microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR101-2 Gene

Subcategory (RNA class) for MIR101-2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR101-2 Gene

  • MicroRNA 101-2 2 3 5
  • Hsa-MiR-101-3p 163 173
  • Hsa-Mir-101-2 2 3
  • MIR101-2 2 5
  • Hsa-Mir-101-P2-V1 178
  • Hsa-Mir-101-P2-V2 178
  • MIMAT0037312 50
  • MIMAT0000099 50
  • MIRN101-2 3
  • Mir-101-2 3
  • MI0000739 50
  • RF00253 168

External Ids for MIR101-2 Gene

Previous HGNC Symbols for MIR101-2 Gene

  • MIRN101-2

Previous GeneCards Identifiers for MIR101-2 Gene

  • GC09P004843
  • GC09P004852
  • GC09P004855
  • GC09P004854
  • GC09P004856
  • GC09P004866
  • GC09P004867
  • GC09P004865
  • GC09P004864
  • GC09P004857
  • GC09P004858
  • GC09P004859
  • GC09P004861
  • GC09P004862

Summaries for MIR101-2 Gene

Entrez Gene Summary for MIR101-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR101-2 Gene

MIR101-2 (MicroRNA 101-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIR101-2 Gene

  • mir-101 microRNA precursor family

Additional gene information for MIR101-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR101-2 Gene

Genomics for MIR101-2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR101-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J004848 Enhancer 1.2 Ensembl ENCODE dbSUPER 600.7 +0.5 453 3.7 GATAD2A REST RFX1 IKZF1 RCOR2 JUND MTA2 ZIC2 RBFOX2 PKNOX1 ENSG00000228165 MIR101-2 JAK2 RCL1 lnc-RCL1-1
GH09J004983 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 +136.0 136003 5.4 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 REST IKZF1 KDM1A ZNF692 JAK2 ENSG00000228165 MIR101-2 MTND6P5 MTCO1P11 RF00017-7408 LOC107987044
GH09J004791 Promoter/Enhancer 1.7 EPDnew ENCODE CraniofacialAtlas 10.9 -57.0 -56979 3.3 SP1 HNRNPL PRDM10 TFE3 RFX1 RFX5 ZNF692 POLR2A BACH1 FOS RCL1 lnc-AK3-5 JAK2 ENSG00000228165 MIR101-2 RF01960-017
GH09J004815 Enhancer 0.9 Ensembl ENCODE 11.9 -34.5 -34496 3.2 IKZF1 STAT3 RELA IKZF2 POLR2A TRIM22 EED ARID3A ZSCAN29 RELB RCL1 MIR101-2 ENSG00000228165 JAK2 KLF4P1
GH09J004886 Enhancer 0.8 Ensembl dbSUPER 11.6 +37.1 37103 1.6 IKZF2 TRIM22 PKNOX1 MGA RUNX3 EZH2 ARNT IKZF1 NR2F1 BHLHE40 lnc-RCL1-3 piR-56580-048 ENSG00000228165 MIR101-2 JAK2 lnc-RCL1-2 RCL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR101-2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR101-2 Gene

Genomic Locations for MIR101-2 Gene
chr9:4,850,297-4,850,375
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr9:4,850,291-4,850,381
(GRCh37/hg19)
Size:
91 bases
Orientation:
Plus strand

Genomic View for MIR101-2 Gene

Genes around MIR101-2 on UCSC Golden Path with GeneCards custom track
MIR101-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR101-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR101-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR101-2 Gene

Proteins for MIR101-2 Gene

Post-translational modifications for MIR101-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR101-2 Gene

Domains & Families for MIR101-2 Gene

Gene Families for MIR101-2 Gene

genes like me logo Genes that share domains with MIR101-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR101-2 Gene

Function for MIR101-2 Gene

Phenotypes From GWAS Catalog for MIR101-2 Gene

Gene Ontology (GO) - Molecular Function for MIR101-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 30692230
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR101-2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR101-2 Gene

Localization for MIR101-2 Gene

Gene Ontology (GO) - Cellular Components for MIR101-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR101-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR101-2 Gene

