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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR100 (MicroRNA 100) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR100 include Oral Squamous Cell Carcinoma and Nasopharyngeal Carcinoma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DNA damage response.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J122152 | Promoter/Enhancer | 0.5 | Ensembl dbSUPER | 600.7 | -0.7 | -693 | 0.4 | MIR100 MIR10526 RF00104-008 LN871062 ENSG00000255219 BLID MIR100HG UBASH3B | ||
GH11J122144 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 0.7 | +3.5 | 3535 | 7.9 | ATF7 REST TCF7 SP1 TCF7L2 FOXA2 JUN USF1 TEAD1 ATF2 | BLID MIR100HG MIR100 MIR10526 MIRLET7A2 RF00104-008 ENSG00000255219 UBASH3B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 27542871 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | miRNAs involved in DNA damage response |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IEA | -- |
GO:0035278 | miRNA mediated inhibition of translation | IDA | 27542871 |
GO:1905064 | negative regulation of vascular smooth muscle cell differentiation | IMP | 18548003 |
GO:2000483 | negative regulation of interleukin-8 secretion | IDA | 27542871 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00001A405B_9606 | miRNA | 22 | 6 |
RefSeq: NR_029515, LncBase: hsa-miR-100-3p, miRBase: MIMAT0004512, MirGeneDB: Hsa-Mir-10-P2a_3p, TarBase: hsa-miR-100-3p, |
URS000040D674_9606 | miRNA | 22 | 6 |
RefSeq: NR_029515, LncBase: hsa-miR-100-5p, miRBase: MIMAT0000098, MirGeneDB: Hsa-Mir-10-P2a_5p, TarBase: hsa-miR-100-5p, ENA: AF480498.1:1..22:ncRNA, LM378785.1:1..22:ncRNA, LM608188.1:13..34:ncRNA, |
URS000054969A_9606 | precursor_RNA | 80 | 5 |
HGNC: 31487, RefSeq: NR_029515, Ensembl: ENST00000385259 (view in UCSC) , miRBase: MI0000102, ENA: AF480538.1:1..80:misc_RNA, LM608188.1:1..80:precursor_RNA, |
URS00006E50D0_9606 | precursor_RNA | 70 | 1 |
Rfam: RF00104, |
URS0000EFE6DB_9606 | precursor_RNA | 58 | 1 |
MirGeneDB: Hsa-Mir-10-P2a, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-100 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-100 31 |
|
ManyToMany | |
Cow (Bos Taurus) |
Mammalia | bta-mir-100 31 |
|
ManyToMany | |
bta-mir-10a 31 |
|
ManyToMany | |||
Mouse (Mus musculus) |
Mammalia | Mir100 31 |
|
ManyToMany | |
Mir10a 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | cfa-mir-99a-2 31 |
|
ManyToMany | |
cfa-mir-10a 31 |
|
ManyToMany | |||
Chicken (Gallus gallus) |
Aves | gga-mir-10a 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-10a 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | mir100-2 31 |
|
ManyToMany | |
dre-mir-100-1 31 |
|
ManyToMany | |||
dre-mir-10a 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
oral squamous cell carcinoma |
|
|
nasopharyngeal carcinoma |
|
|
colorectal cancer |
|
|
ovarian serous carcinoma |
|
|
endometriosis |
|