microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR101-1 Gene

Subcategory (RNA class) for MIR101-1 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR101-1 Gene

  • MicroRNA 101-1 2 3 5
  • Hsa-MiR-101-3p 168 179
  • Hsa-MiR-101-5p 168 179
  • Hsa-Mir-101-1 3
  • MIMAT0004513 53
  • MIMAT0000099 53
  • Mir-101-1 3
  • MIRN101-1 3
  • MI0000103 53
  • MIR101-1 2
  • RF00253 174

External Ids for MIR101-1 Gene

Previous HGNC Symbols for MIR101-1 Gene

  • MIRN101-1

Previous GeneCards Identifiers for MIR101-1 Gene

  • GC01M065297
  • GC01M065524

Summaries for MIR101-1 Gene

Entrez Gene Summary for MIR101-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR101-1 Gene

MIR101-1 (MicroRNA 101-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR101-1 include Lung Carcinoma In Situ and Lung Cancer. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIR101-1 Gene

  • mir-101 microRNA precursor family

Additional gene information for MIR101-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR101-1 Gene

Genomics for MIR101-1 Gene

GeneHancer (GH) Regulatory Elements for MIR101-1 Gene

Promoters and enhancers for MIR101-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J064932 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +124.7 124673 2.8 ZBTB40 CREB1 SP1 MAFK CEBPG SP7 ZNF644 IKZF1 CEBPA RXRA JAK1 MIR101-1 AK4 LEPROT LEPR ENSG00000233877 lnc-RAVER2-3 ENSG00000234784 lnc-RAVER2-2 lnc-AK4-1
GH01J065215 Enhancer 0.9 Ensembl ENCODE 11.5 -157.2 -157192 3.4 CTCF CC2D1A NFYC RAD21 TEAD4 MAFK ARID2 REST HDAC1 ZNF316 AK4 DNAJC6 MIR101-1 LEPR LEPROT RNU2-15P lnc-DNAJC6-2 lnc-DNAJC6-3
GH01J065158 Enhancer 1 Ensembl ENCODE 9.9 -101.0 -100967 2.6 FOXA1 LCORL RBPJ SMARCE1 NR2F6 CREB1 MIXL1 ZNF121 SP1 MAFK AK4 MIR101-1 RPS29P7 lnc-DNAJC6-3 lnc-AK4-1
GH01J065207 Enhancer 0.7 Ensembl 11.4 -150.1 -150092 2.8 CTCF FOXA1 CREB1 L3MBTL2 RAD21 TEAD4 SP1 RXRA REST TRIM22 AK4 MIR101-1 RAVER2 lnc-DNAJC6-3 lnc-DNAJC6-2
GH01J065225 Enhancer 0.7 Ensembl 10.7 -166.4 -166393 1 ZBTB40 L3MBTL2 TEAD4 CBFA2T2 SMARCA4 MTA1 IKZF1 CAVIN1 PKNOX1 CREB1 AK4 LEPROT DNAJC6 MIR101-1 lnc-DNAJC6-2 lnc-DNAJC6-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR101-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR101-1 Gene

Genomic Locations for MIR101-1 Gene
chr1:65,058,434-65,058,508
(GRCh38/hg38)
Size:
75 bases
Orientation:
Minus strand
chr1:65,524,117-65,524,191
(GRCh37/hg19)
Size:
75 bases
Orientation:
Minus strand

Genomic View for MIR101-1 Gene

Genes around MIR101-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR101-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR101-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR101-1 Gene

Proteins for MIR101-1 Gene

Post-translational modifications for MIR101-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR101-1 Gene

Domains & Families for MIR101-1 Gene

Gene Families for MIR101-1 Gene

genes like me logo Genes that share domains with MIR101-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR101-1 Gene

Function for MIR101-1 Gene

Gene Ontology (GO) - Molecular Function for MIR101-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR101-1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR101-1 Gene

Localization for MIR101-1 Gene

Gene Ontology (GO) - Cellular Components for MIR101-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR101-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR101-1 Gene

