Free for academic non-profit institutions. Other users need a Commercial license

MIR1-1 Gene(RNA Gene)

MicroRNA 1-1

GCID:
GC20P062818
GIFtS:
18
Genes Participants
UDN Logo

Aliases for MIR1-1 Gene

Subcategory (RNA class) for MIR1-1 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR1-1 Gene

  • MicroRNA 1-1 2 3 5
  • Hsa-Mir-1-1 3
  • MiRNA1-1 3
  • Mir-1-1 3
  • MIRN1-1 3

External Ids for MIR1-1 Gene

ORGUL Members for MIR1-1 Gene

Previous HGNC Symbols for MIR1-1 Gene

  • MIRN1-1

Previous GeneCards Identifiers for MIR1-1 Gene

  • GC20P060563
  • GC20P061153
  • GC20P061156
  • GC20P061159
  • GC20P062652
  • GC20P062656
  • GC20P062704
  • GC20P062723
  • GC20P062779
  • GC20P062786
  • GC20P062794
  • GC20P062803

Summaries for MIR1-1 Gene

Entrez Gene Summary for MIR1-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1-1 Gene

MIR1-1 (MicroRNA 1-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Cell Differentiation - Index.

Additional gene information for MIR1-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1-1 Gene

Genomics for MIR1-1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR1-1 Gene

Promoters and enhancers for MIR1-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH20J062641 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11 +91.1 91076 8 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 SLCO4A1 MRGBP TAF4 GMEB2 SLCO4A1-AS1 OGFR OGFR-AS1 MIR1-1 MIR1-1HG MIR1-1HG-AS1
GH20J062649 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +97.8 97786 4.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A FEZF1 ENSG00000276317 ENSG00000277496 OGFR YTHDF1 OGFR-AS1 MTG2 MIR1-1 MIR1-1HG MIR1-1HG-AS1 DIDO1
GH20J062738 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +186.4 186378 4.9 ATF1 PKNOX1 SIN3A IRF4 ZNF766 GLIS2 ELK1 ZNF143 ATF7 FOS OGFR NTSR1 LINC00659 LINC00686 OGFR-AS1 MIR1-1 MIR1-1HG-AS1 MIR1-1HG ENSG00000232121 ENSG00000229882
GH20J062425 Enhancer 1.3 Ensembl ENCODE dbSUPER 11 -125.3 -125295 6.4 HDGF CLOCK FOXA2 NEUROD1 SIN3A ZBTB7B ZNF207 SP5 REST ZNF592 LOC105372710 RBBP8NL CABLES2 DIDO1 RPS21 TAF4 LAMA5 MIR1-1 MIR1-1HG-AS1 MIR1-1HG
GH20J062589 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11.7 +35.9 35872 1.8 ELK4 MXI1 MAZ SMARCC1 MAX PAX8 MNT SMARCB1 RAD21 GABPA MIR1-1HG MIR1-1HG-AS1 MIR133A2 ENSG00000229882 ENSG00000232121 MIR1-1 ENSG00000264490 WI2-87327B8.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1-1 Gene

Genomic Locations for MIR1-1 Gene
chr20:62,554,306-62,554,376
(GRCh38/hg38)
Size:
71 bases
Orientation:
Plus strand
chr20:61,151,510-61,151,586
(GRCh37/hg19)
Size:
77 bases
Orientation:
Plus strand

Genomic View for MIR1-1 Gene

Genes around MIR1-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1-1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR1-1 Gene

Proteins for MIR1-1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR1-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1-1 Gene

Domains & Families for MIR1-1 Gene

Gene Families for MIR1-1 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1-1 Gene

Function for MIR1-1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 17397913
genes like me logo Genes that share ontologies with MIR1-1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1-1 Gene

Localization for MIR1-1 Gene

Gene Ontology (GO) - Cellular Components for MIR1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20159880
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with MIR1-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR1-1 Gene

