Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
MIF (Macrophage Migration Inhibitory Factor) is a Protein Coding gene. Diseases associated with MIF include Rheumatoid Arthritis, Systemic Juvenile and Pulmonary Hemosiderosis. Among its related pathways are Tyrosine metabolism and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and cytokine receptor binding. An important paralog of this gene is DDT.
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002020 | protease binding | IEA | -- |
GO:0004167 | dopachrome isomerase activity | IEA,IDA | 17526494 |
GO:0005125 | cytokine activity | IEA,IDA | 12782713 |
GO:0005126 | cytokine receptor binding | IPI | 17045821 |
GO:0005515 | protein binding | IPI | 12681488 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA,TAS | -- |
GO:0005615 | extracellular space | IEA,IDA | 21817065 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 24569872 |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Tyrosine metabolism | ||
3 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
|
MIF Regulation of Innate Immune Cells
.94
|
4 | Metabolism | ||
5 | MIF Action Through Endocytic Pathway |
MIF Action Through Endocytic Pathway
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001516 | prostaglandin biosynthetic process | IDA | 12782713 |
GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002906 | negative regulation of mature B cell apoptotic process | IEA | -- |
GO:0006954 | inflammatory response | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Citric acid | Approved, Vet_approved | Nutra | Activator, Agonist | 1509 | ||
Pirfenidone | Approved, Investigational | Pharma | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 86 | ||
Thalidomide | Approved, Investigational, Withdrawn | Pharma | Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents | 429 | ||
4-Hydroxyphenylpyruvic acid | Experimental | Pharma | Target | 0 | ||
3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
l-dopachrome |
|
89762-39-0 | ||||
2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid |
|
|
||||
5,6-Dihydroxyindole-2-carboxylic acid |
|
4790-08-3 |
|
|||
Enol-phenylpyruvate |
|
5801-57-0 | ||||
AS 101 |
|
106566-58-9 |
|
|
Compound | Action | Cas Number |
---|---|---|
AS 101 | Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release | 106566-58-9 |
GIT 27 | Immunomodulator; reduces production of pro-inflammatory cytokines | 6501-72-0 |
Pirfenidone | Antifibrotic agent; regulates cytokine levels in vivo | 53179-13-8 |
Thalidomide | TNF-alpha synthesis inhibitor | 50-35-1 |
Compound | Action | Cas Number |
---|---|---|
(±)-CPSI 1306 | MIF inhibitor | 1309793-47-2 |
BTZO 1 | MIF binder | 99420-15-2 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MIF 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MIF 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mif 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mif 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MIF 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MIF 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MIF 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mif 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MIF 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mif 30 31 |
|
OneToOne | |
Dr.7856 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | mif-1 31 |
|
OneToMany | |
mif-2 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712657 | Benign: not provided | 23,895,033(+) | C/A | NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT | |
781909 | Benign: not provided | 23,895,031(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT | |
rs761381011 | Uncertain Significance: not provided | 23,894,835(+) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4528n100 | CNV | gain | 25217958 |
dgv4531n100 | CNV | gain | 25217958 |
dgv8039n54 | CNV | gain | 21841781 |
esv2724041 | CNV | deletion | 23290073 |
esv3575443 | CNV | gain | 25503493 |
esv3575444 | CNV | gain | 25503493 |
esv3575445 | CNV | gain | 25503493 |
esv3893457 | CNV | gain | 25118596 |
esv3893461 | CNV | gain | 25118596 |
nsv1062411 | CNV | gain | 25217958 |
nsv1066891 | CNV | gain | 25217958 |
nsv1110863 | OTHER | inversion | 24896259 |
nsv3577 | CNV | insertion | 18451855 |
nsv511075 | OTHER | complex | 20534489 |
nsv526567 | CNV | gain | 19592680 |
nsv588647 | CNV | gain | 21841781 |
nsv7350 | OTHER | inversion | 18451855 |
nsv834155 | CNV | gain+loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
rheumatoid arthritis, systemic juvenile |
|
|
pulmonary hemosiderosis |
|
|
arthritis |
|
|
west nile virus encephalitis |
|
|
plasmodium falciparum malaria |
|