microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR101-1 Gene

Data sources for MIR101-1 Gene:

RNA type for MIR101-1 Gene

miRNA

Aliases for MIR101-1 Gene

External Ids for MIR101-1 Gene

Previous HGNC Symbols for MIR101-1 Gene

  • MIRN101-1

Previous GeneCards Identifiers for MIR101-1 Gene

  • GC01M065297
  • GC01M065524

Summaries for MIR101-1 Gene

Entrez Gene Summary for MIR101-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR101-1 Gene

MIR101-1 (MicroRNA 101-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR101-1 include Lung Cancer and Breast Cancer. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR101-1 Gene

  • mir-101 microRNA precursor family

Additional gene information for MIR101-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR101-1 Gene

Genomics for MIR101-1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR101-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J064932 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +124.7 124673 2.8 IKZF1 ZNF592 CEBPA ZNF10 ATF3 YY1 CEBPB ZNF639 FOXA2 RXRA JAK1 MIR101-1 AK4 LEPROT LEPR lnc-RAVER2-3 ENSG00000234784 lnc-AK4-1 RAVER2
GH01J065215 Enhancer 0.9 Ensembl ENCODE 10.9 -157.3 -157311 1.2 ZNF592 REST CTCF ARNT MAFF RAD21 SMC3 ELF1 ZNF316 MAFK AK4 DNAJC6 MIR101-1 RNU2-15P LEPR LEPROT MK280225-001 lnc-DNAJC6-3
GH01J065158 Enhancer 1 Ensembl ENCODE 9.9 -101.0 -100967 2.6 NCOR1 CEBPA ATF3 CHD4 YY1 REST FOXA1 FOXA2 KDM6A MAFF AK4 MIR101-1 RPS29P7 lnc-DNAJC6-3 DNAJC6 lnc-AK4-1
GH01J065225 Enhancer 0.8 Ensembl 10.7 -166.4 -166393 1 NCOR1 IKZF1 ZNF592 NBN TAL1 RBM22 ZFP91 PRDM10 STAT5A IRF9 AK4 DNAJC6 MIR101-1 MK280225-001 lnc-DNAJC6-3
GH01J065206 Enhancer 0.7 Ensembl 11.4 -149.7 -149693 3.6 ZNF654 YY1 REST TRIM22 CTCF ZNF623 FOXA2 RXRA RAD21 SMC3 AK4 MIR101-1 RAVER2 lnc-DNAJC6-3 MK280225-001 DNAJC6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR101-1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR101-1 Gene

Latest Assembly
chr1:65,058,434-65,058,508
(GRCh38/hg38)
Size:
75 bases
Orientation:
Minus strand

Previous Assembly
chr1:65,524,117-65,524,191
(GRCh37/hg19 by Entrez Gene)
Size:
75 bases
Orientation:
Minus strand

chr1:65,524,117-65,524,191
(GRCh37/hg19 by Ensembl)
Size:
75 bases
Orientation:
Minus strand

Genomic View for MIR101-1 Gene

Genes around MIR101-1 on UCSC Golden Path with GeneCards custom track
MIR101-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR101-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR101-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR101-1 Gene

Proteins for MIR101-1 Gene

Post-translational modifications for MIR101-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR101-1 Gene

Domains & Families for MIR101-1 Gene

Gene Families for MIR101-1 Gene

genes like me logo Genes that share domains with MIR101-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR101-1 Gene

Function for MIR101-1 Gene

Phenotypes From GWAS Catalog for MIR101-1 Gene

Gene Ontology (GO) - Molecular Function for MIR101-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 24592211
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR101-1: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR101-1 Gene

Localization for MIR101-1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR101-1 gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR101-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR101-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR101-1 Gene

Pathways & Interactions for MIR101-1 Gene

PathCards logo

SuperPathways for MIR101-1 Gene

genes like me logo Genes that share pathways with MIR101-1: view

Pathways by source for MIR101-1 Gene

2 BioSystems pathways for MIR101-1 Gene
1 KEGG pathway for MIR101-1 Gene

Gene Ontology (GO) - Biological Process for MIR101-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 31934175
GO:0010629 negative regulation of gene expression IMP 23554480
GO:0031397 negative regulation of protein ubiquitination IDA 24844779
GO:0032691 negative regulation of interleukin-1 beta production IMP 26022377
GO:0032715 negative regulation of interleukin-6 production IMP 26022377
genes like me logo Genes that share ontologies with MIR101-1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR101-1 Gene

