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This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] See more...
Aliases for MIF4GD Gene
Aliases for MIF4GD Gene
External Ids for MIF4GD Gene
- HGNC: 24030
- Entrez Gene: 57409
- Ensembl: ENSG00000125457
- OMIM: 612072
- UniProtKB: A9UHW6
Previous HGNC Symbols for MIF4GD Gene
- MIFD
Previous GeneCards Identifiers for MIF4GD Gene
- GC17M070774
- GC17M073262
- GC17M068672
Summaries for MIF4GD Gene
-
This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
GeneCards Summary for MIF4GD Gene
MIF4GD (MIF4G Domain Containing) is a Protein Coding gene. Diseases associated with MIF4GD include Retinitis Pigmentosa 70. Gene Ontology (GO) annotations related to this gene include RNA binding and protein C-terminus binding. An important paralog of this gene is CTIF.
UniProtKB/Swiss-Prot Summary for MIF4GD Gene
-
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
Additional gene information for MIF4GD Gene
- HGNC(24030)
- Entrez Gene(57409)
- Ensembl(ENSG00000125457)
- OMIM(612072)
- UniProtKB(A9UHW6)
- Open Targets Platform(ENSG00000125457)
- Search for MIF4GD at DataMed
- Search for MIF4GD at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIF4GD Gene
Genomics for MIF4GD Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIF4GD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIF4GD on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MIF4GD
- Top Transcription factor binding sites by QIAGEN in the MIF4GD gene promoter:
-
- AP-4
- c-Ets-1
- c-Myb
- E47
- E4BP4
- ER-alpha
- Lmo2
- Pax-2
- Pax-2a
Genomic Locations for MIF4GD Gene
Genomic Locations for MIF4GD Gene
- chr17:75,266,228-75,271,292
- (GRCh38/hg38)
- Size:
- 5,065 bases
- Orientation:
- Minus strand
- chr17:73,262,309-73,267,373
- (GRCh37/hg19)
- Size:
- 5,065 bases
- Orientation:
- Minus strand
Genomic View for MIF4GD Gene
Genes around MIF4GD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
MIF4GD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIF4GD Gene
Proteins for MIF4GD Gene
-
Protein details for MIF4GD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A9UHW6-MI4GD_HUMAN
- Recommended name:
- MIF4G domain-containing protein
- Protein Accession:
- A9UHW6
- B4DUM7
- Q8N4Q5
- Q9HBL5
Protein attributes for MIF4GD Gene
- Size:
- 222 amino acids
- Molecular mass:
- 25423 Da
- Quaternary structure:
-
- Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5'-end.
- SequenceCaution:
-
- Sequence=AAG09724.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- Depletion of MIF4GD results in cell death and reduced histone mRNA translation.
Protein Expression for MIF4GD Gene
Post-translational modifications for MIF4GD Gene
Other Protein References for MIF4GD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MIF4GD
- Invitrogen Antibodies for MIF4GD (AFLGC-MIF4GD)
Protein Products
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-
Quality Products:
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Signalway Proteins for MIF4GD
-
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Assay Products
-
Signalway ELISA kits for MIF4GD
No data available for DME Specific Peptides for MIF4GD Gene
Domains & Families for MIF4GD Gene
Gene Families for MIF4GD Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MIF4GD Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MIF4GD Gene
- GenScript: Design optimal peptide antigens:
-
- SLBP-interacting protein 1 (MI4GD_HUMAN)
Graphical View of Domain Structure for InterPro Entry
A9UHW6- Family:
-
- Belongs to the MIF4GD family.
