This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an addit... See more...

Aliases for MIF Gene

Aliases for MIF Gene

  • Macrophage Migration Inhibitory Factor 2 3 4 5
  • Phenylpyruvate Tautomerase 2 3 4
  • GIF 2 3 4
  • Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) 2 3
  • Glycosylation-Inhibiting Factor 2 4
  • L-Dopachrome Tautomerase 3 4
  • L-Dopachrome Isomerase 3 4
  • GLIF 3 4
  • MMIF 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • EC 5.3.3.12 4
  • EC 5.3.2.1 4
  • MIF 5

External Ids for MIF Gene

Previous HGNC Symbols for MIF Gene

  • GLIF

Previous GeneCards Identifiers for MIF Gene

  • GC22P020896
  • GC22P022560
  • GC22P022561
  • GC22P022369
  • GC22P024236
  • GC22P007221

Summaries for MIF Gene

Entrez Gene Summary for MIF Gene

  • This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for MIF Gene

MIF (Macrophage Migration Inhibitory Factor) is a Protein Coding gene. Diseases associated with MIF include Rheumatoid Arthritis, Systemic Juvenile and Pulmonary Hemosiderosis. Among its related pathways are Tyrosine metabolism and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and cytokine receptor binding. An important paralog of this gene is DDT.

UniProtKB/Swiss-Prot Summary for MIF Gene

  • Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

Tocris Summary for MIF Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for MIF Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIF Gene

Genomics for MIF Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIF on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MIF

Top Transcription factor binding sites by QIAGEN in the MIF gene promoter:
  • CREB
  • deltaCREB
  • FOXJ2
  • p53
  • Sp1

Genomic Locations for MIF Gene

Genomic Locations for MIF Gene
chr22:23,894,383-23,895,227
(GRCh38/hg38)
Size:
845 bases
Orientation:
Plus strand
chr22:24,236,191-24,237,414
(GRCh37/hg19)
Size:
1,224 bases
Orientation:
Plus strand

Genomic View for MIF Gene

Genes around MIF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIF Gene

Proteins for MIF Gene

  • Protein details for MIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14174-MIF_HUMAN
    Recommended name:
    Macrophage migration inhibitory factor
    Protein Accession:
    P14174
    Secondary Accessions:
    • A5Z1R8
    • B2R4S3
    • Q2V4Y5
    • Q6FHV0

    Protein attributes for MIF Gene

    Size:
    115 amino acids
    Molecular mass:
    12476 Da
    Quaternary structure:
    • Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL.
    Miscellaneous:
    • Serum levels of MIF are elevated in patients with severe sepsis or septic shock. High levels of MIF are correlated with low survival. Drugs that inhibit tautomerase activity protect against death due to sepsis.

    Three dimensional structures from OCA and Proteopedia for MIF Gene

neXtProt entry for MIF Gene

Post-translational modifications for MIF Gene

  • Ubiquitination at Lys78
  • Modification sites at PhosphoSitePlus

Other Protein References for MIF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MIF

No data available for DME Specific Peptides for MIF Gene

Domains & Families for MIF Gene

Gene Families for MIF Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MIF Gene

InterPro:
Blocks:
  • Macrophage migration inhibitory factor
ProtoNet:

Suggested Antigen Peptide Sequences for MIF Gene

GenScript: Design optimal peptide antigens:
  • Macrophage migration inhibitory factor (A6MUU8_HUMAN)
  • Phenylpyruvate tautomerase (MIF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14174

UniProtKB/Swiss-Prot:

MIF_HUMAN :
  • Belongs to the MIF family.
Family:
  • Belongs to the MIF family.
genes like me logo Genes that share domains with MIF: view

Function for MIF Gene

Molecular function for MIF Gene

UniProtKB/Swiss-Prot Function:
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-phenylpyruvate = enol-phenylpyruvate; Xref=Rhea:RHEA:17097, ChEBI:CHEBI:16815, ChEBI:CHEBI:18005; EC=5.3.2.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate; Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509; EC=5.3.3.12;.
UniProtKB/Swiss-Prot Induction:
Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to M.tuberculosis antigens.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=249 uM for phenylpyruvate {ECO:0000269|PubMed:11439086}; KM=168 uM for p-hydroxyphenylpyruvate {ECO:0000269|PubMed:11439086}; Vmax=2113 umol/min/mg enzyme toward phenylpyruvate {ECO:0000269|PubMed:11439086}; Vmax=524 umol/min/mg enzyme toward p-hydroxyphenylpyruvate {ECO:0000269|PubMed:11439086};
GENATLAS Biochemistry:
macrophage migration inhibitory factor,12.3kDa,expressed in T cells and various tissues,including immunologically privileged lens and brain,also involved in mitogenic response and the control of cell cycle progression,maybe the same as DDT

Enzyme Numbers (IUBMB) for MIF Gene

Phenotypes From GWAS Catalog for MIF Gene

Gene Ontology (GO) - Molecular Function for MIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0004167 dopachrome isomerase activity IEA,IDA 17526494
GO:0005125 cytokine activity IEA,IDA 12782713
GO:0005126 cytokine receptor binding IPI 17045821
GO:0005515 protein binding IPI 12681488
genes like me logo Genes that share ontologies with MIF: view
genes like me logo Genes that share phenotypes with MIF: view

Human Phenotype Ontology for MIF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MIF Gene

MGI Knock Outs for MIF:
  • Mif Mif<tm1Mky>
  • Mif Mif<tm1Dvd>
  • Mif Mif<tm1Gfr>

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIF

No data available for Transcription Factor Targets and HOMER Transcription for MIF Gene

Localization for MIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIF Gene

Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. {ECO:0000269 PubMed:15908412}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIF gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 4
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005615 extracellular space IEA,IDA 21817065
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 24569872
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MIF: view

Pathways & Interactions for MIF Gene

PathCards logo

SuperPathways for MIF Gene

SuperPathway Contained pathways
1 Innate Immune System
2 Tyrosine metabolism
3 PEDF Induced Signaling
.94
.94
4 Metabolism
5 MIF Action Through Endocytic Pathway
-
genes like me logo Genes that share pathways with MIF: view

Pathways by source for MIF Gene

3 GeneGo (Thomson Reuters) pathways for MIF Gene
  • Immune response MIF in innate immunity response
  • Immune response MIF-JAB1 signaling
  • Immune response MIF-mediated glucocorticoid regulation
3 Qiagen pathways for MIF Gene
  • MIF Action Through Endocytic Pathway
  • MIF Mediated Glucocorticoid Regulation
  • MIF Regulation of Innate Immune Cells

SIGNOR curated interactions for MIF Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for MIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IDA 12782713
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002376 immune system process IEA --
GO:0002906 negative regulation of mature B cell apoptotic process IEA --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with MIF: view

Drugs & Compounds for MIF Gene

(58) Drugs for MIF Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citric acid Approved, Vet_approved Nutra Activator, Agonist 1509
Pirfenidone Approved, Investigational Pharma TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo 86
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents 429
4-Hydroxyphenylpyruvic acid Experimental Pharma Target 0
3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER Experimental Pharma Target 0

(39) Additional Compounds for MIF Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
l-dopachrome
  • 2-L-Carboxy-2,3-dihydroindole-5,6-quinone
89762-39-0
2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
  • 4,alpha-Dihydroxycinnamic acid
  • 4,a-Dihydroxycinnamate
  • 4,a-Dihydroxycinnamic acid
  • 4,alpha-Dihydroxycinnamate
  • 4,α-dihydroxycinnamate
5,6-Dihydroxyindole-2-carboxylic acid
  • 5,6-DHICA
  • 5,6-Dihydroxy-2-indolecarboxylic acid
  • 5,6-Dihydroxy-2-indolylcarboxylic acid
  • 5,6-Dihydroxyindole-2-carboxylate
  • DHI2c
4790-08-3
Enol-phenylpyruvate
  • enol-Phenylpyruvic acid
  • enol-alpha-Ketohydrocinnamic acid
  • enol-a-Ketohydrocinnamate
  • enol-a-Ketohydrocinnamic acid
  • enol-alpha-Ketohydrocinnamate
5801-57-0
AS 101
106566-58-9

(4) Tocris Compounds for MIF Gene

Compound Action Cas Number
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release 106566-58-9
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines 6501-72-0
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1

(2) ApexBio Compounds for MIF Gene

Compound Action Cas Number
(±)-CPSI 1306 MIF inhibitor 1309793-47-2
BTZO 1 MIF binder 99420-15-2
genes like me logo Genes that share compounds with MIF: view

Transcripts for MIF Gene

mRNA/cDNA for MIF Gene

1 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIF

Alternative Splicing Database (ASD) splice patterns (SP) for MIF Gene

No ASD Table

Relevant External Links for MIF Gene

GeneLoc Exon Structure for
MIF

Expression for MIF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIF Gene

Protein differential expression in normal tissues from HIPED for MIF Gene

This gene is overexpressed in Bone (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MIF Gene



Protein tissue co-expression partners for MIF Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIF

SOURCE GeneReport for Unigene cluster for MIF Gene:

Hs.407995

Evidence on tissue expression from TISSUES for MIF Gene

  • Nervous system(4.9)
  • Lung(4.9)
  • Skin(4.9)
  • Eye(4.8)
  • Liver(4.7)
  • Blood(4.7)
  • Pancreas(4.1)
  • Heart(3.7)
  • Spleen(3.7)
  • Kidney(3.6)
  • Intestine(3.3)
  • Muscle(3.2)
  • Stomach(3.1)
  • Lymph node(3)
  • Bone marrow(3)
  • Thyroid gland(2.8)
  • Adrenal gland(2.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MIF Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • lymphatic
  • nervous
  • skeleton
Regions:
Head and neck:
  • brain
  • head
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • lymph node
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with MIF: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIF Gene

Orthologs for MIF Gene

This gene was present in the common ancestor of animals.

Orthologs for MIF Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MIF 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MIF 30 31
  • 93.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mif 30
  • 89.86 (n)
Mouse
(Mus musculus)
Mammalia Mif 30 17 31
  • 88.7 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MIF 31
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MIF 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MIF 30 31
  • 75.07 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mif 30
  • 65.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia MIF 30
Zebrafish
(Danio rerio)
Actinopterygii mif 30 31
  • 67.54 (n)
OneToOne
Dr.7856 30
Worm
(Caenorhabditis elegans)
Secernentea mif-1 31
  • 33 (a)
OneToMany
mif-2 31
  • 27 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
OneToOne
Species where no ortholog for MIF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MIF Gene

ENSEMBL:
Gene Tree for MIF (if available)
TreeFam:
Gene Tree for MIF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MIF: view image

Paralogs for MIF Gene

Paralogs for MIF Gene

(2) SIMAP similar genes for MIF Gene using alignment to 2 proteins:

  • MIF_HUMAN
  • A6MUU8_HUMAN
genes like me logo Genes that share paralogs with MIF: view

Variants for MIF Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIF Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
712657 Benign: not provided 23,895,033(+) C/A NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
781909 Benign: not provided 23,895,031(+) C/T NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs761381011 Uncertain Significance: not provided 23,894,835(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for MIF Gene

Structural Variations from Database of Genomic Variants (DGV) for MIF Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv4531n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3575444 CNV gain 25503493
esv3575445 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv3577 CNV insertion 18451855
nsv511075 OTHER complex 20534489
nsv526567 CNV gain 19592680
nsv588647 CNV gain 21841781
nsv7350 OTHER inversion 18451855
nsv834155 CNV gain+loss 17160897

Variation tolerance for MIF Gene

Gene Damage Index Score: 0.39; 8.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIF Gene

Human Gene Mutation Database (HGMD)
MIF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIF Gene

Disorders for MIF Gene

MalaCards: The human disease database

(48) MalaCards diseases for MIF Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis, systemic juvenile
  • systemic juvenile rheumatoid arthritis
pulmonary hemosiderosis
  • hemosiderosis, pulmonary, with deficiency of gamma-a globulin
arthritis
  • inflammatory disorder of joint
west nile virus encephalitis
plasmodium falciparum malaria
  • falciparum malaria
- elite association - COSMIC cancer census association via MalaCards
Search MIF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MIF_HUMAN
  • Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. {ECO:0000269 PubMed:11508429}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for MIF

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIF: view

No data available for Genatlas for MIF Gene

Publications for MIF Gene

  1. Association of proinflammatory cytokines with end stage renal disease. (PMID: 20303284) Tripathi G … Agrawal S (Cytokine 2010) 3 23 41
  2. Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia. (PMID: 20380014) Li ZW … Li JY (World journal of gastroenterology 2010) 3 23 41
  3. Serum macrophage migration inhibitory factor (MIF) in the intercritical phase of hereditary periodic fevers and its relationship with the MIF-173G/C polymorphism. (PMID: 17763209) Rigante D … Stabile A (Scandinavian journal of rheumatology 2007) 3 23 41
  4. A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses. (PMID: 17591062) Griga T … Klein W (Hepato-gastroenterology 2007) 3 23 41
  5. A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria. (PMID: 16929348) Awandare GA … Perkins DJ (Genes and immunity 2006) 3 23 41

Products for MIF Gene

Sources for MIF Gene