Aliases for MIF Gene
Aliases for MIF Gene
External Ids for MIF Gene
- HGNC: 7097
- Entrez Gene: 4282
- Ensembl: ENSG00000240972
- OMIM: 153620
- UniProtKB: P14174
Previous HGNC Symbols for MIF Gene
- GLIF
Previous GeneCards Identifiers for MIF Gene
- GC22P020896
- GC22P022560
- GC22P022561
- GC22P022369
- GC22P024236
- GC22P007221
Summaries for MIF Gene
-
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
GeneCards Summary for MIF Gene
MIF (Macrophage Migration Inhibitory Factor) is a Protein Coding gene. Diseases associated with MIF include Rheumatoid Arthritis, Systemic Juvenile and Pulmonary Hemosiderosis. Among its related pathways are Adipogenesis and Photodynamic therapy-induced NF-kB survival signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and cytokine receptor binding. An important paralog of this gene is ENSG00000285762.
UniProtKB/Swiss-Prot for MIF Gene
-
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
-
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
Additional gene information for MIF Gene
- Monarch Initiative
- Search for MIF at DataMed
- Search for MIF at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIF Gene
Genomics for MIF Gene
GeneHancer (GH) Regulatory Elements for MIF Gene
Promoters and enhancers for MIF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIF on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MIF gene promoter:
-
- CREB
- deltaCREB
- FOXJ2
- p53
- Sp1
Genomic Locations for MIF Gene
Genomic Locations for MIF Gene
- chr22:23,894,378-23,895,227
- (GRCh38/hg38)
- Size:
- 850 bases
- Orientation:
- Plus strand
- chr22:24,236,191-24,237,414
- (GRCh37/hg19)
- Size:
- 1,224 bases
- Orientation:
- Plus strand
Genomic View for MIF Gene
Genes around MIF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.23 by HGNC
- 22q11.23 by Entrez Gene
- 22q11.23 by Ensembl
MIF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIF Gene
Proteins for MIF Gene
-
Protein details for MIF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14174-MIF_HUMAN
- Recommended name:
- Macrophage migration inhibitory factor
- Protein Accession:
- P14174
- A5Z1R8
- B2R4S3
- Q2V4Y5
- Q6FHV0
Protein attributes for MIF Gene
- Size:
- 115 amino acids
- Molecular mass:
- 12476 Da
- Quaternary structure:
-
- Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL.
- Miscellaneous:
-
- Serum levels of MIF are elevated in patients with severe sepsis or septic shock. High levels of MIF are correlated with low survival. Drugs that inhibit tautomerase activity protect against death due to sepsis.
Protein Expression for MIF Gene
Post-translational modifications for MIF Gene
Other Protein References for MIF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MIF Antibody (ITA6485-200u) and Immunotag™ MIF Antibody (ITA6485-100u)
- NSJ Bioreagents MIF Antibody
- Atlas Antibodies Anti-MIF Antibody
- GeneTex Anti-MIF antibody [2Ar3] and Anti-MIF antibody [N1C3]
-
Custom Antibody ServicesOriGene Antibodies for MIF
- Novus Biologicals Antibodies for MIF
-
Abcam antibodies for MIF
- Invitrogen Antibodies for MIF (AFLGC-MIF)
- antibodies-online: Search results for 224 available MIF Antibodies ranked by validation data
- Compare Top MIF Antibodies
-
Recommended
- 45 WB Antibodies (anti-mouse)
- 14 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 152 WB Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 4 BCA Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 RIA Antibody (anti-human)
- 45 WB Antibodies (anti-rat)
- 14 FACS Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- Sino Biological Antibodies for MIF
Protein Products
- G Biosciences Human MIF/Macrophage migration inhibitory factor, Liquid
- Atlas Antibodies PrEST Antigen MIF
- Search Origene for MassSpec and Protein Over-expression Lysates for MIF
- Origene Custom Protein Services for MIF
- Sino Biological Recombinant Proteins for MIF
- Sino Biological Cell Lysates for MIF
- ProSpec Recombinant Proteins for MIF
-
Abcam proteins for MIF
Assay Products
- RayBiotech Human MIF ELISA
-
Custom Assay ServicesOriGene ELISA Kits for MIF
- Novus Biologicals ELISA Kits for MIF
- antibodies-online: Search results for 93 available MIF Elisa Kits ranked by validation data
- Compare Top MIF Elisa Kits
-
Recommended
- 1 Cat (Feline) ELISA Kit
- 2 Chicken ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 1 Dog (Canine) ELISA Kit
- 2 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 33 Human ELISA Kits
- 5 Monkey ELISA Kits
- 16 Mouse (Murine) ELISA Kits
- 9 Pig (Porcine) ELISA Kits
- 5 Rabbit ELISA Kits
- 14 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 1 Wild boar (Sus scrofa) ELISA Kit
-
Abcam assays for MIF
No data available for DME Specific Peptides for MIF Gene
Domains & Families for MIF Gene
Gene Families for MIF Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MIF Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MIF Gene
- GenScript: Design optimal peptide antigens:
-
- Macrophage migration inhibitory factor (A6MUU8_HUMAN)
- Phenylpyruvate tautomerase (MIF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P14174- Family:
-
- Belongs to the MIF family.
Function for MIF Gene
Molecular function for MIF Gene
- UniProtKB/Swiss-Prot Function:
- Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3-phenylpyruvate = enol-phenylpyruvate; Xref=Rhea:RHEA:17097, ChEBI:CHEBI:16815, ChEBI:CHEBI:18005; EC=5.3.2.1;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate; Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509; EC=5.3.3.12;.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=249 uM for phenylpyruvate {ECO:0000269 PubMed:11439086}; KM=168 uM for p-hydroxyphenylpyruvate {ECO:0000269 PubMed:11439086}; Vmax=2113 umol/min/mg enzyme toward phenylpyruvate {ECO:0000269 PubMed:11439086}; Vmax=524 umol/min/mg enzyme toward p-hydroxyphenylpyruvate {ECO:0000269 PubMed:11439086};
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to M.tuberculosis antigens.
- GENATLAS Biochemistry:
- macrophage migration inhibitory factor,12.3kDa,expressed in T cells and various tissues,including immunologically privileged lens and brain,also involved in mitogenic response and the control of cell cycle progression,maybe the same as DDT
Enzyme Numbers (IUBMB) for MIF Gene
Phenotypes From GWAS Catalog for MIF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IEA | -- |
| GO:0004167 | dopachrome isomerase activity | IEA,IDA | 17526494 |
| GO:0005102 | signaling receptor binding | IPI | 12782713 |
| GO:0005125 | cytokine activity | IEA,IDA | 12782713 |
| GO:0005126 | cytokine receptor binding | IPI | 17045821 |
Phenotypes for MIF Gene
- MGI mutant phenotypes for MIF:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for MIF:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased transferrin (TF) endocytosis
- Lamellipodia cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIF
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIF - Now 50% OFF >
- * MIF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MIF CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for MIF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MIF
- genomics-online: gRNA clones - Search results for 145 available MIF gene related products
- Overview of 145 available MIF gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for MIF
miRNA for MIF Gene
- miRTarBase miRNAs that target MIF
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MIF
- Browse OriGene Inhibitory RNA Products For MIF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIF
- genomics-online: shRNA clones - Search results for 145 available MIF gene related products
- Overview of 145 available MIF gene related products
Clone Products
- Applied Biological Materials (abm): Clones for MIF - Now 50% OFF >
- * MIF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MIF tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG200478
- MR200478
- MR200478L1
- MR200478L1V
- MR200478L2
- MR200478L2V
- MR200478L3
- MR200478L3V
- MR200478L4
- MR200478L4V
- RC205106
- RC205106L1
- RC205106L1V
- RC205106L2
- RC205106L2V
- RC205106L3
- RC205106L3V
- RC205106L4
- RC205106L4V
- RC505106
- RG205106
- RR212389
- RR212389L1
- RR212389L1V
- RR212389L2
- RR212389L2V
- RR212389L3
- RR212389L3V
- RR212389L4
- RR212389L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MIF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MIF
Cell Line Products
-
Horizon Cell Lines for MIF
No data available for Transcription Factor Targets and HOMER Transcription for MIF Gene
Localization for MIF Gene
Subcellular locations from UniProtKB/Swiss-Prot for MIF Gene
- Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. {ECO:0000269 PubMed:15908412}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005615 | extracellular space | IEA,IDA | 21817065 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for MIF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Phenylalanine metabolism | ||
| 3 | PEDF Induced Signaling | ||
| 4 | Metabolism | ||
| 5 | MIF Action Through Endocytic Pathway | ||
Pathways by source for MIF Gene
2 BioSystems pathways for MIF Gene
5 Reactome pathways for MIF Gene
3 KEGG pathways for MIF Gene
3 GeneGo (Thomson Reuters) pathways for MIF Gene
