microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1-2 Gene

Subcategory (RNA class) for MIR1-2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR1-2 Gene

  • MicroRNA 1-2 2 3 5
  • Hsa-MiR-1-3p 163 173
  • Hsa-Mir-1-2 2 3
  • MIR1-2 2 5
  • MIMAT0000416 50
  • Hsa-Mir-1-P2 178
  • MI0000437 50
  • MiRNA1-2 3
  • MIRN1-2 3
  • Mir-1-2 3
  • RF00103 168

External Ids for MIR1-2 Gene

Previous HGNC Symbols for MIR1-2 Gene

  • MIRN1-2

Previous GeneCards Identifiers for MIR1-2 Gene

  • GC18M017667
  • GC18M019408

Summaries for MIR1-2 Gene

Entrez Gene Summary for MIR1-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1-2 Gene

MIR1-2 (MicroRNA 1-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1-2 include Atrial Standstill 1 and Hepatocellular Carcinoma. Among its related pathways are TarBasePathway and MicroRNAs in cancer.

Rfam classification for MIR1-2 Gene

  • mir-1 microRNA precursor family

Additional gene information for MIR1-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1-2 Gene

Genomics for MIR1-2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J021825 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.7 -0.4 -437 7.9 ZNF316 MAFF MAFK ZBTB17 MAFG HNF4A BACH1 MLLT1 EMSY MIR133A1HG MIR1-2 RF00103-001 MIB1 MIR320C1 ABHD3 MIR133A1 RF00446-001 GATA6
GH18J021852 Enhancer 0.7 Ensembl ENCODE 11.4 -24.1 -24113 1.6 TCF12 PKNOX1 RUNX3 HDGF RFX5 HNF4A SPI1 RAD51 RPL34P32 lnc-ABHD3-5 ENSG00000199977 MIR1-2 MIR133A1 MIR320C1 MIB1 lnc-ABHD3-4 GATA6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1-2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1-2 Gene

Genomic Locations for MIR1-2 Gene
chr18:21,829,004-21,829,088
(GRCh38/hg38)
Size:
85 bases
Orientation:
Minus strand
chr18:19,405,448-19,411,371
(GRCh37/hg19)
Size:
5,924 bases
Orientation:
Minus strand

Genomic View for MIR1-2 Gene

Genes around MIR1-2 on UCSC Golden Path with GeneCards custom track
MIR1-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR1-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1-2 Gene

Proteins for MIR1-2 Gene

Post-translational modifications for MIR1-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1-2 Gene

Domains & Families for MIR1-2 Gene

Gene Families for MIR1-2 Gene

genes like me logo Genes that share domains with MIR1-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1-2 Gene

Function for MIR1-2 Gene

Gene Ontology (GO) - Molecular Function for MIR1-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 17397913
genes like me logo Genes that share ontologies with MIR1-2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1-2 Gene

Localization for MIR1-2 Gene

Gene Ontology (GO) - Cellular Components for MIR1-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20159880
genes like me logo Genes that share ontologies with MIR1-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR1-2 Gene

Pathways & Interactions for MIR1-2 Gene

PathCards logo

SuperPathways for MIR1-2 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
2 TarBasePathway
genes like me logo Genes that share pathways with MIR1-2: view

Pathways by source for MIR1-2 Gene

1 BioSystems pathway for MIR1-2 Gene
1 KEGG pathway for MIR1-2 Gene

Gene Ontology (GO) - Biological Process for MIR1-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 19131648
GO:0010455 positive regulation of cell fate commitment ISS --
GO:0010460 positive regulation of heart rate ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0010831 positive regulation of myotube differentiation ISS --
genes like me logo Genes that share ontologies with MIR1-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1-2 Gene

Drugs & Compounds for MIR1-2 Gene

No Compound Related Data Available

Transcripts for MIR1-2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1-2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001DC04F_9606 miRNA 22 6

RefSeq: NR_029662, NR_029780,

LncBase: hsa-miR-1-3p,

miRBase: MIMAT0000416,

MirGeneDB: Hsa-Mir-1-P1_3p, Hsa-Mir-1-P2_3p,

TarBase: hsa-miR-1-3p,

ENA: BK006540.1:682..703:ncRNA, LM379034.1:1..22:ncRNA, LM608477.1:53..74:ncRNA, LM608609.1:46..67:ncRNA,

URS0000447557_9606 precursor_RNA 85 5

HGNC: 31500,

RefSeq: NR_029662,

Ensembl: ENST00000384961 (view in UCSC) ,

miRBase: MI0000437,

ENA: LM608477.1:1..85:precursor_RNA,

URS0000185C02_9606 precursor_RNA 77 1

Rfam: RF00103,

URS0000EFC31B_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-1-P2,

URS000058AECB_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-1-P2_5p,

MIR1-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR1-2 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1-2 Gene

No ASD Table

Relevant External Links for MIR1-2 Gene

GeneLoc Exon Structure for
MIR1-2

Expression for MIR1-2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR1-2 Gene

This gene is overexpressed in Muscle - Skeletal (x27.9), Heart - Atrial Appendage (x13.0), and Heart - Left Ventricle (x5.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1-2

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1-2 Gene

Orthologs for MIR1-2 Gene

Evolution for MIR1-2 Gene

ENSEMBL:
Gene Tree for MIR1-2 (if available)
TreeFam:
Gene Tree for MIR1-2 (if available)

No data available for Orthologs for MIR1-2 Gene

Paralogs for MIR1-2 Gene

No data available for Paralogs for MIR1-2 Gene

Variants for MIR1-2 Gene

Additional dbSNP identifiers (rs#s) for MIR1-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1-2 Gene

Variant ID Type Subtype PubMed ID
nsv2222 CNV insertion 18451855

Additional Variant Information for MIR1-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1-2 Gene

Disorders for MIR1-2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR1-2 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
atrial standstill 1
  • atrst1
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1-2

genes like me logo Genes that share disorders with MIR1-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1-2 Gene

Publications for MIR1-2 Gene

  1. MicroRNA-1 suppresses glioblastoma in preclinical models by targeting fibronectin. (PMID: 31491450) Yang CH … Pfeffer LM (Cancer letters 2019) 3
  2. Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy. (PMID: 31799933) Nehammer C … Pocock R (eLife 2019) 3
  3. Circulating microRNA-1 in the diagnosis and predicting prognosis of patients with chest pain: a prospective cohort study. (PMID: 30611212) Su T … Li X (BMC cardiovascular disorders 2019) 3
  4. Downregulation of glucose‑6‑phosphate dehydrogenase by microRNA‑1 inhibits the growth of pituitary tumor cells. (PMID: 30272333) He C … Yang J (Oncology reports 2018) 3
  5. miR-1-3p Contributes to Cell Proliferation and Invasion by Targeting Glutaminase in Bladder Cancer Cells. (PMID: 30458442) Zhang J … Yao X (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3

Products for MIR1-2 Gene

Sources for MIR1-2 Gene