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Aliases for MIGA2 Gene

Aliases for MIGA2 Gene

  • Mitoguardin 2 2 3 3 5
  • Family With Sequence Similarity 73, Member B 2 3
  • Protein FAM73B 3 4
  • C9orf54 3 4
  • FAM73B 3 4
  • Family With Sequence Similarity 73 Member B 2
  • Chromosome 9 Open Reading Frame 54 2

External Ids for MIGA2 Gene

Previous HGNC Symbols for MIGA2 Gene

  • C9orf54
  • FAM73B

Summaries for MIGA2 Gene

GeneCards Summary for MIGA2 Gene

MIGA2 (Mitoguardin 2) is a Protein Coding gene. An important paralog of this gene is MIGA1.

UniProtKB/Swiss-Prot for MIGA2 Gene

  • Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.

Gene Wiki entry for MIGA2 Gene

Additional gene information for MIGA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIGA2 Gene

Genomics for MIGA2 Gene

GeneHancer (GH) Regulatory Elements for MIGA2 Gene

Promoters and enhancers for MIGA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J129035 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 660.4 +0.7 689 2.9 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 POLR2B MIGA2 UBE2V1P4 ENSG00000230848 NAIF1 GLE1 TOR1B NUP188 LOC100506100 ZDHHC12 PKN3
GH09J129605 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 +572.3 572278 5.8 CLOCK FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 MCM3 SP3 NTMT1 NUP188 LOC101929314 SPOUT1 PKN3 C9orf50 UBE2V1P4 NCS1 FUBP3 MIGA2
GH09J130026 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +999.6 999633 20.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 IRF4 FNBP1 EXOSC2 USP20 TOR1A C9orf78 ABL1 ENSG00000230684 QRFP MIGA2 C9orf50
GH09J128946 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.8 -88.9 -88913 2.2 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 NUP188 DOLK SPOUT1 LOC101929314 ENSG00000234055 CIZ1 SH3GLB2 GOLGA2 NAIF1 PRRX2
GH09J128549 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 9.9 -481.8 -481810 10.5 FEZF1 IRF4 YY1 E2F8 SP3 MEF2D ZNF610 GLIS1 RCOR2 NBN SPTAN1 URM1 NAIF1 TOR2A NUP188 CDK9 SPOUT1 ODF2 MIGA2 LRRC8A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIGA2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIGA2 Gene

Genomic Locations for MIGA2 Gene
chr9:129,036,605-129,072,082
(GRCh38/hg38)
Size:
35,478 bases
Orientation:
Plus strand
chr9:131,798,900-131,834,361
(GRCh37/hg19)
Size:
35,462 bases
Orientation:
Plus strand

Genomic View for MIGA2 Gene

Genes around MIGA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIGA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIGA2 Gene

Proteins for MIGA2 Gene

  • Protein details for MIGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L4E1-MIGA2_HUMAN
    Recommended name:
    Mitoguardin 2
    Protein Accession:
    Q7L4E1
    Secondary Accessions:
    • Q8NBM3
    • Q8TEJ6
    • Q969E6

    Protein attributes for MIGA2 Gene

    Size:
    593 amino acids
    Molecular mass:
    65531 Da
    Quaternary structure:
    • Homodimer and heterodimer; forms heterodimers with MIGA1 (PubMed:26711011). Interacts with PLD6/MitoPLD (PubMed:26711011).
    SequenceCaution:
    • Sequence=BAB55159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB84953.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW87861.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MIGA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIGA2 Gene

Post-translational modifications for MIGA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIGA2 Gene

No data available for DME Specific Peptides for MIGA2 Gene

Domains & Families for MIGA2 Gene

Gene Families for MIGA2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MIGA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MIGA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L4E1

UniProtKB/Swiss-Prot:

MIGA2_HUMAN :
  • Belongs to the mitoguardin family.
Family:
  • Belongs to the mitoguardin family.
genes like me logo Genes that share domains with MIGA2: view

Function for MIGA2 Gene

Molecular function for MIGA2 Gene

UniProtKB/Swiss-Prot Function:
Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.