3 Qiagen pathways for MIF Gene
Interacting Proteins for MIF Gene
Selected Interacting proteins:
P14174-MIF_HUMAN
ENSP00000215754
for MIF Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MIF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001516 | prostaglandin biosynthetic process | IDA | 12782713 |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002906 | negative regulation of mature B cell apoptotic process | IEA | -- |
| GO:0006954 | inflammatory response | IEA | -- |
Drugs & Compounds for MIF Gene
(57) Drugs for MIF Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Citric Acid | Approved, Vet_approved | Nutra | Agonist, Activator, Target | 1401 | ||
| Pirfenidone | Approved, Investigational | Pharma | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 77 | ||
| Thalidomide | Approved, Investigational, Withdrawn | Pharma | Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents | 624 | ||
| 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER | Experimental | Pharma | Target | 0 | ||
| 3-(4-HYDROXY-PHENYL)PYRUVIC ACID | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| l-dopachrome |
|
89762-39-0 | ||||
| 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid |
|
|
||||
| 4-Hydroxyphenylpyruvic acid |
|
156-39-8 |
|
|||
| 5,6-Dihydroxyindole-2-carboxylic acid |
|
4790-08-3 |
|
|||
| Enol-phenylpyruvate |
|
5801-57-0 |
(4) Tocris Compounds for MIF Gene
| Compound | Action | Cas Number |
|---|---|---|
| AS 101 | Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release | 106566-58-9 |
| GIT 27 | Immunomodulator; reduces production of pro-inflammatory cytokines | 6501-72-0 |
| Pirfenidone | Antifibrotic agent; regulates cytokine levels in vivo | 53179-13-8 |
| Thalidomide | TNF-alpha synthesis inhibitor | 50-35-1 |
(2) ApexBio Compounds for MIF Gene
| Compound | Action | Cas Number |
|---|---|---|
| (±)-CPSI 1306 | MIF inhibitor | 1309793-47-2 |
| BTZO 1 | MIF binder | 99420-15-2 |
Drug Products
- G Biosciences Human MIF/Macrophage migration inhibitory factor, Liquid
- Atlas Antibodies PrEST Antigen MIF
- ApexBio compounds for MIF
Transcripts for MIF Gene
mRNA/cDNA for MIF Gene
- (1) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (1476) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000215754 557 bps (ENST00000215754.7)
- ENST00000465752 589 bps (ENST00000465752.1)
- ENST00000498385 435 bps (ENST00000498385.1)
Unigene Clusters for MIF Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIF - Now 50% OFF >
- * MIF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MIF CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for MIF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MIF
- genomics-online: gRNA clones - Search results for 145 available MIF gene related products
- Overview of 145 available MIF gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for MIF
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MIF
- Browse OriGene Inhibitory RNA Products For MIF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIF
- genomics-online: shRNA clones - Search results for 145 available MIF gene related products
- Overview of 145 available MIF gene related products
Clone Products
- Applied Biological Materials (abm): Clones for MIF - Now 50% OFF >
- * MIF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MIF tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG200478
- MR200478
- MR200478L1
- MR200478L1V
- MR200478L2
- MR200478L2V
- MR200478L3
- MR200478L3V
- MR200478L4
- MR200478L4V
- RC205106
- RC205106L1
- RC205106L1V
- RC205106L2
- RC205106L2V
- RC205106L3
- RC205106L3V
- RC205106L4
- RC205106L4V
- RC505106
- RG205106
- RR212389
- RR212389L1
- RR212389L1V
- RR212389L2
- RR212389L2V
- RR212389L3
- RR212389L3V
- RR212389L4
- RR212389L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MIF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MIF
Expression for MIF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Mesenchymal Stem Cells
- Neural Tube (Nervous System)
- Lung (Respiratory System)
- Bone (Muscoskeletal System)
