This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] See more...

Aliases for MIF4GD Gene

Aliases for MIF4GD Gene

  • MIF4G Domain Containing 2 3 5
  • SLBP-Interacting Protein 1 2 3 4
  • SLIP1 2 3 4
  • MIF4G Domain-Containing Protein 3 4
  • AD023 2 3
  • SLBP (Stem Loop Binding Protein)-Interacting Protein 1 3
  • MGC45027 2
  • MIF4GD 5
  • HSLIP1 4
  • MIFD 3

External Ids for MIF4GD Gene

Previous HGNC Symbols for MIF4GD Gene

  • MIFD

Previous GeneCards Identifiers for MIF4GD Gene

  • GC17M070774
  • GC17M073262
  • GC17M068672

Summaries for MIF4GD Gene

Entrez Gene Summary for MIF4GD Gene

  • This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

GeneCards Summary for MIF4GD Gene

MIF4GD (MIF4G Domain Containing) is a Protein Coding gene. Diseases associated with MIF4GD include Retinitis Pigmentosa 70. Gene Ontology (GO) annotations related to this gene include RNA binding and protein C-terminus binding. An important paralog of this gene is CTIF.

UniProtKB/Swiss-Prot Summary for MIF4GD Gene

  • Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.

Additional gene information for MIF4GD Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIF4GD Gene

Genomics for MIF4GD Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIF4GD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIF4GD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MIF4GD

Top Transcription factor binding sites by QIAGEN in the MIF4GD gene promoter:
  • AP-4
  • c-Ets-1
  • c-Myb
  • E47
  • E4BP4
  • ER-alpha
  • Lmo2
  • Pax-2
  • Pax-2a

Genomic Locations for MIF4GD Gene

Genomic Locations for MIF4GD Gene
chr17:75,266,228-75,271,292
(GRCh38/hg38)
Size:
5,065 bases
Orientation:
Minus strand
chr17:73,262,309-73,267,373
(GRCh37/hg19)
Size:
5,065 bases
Orientation:
Minus strand

Genomic View for MIF4GD Gene

Genes around MIF4GD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIF4GD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIF4GD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIF4GD Gene

Proteins for MIF4GD Gene

  • Protein details for MIF4GD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A9UHW6-MI4GD_HUMAN
    Recommended name:
    MIF4G domain-containing protein
    Protein Accession:
    A9UHW6
    Secondary Accessions:
    • B4DUM7
    • Q8N4Q5
    • Q9HBL5

    Protein attributes for MIF4GD Gene

    Size:
    222 amino acids
    Molecular mass:
    25423 Da
    Quaternary structure:
    • Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5'-end.
    SequenceCaution:
    • Sequence=AAG09724.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • Depletion of MIF4GD results in cell death and reduced histone mRNA translation.

    Alternative splice isoforms for MIF4GD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIF4GD Gene

Post-translational modifications for MIF4GD Gene

  • Ubiquitination at Lys53 and Lys68
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIF4GD Gene

Domains & Families for MIF4GD Gene

Gene Families for MIF4GD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MIF4GD Gene

Suggested Antigen Peptide Sequences for MIF4GD Gene

GenScript: Design optimal peptide antigens:
  • SLBP-interacting protein 1 (MI4GD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A9UHW6

UniProtKB/Swiss-Prot:

MI4GD_HUMAN :
  • Belongs to the MIF4GD family.
Family:
  • Belongs to the MIF4GD family.
genes like me logo Genes that share domains with MIF4GD: view

Function for MIF4GD Gene

Molecular function for MIF4GD Gene

UniProtKB/Swiss-Prot Function:
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.

Phenotypes From GWAS Catalog for MIF4GD Gene

Gene Ontology (GO) - Molecular Function for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008022 protein C-terminus binding IPI 17577209
GO:0008494 translation activator activity IBA 21873635
GO:0042802 identical protein binding IPI 23286197
genes like me logo Genes that share ontologies with MIF4GD: view
genes like me logo Genes that share phenotypes with MIF4GD: view

Animal Models for MIF4GD Gene

MGI Knock Outs for MIF4GD:
  • Mif4gd Mif4gd<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for MIF4GD Gene

miRTarBase miRNAs that target MIF4GD

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIF4GD

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIF4GD Gene

Localization for MIF4GD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIF4GD Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIF4GD gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
extracellular 2
plasma membrane 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Golgi apparatus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IBA,IDA --
genes like me logo Genes that share ontologies with MIF4GD: view

Pathways & Interactions for MIF4GD Gene

PathCards logo

SuperPathways for MIF4GD Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006446 regulation of translational initiation IBA 21873635
GO:0045727 positive regulation of translation IEA --
genes like me logo Genes that share ontologies with MIF4GD: view

No data available for Pathways by source and SIGNOR curated interactions for MIF4GD Gene

Drugs & Compounds for MIF4GD Gene

No Compound Related Data Available

Transcripts for MIF4GD Gene

mRNA/cDNA for MIF4GD Gene

11 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIF4GD

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIF4GD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - - -
SP10:
SP11: - -

Relevant External Links for MIF4GD Gene

GeneLoc Exon Structure for
MIF4GD

Expression for MIF4GD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIF4GD Gene

Protein differential expression in normal tissues from HIPED for MIF4GD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MIF4GD Gene



Protein tissue co-expression partners for MIF4GD Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIF4GD

SOURCE GeneReport for Unigene cluster for MIF4GD Gene:

Hs.325631

Evidence on tissue expression from TISSUES for MIF4GD Gene

  • Muscle(4.3)
  • Blood(4.3)
  • Adrenal gland(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with MIF4GD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIF4GD Gene

Orthologs for MIF4GD Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIF4GD Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MIF4GD 30 31
  • 99.87 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 98 (a)
OneToMany
MIF4GD 30
  • 92.94 (n)
-- 31
  • 61 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia MIF4GD 30 31
  • 94.44 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mif4gd 30 17 31
  • 91.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mif4gd 30
  • 91.29 (n)
Oppossum
(Monodelphis domestica)
Mammalia MIF4GD 31
  • 91 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MIF4GD 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MIF4GD 30 31
  • 78.68 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MIF4GD 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mif4gd 30
  • 72.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53513 30
Zebrafish
(Danio rerio)
Actinopterygii mif4gdb 30 31
  • 72.07 (n)
OneToMany
mif4gda 31
  • 66 (a)
OneToMany
zgc64152 30
Species where no ortholog for MIF4GD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIF4GD Gene

ENSEMBL:
Gene Tree for MIF4GD (if available)
TreeFam:
Gene Tree for MIF4GD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MIF4GD: view image

Paralogs for MIF4GD Gene

Paralogs for MIF4GD Gene

genes like me logo Genes that share paralogs with MIF4GD: view

Variants for MIF4GD Gene

Additional dbSNP identifiers (rs#s) for MIF4GD Gene

Structural Variations from Database of Genomic Variants (DGV) for MIF4GD Gene

Variant ID Type Subtype PubMed ID
nsv1066312 CNV gain 25217958
nsv510727 CNV deletion 20534489
nsv576027 CNV gain 21841781

Variation tolerance for MIF4GD Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIF4GD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIF4GD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIF4GD Gene

Disorders for MIF4GD Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIF4GD Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 70
  • rp70
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIF4GD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIF4GD Gene

Publications for MIF4GD Gene

  1. SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. (PMID: 18025107) Cakmakci NG … Marzluff WF (Molecular and cellular biology 2008) 2 3 4
  2. INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation. (PMID: 22532700) Neusiedler J … Jalinot P (RNA (New York, N.Y.) 2012) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for MIF4GD Gene

  • Signalway ELISA kits for MIF4GD
  • Signalway Proteins for MIF4GD

Sources for MIF4GD Gene