Aliases for MIF4GD Gene
Aliases for MIF4GD Gene
External Ids for MIF4GD Gene
- HGNC: 24030
- Entrez Gene: 57409
- Ensembl: ENSG00000125457
- OMIM: 612072
- UniProtKB: A9UHW6
Previous HGNC Symbols for MIF4GD Gene
- MIFD
Previous GeneCards Identifiers for MIF4GD Gene
- GC17M070774
- GC17M073262
- GC17M068672
Summaries for MIF4GD Gene
-
This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
GeneCards Summary for MIF4GD Gene
MIF4GD (MIF4G Domain Containing) is a Protein Coding gene. Diseases associated with MIF4GD include Retinitis Pigmentosa 70. Gene Ontology (GO) annotations related to this gene include RNA binding and protein C-terminus binding. An important paralog of this gene is CTIF.
UniProtKB/Swiss-Prot for MIF4GD Gene
-
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
Additional gene information for MIF4GD Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIF4GD Gene
Genomics for MIF4GD Gene
GeneHancer (GH) Regulatory Elements for MIF4GD Gene
Promoters and enhancers for MIF4GD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIF4GD on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIF4GD Gene
Genomic Locations for MIF4GD Gene
- chr17:75,266,228-75,271,292
- (GRCh38/hg38)
- Size:
- 5,065 bases
- Orientation:
- Minus strand
- chr17:73,262,309-73,267,373
- (GRCh37/hg19)
Genomic View for MIF4GD Gene
Genes around MIF4GD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by Ensembl
- 17q25.1 by Entrez Gene
- 17q25.1 by HGNC
MIF4GD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIF4GD Gene
Proteins for MIF4GD Gene
-
Protein details for MIF4GD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A9UHW6-MI4GD_HUMAN
- Recommended name:
- MIF4G domain-containing protein
- Protein Accession:
- A9UHW6
- B4DUM7
- Q8N4Q5
- Q9HBL5
Protein attributes for MIF4GD Gene
- Size:
- 222 amino acids
- Molecular mass:
- 25423 Da
- Quaternary structure:
-
- Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5-end.
- Miscellaneous:
-
- Depletion of MIF4GD results in cell death and reduced histone mRNA translation.
- SequenceCaution:
-
- Sequence=AAG09724.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Protein Expression for MIF4GD Gene
Post-translational modifications for MIF4GD Gene
Other Protein References for MIF4GD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001229427.1
- NP_001229429.1
- NP_001229430.1
- NP_065730.2
- XP_005257587.1
- XP_005257589.1
- XP_005257590.1
- XP_011523353.1
- XP_011523354.1
- XP_011523355.1
- XP_011523356.1
- XP_011523357.1
- XP_011523359.1
- XP_016880377.1
- XP_016880378.1
- XP_016880379.1
- XP_016880380.1
- XP_016880381.1
- XP_016880382.1
- XP_016880383.1
- XP_016880384.1
Antibody Products
- Novus Biologicals Antibodies for MIF4GD
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Protein Products
-
OriGene Purified Proteins for MIF4GD
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-
Quality Products:
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-
Abcam proteins for MIF4GD
Assay Products
No data available for DME Specific Peptides for MIF4GD Gene
Domains & Families for MIF4GD Gene
Gene Families for MIF4GD Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MIF4GD Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MIF4GD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A9UHW6- Family:
-
- Belongs to the MIF4GD family.
Function for MIF4GD Gene
Molecular function for MIF4GD Gene
- UniProtKB/Swiss-Prot Function:
- Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
Phenotypes From GWAS Catalog for MIF4GD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008022 | protein C-terminus binding | IPI | 17577209 |
Phenotypes for MIF4GD Gene
- GenomeRNAi human phenotypes for MIF4GD:
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miRNA for MIF4GD Gene
- miRTarBase miRNAs that target MIF4GD
miRNA Products
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Inhibitory RNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MIF4GD gene related products
- orf clones - Search results for available MIF4GD gene related products
- Applied Biological Materials Clones for MIF4GD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for MIF4GD
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ViGene Biosciences adenoviral particle packaged cDNA for MIF4GD gene
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ViGene Biosciences lentiviral particle packaged cDNA for MIF4GD gene
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIF4GD Gene
Localization for MIF4GD Gene
Subcellular locations from UniProtKB/Swiss-Prot for MIF4GD Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
- Cytosol (3)
- Nucleoli (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for MIF4GD Gene
No Data Available
Interacting Proteins for MIF4GD Gene
Selected Interacting proteins:
ENSP00000245551
A9UHW6-MI4GD_HUMAN
for MIF4GD Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006417 | regulation of translation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for MIF4GD Gene
Transcripts for MIF4GD Gene
mRNA/cDNA for MIF4GD Gene
- (21) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (144) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MIF4GD Gene
- MIF4G domain containing:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MIF4GD
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MIF4GD
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MIF4GD
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- genomics-online: shRNA clones - Search results for available MIF4GD gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MIF4GD gene
Clone Products
- Sino Biological Human cDNA Clone for MIF4GD
- VectorBuilder custom plasmid, inducible vectors for MIF4GD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIF4GD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MIF4GD gene related products
- orf clones - Search results for available MIF4GD gene related products
- Applied Biological Materials Clones for MIF4GD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - |
Expression for MIF4GD Gene
This gene is overexpressed in Peripheral blood mononuclear cells (21.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIF4GD Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MIF4GD Gene:
MIF4GDSOURCE GeneReport for Unigene cluster for MIF4GD Gene:
Hs.325631Evidence on tissue expression from TISSUES for MIF4GD Gene
- Adrenal gland(4.2)
- Muscle(4.2)
- Blood(4.1)
Primer Products
-
OriGene qPCR primer pairs for MIF4GD
-
OriGene qPCR primer pairs and template standards for MIF4GD
- genomics-online: primer clones - Search results for available MIF4GD gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIF4GD Gene
Orthologs for MIF4GD Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MIF4GD 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| MIF4GD 33 |
|
||||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | MIF4GD 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mif4gd 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mif4gd 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MIF4GD 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MIF4GD 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MIF4GD 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MIF4GD 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mif4gd 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53513 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mif4gdb 33 34 |
|
||
| mif4gda 34 |
|
OneToMany | |||
| zgc64152 33 |
|
- Species where no ortholog for MIF4GD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIF4GD Gene
Variants for MIF4GD Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs62622012 | uncertain-significance, Amish lethal microcephaly | 75,273,251(-) | C/T | upstream_transcript_variant | |
| rs7198 | likely-benign, Amish lethal microcephaly | 75,273,177(-) | G/C | upstream_transcript_variant | |
| rs73356384 | likely-benign, Amish lethal microcephaly | 75,273,014(-) | A/C | upstream_transcript_variant | |
| rs115006555 | likely-benign, not specified | 75,265,818(-) | G/A | downstream_transcript_variant | |
| rs61745718 | likely-benign, not specified | 75,265,839(-) | C/T | downstream_transcript_variant |
Residual Variation Intolerance Score:
18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.16;
75.80% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MIF4GD Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIF4GD
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIF4GD Gene
Disorders for MIF4GD Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 70 |
|
|
Search MIF4GD in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIF4GD
No data available for UniProtKB/Swiss-Prot and Genatlas for MIF4GD Gene
Publications for MIF4GD Gene
- SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. (PMID: 18025107) Cakmakci NG … Marzluff WF (Molecular and cellular biology 2008) 2 3 4 58
- INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation. (PMID: 22532700) Neusiedler J … Jalinot P (RNA (New York, N.Y.) 2012) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells. (PMID: 28079882) Won KJ … Won M (Cell death & disease 2017) 3 58
- Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 20 available MIF4GD Antibodies ranked by validation data
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Sources for MIF4GD Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
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