- Placenta (Extraembryonic Tissues)
- Uterus (Reproductive System)
- Lower Urinary Tract (Urinary System)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
- Amnion (Extraembryonic Tissues)
This gene is overexpressed in Bone (18.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MIF Gene
NURSA nuclear receptor signaling pathways regulating expression of MIF Gene:
MIFSOURCE GeneReport for Unigene cluster for MIF Gene:
Hs.407995Evidence on tissue expression from TISSUES for MIF Gene
- Lung(4.9)
- Nervous system(4.9)
- Skin(4.8)
- Eye(4.7)
- Blood(4.6)
- Liver(4.6)
- Pancreas(3.9)
- Heart(3.4)
- Spleen(3.4)
- Kidney(3.3)
- Intestine(2.9)
- Muscle(2.8)
- Stomach(2.7)
- Lymph node(2.4)
- Bone marrow(2.3)
- Adrenal gland(2.2)
- Thyroid gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MIF Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- lymphatic
- nervous
- skeleton
Regions:
Head and neck:
- brain
- head
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- lymph node
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for MIF
-
OriGene qPCR primer pairs and template standards for MIF
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIF Gene
Orthologs for MIF Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MIF 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MIF 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mif 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mif 17 35 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MIF 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MIF 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MIF 35 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mif 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MIF 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mif 35 34 |
|
OneToOne | |
| Dr.7856 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | mif-1 35 |
|
OneToMany | |
| mif-2 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for MIF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MIF Gene
- ENSEMBL:
- Gene Tree for MIF (if available)
- TreeFam:
- Gene Tree for MIF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MIF: view image
Paralogs for MIF Gene
Variants for MIF Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs761381011 | uncertain-significance, not provided | 23,894,835(+) | G/A | coding_sequence_variant, missense_variant | |
| rs1002019906 | -- | 23,892,795(+) | T/C | upstream_transcript_variant | |
| rs1002472066 | -- | 23,895,714(+) | T/A/C | downstream_transcript_variant | |
| rs1002754971 | -- | 23,895,533(+) | C/A | downstream_transcript_variant | |
| rs1002990502 | -- | 23,894,523(+) | G/A | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4528n100 | CNV | gain | 25217958 |
| dgv4531n100 | CNV | gain | 25217958 |
| dgv8039n54 | CNV | gain | 21841781 |
| esv2724041 | CNV | deletion | 23290073 |
| esv3575443 | CNV | gain | 25503493 |
| esv3575444 | CNV | gain | 25503493 |
| esv3575445 | CNV | gain | 25503493 |
| esv3893457 | CNV | gain | 25118596 |
| esv3893461 | CNV | gain | 25118596 |
| nsv1062411 | CNV | gain | 25217958 |
| nsv1066891 | CNV | gain | 25217958 |
| nsv1110863 | OTHER | inversion | 24896259 |
| nsv3577 | CNV | insertion | 18451855 |
| nsv511075 | OTHER | complex | 20534489 |
| nsv526567 | CNV | gain | 19592680 |
| nsv588647 | CNV | gain | 21841781 |
| nsv7350 | OTHER | inversion | 18451855 |
| nsv834155 | CNV | gain+loss | 17160897 |
Gene Damage Index Score:
0.39;
8.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MIF Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIF Gene
Disorders for MIF Gene
(26) MalaCards diseases for MIF Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rheumatoid arthritis, systemic juvenile |
|
|
| pulmonary hemosiderosis |
|
|
| systemic onset juvenile idiopathic arthritis |
|
|
| arthritis |
|
|
| photokeratitis |
|
|
Search MIF in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MIF_HUMAN- Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. {ECO:0000269 PubMed:11508429}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. {ECO:0000305}.
