Aliases for MIER3 Gene

Aliases for MIER3 Gene

  • MIER Family Member 3 2 3 5
  • Mesoderm Induction Early Response 1, Family Member 3 2 3
  • Mesoderm Induction Early Response Protein 3 3 4
  • Mi-Er3 3 4
  • DKFZp686L09111 2
  • DKFZp781I1119 2
  • FLJ35954 2
  • MIER3 5

External Ids for MIER3 Gene

Previous GeneCards Identifiers for MIER3 Gene

  • GC05M056253
  • GC05M053187
  • GC05M056215

Summaries for MIER3 Gene

GeneCards Summary for MIER3 Gene

MIER3 (MIER Family Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is MIER1.

UniProtKB/Swiss-Prot Summary for MIER3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIER3 Gene

Genomics for MIER3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIER3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIER3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MIER3

Top Transcription factor binding sites by QIAGEN in the MIER3 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • Nkx6-1

Genomic Locations for MIER3 Gene

Latest Assembly
chr5:56,919,602-56,971,675
(GRCh38/hg38)
Size:
52,074 bases
Orientation:
Minus strand

Previous Assembly
chr5:56,215,430-56,247,950
(GRCh37/hg19 by Entrez Gene)
Size:
32,521 bases
Orientation:
Minus strand

chr5:56,215,429-56,267,502
(GRCh37/hg19 by Ensembl)
Size:
52,074 bases
Orientation:
Minus strand

Genomic View for MIER3 Gene

Genes around MIER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER3 Gene

Proteins for MIER3 Gene

  • Protein details for MIER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3K6-MIER3_HUMAN
    Recommended name:
    Mesoderm induction early response protein 3
    Protein Accession:
    Q7Z3K6
    Secondary Accessions:
    • B4DRI9
    • B8ZZQ0
    • Q5CZI0
    • Q68CS3
    • Q6MZS7
    • Q86YG8
    • Q8NA13

    Protein attributes for MIER3 Gene

    Size:
    550 amino acids
    Molecular mass:
    61437 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41348.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04117.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAD97846.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45951.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI56710.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIER3 Gene

Post-translational modifications for MIER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER3 Gene

Domains & Families for MIER3 Gene

Gene Families for MIER3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MIER3 Gene

Suggested Antigen Peptide Sequences for MIER3 Gene

GenScript: Design optimal peptide antigens:
  • Mesoderm induction early response protein 3 (MIER3_HUMAN)
genes like me logo Genes that share domains with MIER3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIER3 Gene

Function for MIER3 Gene

Molecular function for MIER3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Phenotypes From GWAS Catalog for MIER3 Gene

Gene Ontology (GO) - Molecular Function for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001103 RNA polymerase II repressing transcription factor binding IBA 21873635
GO:0003714 transcription corepressor activity IBA 21873635
GO:0004407 NOT contributes_to histone deacetylase activity IDA 28046085
GO:0005515 protein binding IPI --
GO:0042826 histone deacetylase binding IBA 21873635
genes like me logo Genes that share ontologies with MIER3: view
genes like me logo Genes that share phenotypes with MIER3: view

miRNA for MIER3 Gene

miRTarBase miRNAs that target MIER3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIER3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIER3 Gene

Localization for MIER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIER3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 28046085
GO:0005654 nucleoplasm IBA,IDA --
GO:0032991 protein-containing complex IDA 28046085
genes like me logo Genes that share ontologies with MIER3: view

Pathways & Interactions for MIER3 Gene

PathCards logo

SuperPathways for MIER3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0016575 NOT histone deacetylation IEA,IDA 28046085
genes like me logo Genes that share ontologies with MIER3: view

No data available for Pathways by source and SIGNOR curated interactions for MIER3 Gene

Drugs & Compounds for MIER3 Gene

No Compound Related Data Available

Transcripts for MIER3 Gene

mRNA/cDNA for MIER3 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIER3

Alternative Splicing Database (ASD) splice patterns (SP) for MIER3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for MIER3 Gene

GeneLoc Exon Structure for
MIER3

Expression for MIER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIER3 Gene

Protein differential expression in normal tissues from HIPED for MIER3 Gene

This gene is overexpressed in Frontal cortex (56.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MIER3 Gene



Protein tissue co-expression partners for MIER3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIER3

SOURCE GeneReport for Unigene cluster for MIER3 Gene:

Hs.657594

Evidence on tissue expression from TISSUES for MIER3 Gene

  • Intestine(2.2)
genes like me logo Genes that share expression patterns with MIER3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIER3 Gene

Orthologs for MIER3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MIER3 29 30
  • 99.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MIER3 29 30
  • 94.23 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MIER3 29 30
  • 93.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mier3 29
  • 88.85 (n)
Mouse
(Mus musculus)
Mammalia Mier3 29 16 30
  • 87.93 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MIER3 30
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MIER3 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 30
  • 83 (a)
OneToMany
MIER3 29
  • 81.9 (n)
-- 30
  • 77 (a)
OneToMany
-- 30
  • 65 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia MIER3 30
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mier3 29
  • 73.19 (n)
Zebrafish
(Danio rerio)
Actinopterygii mier3 29 30
  • 65.15 (n)
OneToMany
MIER3 (2 of 2) 30
  • 61 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG1620 30
  • 23 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T07F8.4 30
  • 26 (a)
ManyToMany
F10E7.11 30
  • 21 (a)
ManyToMany
Species where no ortholog for MIER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MIER3 Gene

ENSEMBL:
Gene Tree for MIER3 (if available)
TreeFam:
Gene Tree for MIER3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MIER3: view image
Alliance of Genome Resources:
Additional Orthologs for MIER3

Paralogs for MIER3 Gene

Paralogs for MIER3 Gene

(2) SIMAP similar genes for MIER3 Gene using alignment to 4 proteins:

  • MIER3_HUMAN
  • A8MQD4_HUMAN
  • C9JXP7_HUMAN
  • H7C1J9_HUMAN
genes like me logo Genes that share paralogs with MIER3: view

Variants for MIER3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIER3 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs13177917 -- p.Asn414Lys
rs13181823 -- p.Asn432Asp
rs17854108 -- p.Asp126Gly
rs36017815 -- p.Asn530Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIER3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIER3 Gene

Variant ID Type Subtype PubMed ID
dgv9793n54 CNV gain+loss 21841781
dgv9794n54 CNV gain 21841781
dgv9795n54 CNV loss 21841781
esv23156 CNV loss 19812545
nsv1074832 CNV deletion 25765185
nsv598210 CNV loss 21841781
nsv598211 CNV gain 21841781
nsv598215 CNV gain+loss 21841781
nsv598216 CNV loss 21841781
nsv950063 CNV duplication 24416366

Variation tolerance for MIER3 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIER3 Gene

Human Gene Mutation Database (HGMD)
MIER3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIER3
Leiden Open Variation Database (LOVD)
MIER3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER3 Gene

Disorders for MIER3 Gene

Additional Disease Information for MIER3

No disorders were found for MIER3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIER3 Gene

Publications for MIER3 Gene

  1. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. (PMID: 28046085) Derwish R … Gillespie LL (PloS one 2017) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. (PMID: 28242625) Leung JW … Miller KM (Genes & development 2017) 3

Products for MIER3 Gene

Sources for MIER3 Gene