Aliases for MIGA2 Gene
Aliases for MIGA2 Gene
External Ids for MIGA2 Gene
- HGNC: 23621
- Entrez Gene: 84895
- Ensembl: ENSG00000148343
- OMIM: 616774
- UniProtKB: Q7L4E1
Previous HGNC Symbols for MIGA2 Gene
- C9orf54
- FAM73B
Summaries for MIGA2 Gene
GeneCards Summary for MIGA2 Gene
MIGA2 (Mitoguardin 2) is a Protein Coding gene. An important paralog of this gene is MIGA1.
UniProtKB/Swiss-Prot for MIGA2 Gene
-
Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIGA2 Gene
Genomics for MIGA2 Gene
GeneHancer (GH) Regulatory Elements for MIGA2 Gene
Promoters and enhancers for MIGA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIGA2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIGA2 Gene
Genomic Locations for MIGA2 Gene
- chr9:129,036,605-129,072,082
- (GRCh38/hg38)
- Size:
- 35,478 bases
- Orientation:
- Plus strand
- chr9:131,798,900-131,834,361
- (GRCh37/hg19)
- Size:
- 35,462 bases
- Orientation:
- Plus strand
Genomic View for MIGA2 Gene
Genes around MIGA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.11 by Entrez Gene
- 9q34.11 by HGNC
- 9q34.11 by Ensembl
MIGA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIGA2 Gene
Proteins for MIGA2 Gene
-
Protein details for MIGA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L4E1-MIGA2_HUMAN
- Recommended name:
- Mitoguardin 2
- Protein Accession:
- Q7L4E1
- Q8NBM3
- Q8TEJ6
- Q969E6
Protein attributes for MIGA2 Gene
- Size:
- 593 amino acids
- Molecular mass:
- 65531 Da
- Quaternary structure:
-
- Homodimer and heterodimer; forms heterodimers with MIGA1 (PubMed:26711011). Interacts with PLD6/MitoPLD (PubMed:26711011).
- SequenceCaution:
-
- Sequence=BAB55159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB84953.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW87861.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Post-translational modifications for MIGA2 Gene
Other Protein References for MIGA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MIGA2
- Invitrogen Antibodies for MIGA2 (AFLGC-MIGA2)
- Search GeneTex for Antibodies for MIGA2
-
Boster Bio Antibodies for MIGA2
Protein Products
-
OriGene Purified Proteins for MIGA2
- Search Origene for MassSpec and Protein Over-expression Lysates for MIGA2
- Origene Custom Protein Services for MIGA2
- Search GeneTex for Proteins for MIGA2
Assay Products
No data available for DME Specific Peptides for MIGA2 Gene
Domains & Families for MIGA2 Gene
Gene Families for MIGA2 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for MIGA2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7L4E1- Family:
-
- Belongs to the mitoguardin family.
Function for MIGA2 Gene
Molecular function for MIGA2 Gene
- UniProtKB/Swiss-Prot Function:
- Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.
Phenotypes From GWAS Catalog for MIGA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 26711011 |
| GO:0042803 | protein homodimerization activity | IDA | 26711011 |
| GO:0046982 | protein heterodimerization activity | IDA | 26711011 |
Phenotypes for MIGA2 Gene
- MGI mutant phenotypes for MIGA2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MIGA2:
Animal Models for MIGA2 Gene
- MGI Knock Outs for MIGA2:
-
- Miga2 Miga2<tm1a(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIGA2
-
CRISPR Products
-
OriGene CRISPR knockouts for MIGA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MIGA2
- genomics-online: gRNA clones - Search results for available FAM73B gene related products
- Applied Biological Materials CRISPR for MIGA2
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for MIGA2
miRNA for MIGA2 Gene
- miRTarBase miRNAs that target MIGA2
-
- hsa-mir-92a-3p (MIRT049512)
- hsa-mir-19a-3p (MIRT107274)
- hsa-mir-19b-3p (MIRT107275)
- hsa-mir-130a-3p (MIRT107276)
- hsa-mir-301a-3p (MIRT107277)
- hsa-mir-130b-3p (MIRT107278)
- hsa-mir-519c-3p (MIRT107279)
- hsa-mir-519b-3p (MIRT107280)
- hsa-mir-519a-3p (MIRT107281)
- hsa-mir-555 (MIRT107282)
- hsa-mir-454-3p (MIRT107283)
- hsa-mir-301b-3p (MIRT107284)
- hsa-mir-548f-5p (MIRT107285)
- hsa-mir-548g-5p (MIRT107286)
- hsa-mir-1265 (MIRT107287)
- hsa-mir-3133 (MIRT107288)
- hsa-mir-548x-5p (MIRT107289)
- hsa-mir-4295 (MIRT107290)
- hsa-mir-3666 (MIRT107291)
- hsa-mir-548aj-5p (MIRT107292)
- hsa-mir-4773 (MIRT107295)
- hsa-mir-548aw (MIRT107296)
- hsa-mir-27b-3p (MIRT476984)
- hsa-mir-27a-3p (MIRT476985)
- hsa-mir-513a-5p (MIRT476986)
- hsa-mir-1468-3p (MIRT476987)
- hsa-mir-520e (MIRT476988)
- hsa-mir-520d-3p (MIRT476989)
- hsa-mir-520c-3p (MIRT476990)
- hsa-mir-520b (MIRT476991)
- hsa-mir-520a-3p (MIRT476992)
- hsa-mir-372-3p (MIRT476993)
- hsa-mir-373-3p (MIRT476994)
- hsa-mir-302e (MIRT476995)
- hsa-mir-302d-3p (MIRT476996)
- hsa-mir-302c-3p (MIRT476997)
- hsa-mir-302b-3p (MIRT476998)
- hsa-mir-302a-3p (MIRT476999)
- hsa-mir-4262 (MIRT477000)
- hsa-mir-181d-5p (MIRT477001)
- hsa-mir-181a-5p (MIRT477002)
- hsa-mir-181c-5p (MIRT477003)
- hsa-mir-181b-5p (MIRT477004)
- hsa-mir-6780a-5p (MIRT493860)
- hsa-mir-6779-5p (MIRT493861)
- hsa-mir-3689c (MIRT493862)
- hsa-mir-3689b-3p (MIRT493863)
- hsa-mir-3689a-3p (MIRT493864)
- hsa-mir-30b-3p (MIRT493865)
- hsa-mir-1273h-5p (MIRT493866)
- hsa-mir-6778-5p (MIRT493867)
- hsa-mir-1233-5p (MIRT493868)
- hsa-mir-542-3p (MIRT493869)
- hsa-mir-876-3p (MIRT493870)
- hsa-mir-323a-5p (MIRT493871)
- hsa-mir-6883-5p (MIRT493872)
- hsa-mir-6799-5p (MIRT493873)
- hsa-mir-6785-5p (MIRT493874)
- hsa-mir-4728-5p (MIRT493875)
- hsa-mir-149-3p (MIRT493876)
- hsa-mir-7106-5p (MIRT493877)
- hsa-mir-765 (MIRT493878)
- hsa-mir-6134 (MIRT493879)
- hsa-mir-4784 (MIRT493880)
- hsa-mir-3150b-3p (MIRT493881)
- hsa-mir-4257 (MIRT493882)
- hsa-mir-9-5p (MIRT493883)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MIGA2
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIGA2
- genomics-online: shRNA clones - Search results for available FAM73B gene related products
Clone Products
- Sino Biological Human cDNA Clone for MIGA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MIGA2
- genomics-online: cdna clones - Search results for available FAM73B gene related products
- orf clones - Search results for available FAM73B gene related products
- Applied Biological Materials Clones for MIGA2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MIGA2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIGA2 Gene
Localization for MIGA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MIGA2 Gene
- Mitochondrion outer membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| mitochondrion | 4 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Cell Junctions (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 26711011 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for MIGA2 Gene
No Data Available
Interacting Proteins for MIGA2 Gene
GPS-Prot Interaction Network for MIGA2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008053 | mitochondrial fusion | IDA,IEA | 26711011 |
| GO:0060348 | bone development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for MIGA2 Gene
Transcripts for MIGA2 Gene
mRNA/cDNA for MIGA2 Gene
- (3) REFSEQ mRNAs :
- (128) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000477088 569 bps (uc064wio.1)
- ENST00000474534 631 bps (uc064wip.1)
- ENST00000439290 4345 bps (uc064wiq.1)
- ENST00000445183 3598 bps (uc064wir.1)
- ENST00000358369 3637 bps (uc004bxa.4)
CRISPR Products
-
OriGene CRISPR knockouts for MIGA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MIGA2
- genomics-online: gRNA clones - Search results for available FAM73B gene related products
- Applied Biological Materials CRISPR for MIGA2
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for MIGA2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MIGA2
- Browse OriGene Inhibitory RNA Products For MIGA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIGA2
- genomics-online: shRNA clones - Search results for available FAM73B gene related products
Clone Products
- Sino Biological Human cDNA Clone for MIGA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MIGA2
- genomics-online: cdna clones - Search results for available FAM73B gene related products
- orf clones - Search results for available FAM73B gene related products
- Applied Biological Materials Clones for MIGA2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIGA2 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIGA2 Gene:
MIGA2Evidence on tissue expression from TISSUES for MIGA2 Gene
- Nervous system(4.9)
- Spleen(4.2)
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for MIGA2
-
OriGene qPCR primer pairs and template standards for MIGA2
- genomics-online: primer clones - Search results for available FAM73B gene related products
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIGA2 Gene
Orthologs for MIGA2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM73B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FAM73B 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FAM73B 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fam73b 34 33 |
|
OneToOne | |
| Miga2 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Fam73b 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FAM73B 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | FAM73B 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FAM73B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fam73b 33 |
|
||
| Str.11456 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | fam73b 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011689 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG12125 34 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | K01D12.6 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for MIGA2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MIGA2 Gene
- ENSEMBL:
- Gene Tree for MIGA2 (if available)
- TreeFam:
- Gene Tree for MIGA2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MIGA2: view image
Paralogs for MIGA2 Gene
Variants for MIGA2 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000019761 | -- | 129,042,852(+) | T/C/G | intron_variant | |
| rs1000086655 | -- | 129,036,641(+) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant | |
| rs1000206416 | -- | 129,049,005(+) | C/T | intron_variant | |
| rs1000326455 | -- | 129,056,570(+) | G/ | intron_variant | |
| rs1000366260 | -- | 129,044,843(+) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2665493 | CNV | deletion | 23128226 |
| esv3621823 | CNV | loss | 21293372 |
| nsv509323 | CNV | insertion | 20534489 |
| nsv818725 | CNV | gain | 17921354 |
| nsv831729 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.99;
84.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MIGA2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIGA2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIGA2 Gene
Disorders for MIGA2 Gene
Additional Disease Information for MIGA2
No disorders were found for MIGA2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIGA2 Gene
Publications for MIGA2 Gene
- Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. (PMID: 26716412) Liu XM … Fan HY (Oncotarget 2016) 2 3 58
- Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. (PMID: 26711011) Zhang Y … Tong C (Molecular cell 2016) 3 4 58
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for MIGA2 Gene
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- genomics-online: cdna clones - Search results for available FAM73B gene related products
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Sources for MIGA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
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