Free for academic non-profit institutions. Other users need a Commercial license
Aliases for MINAR2 Gene
Aliases for MINAR2 Gene
- Membrane Integral NOTCH2 Associated Receptor 2 2 3 5
- Major Intrinsically Disordered NOTCH2-Binding Receptor 1-Like 3 4
- KIAA1024 Like 2 3
- KIAA1024L 3 4
- Major Intrinsically Disordered Notch2-Binding Receptor 1-Like 3
- Membrane Integral NOTCH2-Associated Receptor 2 4
- UPF0258 Protein KIAA1024-Like 3
- MINAR2 5
External Ids for MINAR2 Gene
- HGNC: 33914
- Entrez Gene: 100127206
- Ensembl: ENSG00000186367
- UniProtKB: P59773
Previous HGNC Symbols for MINAR2 Gene
- KIAA1024L
Summaries for MINAR2 Gene
GeneCards Summary for MINAR2 Gene
MINAR2 (Membrane Integral NOTCH2 Associated Receptor 2) is a Protein Coding gene. Diseases associated with MINAR2 include Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant and Distal Arthrogryposis. An important paralog of this gene is MINAR1.
Additional gene information for MINAR2 Gene
- HGNC(33914)
- Entrez Gene(100127206)
- Ensembl(ENSG00000186367)
- UniProtKB(P59773)
- Open Targets Platform(ENSG00000186367)
- Search for MINAR2 at DataMed
- Search for MINAR2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MINAR2 Gene
Genomics for MINAR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MINAR2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05J129767 | Enhancer | 0.8 | ENCODE | 0.4 | +20.0 | 19979 | 0.2 | CTCF ARID3A ZNF629 ZNF692 JUND PRDM1 ZNF143 REST RAD21 TRIM22 | MINAR2 piR-37895-135 CHSY3 ENSG00000251680 | |
| GH05J129771 | Enhancer | 0.6 | Ensembl | 0.4 | +23.6 | 23607 | 1 | CTCF FOXA1 PRDM1 REST RAD21 TRIM22 RUNX3 ZNF444 FOXA2 SMC3 | CHSY3 MINAR2 piR-37895-135 ENSG00000251680 | |
| GH05J129723 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | -23.6 | -23551 | 3.1 | TEAD4 FOXA2 POU5F1 | CHSY3 HSPA8P4 ENSG00000251680 piR-38051-229 MINAR2 ADAMTS19 | |
| GH05J129716 | Enhancer | 0.4 | ENCODE | 0.3 | -29.8 | -29826 | 3.5 | ATF7 CEBPB ATF4 | CHSY3 ENSG00000251680 piR-38051-229 MINAR2 piR-39945-004 ADAMTS19 | |
| GH05J129458 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.1 | -287.5 | -287540 | 4.5 | CTCF PRDM10 KDM1A TARDBP PRDM1 ZIC2 ZSCAN4 PATZ1 ZNF501 POLR2A | ADAMTS19 ADAMTS19-AS1 MINAR2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MINAR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MINAR2
Genomic Locations for MINAR2 Gene
Genomic Locations for MINAR2 Gene
- chr5:129,748,094-129,766,732
- (GRCh38/hg38)
- Size:
- 18,639 bases
- Orientation:
- Plus strand
- chr5:129,083,772-129,102,425
- (GRCh37/hg19)
- Size:
- 18,654 bases
- Orientation:
- Plus strand
Genomic View for MINAR2 Gene
Genes around MINAR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q23.3 by HGNC
- 5q23.3 by Entrez Gene
- 5q23.3 by Ensembl
MINAR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MINAR2 Gene
Proteins for MINAR2 Gene
-
Protein details for MINAR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P59773-MNARL_HUMAN
- Recommended name:
- Major intrinsically disordered NOTCH2-binding receptor 1-like
- Protein Accession:
- P59773
- H3BM78
Protein attributes for MINAR2 Gene
- Size:
- 190 amino acids
- Molecular mass:
- 21573 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for MINAR2 Gene
Other Protein References for MINAR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-KIAA1024L polyclonal antibody
- Novus Biologicals Antibodies for MINAR2
- Invitrogen Antibodies for MINAR2 (AFLGC-KIAA1024L)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MINAR2
- Origene Custom Protein Services for MINAR2
- Novus Biologicals proteins for MINAR2
No data available for DME Specific Peptides for MINAR2 Gene
Domains & Families for MINAR2 Gene
Gene Families for MINAR2 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for MINAR2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MINAR2 Gene
- GenScript: Design optimal peptide antigens:
-
- UPF0258 protein KIAA1024-like (K102L_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P59773- Family:
-
- Belongs to the MINAR family.
