Aliases for MIR103A1 Gene
Subcategory (RNA class) for MIR103A1 Gene
miRNA
Quality Score for this RNA gene is
14.2
Aliases for MIR103A1 Gene
External Ids for MIR103A1 Gene
- HGNC: 31490
- Entrez Gene: 406895
- Ensembl: ENSG00000199035
- OMIM: 613187
- miRBase: hsa-mir-103a-1
ORGUL Members for MIR103A1 Gene
Previous HGNC Symbols for MIR103A1 Gene
- MIRN103-1
- MIR103-1
Previous GeneCards Identifiers for MIR103A1 Gene
- GC05M167988
Summaries for MIR103A1 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR103A1 Gene
MIR103A1 (MicroRNA 103a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR103A1 include Diffuse Gastric Cancer. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.
fRNAdb sequence ontologies for MIR103A1 Gene - the ORGUL cluster for this gene includes several descriptions:
-
miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
Additional gene information for MIR103A1 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR103A1 Gene
Genomics for MIR103A1 Gene
GeneHancer (GH) Regulatory Elements for MIR103A1 Gene
Promoters and enhancers for MIR103A1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05I168583 | Enhancer | 0.6 | ENCODE | 11.2 | -23.6 | -23592 | 1.6 | JUNB EBF1 DPF2 BATF POLR2A IKZF1 RCOR1 NFE2 IKZF2 RUNX3 | MIR103A1 RARS ENSG00000254192 FBLL1 PANK3 RPL10P9 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR103A1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR103A1 Gene
Genomic Locations for MIR103A1 Gene
- chr5:168,560,896-168,560,973
- (GRCh38/hg38)
- Size:
- 78 bases
- Orientation:
- Minus strand
- chr5:167,987,897-167,987,982
- (GRCh37/hg19)
Genomic View for MIR103A1 Gene
Genes around MIR103A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q34 by Ensembl
- 5q34 by Entrez Gene
- 5q34 by HGNC
MIR103A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR103A1 Gene
ORGUL Member Location for MIR103A1 Gene
Proteins for MIR103A1 Gene
Post-translational modifications for MIR103A1 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR103A1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR103A1
- Origene Custom Protein Services for MIR103A1
- Search GeneTex for Proteins for MIR103A1
No data available for DME Specific Peptides for MIR103A1 Gene
Domains & Families for MIR103A1 Gene
Gene Families for MIR103A1 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR103A1 Gene
Function for MIR103A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 15131085 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR103A1
-
- Search ViGene Biosciences for MIR103A1
CRISPR Products
- Browse CRISPR knockouts for MIR103A1
- Applied Biological Materials CRISPR for MIR103A1
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR103A1
Clone Products
- GenScript: Custom all cDNA clones Services for MIR103A1
- VectorBuilder custom plasmid, inducible vectors for MIR103A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR103A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR103A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR103A1 Gene
Localization for MIR103A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR103A1 Gene
Pathways & Interactions for MIR103A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | MicroRNAs in cardiomyocyte hypertrophy | ||
Pathways by source for MIR103A1 Gene
1 BioSystems pathway for MIR103A1 Gene
1 KEGG pathway for MIR103A1 Gene
Interacting Proteins for MIR103A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IDA | 15131085 |
No data available for SIGNOR curated interactions for MIR103A1 Gene
Transcripts for MIR103A1 Gene
fRNAdb Secondary structures for MIR103A1 Gene
mRNA/cDNA for MIR103A1 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR103A1
- Applied Biological Materials CRISPR for MIR103A1
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR103A1
Clone Products
- GenScript: Custom all cDNA clones Services for MIR103A1
- VectorBuilder custom plasmid, inducible vectors for MIR103A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR103A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR103A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR103A1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR103A1 Gene:
MIR103A1Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR103A1 Gene
Orthologs for MIR103A1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | bta-mir-103-1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mir103-1 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-103-1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-103-1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-103-1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | gga-mir-103-1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | aca-mir-103 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | dre-mir-103 34 |
|
ManyToMany |
- Species where no ortholog for MIR103A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIR103A1 Gene
No data available for Paralogs for MIR103A1 Gene
Variants for MIR103A1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1002908307 | -- | 168,561,039(-) | T/C | upstream_transcript_variant | |
| rs1003313499 | -- | 168,562,850(-) | A/C | upstream_transcript_variant | |
| rs1003365809 | -- | 168,562,603(-) | C/G | upstream_transcript_variant | |
| rs1003495276 | -- | 168,562,546(-) | G/A | upstream_transcript_variant | |
| rs1003963661 | -- | 168,562,182(-) | C/T | upstream_transcript_variant |
Additional Variant Information for MIR103A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR103A1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR103A1 Gene
Disorders for MIR103A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diffuse gastric cancer |
|
|
Search MIR103A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR103A1
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR103A1 Gene
Publications for MIR103A1 Gene
- Plasma microRNA-103, microRNA-107, and microRNA-194 levels are not biomarkers for human diffuse gastric cancer. (PMID: 27909811) Oze I … Yuasa Y (Journal of cancer research and clinical oncology 2017) 3 58
- Potential Role of Lipometabolism-Related MicroRNAs in Peripheral Blood Mononuclear Cells as Biomarkers for Coronary Artery Disease. (PMID: 27629254) Dong J … Yan YX (Journal of atherosclerosis and thrombosis 2017) 3 58
- Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
- MicroRNAs-103/107 coordinately regulate macropinocytosis and autophagy. (PMID: 27872138) Park JK … Lavker RM (The Journal of cell biology 2016) 3 58
- Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production. (PMID: 27185878) Wu C … Newton-Cheh C (Molecular and cellular biology 2016) 3 58
Products for MIR103A1 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR103A1
- VectorBuilder custom plasmid, inducible vectors for MIR103A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR103A1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR103A1
- Search GeneTex for Proteins for MIR103A1
Sources for MIR103A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (120) Genetics Home Reference
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- (133) ENCODE
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew