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Aliases for MIIP Gene

Aliases for MIIP Gene

  • Migration And Invasion Inhibitory Protein 2 3 5
  • Invasion-Inhibitory Protein 45 3 4
  • IGFBP2-Binding Protein 3 4
  • IIP45 3 4
  • Migration And Invasion-Inhibitory Protein 3
  • Invasion Inhibitory Protein 45 2

External Ids for MIIP Gene

Previous GeneCards Identifiers for MIIP Gene

  • GC01P012004
  • GC01P012079
  • GC01P011234

Summaries for MIIP Gene

Entrez Gene Summary for MIIP Gene

  • This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]

GeneCards Summary for MIIP Gene

MIIP (Migration And Invasion Inhibitory Protein) is a Protein Coding gene. Diseases associated with MIIP include Glioma.

UniProtKB/Swiss-Prot for MIIP Gene

  • Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.

Additional gene information for MIIP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIIP Gene

Genomics for MIIP Gene

GeneHancer (GH) Regulatory Elements for MIIP Gene

Promoters and enhancers for MIIP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I012018 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 628 2.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF143 FOS MIIP UBIAD1 TNFRSF8 RNU6-777P RPL23AP89 PLOD1 KIAA2013 LINC01647 NPPA-AS1 ENSG00000202461
GH01I011978 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18 -36.5 -36510 8.6 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MFN2 ENSG00000226849 EXOSC10 MIIP TNFRSF1B PLOD1 CLCN6 TARDBP KIAA2013 RNU5E-1
GH01I011885 Enhancer 1 VISTA dbSUPER 15.8 -131.8 -131790 4 SMARCA5 CTCF BCOR HLF ZMYM3 NFXL1 POLR2A HDAC2 SCRT2 ZFP36 PLOD1 MFN2 MIIP NPPB KIAA2013 NPPA-AS1 LOC390997 RNU5E-1
GH01I011989 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 13.1 -28.7 -28733 2.2 FOXA2 TAF1 SAP130 MAX ETS1 YY1 TEAD3 HNF4G NR2F6 HOMEZ MFN2 MIIP PLOD1 KIAA2013 RNU5E-1 RNU5E-4P NPPB NPPA ENSG00000270914
GH01I011933 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 6.5 -84.7 -84707 2.1 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 ZNF143 PLOD1 ENSG00000226849 TARDBP MFN2 MIIP MTHFR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIIP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MIIP gene promoter:

Genomic Locations for MIIP Gene

Genomic Locations for MIIP Gene
12,808 bases
Plus strand

Genomic View for MIIP Gene

Genes around MIIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIIP Gene

Proteins for MIIP Gene

  • Protein details for MIIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Migration and invasion-inhibitory protein
    Protein Accession:
    Secondary Accessions:
    • C0KL22
    • Q96HU6
    • Q9H839
    • Q9HA00

    Protein attributes for MIIP Gene

    388 amino acids
    Molecular mass:
    42824 Da
    Quaternary structure:
    • Interacts with IGFBP2.

    Alternative splice isoforms for MIIP Gene


neXtProt entry for MIIP Gene

Post-translational modifications for MIIP Gene

Other Protein References for MIIP Gene

No data available for DME Specific Peptides for MIIP Gene

Domains & Families for MIIP Gene

Gene Families for MIIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MIIP Gene


Suggested Antigen Peptide Sequences for MIIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIIP: view

No data available for UniProtKB/Swiss-Prot for MIIP Gene

Function for MIIP Gene

Molecular function for MIIP Gene

UniProtKB/Swiss-Prot Function:
Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IGFBP2.

Phenotypes From GWAS Catalog for MIIP Gene

Gene Ontology (GO) - Molecular Function for MIIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MIIP: view
genes like me logo Genes that share phenotypes with MIIP: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIIP Gene

Localization for MIIP Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIIP gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MIIP Gene

Pathways & Interactions for MIIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle IEA --
GO:0030336 negative regulation of cell migration IEA --
genes like me logo Genes that share ontologies with MIIP: view

No data available for Pathways by source and SIGNOR curated interactions for MIIP Gene

Drugs & Compounds for MIIP Gene

No Compound Related Data Available

Transcripts for MIIP Gene

Unigene Clusters for MIIP Gene

Migration and invasion inhibitory protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIIP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - -
SP11: -

Relevant External Links for MIIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIIP Gene

This gene is overexpressed in Whole Blood (x6.2).

Protein differential expression in normal tissues from HIPED for MIIP Gene

This gene is overexpressed in Frontal cortex (29.1), Fetal Brain (15.1), Placenta (14.5), and Fetal ovary (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MIIP Gene

Protein tissue co-expression partners for MIIP Gene

NURSA nuclear receptor signaling pathways regulating expression of MIIP Gene:


SOURCE GeneReport for Unigene cluster for MIIP Gene:


mRNA Expression by UniProt/SwissProt for MIIP Gene:

Tissue specificity: Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells.

Evidence on tissue expression from TISSUES for MIIP Gene

  • Skin(4.2)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with MIIP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MIIP Gene

Orthologs for MIIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MIIP 33
  • 98.45 (n)
IIP45 34
  • 97 (a)
(Bos Taurus)
Mammalia MIIP 33 34
  • 81.16 (n)
(Canis familiaris)
Mammalia MIIP 33 34
  • 76.72 (n)
(Mus musculus)
Mammalia Miip 33 16 34
  • 71.24 (n)
(Rattus norvegicus)
Mammalia LOC100911456 33
  • 70.4 (n)
(Ornithorhynchus anatinus)
Mammalia MIIP 34
  • 47 (a)
(Monodelphis domestica)
Mammalia MIIP 34
  • 41 (a)
(Gallus gallus)
Aves MIIP 34
  • 46 (a)
(Danio rerio)
Actinopterygii MIIP 34
  • 28 (a)
Species where no ortholog for MIIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIIP Gene

Gene Tree for MIIP (if available)
Gene Tree for MIIP (if available)

Paralogs for MIIP Gene

No data available for Paralogs for MIIP Gene

Variants for MIIP Gene

Sequence variations from dbSNP and Humsavar for MIIP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000083820 -- 12,019,226(+) T/A upstream_transcript_variant
rs1000364491 -- 12,023,513(+) C/G/T intron_variant
rs1001072325 -- 12,028,990(+) C/A/T intron_variant
rs1001111675 -- 12,023,439(+) T/A intron_variant
rs1001283656 -- 12,028,607(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MIIP Gene

Variant ID Type Subtype PubMed ID
nsv470693 CNV loss 18288195

Variation tolerance for MIIP Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.88; 79.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIIP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIIP Gene

Disorders for MIIP Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIIP Gene - From: GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search MIIP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIIP

genes like me logo Genes that share disorders with MIIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIIP Gene

Publications for MIIP Gene

  1. Inactivation of the invasion inhibitory gene IIp45 by alternative splicing in gliomas. (PMID: 15867349) Song SW … Zhang W (Cancer research 2005) 2 3 4 22 58
  2. IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion. (PMID: 14617774) Song SW … Zhang W (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. (PMID: 27741356) Sun Y … Zhang W (The Journal of pathology 2017) 3 58
  5. MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis. (PMID: 27760566) Wang Y … Zhang W (Journal of hematology & oncology 2016) 3 58

Products for MIIP Gene

Sources for MIIP Gene

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