Additional Disease Information for MIF
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MIF Gene
Publications for MIF Gene
- Serum macrophage migration inhibitory factor (MIF) in the intercritical phase of hereditary periodic fevers and its relationship with the MIF-173G/C polymorphism. (PMID: 17763209) Rigante D … Stabile A (Scandinavian journal of rheumatology 2007) 3 23 45 58
- A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses. (PMID: 17591062) Griga T … Klein W (Hepato-gastroenterology 2007) 3 23 45 58
- A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria. (PMID: 16929348) Awandare GA … Perkins DJ (Genes and immunity 2006) 3 23 45 58
- Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor. (PMID: 16200611) Radstake TR … van Riel PL (Arthritis and rheumatism 2005) 3 23 45 58
- Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. (PMID: 11170644) Orita M … Tanaka A (Journal of medicinal chemistry 2001) 3 4 23 58
ExternalLinks
Products for MIF Gene
- View all 32 R&D Systems MIF (MIF) Products
- View all 3 R&D Systems MIF (MIF) ELISAs
- View all R&D Systems MIF (MIF) Luminex Assays
- View all 24 R&D Systems MIF (MIF) Primary Antibodies
- View all R&D Systems MIF (MIF) Proteins and Enzymes
- View all 3 R&D Systems MIF (MIF) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom MIF antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for MIF
- Custom Assay ServicesOriGene ELISA Kits for MIF
- Search Origene for MassSpec and Protein Over-expression Lysates for MIF
- Origene Custom Protein Services for MIF
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MIF
- Browse OriGene Inhibitory RNA Products For MIF
- OriGene qPCR primer pairs for MIF
- OriGene qPCR primer pairs and template standards for MIF
- OriGene CRISPR knockouts for MIF
- MG200478
- MR200478
- MR200478L1
- MR200478L1V
- MR200478L2
- MR200478L2V
- MR200478L3
- MR200478L3V
- MR200478L4
- MR200478L4V
- RC205106
- RC205106L1
- RC205106L1V
- RC205106L2
- RC205106L2V
- RC205106L3
- RC205106L3V
- RC205106L4
- RC205106L4V
- RC505106
- RG205106
- RR212389
- RR212389L1
- RR212389L1V
- RR212389L2
- RR212389L2V
- RR212389L3
- RR212389L3V
- RR212389L4
- RR212389L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIF
- Sino Biological Human cDNA Clone for MIF
- Sino Biological Recombinant Proteins for MIF
- Sino Biological Cell Lysates for MIF
- Sino Biological Antibodies for MIF
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MIF
- Novus Biologicals proteins and lysates for MIF
- Novus Biologicals ELISA Kits for MIF
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MIF
- Abcam proteins for MIF
- Abcam assays for MIF
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- antibodies-online: Search results for 224 available MIF Antibodies ranked by validation data
- Compare Top MIF Antibodies
- Recommended
- 45 WB Antibodies (anti-mouse)
- 14 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 152 WB Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 4 BCA Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 RIA Antibody (anti-human)
- 45 WB Antibodies (anti-rat)
- 14 FACS Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 93 available MIF Elisa Kits ranked by validation data
- Compare Top MIF Elisa Kits
- Recommended
- 1 Cat (Feline) ELISA Kit
- 2 Chicken ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 1 Dog (Canine) ELISA Kit
- 2 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 33 Human ELISA Kits
- 5 Monkey ELISA Kits
- 16 Mouse (Murine) ELISA Kits
- 9 Pig (Porcine) ELISA Kits
- 5 Rabbit ELISA Kits
- 14 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 1 Wild boar (Sus scrofa) ELISA Kit
- antibodies-online: Search results for 80 available MIF Proteins ranked by validation data
- Compare Top MIF Proteins
- Search Santa Cruz Biotechnology (SCBT) for MIF siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MIF
- Horizon Cell Lines for MIF
- genomics-online: cdna clones - Search results for 145 available MIF gene related products
- Overview of 145 available MIF gene related products
- orf clones - Search results for 145 available MIF gene related products
- Overview of 145 available MIF gene related products
- genomics-online: gRNA clones - Search results for 145 available MIF gene related products
- Overview of 145 available MIF gene related products
- genomics-online: primer clones - Search results for 145 available MIF gene related products
- Overview of 145 available MIF gene related products
- genomics-online: shRNA clones - Search results for 145 available MIF gene related products
- Overview of 145 available MIF gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MIF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MIF
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIF
Sources for MIF Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind