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The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
MINDY3 (MINDY Lysine 48 Deubiquitinase 3) is a Protein Coding gene. An important paralog of this gene is MINDY4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 21499297 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008234 | cysteine-type peptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016807 | cysteine-type carboxypeptidase activity | IDA | 27292798 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0031965 | nuclear membrane | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0071108 | protein K48-linked deubiquitination | IEA | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FAM188A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FAM188A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FAM188A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fam188a 30 31 |
|
OneToOne | |
Mindy3 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Fam188a 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | FAM188A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FAM188A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FAM188A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fam188a 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fam188a 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG7332 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000412 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G43690 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os04g0421800 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2416 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711900 | Benign: not provided | 15,821,734(-) | AAAC/A | INTRON_VARIANT | |
780847 | Benign: not provided | 15,779,079(-) | A/G | SYNONYMOUS_VARIANT | |
780848 | Benign: not provided | 15,789,328(-) | G/GA | INTRON_VARIANT | |
786151 | Benign: not provided | 15,786,653(-) | G/A | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1036973 | CNV | loss | 25217958 |
nsv1045879 | CNV | gain | 25217958 |
nsv831795 | CNV | gain | 17160897 |
No disorders were found for MINDY3 Gene.