Pathways & Interactions for MIR1-1 Gene

genes like me logo Genes that share pathways with MIR1-1: view

Pathways by source for MIR1-1 Gene

1 KEGG pathway for MIR1-1 Gene

Interacting Proteins for MIR1-1 Gene

Gene Ontology (GO) - Biological Process for MIR1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 19131648
GO:0010455 positive regulation of cell fate commitment ISS --
GO:0010460 positive regulation of heart rate ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0010831 positive regulation of myotube differentiation ISS --
genes like me logo Genes that share ontologies with MIR1-1: view

No data available for SIGNOR curated interactions for MIR1-1 Gene

Drugs & Compounds for MIR1-1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR1-1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR1-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1-1 Gene

No ASD Table

Relevant External Links for MIR1-1 Gene

GeneLoc Exon Structure for
MIR1-1
ECgene alternative splicing isoforms for
MIR1-1

Expression for MIR1-1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1-1 Gene

mRNA expression in normal human tissues for MIR1-1 Gene
mRNA expression by GTEx for MIR1-1 Gene
genes like me logo Genes that share expression patterns with MIR1-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1-1 Gene

Orthologs for MIR1-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR1-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-1-1 34
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-1-1 34
  • 100 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-1-1 34
  • 97 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir1a-1 34
  • 96 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-1-2 34
  • 73 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 68 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-mir-1a-1 34
  • 90 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-1a-2 34
  • 70 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii mir1-1 34
  • 63 (a)
 OneToOne
Species where no ortholog for MIR1-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR1-1 Gene

ENSEMBL:
Gene Tree for MIR1-1 (if available)
TreeFam:
Gene Tree for MIR1-1 (if available)

Paralogs for MIR1-1 Gene

No data available for Paralogs for MIR1-1 Gene

Variants for MIR1-1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR1-1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000690030 -- 62,554,625(+) G/A downstream_transcript_variant
rs1001697706 -- 62,554,278(+) T/C upstream_transcript_variant
rs1005200081 -- 62,554,419(+) C/T downstream_transcript_variant
rs1006474434 -- 62,554,082(+) G/A upstream_transcript_variant
rs1007025766 -- 62,554,004(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1-1 Gene

Variant ID Type Subtype PubMed ID
dgv4343n100 CNV gain 25217958
dgv4344n100 CNV gain 25217958
esv2422398 CNV duplication 17116639
nsv459065 CNV gain 19166990
nsv459068 CNV gain 19166990
nsv470556 CNV loss 18288195
nsv586496 CNV gain 21841781
nsv586501 CNV gain 21841781
nsv953302 CNV deletion 24416366

Additional Variant Information for MIR1-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1-1 Gene

Disorders for MIR1-1 Gene

Additional Disease Information for MIR1-1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR1-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1-1 Gene

Publications for MIR1-1 Gene

  1. Functionality of the Tumor Suppressor microRNA-1 in Malignant Tissue and Cell Line Cells of Uterine Leiomyosarcoma. (PMID: 29491084) Stope MB … Mustea A (Anticancer research 2018) 3 58
  2. Suppression of the biological activity of neuroglioma cells by down-regulation of miR-1. (PMID: 28873202) Wang YQ … Zhong XM (Genetics and molecular research : GMR 2017) 3 58
  3. miR-1 suppresses the proliferation and promotes the apoptosis of esophageal carcinoma cells by targeting Src. (PMID: 29034995) Liao Z … Wang T (Cancer medicine 2017) 3 58
  4. Single cell qPCR reveals that additional HAND2 and microRNA-1 facilitate the early reprogramming progress of seven-factor-induced human myocytes. (PMID: 28796841) Bektik E … Fu JD (PloS one 2017) 3 58
  5. MicroRNA-1 inhibits ovarian cancer cell proliferation and migration through c-Met pathway. (PMID: 28698064) Qu W … Yan D (Clinica chimica acta; international journal of clinical chemistry 2017) 3 58

Products for MIR1-1 Gene

Sources for MIR1-1 Gene

Content
Loading form....