Pathways & Interactions for MIR101-1 Gene

genes like me logo Genes that share pathways with MIR101-1: view

Pathways by source for MIR101-1 Gene

2 BioSystems pathways for MIR101-1 Gene
1 KEGG pathway for MIR101-1 Gene

Gene Ontology (GO) - Biological Process for MIR101-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031397 negative regulation of protein ubiquitination IDA 24844779
GO:0035195 gene silencing by miRNA IEA,IDA --
GO:0035278 miRNA mediated inhibition of translation IDA 21172309
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process ISS --
GO:0050821 protein stabilization IDA 24844779
genes like me logo Genes that share ontologies with MIR101-1: view

No data available for SIGNOR curated interactions for MIR101-1 Gene

Drugs & Compounds for MIR101-1 Gene

No Compound Related Data Available

Transcripts for MIR101-1 Gene

mRNA/cDNA for MIR101-1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(2) TarBase transcripts :
(8) ENA transcripts :
(3) miRBase transcripts :
(2) LncBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR101-1 Gene

No ASD Table

Relevant External Links for MIR101-1 Gene

GeneLoc Exon Structure for
MIR101-1
ECgene alternative splicing isoforms for
MIR101-1

Expression for MIR101-1 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR101-1 Gene

Orthologs for MIR101-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR101-1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mir101a 33
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-101-1 33
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-101-1 33
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-101-1 33
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-101-1 33
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-101-1 33
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-101-2 33
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-101-1 33
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-101a 33
  • 86 (a)
OneToOne
Species where no ortholog for MIR101-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR101-1 Gene

ENSEMBL:
Gene Tree for MIR101-1 (if available)
TreeFam:
Gene Tree for MIR101-1 (if available)

Paralogs for MIR101-1 Gene

No data available for Paralogs for MIR101-1 Gene

Variants for MIR101-1 Gene

Sequence variations from dbSNP and Humsavar for MIR101-1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1003375330 -- 65,060,129(-) T/C upstream_transcript_variant
rs1003415260 -- 65,060,499(-) T/C upstream_transcript_variant
rs1008901439 -- 65,058,917(-) T/C upstream_transcript_variant
rs1008953843 -- 65,059,304(-) C/T upstream_transcript_variant
rs1009301304 -- 65,058,000(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR101-1 Gene

Variant ID Type Subtype PubMed ID
esv2676423 CNV deletion 23128226
nsv830059 CNV loss 17160897

Additional Variant Information for MIR101-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR101-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR101-1 Gene

Disorders for MIR101-1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR101-1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lung carcinoma in situ
lung cancer
  • adenocarcinoma of lung
breast cancer
  • breast cancer, familial
cervix disease
  • cervix disorders
cervical cancer
  • cervical cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR101-1

genes like me logo Genes that share disorders with MIR101-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR101-1 Gene

Publications for MIR101-1 Gene

  1. Targeting Ezh2 could overcome docetaxel resistance in prostate cancer cells. (PMID: 30621625) Qiu X … Yang G (BMC cancer 2019) 3 56
  2. MiR-101 relates to chronic peripheral neuropathic pain through targeting KPNB1 and regulating NF-κB signaling. (PMID: 30887716) Liu JC … Qin PJ (The Kaohsiung journal of medical sciences 2019) 3 56
  3. miR‑101 regulates the cell proliferation and apoptosis in diffuse large B‑cell lymphoma by targeting MEK1 via regulation of the ERK/MAPK signaling pathway. (PMID: 30365139) Huang Y … Zheng R (Oncology reports 2019) 3 56
  4. MiR-101-3p inhibits EMT to attenuate proliferation and metastasis in glioblastoma by targeting TRIM44. (PMID: 30539341) Li L … Chen ZC (Journal of neuro-oncology 2019) 3 56
  5. Downregulation of lncRNA NEAT1_2 radiosensitizes hepatocellular carcinoma cells through regulation of miR-101-3p/WEE1 axis. (PMID: 30488993) Chen X … Zhang N (Cell biology international 2019) 3 56

Products for MIR101-1 Gene

Sources for MIR101-1 Gene