Aliases for MINDY4 Gene

Aliases for MINDY4 Gene

  • MINDY Lysine 48 Deubiquitinase 4 2 3 5
  • Probable Ubiquitin Carboxyl-Terminal Hydrolase MINDY-4 3 4
  • Family With Sequence Similarity 188 Member B 2 3
  • Probable Deubiquitinating Enzyme MINDY-4 3 4
  • MINDY Deubiquitinase 4 2 3
  • C7orf67 3 4
  • FAM188B 3 4
  • Water Channel Protein For Red Blood Cells And Kidney Proximal Tubule 3
  • Probable Ubiquitin Carboxyl-Terminal Hydrolase FAM188B 3
  • Chromosome 7 Open Reading Frame 67 2
  • Urine Water Channel 3
  • Protein FAM188B 3
  • Aquaporin-CHIP 3
  • EC 4
  • Aquaporin-1 3
  • CHIP28 3
  • AQP-1 3
  • AQP1 3

External Ids for MINDY4 Gene

Previous HGNC Symbols for MINDY4 Gene

  • C7orf67
  • FAM188B

Summaries for MINDY4 Gene

GeneCards Summary for MINDY4 Gene

MINDY4 (MINDY Lysine 48 Deubiquitinase 4) is a Protein Coding gene. Diseases associated with MINDY4 include Nephrolithiasis, Calcium Oxalate. An important paralog of this gene is MINDY4B.

UniProtKB/Swiss-Prot Summary for MINDY4 Gene

  • Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

Gene Wiki entry for MINDY4 Gene

Additional gene information for MINDY4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MINDY4 Gene

Genomics for MINDY4 Gene

GeneHancer (GH) Regulatory Elements for MINDY4 Gene

Promoters and enhancers for MINDY4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J030770 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 757.5 +0.2 185 2.4 ZBTB40 SIX5 ATF1 CREB1 HCFC1 ELF1 L3MBTL2 POLR2A NFIB CSDE1 MINDY4 PLEKHA8 INMT INMT-MINDY4 ENSG00000229263 lnc-NOD1-1
GH07J030748 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 778.6 -20.2 -20182 5.9 IKZF1 SP1 ZSCAN5C ZBTB17 FOXA2 TRIM28 NR2F2 NFIC ZNF366 CBX5 MINDY4 INMT INMT-MINDY4 CRHR2 SCRN1 ENSG00000244480 ENSG00000223419 lnc-CRHR2-2 LOC105375220 lnc-NOD1-1
GH07J030791 Promoter 0.6 EPDnew 750.4 +20.0 19988 0.1 REST RAD21 CTCF MINDY4 ENSG00000229263 INMT-MINDY4 lnc-NOD1-1
GH07J030790 Promoter 0.3 EPDnew 750.4 +19.4 19426 0.1 MINDY4 INMT ENSG00000229263 INMT-MINDY4 lnc-NOD1-1
GH07J030794 Enhancer 1.2 Ensembl ENCODE dbSUPER 31.4 +27.0 27011 7.9 ZNF24 CTCF CC2D1A ETV6 HLF RAD21 CEBPG SP7 RELA IKZF1 MINDY4 ENSG00000250424 AQP1 INMT ENSG00000229263 ZNRF2 INMT-MINDY4 lnc-NOD1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MINDY4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MINDY4 Gene

Genomic Locations for MINDY4 Gene
120,971 bases
Plus strand
120,970 bases
Plus strand

Genomic View for MINDY4 Gene

Genes around MINDY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINDY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINDY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINDY4 Gene

Proteins for MINDY4 Gene

  • Protein details for MINDY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase MINDY-4
    Protein Accession:
    Secondary Accessions:
    • Q71AZ7
    • Q9H6D2

    Protein attributes for MINDY4 Gene

    757 amino acids
    Molecular mass:
    84372 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ10898.1; Type=Frameshift; Positions=617; Evidence={ECO:0000305}; Sequence=BAB15327.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for MINDY4 Gene

Post-translational modifications for MINDY4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MINDY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MINDY4 Gene

Domains & Families for MINDY4 Gene

Gene Families for MINDY4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MINDY4 Gene


Suggested Antigen Peptide Sequences for MINDY4 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM188B (F188B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
  • Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
genes like me logo Genes that share domains with MINDY4: view

Function for MINDY4 Gene

Molecular function for MINDY4 Gene

UniProtKB/Swiss-Prot Function:
Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=; Evidence=. ;.

Enzyme Numbers (IUBMB) for MINDY4 Gene

Phenotypes From GWAS Catalog for MINDY4 Gene

Gene Ontology (GO) - Molecular Function for MINDY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016807 cysteine-type carboxypeptidase activity IBA 21873635
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with MINDY4: view

Phenotypes for MINDY4 Gene

genes like me logo Genes that share phenotypes with MINDY4: view

miRNA for MINDY4 Gene

miRTarBase miRNAs that target MINDY4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MINDY4 Gene

Localization for MINDY4 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MINDY4 Gene

Pathways & Interactions for MINDY4 Gene

PathCards logo

SuperPathways for MINDY4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MINDY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071108 protein K48-linked deubiquitination IEA --
genes like me logo Genes that share ontologies with MINDY4: view

No data available for Pathways by source and SIGNOR curated interactions for MINDY4 Gene

Drugs & Compounds for MINDY4 Gene

No Compound Related Data Available

Transcripts for MINDY4 Gene

mRNA/cDNA for MINDY4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(170) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MINDY4 Gene

No ASD Table

Relevant External Links for MINDY4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MINDY4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MINDY4 Gene:


Evidence on tissue expression from TISSUES for MINDY4 Gene

  • Nervous system(4)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINDY4 Gene

Orthologs for MINDY4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MINDY4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM188B 33 32
  • 99.43 (n)
(Canis familiaris)
Mammalia FAM188B 33 32
  • 85.28 (n)
(Bos Taurus)
Mammalia FAM188B 33 32
  • 82.32 (n)
(Mus musculus)
Mammalia Fam188b 33 32
  • 80.8 (n)
Mindy4 17
(Rattus norvegicus)
Mammalia Fam188b 32
  • 79.78 (n)
(Ornithorhynchus anatinus)
Mammalia FAM188B 33
  • 65 (a)
(Monodelphis domestica)
Mammalia FAM188B 33
  • 49 (a)
(Gallus gallus)
Aves FAM188B 33 32
  • 61.72 (n)
(Anolis carolinensis)
Reptilia FAM188B 33
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam188b 32
  • 57.93 (n)
Str.11231 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.14505 32
(Danio rerio)
Actinopterygii si:dkey-30h22.11 32
  • 55.59 (n)
FAM188B 33
  • 43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13006 32
Species where no ortholog for MINDY4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MINDY4 Gene

Gene Tree for MINDY4 (if available)
Gene Tree for MINDY4 (if available)
Evolutionary constrained regions (ECRs) for MINDY4: view image

Paralogs for MINDY4 Gene

Paralogs for MINDY4 Gene

genes like me logo Genes that share paralogs with MINDY4: view

Variants for MINDY4 Gene

Sequence variations from dbSNP and Humsavar for MINDY4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000036169 -- 30,840,470(+) A/G intron_variant
rs1000075121 -- 30,826,106(+) A/G intron_variant
rs1000108453 -- 30,847,607(+) A/G intron_variant
rs1000113570 -- 30,884,144(+) G/A intron_variant
rs1000133574 -- 30,776,941(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MINDY4 Gene

Variant ID Type Subtype PubMed ID
dgv1879e212 CNV loss 25503493
dgv6316n100 CNV gain 25217958
esv22626 CNV gain 19812545
esv2390406 CNV deletion 18987734
esv2678492 CNV deletion 23128226
esv2678752 CNV deletion 23128226
esv2734203 CNV deletion 23290073
esv2734204 CNV deletion 23290073
esv2761316 CNV gain 21179565
esv3305464 CNV mobile element insertion 20981092
esv3356059 CNV insertion 20981092
esv3541409 CNV deletion 23714750
esv3571725 CNV loss 25503493
esv3612714 CNV loss 21293372
esv5109 CNV loss 18987735
esv5499 CNV loss 19470904
esv993279 CNV deletion 20482838
nsv1025945 CNV loss 25217958
nsv1068321 OTHER inversion 25765185
nsv1074084 CNV deletion 25765185
nsv1146524 CNV deletion 26484159
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv464416 CNV loss 19166990
nsv526591 CNV loss 19592680
nsv527038 CNV gain 19592680
nsv606507 CNV loss 21841781
nsv606508 CNV loss 21841781
nsv606509 CNV loss 21841781
nsv830938 CNV gain 17160897
nsv830939 CNV loss 17160897
nsv955992 CNV deletion 24416366

Variation tolerance for MINDY4 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.83; 73.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MINDY4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINDY4 Gene

Disorders for MINDY4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MINDY4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nephrolithiasis, calcium oxalate
  • caon
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MINDY4

genes like me logo Genes that share disorders with MINDY4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MINDY4 Gene

Publications for MINDY4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. (PMID: 29576527) Kwasna D … Kulathu Y (Molecular cell 2018) 3 56
  3. FAM188B enhances cell survival via interaction with USP7. (PMID: 29795372) Choi ES … Goh SH (Cell death & disease 2018) 3 56
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 56
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 56

Products for MINDY4 Gene

Sources for MINDY4 Gene