Aliases for MINAR2 Gene

Aliases for MINAR2 Gene

  • Membrane Integral NOTCH2 Associated Receptor 2 2 3 5
  • Major Intrinsically Disordered NOTCH2-Binding Receptor 1-Like 3 4
  • KIAA1024 Like 2 3
  • KIAA1024L 3 4
  • Major Intrinsically Disordered Notch2-Binding Receptor 1-Like 3
  • Membrane Integral NOTCH2-Associated Receptor 2 4
  • UPF0258 Protein KIAA1024-Like 3
  • MINAR2 5

External Ids for MINAR2 Gene

Previous HGNC Symbols for MINAR2 Gene

  • KIAA1024L

Summaries for MINAR2 Gene

GeneCards Summary for MINAR2 Gene

MINAR2 (Membrane Integral NOTCH2 Associated Receptor 2) is a Protein Coding gene. Diseases associated with MINAR2 include Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant and Distal Arthrogryposis. An important paralog of this gene is MINAR1.

Additional gene information for MINAR2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MINAR2 Gene

Genomics for MINAR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MINAR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J129767 Enhancer 0.8 ENCODE 0.4 +20.0 19979 0.2 CTCF ARID3A ZNF629 ZNF692 JUND PRDM1 ZNF143 REST RAD21 TRIM22 MINAR2 piR-37895-135 CHSY3 ENSG00000251680
GH05J129771 Enhancer 0.6 Ensembl 0.4 +23.6 23607 1 CTCF FOXA1 PRDM1 REST RAD21 TRIM22 RUNX3 ZNF444 FOXA2 SMC3 CHSY3 MINAR2 piR-37895-135 ENSG00000251680
GH05J129723 Enhancer 0.6 Ensembl ENCODE 0.4 -23.6 -23551 3.1 TEAD4 FOXA2 POU5F1 CHSY3 HSPA8P4 ENSG00000251680 piR-38051-229 MINAR2 ADAMTS19
GH05J129716 Enhancer 0.4 ENCODE 0.3 -29.8 -29826 3.5 ATF7 CEBPB ATF4 CHSY3 ENSG00000251680 piR-38051-229 MINAR2 piR-39945-004 ADAMTS19
GH05J129458 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.1 -287.5 -287540 4.5 CTCF PRDM10 KDM1A TARDBP PRDM1 ZIC2 ZSCAN4 PATZ1 ZNF501 POLR2A ADAMTS19 ADAMTS19-AS1 MINAR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MINAR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MINAR2

Genomic Locations for MINAR2 Gene

Genomic Locations for MINAR2 Gene
chr5:129,748,094-129,766,732
(GRCh38/hg38)
Size:
18,639 bases
Orientation:
Plus strand
chr5:129,083,772-129,102,425
(GRCh37/hg19)
Size:
18,654 bases
Orientation:
Plus strand

Genomic View for MINAR2 Gene

Genes around MINAR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINAR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINAR2 Gene

Proteins for MINAR2 Gene

  • Protein details for MINAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59773-MNARL_HUMAN
    Recommended name:
    Major intrinsically disordered NOTCH2-binding receptor 1-like
    Protein Accession:
    P59773
    Secondary Accessions:
    • H3BM78

    Protein attributes for MINAR2 Gene

    Size:
    190 amino acids
    Molecular mass:
    21573 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MINAR2 Gene

Post-translational modifications for MINAR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MINAR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MINAR2 Gene

Domains & Families for MINAR2 Gene

Gene Families for MINAR2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MINAR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MINAR2 Gene

GenScript: Design optimal peptide antigens:
  • UPF0258 protein KIAA1024-like (K102L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P59773

UniProtKB/Swiss-Prot:

MNARL_HUMAN :
  • Belongs to the MINAR family.
Family:
  • Belongs to the MINAR family.
genes like me logo Genes that share domains with MINAR2: view

Function for MINAR2 Gene

Phenotypes From GWAS Catalog for MINAR2 Gene

genes like me logo Genes that share phenotypes with MINAR2: view

Animal Models for MINAR2 Gene

MGI Knock Outs for MINAR2:
  • Minar2 Minar2<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for MINAR2 Gene

miRTarBase miRNAs that target MINAR2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MINAR2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MINAR2 Gene

Localization for MINAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MINAR2 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MINAR2 gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MINAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MINAR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MINAR2 Gene

Pathways & Interactions for MINAR2 Gene

PathCards logo

SuperPathways for MINAR2 Gene

No Data Available

Interacting Proteins for MINAR2 Gene

Gene Ontology (GO) - Biological Process for MINAR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MINAR2 Gene

Drugs & Compounds for MINAR2 Gene

No Compound Related Data Available

Transcripts for MINAR2 Gene

mRNA/cDNA for MINAR2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MINAR2

Alternative Splicing Database (ASD) splice patterns (SP) for MINAR2 Gene

No ASD Table

Relevant External Links for MINAR2 Gene

GeneLoc Exon Structure for
MINAR2

Expression for MINAR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MINAR2

SOURCE GeneReport for Unigene cluster for MINAR2 Gene:

Hs.582534
genes like me logo Genes that share expression patterns with MINAR2: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINAR2 Gene

Orthologs for MINAR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MINAR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIAA1024L 30
  • 99.47 (n)
Cow
(Bos Taurus)
Mammalia KIAA1024L 30 31
  • 85.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KIAA1024L 30 31
  • 85.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1312005 30
  • 83.42 (n)
Mouse
(Mus musculus)
Mammalia A730017C20Rik 30 31
  • 83.16 (n)
OneToOne
Minar2 17
Oppossum
(Monodelphis domestica)
Mammalia KIAA1024L 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KIAA1024L 30 31
  • 64.39 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KIAA1024L 31
  • 47 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kiaa1024l 30
  • 63.14 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101882624 30
  • 53.98 (n)
KIAA1024L 31
  • 39 (a)
OneToOne
Species where no ortholog for MINAR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MINAR2 Gene

ENSEMBL:
Gene Tree for MINAR2 (if available)
TreeFam:
Gene Tree for MINAR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MINAR2: view image

Paralogs for MINAR2 Gene

Paralogs for MINAR2 Gene

genes like me logo Genes that share paralogs with MINAR2: view

Variants for MINAR2 Gene

Additional dbSNP identifiers (rs#s) for MINAR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MINAR2 Gene

Variant ID Type Subtype PubMed ID
esv2763498 CNV gain 21179565
nsv599704 CNV gain 21841781

Variation tolerance for MINAR2 Gene

Gene Damage Index Score: 1.42; 27.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MINAR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MINAR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MINAR2 Gene

Disorders for MINAR2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MINAR2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukodystrophy, demyelinating, adult-onset, autosomal dominant
  • adld
distal arthrogryposis
  • freeman-sheldon syndrome
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MINAR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MINAR2 Gene

Publications for MINAR2 Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4

Products for MINAR2 Gene

Sources for MINAR2 Gene