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Aliases for MIER2 Gene

Aliases for MIER2 Gene

  • MIER Family Member 2 2 3 5
  • KIAA1193 2 3 4
  • Mesoderm Induction Early Response 1, Family Member 2 2 3
  • Mi-Er2 3 4
  • Mesoderm Induction Early Response Protein 2 3

External Ids for MIER2 Gene

Previous HGNC Symbols for MIER2 Gene

  • KIAA1193

Previous GeneCards Identifiers for MIER2 Gene

  • GC19M000257
  • GC19M000079

Summaries for MIER2 Gene

GeneCards Summary for MIER2 Gene

MIER2 (MIER Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is MIER3.

UniProtKB/Swiss-Prot for MIER2 Gene

  • Transcriptional repressor.

Additional gene information for MIER2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER2 Gene

Genomics for MIER2 Gene

GeneHancer (GH) Regulatory Elements for MIER2 Gene

Promoters and enhancers for MIER2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I000341 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 559 +1.1 1131 3.5 IRF4 ZNF48 RUNX3 SP5 NFYC ZNF592 KAT8 MBD2 GMEB1 KDM1A MIER2 THEG GC19M000319
GH19I001236 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 61.1 -912.0 -912044 41.1 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 CIRBP C19orf24 MIDN CBARP ATP5F1D SF3A2 TCF3 TMEM259 LOC100288123 PTBP1
GH19I001019 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 48.9 -676.4 -676392 4.4 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 TMEM259 GC19P001025 RNU6-2 TCF3 LOC100288123 DAZAP1 GRIN3B PTBP1 CIRBP MED16
GH19I001202 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 30.3 -861.9 -861942 8 ZFP64 FEZF1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A STK11 CIRBP TMEM259 DAZAP1 LOC100288123 TCF3 PTBP1 GRIN3B DOT1L ENSG00000267317
GH19I000479 Enhancer 1.4 Ensembl ENCODE dbSUPER 50.2 -135.5 -135470 0.8 HDGF PKNOX1 ATF1 ARNT ZNF133 ARID4B SIN3A YBX1 ZNF2 TCF12 DAZAP1 TMEM259 PTBP1 ENSG00000267317 MIER2 GRIN3B MED16 CNN2 RPS15 RNF126
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIER2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MIER2 gene promoter:

Genomic Locations for MIER2 Gene

Genomic Locations for MIER2 Gene
chr19:301,444-344,815
(GRCh38/hg38)
Size:
43,372 bases
Orientation:
Minus strand
chr19:305,575-344,798
(GRCh37/hg19)

Genomic View for MIER2 Gene

Genes around MIER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER2 Gene

Proteins for MIER2 Gene

  • Protein details for MIER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N344-MIER2_HUMAN
    Recommended name:
    Mesoderm induction early response protein 2
    Protein Accession:
    Q8N344
    Secondary Accessions:
    • Q9ULM7

    Protein attributes for MIER2 Gene

    Size:
    545 amino acids
    Molecular mass:
    59944 Da
    Quaternary structure:
    • Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=BAA86507.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for MIER2 Gene

Post-translational modifications for MIER2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER2 Gene

Domains & Families for MIER2 Gene

Gene Families for MIER2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MIER2 Gene

Suggested Antigen Peptide Sequences for MIER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIER2: view

No data available for UniProtKB/Swiss-Prot for MIER2 Gene

Function for MIER2 Gene

Molecular function for MIER2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Phenotypes From GWAS Catalog for MIER2 Gene

Gene Ontology (GO) - Molecular Function for MIER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004407 histone deacetylase activity IDA 28046085
GO:0042826 histone deacetylase binding IPI 28046085
genes like me logo Genes that share ontologies with MIER2: view
genes like me logo Genes that share phenotypes with MIER2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIER2 Gene

Localization for MIER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIER2 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MIER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 28046085
GO:0005737 cytoplasm IDA 28046085
GO:0043234 protein complex IDA 28046085
genes like me logo Genes that share ontologies with MIER2: view

Pathways & Interactions for MIER2 Gene

SuperPathways for MIER2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016575 histone deacetylation IDA 28046085
genes like me logo Genes that share ontologies with MIER2: view

No data available for Pathways by source and SIGNOR curated interactions for MIER2 Gene

Drugs & Compounds for MIER2 Gene

No Compound Related Data Available

Transcripts for MIER2 Gene

Unigene Clusters for MIER2 Gene

Mesoderm induction early response 1, family member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIER2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2:
SP3: -

Relevant External Links for MIER2 Gene

GeneLoc Exon Structure for
MIER2
ECgene alternative splicing isoforms for
MIER2

Expression for MIER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIER2 Gene

Protein differential expression in normal tissues from HIPED for MIER2 Gene

This gene is overexpressed in Liver (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIER2 Gene



Protein tissue co-expression partners for MIER2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MIER2 Gene:

MIER2

SOURCE GeneReport for Unigene cluster for MIER2 Gene:

Hs.101891

Evidence on tissue expression from TISSUES for MIER2 Gene

  • Lung(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MIER2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIER2 Gene

Orthologs for MIER2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIER2 34
  • 100 (a)
OneToOne
LOC455527 33
  • 86.78 (n)
dog
(Canis familiaris)
Mammalia MIER2 33 34
  • 85.2 (n)
cow
(Bos Taurus)
Mammalia MIER2 33 34
  • 82.51 (n)
rat
(Rattus norvegicus)
Mammalia Mier2 33
  • 82.41 (n)
mouse
(Mus musculus)
Mammalia Mier2 33 16 34
  • 80.98 (n)
oppossum
(Monodelphis domestica)
Mammalia MIER2 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MIER2 33 34
  • 68.64 (n)
lizard
(Anolis carolinensis)
Reptilia MIER2 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3590 33
zebrafish
(Danio rerio)
Actinopterygii LOC564723 33
  • 58.79 (n)
mier2 34
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1620 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10E7.11 34
  • 24 (a)
ManyToMany
T07F8.4 34
  • 22 (a)
ManyToMany
Species where no ortholog for MIER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIER2 Gene

ENSEMBL:
Gene Tree for MIER2 (if available)
TreeFam:
Gene Tree for MIER2 (if available)

Paralogs for MIER2 Gene

Paralogs for MIER2 Gene

(2) SIMAP similar genes for MIER2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MIER2: view

Variants for MIER2 Gene

Sequence variations from dbSNP and Humsavar for MIER2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000023456 -- 324,190(-) C/T intron_variant
rs1000025856 -- 326,238(-) A/G intron_variant
rs1000054651 -- 324,340(-) G/A intron_variant
rs1000128993 -- 336,063(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000194970 -- 332,593(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MIER2 Gene

Variant ID Type Subtype PubMed ID
dgv1666n106 CNV duplication 24896259
dgv1667n106 CNV deletion 24896259
dgv1964e59 CNV duplication 20981092
dgv3420n100 CNV gain 25217958
esv1399571 CNV deletion 17803354
esv2016015 CNV deletion 18987734
esv2422333 CNV duplication 17116639
esv2660556 CNV deletion 23128226
esv2666359 CNV deletion 23128226
esv2758742 CNV gain 17122850
esv3555806 CNV deletion 23714750
esv3555807 CNV deletion 23714750
esv3643342 CNV gain 21293372
esv3643343 CNV loss 21293372
esv3643344 CNV gain 21293372
esv3643346 CNV loss 21293372
esv3643347 CNV gain 21293372
nsv1065558 CNV gain 25217958
nsv1071479 CNV deletion 25765185
nsv1077855 CNV duplication 25765185
nsv1117206 CNV tandem duplication 24896259
nsv1141966 CNV deletion 24896259
nsv1148440 CNV duplication 26484159
nsv138180 CNV deletion 16902084
nsv428360 CNV gain 18775914
nsv474264 CNV novel sequence insertion 20440878
nsv577978 CNV gain 21841781
nsv833702 CNV loss 17160897
nsv9656 CNV gain 18304495
nsv9659 CNV gain 18304495

Variation tolerance for MIER2 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIER2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIER2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER2 Gene

Disorders for MIER2 Gene

Additional Disease Information for MIER2

No disorders were found for MIER2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIER2 Gene

Publications for MIER2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. (PMID: 28046085) Derwish R … Gillespie LL (PloS one 2017) 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. (PMID: 27400125) Martin-Almedina S … Ostergaard P (The Journal of clinical investigation 2016) 4 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for MIER2 Gene

Sources for MIER2 Gene

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