Function for MIF4GD Gene
Molecular function for MIF4GD Gene
- UniProtKB/Swiss-Prot Function:
- Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
Phenotypes From GWAS Catalog for MIF4GD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008022 | protein C-terminus binding | IPI | 17577209 |
| GO:0008494 | translation activator activity | IBA | 21873635 |
| GO:0042802 | identical protein binding | IPI | 23286197 |
Phenotypes for MIF4GD Gene
- MGI mutant phenotypes for MIF4GD:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MIF4GD:
Animal Models for MIF4GD Gene
- MGI Knock Outs for MIF4GD:
-
- Mif4gd Mif4gd<tm1b(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
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-
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miRNA for MIF4GD Gene
- miRTarBase miRNAs that target MIF4GD
miRNA Products
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Cell Line Products
-
Horizon Cell Lines for MIF4GD
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIF4GD Gene
Localization for MIF4GD Gene
Subcellular locations from UniProtKB/Swiss-Prot for MIF4GD Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| golgi apparatus | 4 |
| extracellular | 2 |
| plasma membrane | 1 |
| peroxisome | 0 |
- Cytosol (3)
- Nucleoli (3)
- Golgi apparatus (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005829 | cytosol | IBA,IDA | -- |
Pathways & Interactions for MIF4GD Gene
Interacting Proteins for MIF4GD Gene
Selected Interacting proteins:
A9UHW6-MI4GD_HUMAN
ENSP00000463334
for MIF4GD Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MIF4GD
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0006446 | regulation of translational initiation | IBA | 21873635 |
| GO:0045727 | positive regulation of translation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for MIF4GD Gene
Transcripts for MIF4GD Gene
mRNA/cDNA for MIF4GD Gene
- 11 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000245551 1358 nts (view in UCSC)
- ENST00000325102 1306 nts (view in UCSC)
- ENST00000577240 743 nts (view in UCSC)
- ENST00000577542 1531 nts (view in UCSC)
- ENST00000578305 569 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIF4GD - Select products 50% OFF >
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-
OriGene CRISPR knockouts for MIF4GD
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MIF4GD
-
Santa Cruz Biotechnology (SCBT) CRISPR for MIF4GD
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MIF4GD
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Clone Products
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201336
- MG202548
- MR201336
- MR201336L3
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- MR228489
- MR228490
- MR228594
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- RC207489L1
- RC207489L2
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- RC207489L4
- RC232187
- RC232300
- RC232321
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- RG232187
- RG232300
- RG232321
- RR206301
- RR206301L3
- RR206301L4
- MR201336L3V
- MR201336L4V
- MR202548L3V
- MR202548L4V
- RC207489L1V
- RC207489L2V
- RC207489L3V
- RC207489L4V
- RR206301L3V
- RR206301L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MIF4GD
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MIF4GD
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - |
Relevant External Links for MIF4GD Gene
- GeneLoc Exon Structure for
- MIF4GD
Expression for MIF4GD Gene
This gene is overexpressed in Peripheral blood mononuclear cells (21.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MIF4GD Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIF4GD
SOURCE GeneReport for Unigene cluster for MIF4GD Gene:
Hs.325631Evidence on tissue expression from TISSUES for MIF4GD Gene
- Muscle(4.3)
- Blood(4.3)
- Adrenal gland(4.2)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for MIF4GD
-
OriGene qPCR primer pairs and template standards for MIF4GD
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIF4GD Gene
Orthologs for MIF4GD Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MIF4GD 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| MIF4GD 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | MIF4GD 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mif4gd 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mif4gd 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | MIF4GD 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MIF4GD 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MIF4GD 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MIF4GD 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mif4gd 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53513 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mif4gdb 30 31 |
|
OneToMany | |
| mif4gda 31 |
|
OneToMany | |||
| zgc64152 30 |
|
- Species where no ortholog for MIF4GD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MIF4GD Gene
- ENSEMBL:
- Gene Tree for MIF4GD (if available)
- TreeFam:
- Gene Tree for MIF4GD (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MIF4GD: view image
Paralogs for MIF4GD Gene
Variants for MIF4GD Gene
Residual Variation Intolerance Score:
18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.16;
75.80% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MIF4GD Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIF4GD
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIF4GD Gene
Disorders for MIF4GD Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 70 |
|
|
Search MIF4GD in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIF4GD
No data available for UniProtKB/Swiss-Prot and Genatlas for MIF4GD Gene
Publications for MIF4GD Gene
- SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. (PMID: 18025107) Cakmakci NG … Marzluff WF (Molecular and cellular biology 2008) 2 3 4
- INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation. (PMID: 22532700) Neusiedler J … Jalinot P (RNA (New York, N.Y.) 2012) 2 3
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
ExternalLinks
Products for MIF4GD Gene
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- antibodies-online: Show 7 available MIF4GD Antibodies ranked by validation data
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Sources for MIF4GD Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
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