Pathways & Interactions for MIR101-2 Gene

PathCards logo

SuperPathways for MIR101-2 Gene

genes like me logo Genes that share pathways with MIR101-2: view

Pathways by source for MIR101-2 Gene

1 BioSystems pathway for MIR101-2 Gene
1 KEGG pathway for MIR101-2 Gene

Gene Ontology (GO) - Biological Process for MIR101-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 31934175
GO:0010629 negative regulation of gene expression IMP 23554480
GO:0031397 negative regulation of protein ubiquitination IDA 24844779
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 21172309
genes like me logo Genes that share ontologies with MIR101-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR101-2 Gene

Drugs & Compounds for MIR101-2 Gene

No Compound Related Data Available

Transcripts for MIR101-2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR101-2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A0E6_9606 precursor_RNA 79 5

HGNC: 31489,

RefSeq: NR_029836,

Ensembl: ENST00000362195 (view in UCSC) ,

miRBase: MI0000739,

ENA: LM608666.1:1..79:precursor_RNA,

URS00001230A0_9606 miRNA 21 5

RefSeq: NR_029516, NR_029836,

LncBase: hsa-miR-101-3p,

miRBase: MIMAT0000099,

TarBase: hsa-miR-101-3p,

ENA: LM378786.1:1..21:ncRNA, LM608189.1:47..67:ncRNA, LM608666.1:49..69:ncRNA,

URS000075EB3E_9606 miRNA 22 2

RefSeq: NR_029836,

miRBase: MIMAT0037312,

URS000058D5C7_9606 precursor_RNA 75 2

Rfam: RF00253,

ENA: AF480540.1:1..75:misc_RNA,

URS00005FF45E_9606 miRNA 22 2

MirGeneDB: Hsa-Mir-101-P1-v2_3p, Hsa-Mir-101-P2-v2_3p,

ENA: AF480499.1:1..22:ncRNA,

MIR101-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR101-2 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR101-2 Gene

No ASD Table

Relevant External Links for MIR101-2 Gene

GeneLoc Exon Structure for
MIR101-2

Expression for MIR101-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR101-2

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR101-2 Gene

Orthologs for MIR101-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR101-2 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-101-2 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-101-2 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-101-2 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-101-2 31
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-101-2 31 31
  • 97 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Mir101b 31
  • 89 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-101-1 31
  • 95 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-101-2 31
  • 98 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-101b 31
  • 64 (a)
OneToOne
Species where no ortholog for MIR101-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR101-2 Gene

ENSEMBL:
Gene Tree for MIR101-2 (if available)
TreeFam:
Gene Tree for MIR101-2 (if available)

Paralogs for MIR101-2 Gene

No data available for Paralogs for MIR101-2 Gene

Variants for MIR101-2 Gene

Additional dbSNP identifiers (rs#s) for MIR101-2 Gene

Additional Variant Information for MIR101-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR101-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR101-2 Gene

Disorders for MIR101-2 Gene

Additional Disease Information for MIR101-2

No disorders were found for MIR101-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR101-2 Gene

Publications for MIR101-2 Gene

  1. Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression. (PMID: 31407591) Zhang H … Li L (Artificial cells, nanomedicine, and biotechnology 2019) 3
  2. The upregulation of miR-101 promotes vascular endothelial cell apoptosis and suppresses cell migration in acute coronary syndrome by targeting CDH5. (PMID: 31934175) Cao S … Kang X (International journal of clinical and experimental pathology 2019) 3
  3. Everolimus resistance in clear cell renal cell carcinoma: miRNA-101 and HIF-2α as molecular triggers? (PMID: 31267758) Nogueira I … Medeiros R (Future oncology (London, England) 2019) 3
  4. O-GlcNAcylation promotes colorectal cancer metastasis via the miR-101-O-GlcNAc/EZH2 regulatory feedback circuit. (PMID: 30093632) Jiang M … Fan D (Oncogene 2019) 3
  5. miR-101 suppresses the development of MLL-rearranged acute myeloid leukemia. (PMID: 30792205) Gonzales-Aloy E … Wang JY (Haematologica 2019) 3

Products for MIR101-2 Gene

Sources for MIR101-2 Gene