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Aliases for MILR1 Gene

Aliases for MILR1 Gene

  • Mast Cell Immunoglobulin Like Receptor 1 2 3 5
  • Allergy Inhibitory Receptor 1 2 3 4
  • Mast Cell Antigen 32 2 3 4
  • Mast Cell Immunoglobulin-Like Receptor 1 2 4
  • C17orf60 3 4
  • MCA-32 3 4
  • MCA32 3 4
  • Probable Mast Cell Antigen 32 Homolog 3
  • Chromosome 17 Open Reading Frame 60 2
  • Allergin-1 3

External Ids for MILR1 Gene

Previous HGNC Symbols for MILR1 Gene

  • C17orf60

Previous GeneCards Identifiers for MILR1 Gene

  • GC17P062462

Summaries for MILR1 Gene

GeneCards Summary for MILR1 Gene

MILR1 (Mast Cell Immunoglobulin Like Receptor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MILR1 Gene

  • Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

Additional gene information for MILR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MILR1 Gene

Genomics for MILR1 Gene

GeneHancer (GH) Regulatory Elements for MILR1 Gene

Promoters and enhancers for MILR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I064495 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17.9 +50.3 50297 3.5 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A DMAP1 POLG2 SMARCD2 PLEKHM1P1 ENSG00000265982 DDX5 FTSJ3 CEP95 SLC16A6P1 DDX42 ENSG00000281311
GH17I064500 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.5 +57.5 57523 7.7 CLOCK FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 DDX5 CEP95 POLG2 FTSJ3 DDX42 PLEKHM1P1 ENSG00000265982 SMARCD2 SLC16A6P1 ENSG00000281311
GH17I064657 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.8 +213.0 212997 6.5 PKNOX1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B SMURF2 CEP95 DDX42 SMARCD2 DDX5 FTSJ3 PLEKHM1P1 POLG2 ENSG00000281311 ENSG00000265982
GH17I064619 Enhancer 1 ENCODE dbSUPER 13.2 +172.6 172638 1.7 HDAC1 PKNOX1 FOXA2 ARNT RARA TCF12 GATA2 CREM CEBPB NCOA1 MILR1 GC17P064641 SMURF2 ENSG00000271779
GH17I064598 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.4 +152.2 152206 1.4 HDAC1 PKNOX1 TAF9B NFRKB ZBTB40 POLR2B RUNX3 SMARCA5 SMAD5 REST MILR1 ENSG00000271779 GC17P064641 SMURF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MILR1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MILR1 Gene

Genomic Locations for MILR1 Gene
32,135 bases
Plus strand

Genomic View for MILR1 Gene

Genes around MILR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MILR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MILR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MILR1 Gene

Proteins for MILR1 Gene

  • Protein details for MILR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1L458
    • B4DUS1
    • B7ZM50
    • B9EGN0
    • D6RUW6
    • D6RUW8

    Protein attributes for MILR1 Gene

    343 amino acids
    Molecular mass:
    38735 Da
    Quaternary structure:
    • Monomer. Interacts (tyrosine-phosphorylated) with PTPN6, PTPN11 and INPP5D.
    • Sequence=AAI36595.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG62433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MILR1 Gene


neXtProt entry for MILR1 Gene

Post-translational modifications for MILR1 Gene

  • N-glycosylated.
  • Glycosylation at posLast=5151, isoforms=260, posLast=8989, posLast=151151, posLast=157157, and posLast=182182
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MILR1 Gene

Domains & Families for MILR1 Gene

Gene Families for MILR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MILR1 Gene

Suggested Antigen Peptide Sequences for MILR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MILR1: view

No data available for UniProtKB/Swiss-Prot for MILR1 Gene

Function for MILR1 Gene

Molecular function for MILR1 Gene

UniProtKB/Swiss-Prot Function:
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

Phenotypes From GWAS Catalog for MILR1 Gene

genes like me logo Genes that share phenotypes with MILR1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MILR1 Gene

Localization for MILR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MILR1 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for MILR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane NAS 20526344
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0042629 mast cell granule IEA --
genes like me logo Genes that share ontologies with MILR1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MILR1 Gene

Pathways & Interactions for MILR1 Gene

SuperPathways for MILR1 Gene

No Data Available

Interacting Proteins for MILR1 Gene

Gene Ontology (GO) - Biological Process for MILR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033004 negative regulation of mast cell activation ISS --
GO:0043303 mast cell degranulation ISS --
genes like me logo Genes that share ontologies with MILR1: view

No data available for Pathways by source and SIGNOR curated interactions for MILR1 Gene

Drugs & Compounds for MILR1 Gene

No Compound Related Data Available

Transcripts for MILR1 Gene

Unigene Clusters for MILR1 Gene

Mast cell immunoglobulin-like receptor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MILR1 Gene

No ASD Table

Relevant External Links for MILR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MILR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MILR1 Gene

mRNA differential expression in normal tissues according to GTEx for MILR1 Gene

This gene is overexpressed in Whole Blood (x13.9) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for MILR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.4), Monocytes (9.5), and Adipocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MILR1 Gene

Protein tissue co-expression partners for MILR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MILR1 Gene:


SOURCE GeneReport for Unigene cluster for MILR1 Gene:


mRNA Expression by UniProt/SwissProt for MILR1 Gene:

Tissue specificity: Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level).
genes like me logo Genes that share expression patterns with MILR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MILR1 Gene

Orthologs for MILR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MILR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MILR1 33 34
  • 98.54 (n)
(Canis familiaris)
Mammalia MILR1 33 34
  • 78.34 (n)
(Bos Taurus)
Mammalia MILR1 33 34
  • 77.25 (n)
(Mus musculus)
Mammalia Milr1 34
  • 6 (a)
(Ornithorhynchus anatinus)
Mammalia MILR1 34
  • 3 (a)
(Gallus gallus)
Aves MILR1 33 34
  • 47.56 (n)
Species where no ortholog for MILR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MILR1 Gene

Gene Tree for MILR1 (if available)
Gene Tree for MILR1 (if available)

Paralogs for MILR1 Gene

No data available for Paralogs for MILR1 Gene

Variants for MILR1 Gene

Sequence variations from dbSNP and Humsavar for MILR1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000100577 -- 64,451,165(+) C/G intron_variant
rs1000168071 -- 64,452,357(+) A/G intron_variant
rs1000205152 -- 64,469,239(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000299854 -- 64,469,491(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000410387 -- 64,450,964(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MILR1 Gene

Variant ID Type Subtype PubMed ID
nsv2120 CNV insertion 18451855

Additional Variant Information for MILR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MILR1 Gene

Disorders for MILR1 Gene

Additional Disease Information for MILR1

No disorders were found for MILR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MILR1 Gene

Publications for MILR1 Gene

  1. An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. (PMID: 20526344) Hitomi K … Shibuya A (Nature immunology 2010) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Influence of MILR1 promoter polymorphism on expression levels and the phenotype of atopy. (PMID: 25007884) Nanatsue K … Noguchi E (Journal of human genetics 2014) 3 58
  4. Expression and function of Allergin-1 on human primary mast cells. (PMID: 24116093) Nagai K … Shibuya A (PloS one 2013) 3 58
  5. [Immunoglobulin-like receptor, allergin-1 regulates the activation of mast cells]. (PMID: 24552759) Tahara-Hanaoka S … Shibuya A (Arerugi = [Allergy] 2013) 3 58

Products for MILR1 Gene

Sources for MILR1 Gene

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