microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR100 Gene

Subcategory (RNA class) for MIR100 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR100 Gene

  • MicroRNA 100 2 3 5
  • Hsa-MiR-100-3p 168 179
  • Hsa-MiR-100-5p 168 179
  • MIMAT0004512 53
  • MIMAT0000098 53
  • Hsa-Mir-100 3
  • MI0000102 53
  • MiR-100 3
  • MIRN100 3
  • RF00104 174
  • MIR100 2

External Ids for MIR100 Gene

Previous HGNC Symbols for MIR100 Gene

  • MIRN100

Previous GeneCards Identifiers for MIR100 Gene

  • GC11M121531
  • GC11M122023
  • GC11M122027
  • GC11M122030
  • GC11M122033

Summaries for MIR100 Gene

Entrez Gene Summary for MIR100 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR100 Gene

MIR100 (MicroRNA 100) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR100 include Oral Squamous Cell Carcinoma and Nasopharyngeal Carcinoma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DNA damage response.

Rfam classification for MIR100 Gene

  • mir-10 microRNA precursor family

Additional gene information for MIR100 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR100 Gene

Genomics for MIR100 Gene

GeneHancer (GH) Regulatory Elements for MIR100 Gene

Promoters and enhancers for MIR100 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J122152 Promoter/Enhancer 0.5 Ensembl dbSUPER 750.6 -0.7 -693 0.4 MIR100 MIR10526-001 RF00104-008 LN871062 MIR100HG
GH11J122144 Enhancer 1 Ensembl ENCODE dbSUPER 0.6 +3.5 3535 7.9 USF2 HLF RERE ZBTB33 HMG20B TCF7L2 REST ATF7 JUN JUND BLID MIR100HG MIR100 MIR10526-001 MIRLET7A2 RF00104-008
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR100 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR100 Gene

Genomic Locations for MIR100 Gene
chr11:122,152,229-122,152,308
(GRCh38/hg38)
Size:
80 bases
Orientation:
Minus strand
chr11:122,022,937-122,023,016
(GRCh37/hg19)
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR100 Gene

Genes around MIR100 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR100 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR100 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR100 Gene

Proteins for MIR100 Gene

Post-translational modifications for MIR100 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR100 Gene

Domains & Families for MIR100 Gene

Gene Families for MIR100 Gene

genes like me logo Genes that share domains with MIR100: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR100 Gene

Function for MIR100 Gene

Phenotypes From GWAS Catalog for MIR100 Gene

Gene Ontology (GO) - Molecular Function for MIR100 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 27542871
genes like me logo Genes that share ontologies with MIR100: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR100 Gene

Localization for MIR100 Gene

Gene Ontology (GO) - Cellular Components for MIR100 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR100: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR100 Gene

Pathways & Interactions for MIR100 Gene

genes like me logo Genes that share pathways with MIR100: view

Pathways by source for MIR100 Gene

1 BioSystems pathway for MIR100 Gene
1 KEGG pathway for MIR100 Gene

Gene Ontology (GO) - Biological Process for MIR100 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 27542871
GO:1905064 negative regulation of vascular smooth muscle cell differentiation IMP 18548003
genes like me logo Genes that share ontologies with MIR100: view

No data available for SIGNOR curated interactions for MIR100 Gene

Drugs & Compounds for MIR100 Gene

No Compound Related Data Available

Transcripts for MIR100 Gene

mRNA/cDNA for MIR100 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(7) ENA transcripts :
(1) Rfam transcripts :
(2) TarBase transcripts :
(3) miRBase transcripts :
(2) LncBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR100 Gene

No ASD Table

Relevant External Links for MIR100 Gene

GeneLoc Exon Structure for
MIR100
ECgene alternative splicing isoforms for
MIR100

Expression for MIR100 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR100 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR100 Gene:

MIR100
genes like me logo Genes that share expression patterns with MIR100: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR100 Gene

Orthologs for MIR100 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR100 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-100 33
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-100 33
  • 93 (a)
ManyToMany
bta-mir-10a 33
  • 45 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-100 33
  • 93 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mir100 33
  • 90 (a)
ManyToMany
Mir10a 33
  • 45 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia cfa-mir-99a-2 33
  • 88 (a)
ManyToMany
cfa-mir-10a 33
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-10a 33
  • 57 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-10a 33
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mir100-2 33
  • 84 (a)
ManyToMany
dre-mir-100-1 33
  • 73 (a)
ManyToMany
dre-mir-10a 33
  • 45 (a)
ManyToMany
Species where no ortholog for MIR100 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR100 Gene

ENSEMBL:
Gene Tree for MIR100 (if available)
TreeFam:
Gene Tree for MIR100 (if available)

Paralogs for MIR100 Gene

No data available for Paralogs for MIR100 Gene

Variants for MIR100 Gene

Sequence variations from dbSNP and Humsavar for MIR100 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000145703 -- 122,152,421(-) G/A upstream_transcript_variant
rs1000408935 -- 122,152,670(-) AT/ upstream_transcript_variant
rs1000477387 -- 122,153,768(-) A/T upstream_transcript_variant
rs1002966616 -- 122,153,140(-) A/G upstream_transcript_variant
rs1003067767 -- 122,153,403(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR100 Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV gain 17160897

Additional Variant Information for MIR100 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR100

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR100 Gene

Disorders for MIR100 Gene

MalaCards: The human disease database

(15) MalaCards diseases for MIR100 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
nasopharyngeal carcinoma
  • npc
colorectal cancer
  • crc
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
endometriosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR100

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR100: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR100 Gene

Publications for MIR100 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 43 56
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 43 56
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 43 56
  4. Expression of miR-100 and miR-138 as prognostic biomarkers in non-muscle-invasive bladder cancer. (PMID: 31231851) Blanca A … Lopez-Beltran A (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2019) 3 56
  5. MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs. (PMID: 30102375) Sun Q … Prasanth KV (Nucleic acids research 2018) 3 56

Products for MIR100 Gene

Sources for MIR100 Gene