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Aliases for MIER3 Gene

Aliases for MIER3 Gene

  • MIER Family Member 3 2 3 5
  • Mesoderm Induction Early Response 1, Family Member 3 2 3
  • Mi-Er3 3 4
  • Mesoderm Induction Early Response Protein 3 3

External Ids for MIER3 Gene

Previous GeneCards Identifiers for MIER3 Gene

  • GC05M056253
  • GC05M053187
  • GC05M056215

Summaries for MIER3 Gene

GeneCards Summary for MIER3 Gene

MIER3 (MIER Family Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is MIER1.

UniProtKB/Swiss-Prot for MIER3 Gene

  • Transcriptional repressor.

Additional gene information for MIER3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER3 Gene

Genomics for MIER3 Gene

GeneHancer (GH) Regulatory Elements for MIER3 Gene

Promoters and enhancers for MIER3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I056950 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.3 +20.1 20088 2.8 SIN3A FEZF1 YY1 GLIS2 SP5 MXD4 GMEB1 SMARCA4 GLIS1 NR2C1 MIER3 SETD9 LOC105378980 ENSG00000235635
GH05I057315 Enhancer 1.2 Ensembl ENCODE dbSUPER 54.7 -345.7 -345740 3.1 ZFP64 ZNF140 EBF1 ZNF697 ZNF664 ZFHX2 ZNF791 ZNF213 POLR2A FOS GC05P057318 GC05P057319 PIR57224 PIR61821 MIER3 ENSG00000271828 RPL26P19 GPBP1 ACTBL2 LOC100288510
GH05I056908 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.8 +62.0 62017 3.3 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SETD9 LOC105378980 ENSG00000271828 MIER3
GH05I057171 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.1 -204.6 -204609 9.2 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 ZNF610 GLIS1 GPBP1 ENSG00000271828 MIER3 MAP3K1 SETD9 GC05M057277
GH05I056636 Enhancer 1.5 FANTOM5 Ensembl ENCODE 16.7 +333.5 333460 3.5 PKNOX1 FOXA2 ZFP64 ARID4B FEZF1 ZNF2 YY1 ZNF213 SP3 SP5 MIER3 C5orf67 LINC01948 MAP3K1 ENSG00000228650
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIER3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MIER3 gene promoter:

Genomic Locations for MIER3 Gene

Genomic Locations for MIER3 Gene
52,074 bases
Minus strand

Genomic View for MIER3 Gene

Genes around MIER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER3 Gene

Proteins for MIER3 Gene

  • Protein details for MIER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mesoderm induction early response protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DRI9
    • B8ZZQ0
    • Q5CZI0
    • Q68CS3
    • Q6MZS7
    • Q86YG8
    • Q8NA13

    Protein attributes for MIER3 Gene

    550 amino acids
    Molecular mass:
    61437 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH41348.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04117.1; Type=Frameshift; Positions=9, 46, 49, 466; Evidence={ECO:0000305}; Sequence=CAD97846.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45951.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI56710.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER3 Gene


neXtProt entry for MIER3 Gene

Post-translational modifications for MIER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER3 Gene

Domains & Families for MIER3 Gene

Gene Families for MIER3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MIER3 Gene

Suggested Antigen Peptide Sequences for MIER3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIER3: view

No data available for UniProtKB/Swiss-Prot for MIER3 Gene

Function for MIER3 Gene

Molecular function for MIER3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Phenotypes From GWAS Catalog for MIER3 Gene

Gene Ontology (GO) - Molecular Function for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004407 NOT histone deacetylase activity IDA 28046085
genes like me logo Genes that share ontologies with MIER3: view
genes like me logo Genes that share phenotypes with MIER3: view

Animal Model Products

miRNA for MIER3 Gene

miRTarBase miRNAs that target MIER3

Clone Products

  • Addgene plasmids for MIER3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIER3 Gene

Localization for MIER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIER3 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 28046085
GO:0005654 nucleoplasm IDA --
GO:0043234 protein complex IDA 28046085
genes like me logo Genes that share ontologies with MIER3: view

Pathways & Interactions for MIER3 Gene

SuperPathways for MIER3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016575 NOT histone deacetylation IDA 28046085
genes like me logo Genes that share ontologies with MIER3: view

No data available for Pathways by source and SIGNOR curated interactions for MIER3 Gene

Drugs & Compounds for MIER3 Gene

No Compound Related Data Available

Transcripts for MIER3 Gene

Unigene Clusters for MIER3 Gene

Mesoderm induction early response 1, family member 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for MIER3

Alternative Splicing Database (ASD) splice patterns (SP) for MIER3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP5: -

Relevant External Links for MIER3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIER3 Gene

Protein differential expression in normal tissues from HIPED for MIER3 Gene

This gene is overexpressed in Frontal cortex (56.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIER3 Gene

Protein tissue co-expression partners for MIER3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIER3 Gene:


SOURCE GeneReport for Unigene cluster for MIER3 Gene:

genes like me logo Genes that share expression patterns with MIER3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIER3 Gene

Orthologs for MIER3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MIER3 33 34
  • 99.7 (n)
(Canis familiaris)
Mammalia MIER3 33 34
  • 94.23 (n)
(Bos Taurus)
Mammalia MIER3 33 34
  • 93.93 (n)
(Rattus norvegicus)
Mammalia Mier3 33
  • 88.85 (n)
(Mus musculus)
Mammalia Mier3 33 16 34
  • 87.93 (n)
(Monodelphis domestica)
Mammalia MIER3 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia MIER3 34
  • 85 (a)
(Gallus gallus)
Aves -- 34
  • 83 (a)
MIER3 33
  • 81.9 (n)
-- 34
  • 77 (a)
-- 34
  • 65 (a)
(Anolis carolinensis)
Reptilia MIER3 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mier3 33
  • 73.19 (n)
(Danio rerio)
Actinopterygii mier3 33 34
  • 65.15 (n)
MIER3 (2 of 2) 34
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1620 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea T07F8.4 34
  • 26 (a)
F10E7.11 34
  • 21 (a)
Species where no ortholog for MIER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIER3 Gene

Gene Tree for MIER3 (if available)
Gene Tree for MIER3 (if available)

Paralogs for MIER3 Gene

Paralogs for MIER3 Gene

(2) SIMAP similar genes for MIER3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIER3: view

Variants for MIER3 Gene

Sequence variations from dbSNP and Humsavar for MIER3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000028732 -- 56,946,600(-) G/ intron_variant
rs1000029254 -- 56,924,297(-) G/A intron_variant
rs1000060002 -- 56,946,743(-) G/A intron_variant
rs1000094389 -- 56,952,271(-) C/A upstream_transcript_variant
rs1000103388 -- 56,952,774(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIER3 Gene

Variant ID Type Subtype PubMed ID
dgv9793n54 CNV gain+loss 21841781
dgv9794n54 CNV gain 21841781
dgv9795n54 CNV loss 21841781
esv23156 CNV loss 19812545
nsv1074832 CNV deletion 25765185
nsv598210 CNV loss 21841781
nsv598211 CNV gain 21841781
nsv598215 CNV gain+loss 21841781
nsv598216 CNV loss 21841781
nsv950063 CNV duplication 24416366

Variation tolerance for MIER3 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIER3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER3 Gene

Disorders for MIER3 Gene

Additional Disease Information for MIER3

No disorders were found for MIER3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIER3 Gene

Publications for MIER3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. (PMID: 28046085) Derwish R … Gillespie LL (PloS one 2017) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for MIER3 Gene

  • Addgene plasmids for MIER3

Sources for MIER3 Gene

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