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This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
MIF4GD (MIF4G Domain Containing) is a Protein Coding gene. Diseases associated with MIF4GD include Retinitis Pigmentosa 70. Gene Ontology (GO) annotations related to this gene include RNA binding and protein C-terminus binding. An important paralog of this gene is CTIF.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0008022 | protein C-terminus binding | IPI | 17577209 |
GO:0008494 | translation activator activity | IBA | 21873635 |
GO:0042802 | identical protein binding | IPI | 23286197 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005794 | Golgi apparatus | IDA | -- |
GO:0005829 | cytosol | IBA,IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006417 | regulation of translation | IEA | -- |
GO:0006446 | regulation of translational initiation | IBA | 21873635 |
GO:0045727 | positive regulation of translation | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MIF4GD 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
MIF4GD 30 |
|
||||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | MIF4GD 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mif4gd 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mif4gd 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | MIF4GD 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MIF4GD 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MIF4GD 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MIF4GD 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mif4gd 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC53513 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mif4gdb 30 31 |
|
OneToMany | |
mif4gda 31 |
|
OneToMany | |||
zgc64152 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
retinitis pigmentosa 70 |
|
|