Function for MINAR2 Gene
Phenotypes From GWAS Catalog for MINAR2 Gene
Phenotypes for MINAR2 Gene
Animal Models for MINAR2 Gene
- MGI Knock Outs for MINAR2:
-
- Minar2 Minar2<tm1b(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MINAR2 - Select products 50% OFF >
- * MINAR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MINAR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MINAR2
miRNA for MINAR2 Gene
- miRTarBase miRNAs that target MINAR2
miRNA Products
Inhibitory RNA Products
- Origene shrna and sirna products in human, mouse, rat for MINAR2
- Browse OriGene Inhibitory RNA Products For MINAR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MINAR2
Clone Products
- Applied Biological Materials (abm): Clones for MINAR2 - Select products 50% OFF >
- * MINAR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MINAR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MINAR2
Cell Line Products
-
Horizon Cell Lines for MINAR2
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MINAR2 Gene
Localization for MINAR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MINAR2 Gene
- Membrane. Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MINAR2 Gene
Transcripts for MINAR2 Gene
mRNA/cDNA for MINAR2 Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000564719 2339 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MINAR2 - Select products 50% OFF >
- * MINAR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MINAR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MINAR2
miRNA Products
Inhibitory RNA Products
- Origene shrna and sirna products in human, mouse, rat for MINAR2
- Browse OriGene Inhibitory RNA Products For MINAR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MINAR2
Clone Products
- Applied Biological Materials (abm): Clones for MINAR2 - Select products 50% OFF >
- * MINAR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MINAR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MINAR2
Relevant External Links for MINAR2 Gene
- GeneLoc Exon Structure for
- MINAR2
Expression for MINAR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Epithelial Cells
- Dental Placode Cells Dental Placode
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Ovary (Reproductive System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MINAR2
SOURCE GeneReport for Unigene cluster for MINAR2 Gene:
Hs.582534Primer Products
-
OriGene qPCR primer pairs for MINAR2
-
OriGene qPCR primer pairs and template standards for MINAR2
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINAR2 Gene
Orthologs for MINAR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KIAA1024L 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | KIAA1024L 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KIAA1024L 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | RGD1312005 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | A730017C20Rik 30 31 |
|
OneToOne | |
| Minar2 17 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | KIAA1024L 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | KIAA1024L 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | KIAA1024L 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | kiaa1024l 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC101882624 30 |
|
||
| KIAA1024L 31 |
|
OneToOne |
- Species where no ortholog for MINAR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MINAR2 Gene
- ENSEMBL:
- Gene Tree for MINAR2 (if available)
- TreeFam:
- Gene Tree for MINAR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MINAR2: view image
Paralogs for MINAR2 Gene
Variants for MINAR2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2763498 | CNV | gain | 21179565 |
| nsv599704 | CNV | gain | 21841781 |
Gene Damage Index Score:
1.42;
27.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MINAR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MINAR2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MINAR2 Gene
Disorders for MINAR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukodystrophy, demyelinating, adult-onset, autosomal dominant |
|
|
| distal arthrogryposis |
|
|
Search MINAR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MINAR2
No data available for UniProtKB/Swiss-Prot and Genatlas for MINAR2 Gene
Publications for MINAR2 Gene
- The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4
ExternalLinks
Products for MINAR2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MINAR2
- Origene Custom Protein Services for MINAR2
- Origene shrna and sirna products in human, mouse, rat for MINAR2
- Browse OriGene Inhibitory RNA Products For MINAR2
- OriGene qPCR primer pairs for MINAR2
- OriGene qPCR primer pairs and template standards for MINAR2
- OriGene CRISPR knockouts for MINAR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MINAR2
- Sino Biological Human cDNA Clone for MINAR2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MINAR2
- Novus Biologicals proteins for MINAR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for MINAR2 (AFLGC-KIAA1024L)
- VectorBuilder Custom and pre-made DNA vectors for MINAR2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MINAR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MINAR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MINAR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MINAR2
- antibodies-online: Search results for available KIAA1024L related products ranked by validation data
- antibodies-online: Search results for available KIAA1024L related products ranked by validation data
- antibodies-online: Search results for available KIAA1024L related products ranked by validation data
- Horizon Cell Lines for MINAR2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MINAR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MINAR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MINAR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MINAR2
Sources for MINAR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB