This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development... See more...

Aliases for MINK1 Gene

Aliases for MINK1 Gene

  • Misshapen Like Kinase 1 2 3 5
  • Misshapen/NIK-Related Kinase 2 3 4
  • Misshapen-Like Kinase 1 2 3 4
  • MAP4K6 2 3 4
  • MINK 2 3 4
  • YSK2 2 3 4
  • B55 2 3 4
  • ZC3 2 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 6 3 4
  • MAPK/ERK Kinase Kinase Kinase 6 3 4
  • MEK Kinase Kinase 6 3 4
  • EC 2.7.11.1 4 51
  • MEKKK 6 3 4
  • Misshapen-Like Kinase 1 (Zebrafish) 2
  • GCK Family Kinase MINK 3
  • GCK Family Kinase MiNK 4
  • EC 2.7.11 51
  • MINK1 5

External Ids for MINK1 Gene

Previous GeneCards Identifiers for MINK1 Gene

  • GC17P004684
  • GC17P004736

Summaries for MINK1 Gene

Entrez Gene Summary for MINK1 Gene

  • This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]

GeneCards Summary for MINK1 Gene

MINK1 (Misshapen Like Kinase 1) is a Protein Coding gene. Diseases associated with MINK1 include Alzheimer Disease 15 and Shipyard Eye. Among its related pathways are Cellular Senescence (REACTOME) and Angiopoietin Like Protein 8 Regulatory Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNIK.

UniProtKB/Swiss-Prot Summary for MINK1 Gene

  • Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
  • Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Gene Wiki entry for MINK1 Gene

Additional gene information for MINK1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MINK1 Gene

Genomics for MINK1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MINK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MINK1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MINK1

Top Transcription factor binding sites by QIAGEN in the MINK1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for MINK1 Gene

Genomic Locations for MINK1 Gene
chr17:4,833,340-4,898,061
(GRCh38/hg38)
Size:
64,722 bases
Orientation:
Plus strand
chr17:4,736,635-4,801,356
(GRCh37/hg19)
Size:
64,722 bases
Orientation:
Plus strand

Genomic View for MINK1 Gene

Genes around MINK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINK1 Gene

Proteins for MINK1 Gene

  • Protein details for MINK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4C8-MINK1_HUMAN
    Recommended name:
    Misshapen-like kinase 1
    Protein Accession:
    Q8N4C8
    Secondary Accessions:
    • D3DTK3
    • D3DTK4
    • Q5U8Z0
    • Q9P1X1
    • Q9P2R8

    Protein attributes for MINK1 Gene

    Size:
    1332 amino acids
    Molecular mass:
    149822 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with TANC1 (By similarity). Interacts with RAP2A. Isoform 4 interacts with NCK1.

    Alternative splice isoforms for MINK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MINK1 Gene

Selected DME Specific Peptides for MINK1 Gene

Q8N4C8:
  • FIGTPYWMAPEV
  • PFIRDQP
  • EGVYVNTYGR
  • VVLQWGEMP
  • TGHLDGVFMHK
  • VIHRDIKGQNVLLT
  • SVVNVNPTN
  • MEFCGAGS
  • EILCAALWGVNLL
  • RNDKVFF
  • LRDPAGIFEL
  • VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
  • ILHNDPEVEKKQGW
  • PRLKSKKWSKKF
  • ERQVRIQLKDHIDR
  • GITAIEMAEGAPPLC
  • RVYYLSWLR
  • GLMLLDRSGQGKVY
  • LNLLITISG
  • ETEYEYSGSEEE
  • YAWAPKPYHKFM
  • WMAPEVI
  • VKLVDFGVSAQL
  • RRRFQQMDVLEGLN
  • ATYYGAFIKK
  • GTPYWMAPE
  • DQLWLVMEFCG
  • KAIEIRSV
  • YERIKFLV
  • AAIKVMDVTEDEEEEI
  • PEIRKYKK
  • DYSSSSEE

Post-translational modifications for MINK1 Gene

Domains & Families for MINK1 Gene

Gene Families for MINK1 Gene

Protein Domains for MINK1 Gene

Suggested Antigen Peptide Sequences for MINK1 Gene

GenScript: Design optimal peptide antigens:
  • Mitogen-activated protein kinase kinase kinase kinase 6 (MINK1_HUMAN)
  • Misshapen/NIKs-related kinase isoform beta (Q5U8Z0_HUMAN)
  • GCK family kinase (Q8NG69_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N4C8

UniProtKB/Swiss-Prot:

MINK1_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MINK1: view

Function for MINK1 Gene

Molecular function for MINK1 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
UniProtKB/Swiss-Prot Function:
Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q9JM52};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q9JM52};.
UniProtKB/Swiss-Prot Induction:
Activated after Ras induction via a mechanism involving reactive oxygen species.

Enzyme Numbers (IUBMB) for MINK1 Gene

Phenotypes From GWAS Catalog for MINK1 Gene

Gene Ontology (GO) - Molecular Function for MINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 10708748
GO:0004674 protein serine/threonine kinase activity IBA,IDA 18930710
GO:0005515 protein binding IPI 15469942
GO:0005524 ATP binding IEA,ISS --
genes like me logo Genes that share ontologies with MINK1: view
genes like me logo Genes that share phenotypes with MINK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MINK1

CRISPR Products

miRNA for MINK1 Gene

miRTarBase miRNAs that target MINK1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MINK1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MINK1 Gene

Localization for MINK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MINK1 Gene

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell projection, axon. Cell projection, dendrite.
[Isoform 4]: Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MINK1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
extracellular 4
nucleus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 18930710
GO:0005794 Golgi apparatus IEA,IDA 15469942
GO:0005829 cytosol TAS --
GO:0014069 postsynaptic density IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with MINK1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MINK1 Gene

Pathways & Interactions for MINK1 Gene

genes like me logo Genes that share pathways with MINK1: view

Pathways by source for MINK1 Gene

SIGNOR curated interactions for MINK1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001952 regulation of cell-matrix adhesion IMP 15469942
GO:0006468 protein phosphorylation IEA,ISS --
GO:0007254 JNK cascade TAS 10708748
GO:0007268 chemical synaptic transmission ISS --
GO:0007275 multicellular organism development ISS --
genes like me logo Genes that share ontologies with MINK1: view

Drugs & Compounds for MINK1 Gene

(3) Drugs for MINK1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for MINK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with MINK1: view

Transcripts for MINK1 Gene

mRNA/cDNA for MINK1 Gene

5 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MINK1

Alternative Splicing Database (ASD) splice patterns (SP) for MINK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a ·
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: - - - - - - - - - - - - - - - -
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 20b · 20c ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c
SP1: -
SP2:
SP3: -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9: - -
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MINK1 Gene

GeneLoc Exon Structure for
MINK1

Expression for MINK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MINK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MINK1 Gene

This gene is overexpressed in Brain (29.9), Heart (10.6), and Frontal cortex (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MINK1 Gene



Protein tissue co-expression partners for MINK1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MINK1

SOURCE GeneReport for Unigene cluster for MINK1 Gene:

Hs.443417

mRNA Expression by UniProt/SwissProt for MINK1 Gene:

Q8N4C8-MINK1_HUMAN
Tissue specificity: Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.

Evidence on tissue expression from TISSUES for MINK1 Gene

  • Nervous system(4.8)
  • Blood(4.5)
  • Liver(4.4)
  • Skin(3)
  • Intestine(2.5)
  • Lung(2.5)
  • Eye(2.5)
  • Spleen(2.4)
  • Kidney(2.4)
  • Lymph node(2.4)
  • Heart(2.1)
  • Muscle(2.1)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with MINK1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINK1 Gene

Orthologs for MINK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MINK1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MINK1 30 31
  • 99.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MINK 31
  • 94 (a)
OneToOne
MINK1 30
  • 89.81 (n)
Oppossum
(Monodelphis domestica)
Mammalia MINK1 31
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MINK1 30 31
  • 91.95 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mink1 30 17 31
  • 91.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mink1 30
  • 90.46 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 48 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves NRK 31
  • 58 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia MINK1 31
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mink1 30
  • 77.1 (n)
Zebrafish
(Danio rerio)
Actinopterygii mink1 31
  • 76 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.538 30
Fruit Fly
(Drosophila melanogaster)
Insecta msn 31
  • 43 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea mig-15 31
  • 51 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3520 31
  • 46 (a)
OneToMany
Species where no ortholog for MINK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MINK1 Gene

ENSEMBL:
Gene Tree for MINK1 (if available)
TreeFam:
Gene Tree for MINK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MINK1: view image

Paralogs for MINK1 Gene

(40) SIMAP similar genes for MINK1 Gene using alignment to 5 proteins:

  • MINK1_HUMAN
  • I3L1U1_HUMAN
  • I3L203_HUMAN
  • I3L2I2_HUMAN
  • I3L4T2_HUMAN
genes like me logo Genes that share paralogs with MINK1: view

Variants for MINK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MINK1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
713208 Benign: not provided 4,894,236(+) C/T SYNONYMOUS_VARIANT
735186 Benign: not provided 4,892,427(+) A/C MISSENSE_VARIANT,INTRON_VARIANT
739064 Likely Benign: not provided 4,896,010(+) C/T SYNONYMOUS_VARIANT
777100 Benign: not provided 4,896,258(+) C/T SYNONYMOUS_VARIANT
890890 Uncertain Significance: Congenital myasthenic syndrome 4,897,881(+) G/A THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for MINK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MINK1 Gene

Variant ID Type Subtype PubMed ID
dgv3088n100 CNV gain 25217958
esv1005973 CNV insertion 20482838
esv1520671 CNV insertion 17803354
esv2537517 CNV insertion 19546169
esv2715558 CNV deletion 23290073
esv2715559 CNV deletion 23290073
esv3341973 CNV duplication 20981092
esv3440715 CNV insertion 20981092
esv3572365 CNV gain 25503493
esv3582499 CNV loss 25503493
esv3639796 CNV loss 21293372
nsv1953 CNV insertion 18451855
nsv474658 CNV novel sequence insertion 20440878
nsv480316 CNV novel sequence insertion 20440878
nsv480688 CNV novel sequence insertion 20440878
nsv480726 CNV novel sequence insertion 20440878
nsv480878 CNV novel sequence insertion 20440878
nsv509647 CNV insertion 20534489
nsv574273 CNV gain 21841781
nsv574275 CNV gain 21841781
nsv833346 CNV loss 17160897
nsv833347 CNV loss 17160897
nsv833349 CNV loss 17160897
nsv833350 CNV loss 17160897
nsv952112 CNV deletion 24416366
nsv952113 CNV deletion 24416366
nsv960043 CNV duplication 23825009

Variation tolerance for MINK1 Gene

Residual Variation Intolerance Score: 4.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MINK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MINK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINK1 Gene

Disorders for MINK1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MINK1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease 15
  • ad15
shipyard eye
  • ekc
perforated corneal ulcer
acute hemorrhagic conjunctivitis
  • apollo disease
congenital myasthenic syndrome
  • congenital myasthenic syndromes
- elite association - COSMIC cancer census association via MalaCards
Search MINK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MINK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MINK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MINK1 Gene

Publications for MINK1 Gene

  1. Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. (PMID: 15469942) Hu Y … Xu X (The Journal of biological chemistry 2004) 3 4 23
  2. Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. (PMID: 10708748) Dan I … Kusumi A (FEBS letters 2000) 2 3 4
  3. Smad inhibition by the Ste20 kinase Misshapen. (PMID: 21690388) Kaneko S … Xu L (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4
  4. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. (PMID: 18930710) Nonaka H … Kariya KI (Biochemical and biophysical research communications 2008) 3 4
  5. Molecular genetic analysis of long QT syndrome in Norway indicating a high prevalence of heterozygous mutation carriers. (PMID: 18752142) Berge KE … Leren TP (Scandinavian journal of clinical and laboratory investigation 2008) 3 41

Products for MINK1 Gene

  • Signalway ELISA kits for MINK1

Sources for MINK1 Gene