This gene produces long non-coding RNAs that act as regulators of cell proliferation. Alternative promoter usage and splicing results in multiple transcript variants. Some transcript variants may promote growth, while others may act to negatively regulate cell division. [provided by RefSeq, May 2016] See more...

Aliases for MIR100HG Gene

Data sources for MIR100HG Gene:

RNA type for MIR100HG Gene

lncRNA

Aliases for MIR100HG Gene

External Ids for MIR100HG Gene

Previous GeneCards Identifiers for MIR100HG Gene

  • GC11M121961
  • GC11M121902
  • GC11M122089

Summaries for MIR100HG Gene

Entrez Gene Summary for MIR100HG Gene

  • This gene produces long non-coding RNAs that act as regulators of cell proliferation. Alternative promoter usage and splicing results in multiple transcript variants. Some transcript variants may promote growth, while others may act to negatively regulate cell division. [provided by RefSeq, May 2016]

GeneCards Summary for MIR100HG Gene

MIR100HG (Mir-100-Let-7a-2-Mir-125b-1 Cluster Host Gene) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MIR100HG include Myeloid Leukemia and Myopia.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR100HG Gene

Genomics for MIR100HG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR100HG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J122556 Promoter/Enhancer 0.9 Ensembl ENCODE 250.7 +0.0 21 1.4 CTCF YY1 ZNF316 GABPB1 NFE2 NFYC L3MBTL2 RAD21 TFDP1 POLR2A HSALNG0087786 MIR100HG UBASH3B BLID
GH11J122090 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.3 +458.1 458055 16.4 JUND CTCF FOXA2 RAD21 MAFK SIN3A GATA2 TRIM28 POLR2A CHD1 MIR125B1 lnc-BLID-5 MIR100HG BLID SORL1
GH11J122174 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +377.9 377927 8.4 JUND CEBPB EP300 MAFF ZNF316 NFE2 MAFK MAFG NFE2L2 BHLHE40 BLID MIR100HG ENSG00000255219 lnc-UBASH3B-2 HSALNG0087764 UBASH3B
GH11J122185 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +364.3 364338 13.6 JUND BCL11A CEBPB MAX EP300 FOXA2 PRDM1 MAFF RXRA RAD21 MIRLET7A2 BLID MIR100HG ENSG00000255219 piR-41306-051 lnc-UBASH3B-5 lnc-UBASH3B-6 lnc-UBASH3B-2 UBASH3B
GH11J122135 Enhancer 1 Ensembl ENCODE dbSUPER 11.6 +417.8 417844 7.3 JUND BRCA1 YY1 ETS1 EP300 PRDM1 FOXA2 RXRA STAT3 HNF4A BLID MIR100HG ENSG00000255219 HSALNG0087766 UBASH3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR100HG on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR100HG Gene

Latest Assembly
chr11:122,028,203-122,556,721
(GRCh38/hg38)
Size:
528,519 bases
Orientation:
Minus strand

Previous Assembly
chr11:121,899,037-122,293,579
(GRCh37/hg19 by Entrez Gene)
Size:
394,543 bases
Orientation:
Minus strand

chr11:121,899,063-121,987,031
(GRCh37/hg19 by Ensembl)
Size:
87,969 bases
Orientation:
Minus strand

Genomic View for MIR100HG Gene

Genes around MIR100HG on UCSC Golden Path with GeneCards custom track
MIR100HG in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR100HG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR100HG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR100HG Gene

Proteins for MIR100HG Gene

Post-translational modifications for MIR100HG Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR100HG Gene

Domains & Families for MIR100HG Gene

Gene Families for MIR100HG Gene

genes like me logo Genes that share domains with MIR100HG: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR100HG Gene

Function for MIR100HG Gene

Phenotypes From GWAS Catalog for MIR100HG Gene

Phenotypes for MIR100HG Gene

genes like me logo Genes that share phenotypes with MIR100HG: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR100HG Gene

Localization for MIR100HG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR100HG gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR100HG Gene

