microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR101-2 Gene

Data sources for MIR101-2 Gene:

RNA type for MIR101-2 Gene

miRNA

Aliases for MIR101-2 Gene

External Ids for MIR101-2 Gene

Previous HGNC Symbols for MIR101-2 Gene

  • MIRN101-2

Previous GeneCards Identifiers for MIR101-2 Gene

  • GC09P004843
  • GC09P004852
  • GC09P004855
  • GC09P004854
  • GC09P004856
  • GC09P004866
  • GC09P004867
  • GC09P004865
  • GC09P004864
  • GC09P004857
  • GC09P004858
  • GC09P004859
  • GC09P004861
  • GC09P004862

Summaries for MIR101-2 Gene

Entrez Gene Summary for MIR101-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR101-2 Gene

MIR101-2 (MicroRNA 101-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIR101-2 Gene

  • mir-101 microRNA precursor family

Additional gene information for MIR101-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR101-2 Gene

Genomics for MIR101-2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR101-2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR101-2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR101-2 Gene

Latest Assembly
chr9:4,850,297-4,850,375
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand

Previous Assembly
chr9:4,850,297-4,850,375
(GRCh37/hg19 by Entrez Gene)
Size:
79 bases
Orientation:
Plus strand

chr9:4,850,291-4,850,381
(GRCh37/hg19 by Ensembl)
Size:
91 bases
Orientation:
Plus strand

Genomic View for MIR101-2 Gene

Genes around MIR101-2 on UCSC Golden Path with GeneCards custom track
MIR101-2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR101-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR101-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR101-2 Gene

Proteins for MIR101-2 Gene

Post-translational modifications for MIR101-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR101-2 Gene

Domains & Families for MIR101-2 Gene

Gene Families for MIR101-2 Gene

genes like me logo Genes that share domains with MIR101-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR101-2 Gene

Function for MIR101-2 Gene

Phenotypes From GWAS Catalog for MIR101-2 Gene

Gene Ontology (GO) - Molecular Function for MIR101-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA --
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIR101-2: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR101-2 Gene

Localization for MIR101-2 Gene

Gene Ontology (GO) - Cellular Components for MIR101-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA --
GO:1903561 extracellular vesicle HDA --
genes like me logo Genes that share ontologies with MIR101-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR101-2 Gene

Pathways & Interactions for MIR101-2 Gene

PathCards logo

SuperPathways for MIR101-2 Gene

genes like me logo Genes that share pathways with MIR101-2: view

Pathways by source for MIR101-2 Gene

1 BioSystems pathway for MIR101-2 Gene
1 KEGG pathway for MIR101-2 Gene

Gene Ontology (GO) - Biological Process for MIR101-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA --
GO:0010629 negative regulation of gene expression IMP --
GO:0031397 negative regulation of protein ubiquitination IDA --
GO:0032691 negative regulation of interleukin-1 beta production IMP --
GO:0032715 negative regulation of interleukin-6 production IMP --
genes like me logo Genes that share ontologies with MIR101-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR101-2 Gene

Drugs & Compounds for MIR101-2 Gene

No Compound Related Data Available

Transcripts for MIR101-2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR101-2 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00001230A0_9606 miRNA 21 5

RefSeq: NR_029516, NR_029836,

LncBase: hsa-miR-101-3p,

miRBase: MIMAT0000099,

TarBase: hsa-miR-101-3p,

ENA: LM378786.1:1..21:ncRNA, LM608189.1:47..67:ncRNA, LM608666.1:49..69:ncRNA,

URS000075A0E6_9606 pre_miRNA 79 4

RefSeq: NR_029836,

Ensembl: ENST00000362195 (view in UCSC) ,

miRBase: MI0000739,

ENA: LM608666.1:1..79:precursor_RNA,

URS000075EB3E_9606 miRNA 22 2

RefSeq: NR_029836,

miRBase: MIMAT0037312,

URS000058D5C7_9606 pre_miRNA 75 2

Rfam: RF00253,

ENA: AF480540.1:1..75:misc_RNA,

URS00005FF45E_9606 miRNA 22 2

MirGeneDB: Hsa-Mir-101-P1-v2_3p, Hsa-Mir-101-P2-v2_3p,

ENA: AF480499.1:1..22:ncRNA,

MIR101-2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR101-2 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR101-2 Gene

No ASD Table

Relevant External Links for MIR101-2 Gene

GeneLoc Exon Structure for
MIR101-2

Expression for MIR101-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR101-2

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR101-2 Gene

Orthologs for MIR101-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR101-2 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-101-2 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-101-2 30
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-101-2 30
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-101-2 30
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-101-2 30 30
  • 97 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Mir101b 30
  • 89 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-101-1 30
  • 95 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-101-2 30
  • 98 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-101b 30
  • 64 (a)
OneToOne
Species where no ortholog for MIR101-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR101-2 Gene

ENSEMBL:
Gene Tree for MIR101-2 (if available)
TreeFam:
Gene Tree for MIR101-2 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR101-2

Paralogs for MIR101-2 Gene

No data available for Paralogs for MIR101-2 Gene

Variants for MIR101-2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR101-2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR101-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR101-2
Leiden Open Variation Database (LOVD)
MIR101-2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR101-2 Gene

Disorders for MIR101-2 Gene

Additional Disease Information for MIR101-2

No disorders were found for MIR101-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR101-2 Gene

Publications for MIR101-2 Gene

  1. Down-regulation of HCP5 inhibits cell proliferation, migration, and invasion through regulating EPHA7 by competitively binding miR-101 in osteosarcoma. (PMID: 33439936) Tu Y … Xu M (Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2021) 3
  2. Long noncoding RNA CRNDE promotes proliferation, migration and invasion in prostate cancer through miR-101/Rap1A. (PMID: 32182086) Chen JH … Wang JZ (Neoplasma 2020) 3
  3. RNA-sequence-based microRNA expression signature in breast cancer: tumor-suppressive miR-101-5p regulates molecular pathogenesis. (PMID: 31755218) Toda H … Natsugoe S (Molecular oncology 2020) 3
  4. MicroRNA-101-3p Downregulates TLR2 Expression, Leading to Reduction in Cytokine Production by Treponema pallidum-Stimulated Macrophages. (PMID: 31930972) Huang T … Zheng H (The Journal of investigative dermatology 2020) 3
  5. Regulation of osteogenesis via miR-101-3p in mesenchymal stem cells by human gingival fibroblasts. (PMID: 31970478) Kaneda-Ikeda E … Kurihara H (Journal of bone and mineral metabolism 2020) 3

Products for MIR101-2 Gene

Sources for MIR101-2 Gene