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Aliases for MIOX Gene

Aliases for MIOX Gene

  • Myo-Inositol Oxygenase 2 3 4 5
  • Kidney-Specific Protein 32 2 3 4
  • Aldehyde Reductase (Aldose Reductase) Like 6 2 3
  • Renal-Specific Oxidoreductase 3 4
  • Aldehyde Reductase-Like 6 3 4
  • MI Oxygenase 3 4
  • EC 4 56
  • ALDRL6 3 4
  • Inositol Oxygenase 3
  • KSP32 4
  • RSOR 4

External Ids for MIOX Gene

Previous HGNC Symbols for MIOX Gene

  • ALDRL6

Previous GeneCards Identifiers for MIOX Gene

  • GC22P049216
  • GC22P049272
  • GC22P050925
  • GC22P033815

Summaries for MIOX Gene

GeneCards Summary for MIOX Gene

MIOX (Myo-Inositol Oxygenase) is a Protein Coding gene. Among its related pathways are Porphyrin and chlorophyll metabolism and Inositol phosphate metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on NAD(P)H.

Additional gene information for MIOX Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIOX Gene

Genomics for MIOX Gene

GeneHancer (GH) Regulatory Elements for MIOX Gene

Promoters and enhancers for MIOX Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I050486 Promoter 0.8 EPDnew 550.8 +2.9 2852 0.1 NFIL3 GLIS1 HLF ETV4 DMAP1 ZIC2 KAT8 MIOX LMF2
GH22I050505 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.1 +23.9 23865 4.2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 LMF2 NCAPH2 SYCE3 CHKB ALG12 ENSG00000273192 TRABD PLXNB2 TYMP MIOX
GH22I050451 Enhancer 0.9 FANTOM5 ENCODE 16.8 -31.3 -31255 1.7 ZNF362 CEBPG ZEB2 DPF2 ZNF324 FOSL1 ATF4 ZNF629 PATZ1 ZBTB20 MIOX DENND6B TUBGCP6 CHKB PPP6R2 SBF1 NCAPH2 MOV10L1 HDAC10 PIR32267
GH22I050398 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.8 -84.3 -84301 2.4 CTCF FOXA2 USF1 SAP130 ARID4B MAX ZIC2 RAD21 YY1 HNF4G GC22P050399 TYMP ODF3B MIOX PIM3 PLXNB2 TRABD CHKB SCO2 HDAC10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIOX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MIOX gene promoter:

Genomic Locations for MIOX Gene

Genomic Locations for MIOX Gene
6,661 bases
Plus strand

Genomic View for MIOX Gene

Genes around MIOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIOX Gene

Proteins for MIOX Gene

  • Protein details for MIOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol oxygenase
    Protein Accession:
    Secondary Accessions:
    • Q05DJ6
    • Q5S8C9
    • Q9BZZ1
    • Q9UHB8

    Protein attributes for MIOX Gene

    285 amino acids
    Molecular mass:
    33010 Da
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MIOX Gene

    Alternative splice isoforms for MIOX Gene


neXtProt entry for MIOX Gene

Selected DME Specific Peptides for MIOX Gene


Post-translational modifications for MIOX Gene

No Post-translational modifications

Other Protein References for MIOX Gene

Domains & Families for MIOX Gene

Gene Families for MIOX Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MIOX Gene

Suggested Antigen Peptide Sequences for MIOX Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the myo-inositol oxygenase family.
  • Belongs to the myo-inositol oxygenase family.
genes like me logo Genes that share domains with MIOX: view

Function for MIOX Gene

Molecular function for MIOX Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Myo-inositol + O(2) = D-glucuronate + H(2)O.

Enzyme Numbers (IUBMB) for MIOX Gene

Gene Ontology (GO) - Molecular Function for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity ISS --
GO:0005506 iron ion binding IEA --
GO:0008199 ferric iron binding IDA 18364358
GO:0016491 oxidoreductase activity IEA --
GO:0016651 oxidoreductase activity, acting on NAD(P)H IEA --
genes like me logo Genes that share ontologies with MIOX: view
genes like me logo Genes that share phenotypes with MIOX: view

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIOX Gene

Localization for MIOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIOX Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIOX gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IEA --
GO:0005829 cytosol TAS --
GO:0016234 inclusion body ISS --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with MIOX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MIOX Gene

Pathways & Interactions for MIOX Gene

genes like me logo Genes that share pathways with MIOX: view

Pathways by source for MIOX Gene

UniProtKB/Swiss-Prot Q9UGB7-MIOX_HUMAN

  • Pathway: Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.

