microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1-1 Gene

Subcategory (RNA class) for MIR1-1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR1-1 Gene

  • MicroRNA 1-1 2 3 5
  • Hsa-MiR-1-3p 163 173
  • Hsa-Mir-1-1 2 3
  • MIR1-1 2 5
  • Hsa-Mir-1-P1 178
  • MIMAT0031892 50
  • MIMAT0000416 50
  • MI0000651 50
  • MiRNA1-1 3
  • MIRN1-1 3
  • Mir-1-1 3
  • RF00103 168

External Ids for MIR1-1 Gene

Previous HGNC Symbols for MIR1-1 Gene

  • MIRN1-1

Previous GeneCards Identifiers for MIR1-1 Gene

  • GC20P060563
  • GC20P061153
  • GC20P061156
  • GC20P061159
  • GC20P062652
  • GC20P062656
  • GC20P062836
  • GC20P062845
  • GC20P062853
  • GC20P062873
  • GC20P062704
  • GC20P062723
  • GC20P062779
  • GC20P062786
  • GC20P062794
  • GC20P062803
  • GC20P062818
  • GC20P062826

Summaries for MIR1-1 Gene

Entrez Gene Summary for MIR1-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1-1 Gene

MIR1-1 (MicroRNA 1-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1-1 include Anisakiasis. Among its related pathways are Heart Development and TFs Regulate miRNAs related to cardiac hypertrophy.

Rfam classification for MIR1-1 Gene

  • mir-1 microRNA precursor family

Additional gene information for MIR1-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1-1 Gene

Genomics for MIR1-1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1-1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1-1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1-1 Gene

Genomic Locations for MIR1-1 Gene
chr20:62,554,303-62,554,379
(GRCh38/hg38)
Size:
77 bases
Orientation:
Plus strand
chr20:61,151,510-61,151,586
(GRCh37/hg19)
Size:
77 bases
Orientation:
Plus strand

Genomic View for MIR1-1 Gene

Genes around MIR1-1 on UCSC Golden Path with GeneCards custom track
MIR1-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR1-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1-1 Gene

Proteins for MIR1-1 Gene

Post-translational modifications for MIR1-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1-1 Gene

Domains & Families for MIR1-1 Gene

Gene Families for MIR1-1 Gene

genes like me logo Genes that share domains with MIR1-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1-1 Gene

Function for MIR1-1 Gene

Phenotypes From GWAS Catalog for MIR1-1 Gene

Gene Ontology (GO) - Molecular Function for MIR1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 17397913
genes like me logo Genes that share ontologies with MIR1-1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1-1 Gene

Localization for MIR1-1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1-1 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20159880
genes like me logo Genes that share ontologies with MIR1-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR1-1 Gene

Pathways & Interactions for MIR1-1 Gene

genes like me logo Genes that share pathways with MIR1-1: view

Pathways by source for MIR1-1 Gene

Gene Ontology (GO) - Biological Process for MIR1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 19131648
GO:0010455 positive regulation of cell fate commitment ISS --
GO:0010460 positive regulation of heart rate ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0010831 positive regulation of myotube differentiation ISS --
genes like me logo Genes that share ontologies with MIR1-1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1-1 Gene

Drugs & Compounds for MIR1-1 Gene

No Compound Related Data Available

Transcripts for MIR1-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1-1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001DC04F_9606 miRNA 22 6

RefSeq: NR_029662, NR_029780,

LncBase: hsa-miR-1-3p,

miRBase: MIMAT0000416,

MirGeneDB: Hsa-Mir-1-P1_3p, Hsa-Mir-1-P2_3p,

TarBase: hsa-miR-1-3p,

ENA: BK006540.1:682..703:ncRNA, LM379034.1:1..22:ncRNA, LM608477.1:53..74:ncRNA, LM608609.1:46..67:ncRNA,

URS000075CF56_9606 precursor_RNA 71 5

HGNC: 31499,

RefSeq: NR_029780,

Ensembl: ENST00000362147 (view in UCSC) ,

miRBase: MI0000651,

ENA: LM608609.1:1..71:precursor_RNA,

URS000075C105_9606 miRNA 22 3

RefSeq: NR_029780,

miRBase: MIMAT0031892,

ENA: LM383306.1:1..22:ncRNA, LM608609.1:7..28:ncRNA,

URS00001F3F45_9606 precursor_RNA 77 1

Rfam: RF00103,

URS0000EFBDB3_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-1-P1,

MIR1-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR1-1 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1-1 Gene

No ASD Table

Relevant External Links for MIR1-1 Gene

GeneLoc Exon Structure for
MIR1-1

Expression for MIR1-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1-1

genes like me logo Genes that share expression patterns with MIR1-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1-1 Gene

Orthologs for MIR1-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR1-1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-1-1 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1-1 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-1-1 31
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir1a-1 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-1-2 31
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-1a-1 31
  • 90 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-1a-2 31
  • 70 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii mir1-1 31
  • 63 (a)
OneToOne
Species where no ortholog for MIR1-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR1-1 Gene

ENSEMBL:
Gene Tree for MIR1-1 (if available)
TreeFam:
Gene Tree for MIR1-1 (if available)

Paralogs for MIR1-1 Gene

No data available for Paralogs for MIR1-1 Gene

Variants for MIR1-1 Gene

Additional dbSNP identifiers (rs#s) for MIR1-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1-1 Gene

Variant ID Type Subtype PubMed ID
dgv4343n100 CNV gain 25217958
dgv4344n100 CNV gain 25217958
esv2422398 CNV duplication 17116639
nsv459065 CNV gain 19166990
nsv459068 CNV gain 19166990
nsv470556 CNV loss 18288195
nsv586496 CNV gain 21841781
nsv586501 CNV gain 21841781
nsv953302 CNV deletion 24416366

Additional Variant Information for MIR1-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1-1 Gene

Disorders for MIR1-1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR1-1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anisakiasis
  • infection by anisakis larva
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1-1

genes like me logo Genes that share disorders with MIR1-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1-1 Gene

Publications for MIR1-1 Gene

  1. MiR-1 Suppresses Proliferation of Osteosarcoma Cells by Up-regulating p21 via PAX3. (PMID: 30587501) Fujii R … Tokuhashi Y (Cancer genomics & proteomics 2019) 3
  2. MicroRNA-1 suppresses glioblastoma in preclinical models by targeting fibronectin. (PMID: 31491450) Yang CH … Pfeffer LM (Cancer letters 2019) 3
  3. MiR-1/GOLPH3/Foxo1 Signaling Pathway Regulates Proliferation of Bladder Cancer. (PMID: 31714185) Liu MK … Zhang W (Technology in cancer research & treatment 2019) 3
  4. Overexpression of MicroRNA-1 in Prostate Cancer Cells Modulates the Blood Vessel System of an In Vivo Hen's Egg Test-Chorioallantoic Membrane Model. (PMID: 30587600) Reuter A … Stope MB (In vivo (Athens, Greece) 2019) 3
  5. MiR-1-5p is down-regulated in gallbladder carcinoma and suppresses cell proliferation, migration and invasion by targeting Notch2. (PMID: 30497876) Hua CB … Li XZ (Pathology, research and practice 2019) 3

Products for MIR1-1 Gene

Sources for MIR1-1 Gene