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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR1-1 (MicroRNA 1-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1-1 include Anisakiasis. Among its related pathways are Heart Development and TFs Regulate miRNAs related to cardiac hypertrophy.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000993 | RNA polymerase II complex binding | IDA | 25336585 |
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 17397913 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 20159880 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Cell Differentiation - Index | ||
3 | Heart Development | ||
4 | TarBasePathway | ||
5 | TFs Regulate miRNAs related to cardiac hypertrophy |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001934 | positive regulation of protein phosphorylation | IDA | 19131648 |
GO:0010455 | positive regulation of cell fate commitment | ISS | -- |
GO:0010460 | positive regulation of heart rate | ISS | -- |
GO:0010614 | negative regulation of cardiac muscle hypertrophy | ISS | -- |
GO:0010831 | positive regulation of myotube differentiation | ISS | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00001DC04F_9606 | miRNA | 22 | 6 |
LncBase: hsa-miR-1-3p, miRBase: MIMAT0000416, MirGeneDB: Hsa-Mir-1-P1_3p, Hsa-Mir-1-P2_3p, TarBase: hsa-miR-1-3p, ENA: BK006540.1:682..703:ncRNA, LM379034.1:1..22:ncRNA, LM608477.1:53..74:ncRNA, LM608609.1:46..67:ncRNA, |
URS000075CF56_9606 | precursor_RNA | 71 | 5 |
HGNC: 31499, RefSeq: NR_029780, Ensembl: ENST00000362147 (view in UCSC) , miRBase: MI0000651, |
URS000075C105_9606 | miRNA | 22 | 3 |
RefSeq: NR_029780, miRBase: MIMAT0031892, |
URS00001F3F45_9606 | precursor_RNA | 77 | 1 |
Rfam: RF00103, |
URS0000EFBDB3_9606 | precursor_RNA | 62 | 1 |
MirGeneDB: Hsa-Mir-1-P1, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | cfa-mir-1-1 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-1-1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-1-1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir1a-1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-1-2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-1a-1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-1a-2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | mir1-1 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4343n100 | CNV | gain | 25217958 |
dgv4344n100 | CNV | gain | 25217958 |
esv2422398 | CNV | duplication | 17116639 |
nsv459065 | CNV | gain | 19166990 |
nsv459068 | CNV | gain | 19166990 |
nsv470556 | CNV | loss | 18288195 |
nsv586496 | CNV | gain | 21841781 |
nsv586501 | CNV | gain | 21841781 |
nsv953302 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
anisakiasis |
|
|