Interacting Proteins for MIOX Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: ENSP00000216075 Q9UGB7-MIOX_HUMAN for MIOX Gene via STRING IID

Gene Ontology (GO) - Biological Process for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019310 inositol catabolic process ISS,IEA --
GO:0043647 inositol phosphate metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MIOX: view

No data available for SIGNOR curated interactions for MIOX Gene

Drugs & Compounds for MIOX Gene

(7) Drugs for MIOX Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
D-Glucuronic acid Experimental Pharma 0

(4) Additional Compounds for MIOX Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
genes like me logo Genes that share compounds with MIOX: view

Transcripts for MIOX Gene

Unigene Clusters for MIOX Gene

Myo-inositol oxygenase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIOX Gene

No ASD Table

Relevant External Links for MIOX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIOX Gene

This gene is overexpressed in Kidney - Cortex (x50.8).

Protein differential expression in normal tissues from HIPED for MIOX Gene

This gene is overexpressed in Kidney (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MIOX Gene

Protein tissue co-expression partners for MIOX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MIOX Gene:


SOURCE GeneReport for Unigene cluster for MIOX Gene:


mRNA Expression by UniProt/SwissProt for MIOX Gene:

Tissue specificity: Kidney specific.

Evidence on tissue expression from TISSUES for MIOX Gene

  • Kidney(4.8)
  • Intestine(4)
genes like me logo Genes that share expression patterns with MIOX: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MIOX Gene

Orthologs for MIOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MIOX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MIOX 34
  • 100 (a)
(Bos Taurus)
Mammalia MIOX 33 34
  • 87.72 (n)
(Canis familiaris)
Mammalia MIOX 33 34
  • 86.78 (n)
(Mus musculus)
Mammalia Miox 33 16 34
  • 86.08 (n)
(Rattus norvegicus)
Mammalia Miox 33
  • 85.5 (n)
(Monodelphis domestica)
Mammalia MIOX 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia MIOX 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia miox 33
  • 66.67 (n)
(Danio rerio)
Actinopterygii miox 33 34
  • 68.82 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9888 33
fruit fly
(Drosophila melanogaster)
Insecta CG6910 33 34
  • 62.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003636 33
  • 61.78 (n)
(Caenorhabditis elegans)
Secernentea C54E4.5 33 34
  • 57.38 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR482W 33
  • 51.84 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10737g 33
  • 49.93 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MIOX1 33
  • 55.04 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6304 33
(Oryza sativa)
Liliopsida Os06g0561000 33
  • 62.13 (n)
Os.6345 33
(Hordeum vulgare)
Liliopsida Hv.1000 33
(Triticum aestivum)
Liliopsida Ta.2631 33
(Zea mays)
Liliopsida Zm.16227 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.33 34
  • 57 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08856 33
  • 52.64 (n)
Species where no ortholog for MIOX was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MIOX Gene

Gene Tree for MIOX (if available)
Gene Tree for MIOX (if available)

Paralogs for MIOX Gene Pseudogenes for MIOX Gene

genes like me logo Genes that share paralogs with MIOX: view

No data available for Paralogs for MIOX Gene

Variants for MIOX Gene

Sequence variations from dbSNP and Humsavar for MIOX Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000347587 -- 50,485,686(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000363279 -- 50,487,117(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000400122 -- 50,482,969(+) C/G upstream_transcript_variant
rs1000756854 -- 50,488,107(+) A/C intron_variant
rs1000782721 -- 50,485,475(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIOX Gene

Variant ID Type Subtype PubMed ID
nsv1057656 CNV gain 25217958
nsv1073179 CNV deletion 25765185
nsv1160782 CNV deletion 26073780
nsv3669 CNV insertion 18451855
nsv471224 CNV loss 18288195
nsv829338 CNV gain 20364138
nsv834238 CNV loss 17160897
nsv834239 CNV loss 17160897
nsv955201 CNV deletion 24416366

Variation tolerance for MIOX Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIOX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIOX Gene

Disorders for MIOX Gene

Additional Disease Information for MIOX

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIOX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIOX Gene

Publications for MIOX Gene

  1. Structural and biophysical characterization of human myo-inositol oxygenase. (PMID: 18364358) Thorsell AG … Hallberg BM (The Journal of biological chemistry 2008) 3 4 22 58
  2. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney. (PMID: 15504367) Arner RJ … Reddy CC (Biochemical and biophysical research communications 2004) 3 4 22 58
  3. Identification of a renal-specific oxido-reductase in newborn diabetic mice. (PMID: 10944187) Yang Q … Kanwar YS (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4 58
  4. Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus. (PMID: 19896870) Yang B … Demaine AG (Journal of diabetes and its complications 2010) 3 44 58
  5. Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells. (PMID: 15778219) Prabhu KS … Reddy CC (The Journal of biological chemistry 2005) 3 22 58

Products for MIOX Gene

Sources for MIOX Gene

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