Aliases for MINPP1 Gene
- Multiple Inositol-Polyphosphate Phosphatase 1 2 3 5
- MIPP 2 3 4
- Multiple Inositol Polyphosphate Histidine Phosphatase, 1 2 3
- Inositol (1,3,4,5)-Tetrakisphosphate 3-Phosphatase 3 4
- Multiple Inositol Polyphosphate Phosphatase 1 3 4
- 2,3-Bisphosphoglycerate 3-Phosphatase 3 4
- Ins(1,3,4,5)P(4) 3-Phosphatase 3 4
External Ids for MINPP1 Gene
Previous GeneCards Identifiers for MINPP1 Gene
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]
GeneCards Summary for MINPP1 Gene
MINPP1 (Multiple Inositol-Polyphosphate Phosphatase 1) is a Protein Coding gene. Diseases associated with MINPP1 include Thyroid Cancer, Nonmedullary, 2 and Follicular Adenoma. Among its related pathways are Glucose metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphatase activity.
UniProtKB/Swiss-Prot Summary for MINPP1 Gene
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity).