Aliases for MINDY4B Gene

Aliases for MINDY4B Gene

  • MINDY Family Member 4B 2 3 5
  • Inactive Ubiquitin Carboxyl-Terminal Hydrolase MINDY-4B 3 4
  • Family With Sequence Similarity 188 Member B2 2 3
  • Protein FAM188B2 3 4
  • FAM188B2 3 4
  • C3orf76 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Chromosome 3 Open Reading Frame 76 2
  • Putative UPF0526 Protein B 3

External Ids for MINDY4B Gene

Previous HGNC Symbols for MINDY4B Gene

  • C3orf76
  • FAM188B2

Summaries for MINDY4B Gene

GeneCards Summary for MINDY4B Gene

MINDY4B (MINDY Family Member 4B) is a Protein Coding gene. An important paralog of this gene is MINDY4.

Additional gene information for MINDY4B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MINDY4B Gene

Genomics for MINDY4B Gene

GeneHancer (GH) Regulatory Elements for MINDY4B Gene

Promoters and enhancers for MINDY4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J150723 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +171.2 171225 22.8 EP300 FOXK2 ZNF217 POLR2G NCOR1 JUND FOS TEAD4 PHB2 ZBTB5 ERICH6-AS1 SERP1 SIAH2 ERICH6 SIAH2-AS1 ENSG00000243273 MINDY4B SELENOT TSC22D2 CLRN1
GH03J150865 Enhancer 1 Ensembl ENCODE 12.3 +39.9 39866 0.7 ZNF217 CTCF NRF1 MYC CLOCK ZBTB26 REST CUX1 RAD21 EP300 ENSG00000243273 MINDY4B CLRN1 piR-32651-009 CLRN1-AS1 SIAH2-AS1
GH03J151145 Enhancer 0.9 ENCODE dbSUPER 10.8 -240.8 -240768 1.7 CTCF JUND REST RAD21 TRIM22 SMC3 MXI1 DEK GATA3 CEBPG MED12L P2RY14 MINDY4B ENSG00000243273 CLRN1 CLRN1-AS1 RF00994-691 lnc-SELENOT-5
GH03J151002 Enhancer 0.7 Ensembl ENCODE 10.3 -97.7 -97735 1.7 ZNF316 MAFF MAFK SMAD4 BCL6 GLIS1 JUND FOS GATAD2A CREB1 RF00017-4140 CLRN1 MED12L CLRN1-AS1 MINDY4B ENSG00000243273 piR-41306-194
GH03J150869 Enhancer 0.6 Ensembl ENCODE 12.3 +34.3 34298 3.3 FOS CEBPB STAT3 MYC EZH2 MINDY4B CLRN1 piR-32651-009 ENSG00000243273 CLRN1-AS1 lnc-MINDY4B-1 SIAH2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MINDY4B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MINDY4B

Genomic Locations for MINDY4B Gene

Genomic Locations for MINDY4B Gene
chr3:150,870,376-150,905,439
(GRCh38/hg38)
Size:
35,064 bases
Orientation:
Minus strand
chr3:150,588,832-150,612,089
(GRCh37/hg19)
Size:
23,258 bases
Orientation:
Minus strand

Genomic View for MINDY4B Gene

Genes around MINDY4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINDY4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINDY4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINDY4B Gene

Proteins for MINDY4B Gene

  • Protein details for MINDY4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYZ0-MIY4B_HUMAN
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B
    Protein Accession:
    A8MYZ0
    Secondary Accessions:
    • A0A1W2PQ44

    Protein attributes for MINDY4B Gene

    Size:
    460 amino acids
    Molecular mass:
    51976 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MINDY4B Gene

Post-translational modifications for MINDY4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MINDY4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MINDY4B Gene

Domains & Families for MINDY4B Gene

Gene Families for MINDY4B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MINDY4B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MINDY4B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM188B2 (F1882_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A8MYZ0

UniProtKB/Swiss-Prot:

MIY4B_HUMAN :
  • Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
Family:
  • Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
genes like me logo Genes that share domains with MINDY4B: view

Function for MINDY4B Gene

Phenotypes From GWAS Catalog for MINDY4B Gene

Gene Ontology (GO) - Molecular Function for MINDY4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016807 cysteine-type carboxypeptidase activity IBA 21873635
GO:1990380 Lys48-specific deubiquitinase activity IBA 21873635
genes like me logo Genes that share ontologies with MINDY4B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MINDY4B Gene

Localization for MINDY4B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MINDY4B Gene

Pathways & Interactions for MINDY4B Gene

PathCards logo

SuperPathways for MINDY4B Gene

No Data Available

Interacting Proteins for MINDY4B Gene

;

Gene Ontology (GO) - Biological Process for MINDY4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071108 protein K48-linked deubiquitination IEA --
genes like me logo Genes that share ontologies with MINDY4B: view

No data available for Pathways by source and SIGNOR curated interactions for MINDY4B Gene

Drugs & Compounds for MINDY4B Gene

No Compound Related Data Available

Transcripts for MINDY4B Gene

mRNA/cDNA for MINDY4B Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MINDY4B Gene

No ASD Table

Relevant External Links for MINDY4B Gene

GeneLoc Exon Structure for
MINDY4B

Expression for MINDY4B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MINDY4B

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINDY4B Gene

Orthologs for MINDY4B Gene

This gene was present in the common ancestor of animals.

Orthologs for MINDY4B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FAM188B2 31
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM188B2 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 17 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FAM188B2 31
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM188B2 31
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FAM188B2 31
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14142 31
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
OneToOne
Species where no ortholog for MINDY4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MINDY4B Gene

ENSEMBL:
Gene Tree for MINDY4B (if available)
TreeFam:
Gene Tree for MINDY4B (if available)

Paralogs for MINDY4B Gene

Paralogs for MINDY4B Gene

genes like me logo Genes that share paralogs with MINDY4B: view

Variants for MINDY4B Gene

Additional dbSNP identifiers (rs#s) for MINDY4B Gene

Variation tolerance for MINDY4B Gene

Gene Damage Index Score: 1.70; 32.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MINDY4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MINDY4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for MINDY4B Gene

Disorders for MINDY4B Gene

Additional Disease Information for MINDY4B

No disorders were found for MINDY4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINDY4B Gene

Publications for MINDY4B Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. Alternative splice variants of the USH3A gene Clarin 1 (CLRN1). (PMID: 20717163) Västinsalo H … Sankila EM (European journal of human genetics : EJHG 2011) 3 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 54

Products for MINDY4B Gene

Sources for MINDY4B Gene