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This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an addit... See more...
Aliases for MIF Gene
Aliases for MIF Gene
External Ids for MIF Gene
- HGNC: 7097
- NCBI Entrez Gene: 4282
- Ensembl: ENSG00000240972
- OMIM®: 153620
- UniProtKB/Swiss-Prot: P14174
Previous HGNC Symbols for MIF Gene
- GLIF
Previous GeneCards Identifiers for MIF Gene
- GC22P020896
- GC22P022560
- GC22P022561
- GC22P022369
- GC22P024236
- GC22P007221
Summaries for MIF Gene
-
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
GeneCards Summary for MIF Gene
MIF (Macrophage Migration Inhibitory Factor) is a Protein Coding gene. Diseases associated with MIF include Rheumatoid Arthritis, Systemic Juvenile and Systemic Onset Juvenile Idiopathic Arthritis. Among its related pathways are Spinal Cord Injury and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and cytokine receptor binding. An important paralog of this gene is ENSG00000285762.
UniProtKB/Swiss-Prot Summary for MIF Gene
-
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
-
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
Additional gene information for MIF Gene
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIF Gene
Genomics for MIF Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIF on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MIF
- Top Transcription factor binding sites by QIAGEN in the MIF gene promoter:
-
- CREB
- deltaCREB
- FOXJ2
- p53
- Sp1
Genomic Locations for MIF Gene
Latest Assembly
- chr22:23,894,383-23,895,227
- (GRCh38/hg38)
- Size:
- 845 bases
- Orientation:
- Plus strand
Previous Assembly
- chr22:24,236,570-24,237,410
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 841 bases
- Orientation:
- Plus strand
Alternative Locations (GRCh38/hg38)
- chr22(ALT_REF_LOCI_1):130,745-131,585 (+)
Genomic View for MIF Gene
Genes around MIF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.23 by HGNC
- 22q11.23 by Entrez Gene
- 22q11.23 by Ensembl
MIF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIF Gene
Proteins for MIF Gene
-
Protein details for MIF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14174-MIF_HUMAN
- Recommended name:
- Macrophage migration inhibitory factor
- Protein Accession:
- P14174
- A5Z1R8
- B2R4S3
- Q2V4Y5
- Q6FHV0
Protein attributes for MIF Gene
- Size:
- 115 amino acids
- Molecular mass:
- 12476 Da
- Quaternary structure:
-
- Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL.
- Miscellaneous:
-
- Serum levels of MIF are elevated in patients with severe sepsis or septic shock. High levels of MIF are correlated with low survival. Drugs that inhibit tautomerase activity protect against death due to sepsis.
Protein Expression for MIF Gene
Post-translational modifications for MIF Gene
Other Protein References for MIF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences MIF Antibody and MIF Monoclonal Antibody
- G Biosciences Immunotag™ MIF Antibody
- GeneTex Anti-MIF antibody [N1C3] and Anti-MIF antibody [2Ar3]
- NSJ Bioreagents MIF Antibody
-
Custom Antibody ServicesOriGene Antibodies for MIF
- Novus Biologicals Antibodies for MIF
-
Abcam antibodies for MIF
- Invitrogen Antibodies for MIF (AFLGC-Mif)
- antibodies-online: Show 457 available MIF Antibodies ranked by validation data
- Compare Top MIF Antibodies
-
Recommended
- 48 WB Antibodies (anti-mouse)
- 7 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 157 WB Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 BCA Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 RIA Antibody (anti-human)
- 46 WB Antibodies (anti-rat)
- 7 FACS Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- Sino Biological Antibodies for MIF
Protein products for research
- G Biosciences Human MIF/Macrophage migration inhibitory factor, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for MIF
- Origene Custom Protein Services for MIF
- Sino Biological Recombinant Proteins for MIF
- Sino Biological Cell Lysates for MIF
- ProSpec Recombinant Proteins for MIF
- antibodies-online: Show 79 available MIF Proteins ranked by validation data
- Compare Top MIF Proteins
-
Abcam proteins for MIF
Assay products for research
- RayBiotech Human MIF ELISA
- antibodies-online: Show 116 available MIF Elisa Kits ranked by validation data
- Compare Top MIF Elisa Kits
-
Quality Products:
- ABIN6574190
- ABIN625252
- ABIN1115864
- ABIN411399
- ABIN365424
- ABIN414414
- ABIN1029197
- ABIN3032961
- ABIN924885
- ABIN5564627
- ABIN1115866
- ABIN415583
- ABIN455789
- ABIN366309
- ABIN1029199
- ABIN5525104
- ABIN5670258
- ABIN1081723
- ABIN628103
- ABIN5594948
- ABIN1115865
- ABIN365559
- ABIN416296
- ABIN1571219
- ABIN4947846
- ABIN5525106
- ABIN5670951
- ABIN578966
- ABIN627289
- ABIN5594950
- ABIN833973
- ABIN5510590
- ABIN1055897
- ABIN1563871
- ABIN6231280
-
Abcam assays for MIF
No data available for DME Specific Peptides for MIF Gene
Domains & Families for MIF Gene
Gene Families for MIF Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for MIF Gene
- InterPro:
- Blocks:
-
- Macrophage migration inhibitory factor
Suggested Antigen Peptide Sequences for MIF Gene
- GenScript: Design optimal peptide antigens:
-
- Macrophage migration inhibitory factor (A6MUU8_HUMAN)
- Phenylpyruvate tautomerase (MIF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P14174- Family:
-
- Belongs to the MIF family.
Function for MIF Gene
Molecular function for MIF Gene
- UniProtKB/Swiss-Prot Function:
- Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3-phenylpyruvate = enol-phenylpyruvate; Xref=Rhea:RHEA:17097, ChEBI:CHEBI:16815, ChEBI:CHEBI:18005; EC=5.3.2.1;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate; Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509; EC=5.3.3.12;.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to M.tuberculosis antigens.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=249 uM for phenylpyruvate {ECO:0000269|PubMed:11439086}; KM=168 uM for p-hydroxyphenylpyruvate {ECO:0000269|PubMed:11439086}; Vmax=2113 umol/min/mg enzyme toward phenylpyruvate {ECO:0000269|PubMed:11439086}; Vmax=524 umol/min/mg enzyme toward p-hydroxyphenylpyruvate {ECO:0000269|PubMed:11439086};
- GENATLAS Biochemistry:
- macrophage migration inhibitory factor,12.3kDa,expressed in T cells and various tissues,including immunologically privileged lens and brain,also involved in mitogenic response and the control of cell cycle progression,maybe the same as DDT
Enzyme Numbers (IUBMB) for MIF Gene
Phenotypes From GWAS Catalog for MIF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004167 | dopachrome isomerase activity | IEA,IDA | 17526494 |
| GO:0005125 | cytokine activity | IEA,IDA | 12782713 |
| GO:0005126 | cytokine receptor binding | IPI | 17045821 |
| GO:0005515 | protein binding | IPI | 12681488 |
| GO:0016853 | isomerase activity | IEA | -- |
Phenotypes for MIF Gene
- MGI mutant phenotypes for MIF:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for MIF:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Decreased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Proliferating cells
- Decreased shRNA abundance (Z-score < -2)
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIF - Starting at $85 >
- * MIF CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MIF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MIF
-
Santa Cruz Biotechnology (SCBT) CRISPR for MIF
miRNA for MIF Gene
- miRTarBase miRNAs that target MIF
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MIF
- Browse OriGene Inhibitory RNA Products For MIF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIF
Clone products for research
- Applied Biological Materials (abm): Clones for MIF - Starting at $45 >
- * MIF as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MIF
- Addgene plasmids for MIF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MIF
Cell Lines for research
-
Horizon Cell Lines for MIF
No data available for Transcription Factor Targets and HOMER Transcription for MIF Gene
Localization for MIF Gene
Subcellular locations from UniProtKB/Swiss-Prot for MIF Gene
- Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. {ECO:0000269 PubMed:15908412}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005615 | extracellular space | IEA,IDA | 21817065 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 24569872 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for MIF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Phenylalanine metabolism | ||
| 3 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
|
MIF Regulation of Innate Immune Cells
.94
|
| 4 | Metabolism | ||
| 5 | MIF Action Through Endocytic Pathway |
MIF Action Through Endocytic Pathway
-
|
|
Pathways by source for MIF Gene
2 BioSystems pathways for MIF Gene
5 Reactome pathways for MIF Gene
3 KEGG pathways for MIF Gene
3 GeneGo (Thomson Reuters) pathways for MIF Gene
- Immune response MIF in innate immunity response
- Immune response MIF-JAB1 signaling
- Immune response MIF-mediated glucocorticoid regulation
3 Qiagen pathways for MIF Gene
- MIF Action Through Endocytic Pathway
- MIF Mediated Glucocorticoid Regulation
- MIF Regulation of Innate Immune Cells
Interacting Proteins for MIF Gene
Selected Interacting proteins:
P14174-MIF_HUMAN
ENSP00000215754
for MIF Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MIF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001516 | prostaglandin biosynthetic process | IDA | 12782713 |
| GO:0001819 | positive regulation of cytokine production | IDA | 19602265 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | IDA | 12782713 |
Drugs & Compounds for MIF Gene
(58) Drugs for MIF Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Citric acid | Approved, Vet_approved | Nutra | 1606 | |||
| Pirfenidone | Approved, Investigational | Pharma | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 92 | ||
| Thalidomide | Approved, Investigational, Withdrawn | Pharma | Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents | 440 | ||
| 4-Hydroxyphenylpyruvic acid | Experimental | Pharma | Target | 0 | ||
| 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| l-dopachrome |
|
89762-39-0 | ||||
| 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid |
|
|
||||
| 5,6-Dihydroxyindole-2-carboxylic acid |
|
4790-08-3 |
|
|||
| Enol-phenylpyruvate |
|
5801-57-0 | ||||
| AS 101 |
|
106566-58-9 |
|
|
(4) Tocris Compounds for MIF Gene
| Compound | Action | Cas Number |
|---|---|---|
| AS 101 | Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release | 106566-58-9 |
| GIT 27 | Immunomodulator; reduces production of pro-inflammatory cytokines | 6501-72-0 |
| Pirfenidone | Antifibrotic agent; regulates cytokine levels in vivo | 53179-13-8 |
| Thalidomide | TNF-alpha synthesis inhibitor | 50-35-1 |
(2) ApexBio Compounds for MIF Gene
| Compound | Action | Cas Number |
|---|---|---|
| (±)-CPSI 1306 | MIF inhibitor | 1309793-47-2 |
| BTZO 1 | MIF binder | 99420-15-2 |
Drug products for research
- G Biosciences Human MIF/Macrophage migration inhibitory factor, Liquid
- ApexBio compounds for MIF
Transcripts for MIF Gene
mRNA/cDNA for MIF Gene
- 1 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000215754 557 nts (view in UCSC)
- ENST00000465752 589 nts (view in UCSC)
- ENST00000498385 435 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIF - Starting at $85 >
- * MIF CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MIF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MIF
-
Santa Cruz Biotechnology (SCBT) CRISPR for MIF
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MIF
- Browse OriGene Inhibitory RNA Products For MIF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIF
Clone products for research
- Applied Biological Materials (abm): Clones for MIF - Starting at $45 >
- * MIF as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MIF
- Addgene plasmids for MIF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MIF
Relevant External Links for MIF Gene
- GeneLoc Exon Structure for
- MIF
Expression for MIF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Mesenchymal Stem Cells
- Neural Tube (Nervous System)
- Lung (Respiratory System)
- Bone (Muscoskeletal System)
- Placenta (Extraembryonic Tissues)
- Uterus (Reproductive System)
- Lower Urinary Tract (Urinary System)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
- Amnion (Extraembryonic Tissues)
This gene is overexpressed in Bone (18.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MIF Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIF
SOURCE GeneReport for Unigene cluster for MIF Gene:
Hs.407995Evidence on tissue expression from TISSUES for MIF Gene
- Nervous system(4.9)
- Lung(4.9)
- Skin(4.8)
- Eye(4.8)
- Liver(4.7)
- Blood(4.6)
- Pancreas(4)
- Heart(3.6)
- Spleen(3.5)
- Kidney(3.5)
- Intestine(3.2)
- Muscle(3)
- Stomach(3)
- Bone marrow(2.8)
- Lymph node(2.8)
- Thyroid gland(2.7)
- Adrenal gland(2.6)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MIF Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- lymphatic
- nervous
- skeleton
Regions:
Head and neck:
- brain
- head
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- lymph node
- skin
- white blood cell
Primer products for research
-
OriGene qPCR primer pairs for MIF
-
OriGene qPCR primer pairs and template standards for MIF
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIF Gene
Orthologs for MIF Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MIF 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MIF 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mif 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mif 29 16 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MIF 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MIF 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MIF 29 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mif 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MIF 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mif 29 30 |
|
OneToOne | |
| Dr.7856 29 |
|
||||
| Worm (Caenorhabditis elegans) |
Secernentea | mif-1 30 |
|
OneToMany | |
| mif-2 30 |
|
OneToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToOne |
- Species where no ortholog for MIF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MIF Gene
- ENSEMBL:
- Gene Tree for MIF (if available)
- TreeFam:
- Gene Tree for MIF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MIF: view image
- Alliance of Genome Resources:
- Additional Orthologs for MIF
Paralogs for MIF Gene
Variants for MIF Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIF Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs189811391 | Benign: not provided | 23,895,031(+) |
C/T NM_002415.2(MIF):c.282-9C>T |
NON_CODING_TRANSCRIPT_VARIANT,INTRON | |
| rs35625249 | Benign: not provided | 23,895,033(+) |
C/A NM_002415.2(MIF):c.282-7C>A |
NON_CODING_TRANSCRIPT_VARIANT,INTRON | |
| rs761381011 | Uncertain Significance: not provided | 23,894,835(+) |
G/A NM_002415.2(MIF):c.172G>A (p.Ala58Thr) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4528n100 | CNV | gain | 25217958 |
| dgv4531n100 | CNV | gain | 25217958 |
| dgv8039n54 | CNV | gain | 21841781 |
| esv2724041 | CNV | deletion | 23290073 |
| esv3575443 | CNV | gain | 25503493 |
| esv3575444 | CNV | gain | 25503493 |
| esv3575445 | CNV | gain | 25503493 |
| esv3893457 | CNV | gain | 25118596 |
| esv3893461 | CNV | gain | 25118596 |
| nsv1062411 | CNV | gain | 25217958 |
| nsv1066891 | CNV | gain | 25217958 |
| nsv1110863 | OTHER | inversion | 24896259 |
| nsv3577 | CNV | insertion | 18451855 |
| nsv511075 | OTHER | complex | 20534489 |
| nsv526567 | CNV | gain | 19592680 |
| nsv588647 | CNV | gain | 21841781 |
| nsv7350 | OTHER | inversion | 18451855 |
| nsv834155 | CNV | gain+loss | 17160897 |
Gene Damage Index Score:
0.39;
8.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MIF Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIF Gene
Disorders for MIF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rheumatoid arthritis, systemic juvenile |
|
|
| systemic onset juvenile idiopathic arthritis |
|
|
| arthritis |
|
|
| pulmonary hemosiderosis |
|
|
| west nile virus encephalitis |
|
|
Search MIF in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MIF_HUMAN- Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. {ECO:0000269 PubMed:11508429}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
Additional Disease Information for MIF
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for MIF Gene
Publications for MIF Gene
- A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. (PMID: 11508429) Donn RP … British Paediatric Rheumatology Study Group (Arthritis and rheumatism 2001) 3 4 40 72
- Association of proinflammatory cytokines with end stage renal disease. (PMID: 20303284) Tripathi G … Agrawal S (Cytokine 2010) 3 22 40
- Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia. (PMID: 20380014) Li ZW … Li JY (World journal of gastroenterology 2010) 3 22 40
- Serum macrophage migration inhibitory factor (MIF) in the intercritical phase of hereditary periodic fevers and its relationship with the MIF-173G/C polymorphism. (PMID: 17763209) Rigante D … Stabile A (Scandinavian journal of rheumatology 2007) 3 22 40
- A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses. (PMID: 17591062) Griga T … Klein W (Hepato-gastroenterology 2007) 3 22 40
ExternalLinks
Products for MIF Gene
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Sources for MIF Gene
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