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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR103A1 (MicroRNA 103a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR103A1 include Bladder Cancer and Galloway-Mowat Syndrome 2. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH05J168583 | Enhancer | 0.8 | Ensembl ENCODE | 11.2 | -23.4 | -23407 | 2 | DPF2 RUNX3 NFE2 IKZF1 JUNB SPI1 RCOR1 BATF EBF1 TBL1XR1 | FBLL1 MIR103A1 RARS1 ENSG00000254192 PANK3 HSALNG0046447 RPL10P9 SLIT3 | |
GH05J168531 | Enhancer | 0.4 | Ensembl | 11.2 | +28.7 | 28672 | 1.4 | ZIC2 POLR2A SMARCA4 | FBLL1 PANK3 MIR103A1 RARS1 lnc-PANK3-13-001 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IGI | 30089260 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 18766170 |
GO:0005623 | cell | IEA | -- |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | MicroRNAs in cardiomyocyte hypertrophy |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001678 | cellular glucose homeostasis | ISS | 24000013 |
GO:0010801 | negative regulation of peptidyl-threonine phosphorylation | IDA | 27343180 |
GO:0032869 | cellular response to insulin stimulus | ISS | 24000013 |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0035278 | miRNA mediated inhibition of translation | IDA,IGI | 30089260 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000561D92_9606 | precursor_RNA | 78 | 6 |
HGNC: 31490, RefSeq: NR_029520, Ensembl: ENST00000362165 (view in UCSC) , miRBase: MI0000109, Rfam: RF00129, ENA: AF480545.1:1..78:misc_RNA, LM608193.1:1..78:precursor_RNA, |
URS0000476BE1_9606 | miRNA | 23 | 6 |
LncBase: hsa-miR-103a-3p, miRBase: MIMAT0000101, MirGeneDB: Hsa-Mir-103-P1_3p, Hsa-Mir-103-P2_3p, TarBase: hsa-miR-103a-3p, ENA: AF480501.1:1..23:ncRNA, LM378788.1:1..23:ncRNA, LM608192.1:48..70:ncRNA, LM608193.1:48..70:ncRNA, |
URS00005812A9_9606 | miRNA | 23 | 3 |
RefSeq: NR_029520, miRBase: MIMAT0037306, MirGeneDB: Hsa-Mir-103-P1_5p, |
URS0000EFDC01_9606 | precursor_RNA | 61 | 1 |
MirGeneDB: Hsa-Mir-103-P1, |
URS000045A2E1_9606 | miRNA | 24 | 1 |
ENA: AB372800.1:1..24:ncRNA, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | bta-mir-103-1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir103-1 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-103-1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-103-1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-103-1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-103-1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-103 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-103 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
bladder cancer |
|
|
galloway-mowat syndrome 2 |
|
|
joubert syndrome 20 |
|
|
neurodegeneration with brain iron accumulation 1 |
|
|
differentiating neuroblastoma |
|
|