microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR100 Gene

Subcategory (RNA class) for MIR100 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR100 Gene

  • MicroRNA 100 2 3 5
  • Hsa-MiR-100-3p 163 173
  • Hsa-MiR-100-5p 163 173
  • Hsa-Mir-100 2 3
  • MIR100 2 5
  • Hsa-Mir-10-P2a 178
  • MIMAT0000098 50
  • MIMAT0004512 50
  • MI0000102 50
  • MIRN100 3
  • MiR-100 3
  • RF00104 168

External Ids for MIR100 Gene

Previous HGNC Symbols for MIR100 Gene

  • MIRN100

Previous GeneCards Identifiers for MIR100 Gene

  • GC11M121531
  • GC11M122023
  • GC11M122027
  • GC11M122030
  • GC11M122033

Summaries for MIR100 Gene

Entrez Gene Summary for MIR100 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR100 Gene

MIR100 (MicroRNA 100) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR100 include Oral Squamous Cell Carcinoma and Nasopharyngeal Carcinoma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DNA damage response.

Rfam classification for MIR100 Gene

  • mir-10 microRNA precursor family

Additional gene information for MIR100 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR100 Gene

Genomics for MIR100 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR100 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J122152 Promoter/Enhancer 0.5 Ensembl dbSUPER 600.7 -0.7 -693 0.4 MIR100 MIR10526 RF00104-008 LN871062 ENSG00000255219 BLID MIR100HG UBASH3B
GH11J122144 Enhancer 1 Ensembl ENCODE dbSUPER 0.7 +3.5 3535 7.9 ATF7 REST TCF7 SP1 TCF7L2 FOXA2 JUN USF1 TEAD1 ATF2 BLID MIR100HG MIR100 MIR10526 MIRLET7A2 RF00104-008 ENSG00000255219 UBASH3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR100 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR100 Gene

Genomic Locations for MIR100 Gene
chr11:122,152,229-122,152,308
(GRCh38/hg38)
Size:
80 bases
Orientation:
Minus strand
chr11:122,022,937-122,023,016
(GRCh37/hg19)
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR100 Gene

Genes around MIR100 on UCSC Golden Path with GeneCards custom track
MIR100 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR100 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR100 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR100 Gene

Proteins for MIR100 Gene

Post-translational modifications for MIR100 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR100 Gene

Domains & Families for MIR100 Gene

Gene Families for MIR100 Gene

genes like me logo Genes that share domains with MIR100: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR100 Gene

Function for MIR100 Gene

Phenotypes From GWAS Catalog for MIR100 Gene

Gene Ontology (GO) - Molecular Function for MIR100 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 27542871
genes like me logo Genes that share ontologies with MIR100: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR100 Gene

Localization for MIR100 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR100 gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR100 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR100: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR100 Gene

Pathways & Interactions for MIR100 Gene

genes like me logo Genes that share pathways with MIR100: view

Pathways by source for MIR100 Gene

1 BioSystems pathway for MIR100 Gene
1 KEGG pathway for MIR100 Gene

Gene Ontology (GO) - Biological Process for MIR100 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 27542871
GO:1905064 negative regulation of vascular smooth muscle cell differentiation IMP 18548003
GO:2000483 negative regulation of interleukin-8 secretion IDA 27542871
genes like me logo Genes that share ontologies with MIR100: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR100 Gene

Drugs & Compounds for MIR100 Gene

No Compound Related Data Available

Transcripts for MIR100 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR100 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001A405B_9606 miRNA 22 6

RefSeq: NR_029515,

LncBase: hsa-miR-100-3p,

miRBase: MIMAT0004512,

MirGeneDB: Hsa-Mir-10-P2a_3p,

TarBase: hsa-miR-100-3p,

ENA: LM380191.1:1..22:ncRNA, LM608188.1:48..69:ncRNA,

URS000040D674_9606 miRNA 22 6

RefSeq: NR_029515,

LncBase: hsa-miR-100-5p,

miRBase: MIMAT0000098,

MirGeneDB: Hsa-Mir-10-P2a_5p,

TarBase: hsa-miR-100-5p,

ENA: AF480498.1:1..22:ncRNA, LM378785.1:1..22:ncRNA, LM608188.1:13..34:ncRNA,

URS000054969A_9606 precursor_RNA 80 5

HGNC: 31487,

RefSeq: NR_029515,

Ensembl: ENST00000385259 (view in UCSC) ,

miRBase: MI0000102,

ENA: AF480538.1:1..80:misc_RNA, LM608188.1:1..80:precursor_RNA,

URS00006E50D0_9606 precursor_RNA 70 1

Rfam: RF00104,

URS0000EFE6DB_9606 precursor_RNA 58 1

MirGeneDB: Hsa-Mir-10-P2a,

MIR100 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR100 Gene

3 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR100 Gene

No ASD Table

Relevant External Links for MIR100 Gene

GeneLoc Exon Structure for
MIR100

Expression for MIR100 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR100 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR100

Evidence on tissue expression from TISSUES for MIR100 Gene

  • Blood(2.2)
genes like me logo Genes that share expression patterns with MIR100: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR100 Gene

Orthologs for MIR100 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR100 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-100 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-100 31
  • 93 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia bta-mir-100 31
  • 93 (a)
ManyToMany
bta-mir-10a 31
  • 45 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Mir100 31
  • 90 (a)
ManyToMany
Mir10a 31
  • 45 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia cfa-mir-99a-2 31
  • 88 (a)
ManyToMany
cfa-mir-10a 31
  • 54 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves gga-mir-10a 31
  • 57 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia aca-mir-10a 31
  • 42 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii mir100-2 31
  • 84 (a)
ManyToMany
dre-mir-100-1 31
  • 73 (a)
ManyToMany
dre-mir-10a 31
  • 45 (a)
ManyToMany
Species where no ortholog for MIR100 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR100 Gene

ENSEMBL:
Gene Tree for MIR100 (if available)
TreeFam:
Gene Tree for MIR100 (if available)

Paralogs for MIR100 Gene

No data available for Paralogs for MIR100 Gene

Variants for MIR100 Gene

Additional dbSNP identifiers (rs#s) for MIR100 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR100 Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV gain 17160897

Additional Variant Information for MIR100 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR100

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR100 Gene

Disorders for MIR100 Gene

MalaCards: The human disease database

(31) MalaCards diseases for MIR100 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
nasopharyngeal carcinoma
  • npc
colorectal cancer
  • crc
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
endometriosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR100

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR100: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR100 Gene

Publications for MIR100 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 41
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 41
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 41
  4. miR-100-5p confers resistance to ALK tyrosine kinase inhibitors Crizotinib and Lorlatinib in EML4-ALK positive NSCLC. (PMID: 30791979) Lai Y … Ekman S (Biochemical and biophysical research communications 2019) 3
  5. Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson's disease via regulating miR-100/ATG10 axis and PI3K/Akt/mTOR pathway activation. (PMID: 31298038) Peng T … Lu H (Artificial cells, nanomedicine, and biotechnology 2019) 3

Products for MIR100 Gene

Sources for MIR100 Gene