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Aliases for MIF4GD Gene

Aliases for MIF4GD Gene

  • MIF4G Domain Containing 2 3 5
  • SLBP-Interacting Protein 1 2 3 4
  • SLIP1 3 4
  • SLBP (Stem Loop Binding Protein)-Interacting Protein 1 3
  • MIF4G Domain-Containing Protein 3
  • HSLIP1 4
  • AD023 3
  • MIFD 3

External Ids for MIF4GD Gene

Previous HGNC Symbols for MIF4GD Gene

  • MIFD

Previous GeneCards Identifiers for MIF4GD Gene

  • GC17M070774
  • GC17M073262
  • GC17M068672

Summaries for MIF4GD Gene

Entrez Gene Summary for MIF4GD Gene

  • This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

GeneCards Summary for MIF4GD Gene

MIF4GD (MIF4G Domain Containing) is a Protein Coding gene. Diseases associated with MIF4GD include Retinitis Pigmentosa 70. Gene Ontology (GO) annotations related to this gene include RNA binding and protein C-terminus binding. An important paralog of this gene is CTIF.

UniProtKB/Swiss-Prot for MIF4GD Gene

  • Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.

Additional gene information for MIF4GD Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIF4GD Gene

Genomics for MIF4GD Gene

GeneHancer (GH) Regulatory Elements for MIF4GD Gene

Promoters and enhancers for MIF4GD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I075269 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.1 -75 3.5 HDGF FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 LOC100287042 MIF4GD NUP85 NT5C UNK ENSG00000266980 GGA3 TRIM65 MYO15B ENSG00000267342
GH17I074511 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.5 +757.7 757688 3.3 YBX1 FEZF1 ZNF213 ZNF416 ZNF548 SP3 ZFP41 MEF2D ZNF610 GLIS1 NUP85 NAT9 NT5C GGA3 RN7SL573P HID1-AS1 CD300E SLC16A5 MIF4GD CDR2L
GH17I075085 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 +179.8 179796 11.9 CLOCK MLX ZFP64 YBX1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3 SLC16A5 ENSG00000206713 GC17M075090 NUP85 UNK NT5C ENSG00000266980 ENSG00000267342 GGA3 NAT9
GH17I075776 Promoter/Enhancer 2.7 UCNEbase EPDnew Ensembl ENCODE dbSUPER 10.3 -507.2 -507234 4.9 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 H3F3B GC17M075778 GC17P075777 UNK NT5C SRSF2 NUP85 ENSG00000266980 GGA3 METTL23
GH17I075260 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 +9.5 9493 3 HDGF PKNOX1 SMAD1 ARNT ZFP64 SIN3A DMAP1 ZNF2 YY1 SLC30A9 GGA3 MRPS7 NUP85 NT5C UNK SAP30BP NAT9 CDR2L ENSG00000266980 TRIM65
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIF4GD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MIF4GD gene promoter:

Genomic Locations for MIF4GD Gene

Genomic Locations for MIF4GD Gene
5,065 bases
Minus strand

Genomic View for MIF4GD Gene

Genes around MIF4GD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIF4GD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIF4GD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIF4GD Gene

Proteins for MIF4GD Gene

  • Protein details for MIF4GD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MIF4G domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • B4DUM7
    • Q8N4Q5
    • Q9HBL5

    Protein attributes for MIF4GD Gene

    222 amino acids
    Molecular mass:
    25423 Da
    Quaternary structure:
    • Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5-end.
    • Depletion of MIF4GD results in cell death and reduced histone mRNA translation.
    • Sequence=AAG09724.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for MIF4GD Gene


neXtProt entry for MIF4GD Gene

Post-translational modifications for MIF4GD Gene

  • Ubiquitination at posLast=5353 and isoforms=2, 368
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIF4GD Gene

Domains & Families for MIF4GD Gene

Gene Families for MIF4GD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MIF4GD Gene

Suggested Antigen Peptide Sequences for MIF4GD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MIF4GD family.
  • Belongs to the MIF4GD family.
genes like me logo Genes that share domains with MIF4GD: view

Function for MIF4GD Gene

Molecular function for MIF4GD Gene

UniProtKB/Swiss-Prot Function:
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.

Phenotypes From GWAS Catalog for MIF4GD Gene

Gene Ontology (GO) - Molecular Function for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008022 protein C-terminus binding IPI 17577209
genes like me logo Genes that share ontologies with MIF4GD: view
genes like me logo Genes that share phenotypes with MIF4GD: view

Animal Model Products

CRISPR Products

miRNA for MIF4GD Gene

miRTarBase miRNAs that target MIF4GD

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIF4GD Gene

Localization for MIF4GD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIF4GD Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIF4GD gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MIF4GD: view

Pathways & Interactions for MIF4GD Gene

SuperPathways for MIF4GD Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with MIF4GD: view

No data available for Pathways by source and SIGNOR curated interactions for MIF4GD Gene

Drugs & Compounds for MIF4GD Gene

No Compound Related Data Available

Transcripts for MIF4GD Gene

Unigene Clusters for MIF4GD Gene

MIF4G domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIF4GD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - - -
SP11: - -

Relevant External Links for MIF4GD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIF4GD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIF4GD Gene

Protein differential expression in normal tissues from HIPED for MIF4GD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIF4GD Gene

Protein tissue co-expression partners for MIF4GD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MIF4GD Gene:


SOURCE GeneReport for Unigene cluster for MIF4GD Gene:


Evidence on tissue expression from TISSUES for MIF4GD Gene

  • Adrenal gland(4.2)
  • Muscle(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with MIF4GD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIF4GD Gene

Orthologs for MIF4GD Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIF4GD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MIF4GD 33 34
  • 99.87 (n)
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
  • 92.94 (n)
-- 34
  • 61 (a)
(Bos Taurus)
Mammalia MIF4GD 33 34
  • 94.44 (n)
(Mus musculus)
Mammalia Mif4gd 33 16 34
  • 91.29 (n)
(Rattus norvegicus)
Mammalia Mif4gd 33
  • 91.29 (n)
(Monodelphis domestica)
Mammalia MIF4GD 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia MIF4GD 34
  • 77 (a)
(Gallus gallus)
Aves MIF4GD 33 34
  • 78.68 (n)
(Anolis carolinensis)
Reptilia MIF4GD 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mif4gd 33
  • 72.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53513 33
(Danio rerio)
Actinopterygii mif4gdb 33 34
  • 72.07 (n)
mif4gda 34
  • 66 (a)
zgc64152 33
Species where no ortholog for MIF4GD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIF4GD Gene

Gene Tree for MIF4GD (if available)
Gene Tree for MIF4GD (if available)

Paralogs for MIF4GD Gene

Paralogs for MIF4GD Gene

genes like me logo Genes that share paralogs with MIF4GD: view

Variants for MIF4GD Gene

Sequence variations from dbSNP and Humsavar for MIF4GD Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs62622012 uncertain-significance, Amish lethal microcephaly 75,273,251(-) C/T upstream_transcript_variant
rs7198 likely-benign, Amish lethal microcephaly 75,273,177(-) G/C upstream_transcript_variant
rs73356384 likely-benign, Amish lethal microcephaly 75,273,014(-) A/C upstream_transcript_variant
rs115006555 likely-benign, not specified 75,265,818(-) G/A downstream_transcript_variant
rs61745718 likely-benign, not specified 75,265,839(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIF4GD Gene

Variant ID Type Subtype PubMed ID
nsv1066312 CNV gain 25217958
nsv510727 CNV deletion 20534489
nsv576027 CNV gain 21841781

Variation tolerance for MIF4GD Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIF4GD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIF4GD Gene

Disorders for MIF4GD Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIF4GD Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 70
  • rp70
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIF4GD

genes like me logo Genes that share disorders with MIF4GD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIF4GD Gene

Publications for MIF4GD Gene

  1. SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. (PMID: 18025107) Cakmakci NG … Marzluff WF (Molecular and cellular biology 2008) 2 3 4 58
  2. INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation. (PMID: 22532700) Neusiedler J … Jalinot P (RNA (New York, N.Y.) 2012) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells. (PMID: 28079882) Won KJ … Won M (Cell death & disease 2017) 3 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for MIF4GD Gene

Sources for MIF4GD Gene

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