR103A1 gene in Mastermind

Products for MIR103A1 Gene

Sources for MIR103A1 Gene