Drugs & Compounds for MIR101-1 Gene

No Compound Related Data Available

Transcripts for MIR101-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR101-1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000017D10B_9606 miRNA 22 6

RefSeq: NR_029516,

LncBase: hsa-miR-101-5p,

miRBase: MIMAT0004513,

MirGeneDB: Hsa-Mir-101-P1-v1_5p,

TarBase: hsa-miR-101-5p,

ENA: LM380192.1:1..22:ncRNA, LM608189.1:11..32:ncRNA,

URS0000370AC5_9606 pre_miRNA 75 5

RefSeq: NR_029516,

Ensembl: ENST00000362265 (view in UCSC) ,

miRBase: MI0000103,

Rfam: RF00253,

ENA: AF480539.1:1..75:misc_RNA, LM608189.1:1..75:precursor_RNA,

URS00001230A0_9606 miRNA 21 5

RefSeq: NR_029516, NR_029836,

LncBase: hsa-miR-101-3p,

miRBase: MIMAT0000099,

TarBase: hsa-miR-101-3p,

ENA: LM378786.1:1..21:ncRNA, LM608189.1:47..67:ncRNA, LM608666.1:49..69:ncRNA,

URS00005FF45E_9606 miRNA 22 2

MirGeneDB: Hsa-Mir-101-P1-v2_3p, Hsa-Mir-101-P2-v2_3p,

ENA: AF480499.1:1..22:ncRNA,

URS0001BCA1AA_9606 pre_miRNA 75 1

Rfam: RF00253,

MIR101-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR101-1 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR101-1 Gene

No ASD Table

Relevant External Links for MIR101-1 Gene

GeneLoc Exon Structure for
MIR101-1

Expression for MIR101-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR101-1

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR101-1 Gene

Orthologs for MIR101-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR101-1 Gene

Organism Taxonomy Gene Similarity Type Details
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-101-1 30
  • 89 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-101-1 30
  • 89 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-101-1 30
  • 89 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-101-1 30
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir101a 30
  • 89 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-101-1 30
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-101-2 30
  • 95 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-101-1 30
  • 88 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-101a 30
  • 86 (a)
OneToOne
Species where no ortholog for MIR101-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR101-1 Gene

ENSEMBL:
Gene Tree for MIR101-1 (if available)
TreeFam:
Gene Tree for MIR101-1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR101-1

Paralogs for MIR101-1 Gene

No data available for Paralogs for MIR101-1 Gene

Variants for MIR101-1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR101-1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR101-1 Gene

Variant ID Type Subtype PubMed ID
esv2676423 CNV deletion 23128226
nsv830059 CNV loss 17160897

Additional Variant Information for MIR101-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR101-1
Leiden Open Variation Database (LOVD)
MIR101-1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR101-1 Gene

Disorders for MIR101-1 Gene

MalaCards: The human disease database

(21) MalaCards diseases for MIR101-1 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
breast cancer
  • breast cancer, familial
cervix disease
  • cervix disorders
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
uterine anomalies
  • uterine disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR101-1

genes like me logo Genes that share disorders with MIR101-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR101-1 Gene

Publications for MIR101-1 Gene

  1. Down-regulation of HCP5 inhibits cell proliferation, migration, and invasion through regulating EPHA7 by competitively binding miR-101 in osteosarcoma. (PMID: 33439936) Tu Y … Xu M (Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2021) 3
  2. MicroRNA-101a-3p could be involved in the pathogenesis of temporomandibular joint osteoarthritis by mediating UBE2D1 and FZD4. (PMID: 33187014) Mao D … Chen F (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2021) 3
  3. Long noncoding RNA CRNDE promotes proliferation, migration and invasion in prostate cancer through miR-101/Rap1A. (PMID: 32182086) Chen JH … Wang JZ (Neoplasma 2020) 3
  4. Replisome genes regulation by antitumor miR-101-5p in clear cell renal cell carcinoma. (PMID: 31975570) Yamada Y … Seki N (Cancer science 2020) 3
  5. MicroRNA-101-3p suppresses proliferation and migration in hepatocellular carcinoma by targeting the HGF/c-Met pathway. (PMID: 30929159) Liu Y … Chen L (Investigational new drugs 2020) 3

Products for MIR101-1 Gene

Sources for MIR101-1 Gene