Aliases for MIR100 Gene
Subcategory (RNA class) for MIR100 Gene
miRNA
Quality Score for this RNA gene is
13.2
External Ids for MIR100 Gene
- HGNC: 31487
- Entrez Gene: 406892
- Ensembl: ENSG00000207994
- OMIM: 613186
- miRBase: hsa-mir-100
ORGUL Members for MIR100 Gene
Previous HGNC Symbols for MIR100 Gene
- MIRN100
Previous GeneCards Identifiers for MIR100 Gene
- GC11M121531
- GC11M122023
- GC11M122027
- GC11M122030
- GC11M122033
Summaries for MIR100 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR100 Gene
MIR100 (MicroRNA 100) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response and MicroRNAs in cancer.
fRNAdb sequence ontologies for MIR100 Gene
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
Additional gene information for MIR100 Gene
- Monarch Initiative
- Search for MIR100 at DataMed
- Search for MIR100 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR100 Gene
Genomics for MIR100 Gene
GeneHancer (GH) Regulatory Elements for MIR100 Gene
Promoters and enhancers for MIR100 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11I122150 | Enhancer | 0.9 | ENCODE dbSUPER | 550.8 | +0.8 | 768 | 2.4 | FOXA2 ZNF792 TEAD3 RERE FOSL2 TCF7L2 HMG20B TEAD1 HLF FOXA3 | GC11M122153 GC11M122154 GC11M122156 MIR100 BLID MIR100HG MIRLET7A2 | |
| GH11I122174 | Promoter/Enhancer | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 0.3 | -26.5 | -26486 | 8.4 | BACH1 SIN3A ZNF316 POLR2A SCRT2 NFE2 FOSL2 FOS MAFK NFE2L2 | BLID MIR100HG ENSG00000255219 GC11P122184 GC11M122182 GC11M122154 GC11M122156 MIR100 | |
| GH11I122153 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 0.4 | -10.2 | -10219 | 18.5 | JUN ZSCAN4 MNT SP1 JUND MAFF POLR2A FOS FOSL2 | BLID MIR100HG ENSG00000255015 UBASH3B GC11M122154 GC11M122156 MIR100 GC11P122184 | |
| GH11I122172 | Enhancer | 0.6 | Ensembl ENCODE dbSUPER | 0.3 | -20.8 | -20830 | 1.6 | BLID MIR100HG GC11P122184 GC11M122156 GC11M122154 MIR100 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR100 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR100 Gene
Genomic Locations for MIR100 Gene
- chr11:122,152,229-122,152,308
- (GRCh38/hg38)
- Size:
- 80 bases
- Orientation:
- Minus strand
- chr11:122,022,937-122,023,016
- (GRCh37/hg19)
Genomic View for MIR100 Gene
Genes around MIR100 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.1 by Ensembl
- 11q24.1 by Entrez Gene
- 11q24.1 by HGNC
MIR100 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR100 Gene
ORGUL Member Location for MIR100 Gene
Proteins for MIR100 Gene
Post-translational modifications for MIR100 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR100
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR100
- Origene Custom Protein Services for MIR100
- Search GeneTex for Proteins for MIR100
No data available for DME Specific Peptides for MIR100 Gene
Domains & Families for MIR100 Gene
Gene Families for MIR100 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR100 Gene
Function for MIR100 Gene
Phenotypes From GWAS Catalog for MIR100 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR100
-
- Search ViGene Biosciences for MIR100
CRISPR Products
- Browse CRISPR knockouts for MIR100
- Applied Biological Materials CRISPR for MIR100
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR100
Clone Products
- GenScript: Custom all cDNA clones Services for MIR100
- VectorBuilder custom plasmid, inducible vectors for MIR100
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR100
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR100
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR100 Gene
Localization for MIR100 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR100 Gene
Pathways & Interactions for MIR100 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | miRNAs involved in DNA damage response | ||
Pathways by source for MIR100 Gene
1 BioSystems pathway for MIR100 Gene
1 KEGG pathway for MIR100 Gene
Interacting Proteins for MIR100 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1905064 | negative regulation of vascular smooth muscle cell differentiation | IMP | 18548003 |
No data available for SIGNOR curated interactions for MIR100 Gene
Transcripts for MIR100 Gene
fRNAdb Secondary structures for MIR100 Gene
mRNA/cDNA for MIR100 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR100
- Applied Biological Materials CRISPR for MIR100
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR100
Clone Products
- GenScript: Custom all cDNA clones Services for MIR100
- VectorBuilder custom plasmid, inducible vectors for MIR100
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR100
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR100
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR100 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR100 Gene:
MIR100Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR100 Gene
Orthologs for MIR100 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-100 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | bta-mir-100 34 |
|
ManyToMany | |
| bta-mir-10a 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-100 34 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Mir100 34 |
|
ManyToMany | |
| Mir10a 34 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | cfa-mir-99a-2 34 |
|
ManyToMany | |
| cfa-mir-10a 34 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | gga-mir-10a 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | aca-mir-10a 34 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | mir100-2 34 |
|
ManyToMany | |
| dre-mir-100-1 34 |
|
ManyToMany | |||
| dre-mir-10a 34 |
|
ManyToMany |
- Species where no ortholog for MIR100 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIR100 Gene
No data available for Paralogs for MIR100 Gene
Variants for MIR100 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000145703 | -- | 122,152,421(-) | G/A | upstream_transcript_variant | |
| rs1000408935 | -- | 122,152,670(-) | AT/ | upstream_transcript_variant | |
| rs1000477387 | -- | 122,153,768(-) | A/T | upstream_transcript_variant | |
| rs1002966616 | -- | 122,153,140(-) | A/G | upstream_transcript_variant | |
| rs1003067767 | -- | 122,153,403(-) | C/G | upstream_transcript_variant |
Additional Variant Information for MIR100 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR100
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR100 Gene
Disorders for MIR100 Gene
Additional Disease Information for MIR100
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MIR100 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR100 Gene
Publications for MIR100 Gene
- Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 44 58
- Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 44 58
- Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 44 58
- lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling. (PMID: 29035371) Lu Y … Coffey RJ (Nature medicine 2017) 3 58
- Cisplatin-resistant lung cancer cell-derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100-5p-dependent manner. (PMID: 28553110) Qin X … Feng J (International journal of nanomedicine 2017) 3 58
Products for MIR100 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR100
- Origene Custom Protein Services for MIR100
- Browse OriGene Inhibitory RNA Products For MIR100
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR100
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR100
- GenScript: Custom all cDNA clones Services for MIR100
- GenScript Custom Purified and Recombinant Proteins Services for MIR100
- GenScript Custom Assay Services for MIR100
- GenScript Custom overexpressing Cell Line Services for MIR100
- Browse GenScript CRISPR for MIR100
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MIR100
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR100
- VectorBuilder custom plasmid, inducible vectors for MIR100
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR100
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR100
- Search GeneTex for Proteins for MIR100
- Search ViGene Biosciences for MIR100
Sources for MIR100 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