Pathways & Interactions for MIR100HG Gene

PathCards logo

SuperPathways for MIR100HG Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR100HG Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR100HG Gene

Drugs & Compounds for MIR100HG Gene

No Compound Related Data Available

Transcripts for MIR100HG Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR100HG Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00001E2846_9606 lncRNA 3334 4

Ensembl: ENST00000529823 (view in UCSC) ,

LncBook: HSALNT0182428,

LNCipedia: MIR100HG:18,

NONCODE: NONHSAT024779.2,

URS000001E8C7_9606 lncRNA 2684 4

Ensembl: ENST00000524376 (view in UCSC) ,

LncBook: HSALNT0182432,

LNCipedia: MIR100HG:29,

NONCODE: NONHSAT024781.2,

URS000077FE23_9606 lncRNA 1177 4

Ensembl: ENST00000532315 (view in UCSC) ,

LncBook: HSALNT0182441,

LNCipedia: MIR100HG:15,

NONCODE: NONHSAT024785.2,

URS00001F1282_9606 lncRNA 588 4

Ensembl: ENST00000534195 (view in UCSC) ,

LncBook: HSALNT0182437,

LNCipedia: MIR100HG:16,

NONCODE: NONHSAT024783.2,

URS00007CE945_9606 lncRNA 587 4

Ensembl: ENST00000529733 (view in UCSC) ,

LncBook: HSALNT0182490,

LNCipedia: MIR100HG:4, MIR100HG:57,

NONCODE: NONHSAT024808.2,

MIR100HG in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR100HG Gene

26 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR100HG Gene

No ASD Table

Relevant External Links for MIR100HG Gene

GeneLoc Exon Structure for
MIR100HG

Expression for MIR100HG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR100HG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR100HG

SOURCE GeneReport for Unigene cluster for MIR100HG Gene:

Hs.44098
genes like me logo Genes that share expression patterns with MIR100HG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR100HG Gene

Orthologs for MIR100HG Gene

Evolution for MIR100HG Gene

ENSEMBL:
Gene Tree for MIR100HG (if available)
TreeFam:
Gene Tree for MIR100HG (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR100HG

No data available for Orthologs for MIR100HG Gene

Paralogs for MIR100HG Gene

No data available for Paralogs for MIR100HG Gene

Variants for MIR100HG Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR100HG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR100HG Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV gain 17160897
esv275465 CNV gain+loss 21479260
esv3310060 CNV mobile element insertion 20981092
nsv1119921 CNV deletion 24896259
nsv476130 CNV novel sequence insertion 20440878
nsv477824 CNV novel sequence insertion 20440878

Additional Variant Information for MIR100HG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR100HG
Leiden Open Variation Database (LOVD)
MIR100HG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR100HG Gene

Disorders for MIR100HG Gene

MalaCards: The human disease database

(9) MalaCards diseases for MIR100HG Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
myeloid leukemia
  • leukaemia myelogenous
myopia
  • near vision
neuroblastoma
  • nb
cervical cancer
  • cervical cancer, somatic
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR100HG

genes like me logo Genes that share disorders with MIR100HG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR100HG Gene

Publications for MIR100HG Gene

  1. LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia. (PMID: 25027842) Emmrich S … Klusmann JH (Molecular cancer 2014) 2 3 72
  2. TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. (PMID: 29748571) Ottaviani S … Castellano L (Nature communications 2018) 2 3
  3. Identification of linc-NeD125, a novel long non coding RNA that hosts miR-125b-1 and negatively controls proliferation of human neuroblastoma cells. (PMID: 26480000) Bevilacqua V … Caffarelli E (RNA biology 2015) 3 72
  4. Evaluation of BLID and LOC399959 as candidate genes for high myopia in the Chinese Han population. (PMID: 21031016) Zhao F … Zhou X (Molecular vision 2010) 2 3
  5. Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. (PMID: 19531736) Kikuchi K … Aizawa Y (Nucleic acids research 2009) 2 3

Products for MIR100HG Gene

Sources for MIR100HG Gene