Phenotypes From GWAS Catalog for MIGA2 Gene

Gene Ontology (GO) - Molecular Function for MIGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26711011
GO:0042803 protein homodimerization activity IDA 26711011
GO:0046982 protein heterodimerization activity IDA 26711011
genes like me logo Genes that share ontologies with MIGA2: view
genes like me logo Genes that share phenotypes with MIGA2: view

Animal Models for MIGA2 Gene

MGI Knock Outs for MIGA2:
  • Miga2 Miga2<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for MIGA2 Gene

miRTarBase miRNAs that target MIGA2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIGA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIGA2 Gene

Localization for MIGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIGA2 Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIGA2 gene
Compartment Confidence
plasma membrane 5
mitochondrion 4
endoplasmic reticulum 2
cytosol 2
extracellular 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MIGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005887 integral component of plasma membrane IDA 26711011
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIGA2: view

Pathways & Interactions for MIGA2 Gene

SuperPathways for MIGA2 Gene

No Data Available

Interacting Proteins for MIGA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351138%0d%0a9606.ENSP00000417175%0d%0a
Selected Interacting proteins: Q7L4E1-MIGA2_HUMAN ENSP00000351138 for MIGA2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MIGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008053 mitochondrial fusion IDA,IEA 26711011
GO:0060348 bone development IEA --
genes like me logo Genes that share ontologies with MIGA2: view

No data available for Pathways by source and SIGNOR curated interactions for MIGA2 Gene

Drugs & Compounds for MIGA2 Gene

No Compound Related Data Available

Transcripts for MIGA2 Gene

mRNA/cDNA for MIGA2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIGA2

Alternative Splicing Database (ASD) splice patterns (SP) for MIGA2 Gene

No ASD Table

Relevant External Links for MIGA2 Gene

GeneLoc Exon Structure for
MIGA2
ECgene alternative splicing isoforms for
MIGA2

Expression for MIGA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIGA2 Gene:

MIGA2

Evidence on tissue expression from TISSUES for MIGA2 Gene

  • Nervous system(4.9)
  • Spleen(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIGA2 Gene

Orthologs for MIGA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIGA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM73B 34 33
  • 99.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM73B 34 33
  • 90.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM73B 34 33
  • 89.09 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam73b 34 33
  • 86.68 (n)
OneToOne
Miga2 16
rat
(Rattus norvegicus)
Mammalia Fam73b 33
  • 86.04 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM73B 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM73B 34 33
  • 74.48 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM73B 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam73b 33
  • 66.37 (n)
Str.11456 33
zebrafish
(Danio rerio)
Actinopterygii fam73b 34 33
  • 62.9 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011689 33
  • 52.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12125 34 33
  • 49.81 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K01D12.6 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToMany
Species where no ortholog for MIGA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIGA2 Gene

ENSEMBL:
Gene Tree for MIGA2 (if available)
TreeFam:
Gene Tree for MIGA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MIGA2: view image

Paralogs for MIGA2 Gene

Paralogs for MIGA2 Gene

genes like me logo Genes that share paralogs with MIGA2: view

Variants for MIGA2 Gene

Sequence variations from dbSNP and Humsavar for MIGA2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000019761 -- 129,042,852(+) T/C/G intron_variant
rs1000086655 -- 129,036,641(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000206416 -- 129,049,005(+) C/T intron_variant
rs1000326455 -- 129,056,570(+) G/ intron_variant
rs1000366260 -- 129,044,843(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MIGA2 Gene

Variant ID Type Subtype PubMed ID
esv2665493 CNV deletion 23128226
esv3621823 CNV loss 21293372
nsv509323 CNV insertion 20534489
nsv818725 CNV gain 17921354
nsv831729 CNV loss 17160897

Variation tolerance for MIGA2 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.99; 84.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIGA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIGA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIGA2 Gene

Disorders for MIGA2 Gene

No disorders were found for MIGA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIGA2 Gene

Publications for MIGA2 Gene

  1. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. (PMID: 26716412) Liu XM … Fan HY (Oncotarget 2016) 2 3 58
  2. Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. (PMID: 26711011) Zhang Y … Tong C (Molecular cell 2016) 3 4 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for MIGA2 Gene

Sources for MIGA2 Gene

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