This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013] See more...

Aliases for MIER1 Gene

Aliases for MIER1 Gene

  • MIER1 Transcriptional Regulator 2 3 5
  • Mesoderm Induction Early Response 1, Transcriptional Regulator 2 3
  • Mesoderm Induction Early Response Protein 1 3 4
  • KIAA1610 2 4
  • MI-ER1 2 3
  • Mesoderm Induction Early Response 1 Homolog (Xenopus Laevis) 2
  • Mesoderm Induction Early Response 1 Homolog 3
  • Early Response 1 4
  • HMI-ER1 2
  • HMi-Er1 4
  • Mi-Er1 4
  • MIER1 5
  • ER1 3
  • Er1 4

External Ids for MIER1 Gene

Previous GeneCards Identifiers for MIER1 Gene

  • GC01P067103
  • GC01P067390
  • GC01P065499

Summaries for MIER1 Gene

Entrez Gene Summary for MIER1 Gene

  • This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

GeneCards Summary for MIER1 Gene

MIER1 (MIER1 Transcriptional Regulator) is a Protein Coding gene. Diseases associated with MIER1 include Amelogenesis Imperfecta, Type Ig and Hairy Tongue. Gene Ontology (GO) annotations related to this gene include chromatin binding and obsolete signal transducer activity. An important paralog of this gene is MIER3.

UniProtKB/Swiss-Prot Summary for MIER1 Gene

  • Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Gene Wiki entry for MIER1 Gene

Additional gene information for MIER1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIER1 Gene

Genomics for MIER1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIER1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J066923 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 637.4 +0.5 529 4.4 ZNF221 SP1 HNRNPL GATAD2A TEAD4 PRDM10 REST ZNF629 RFX1 LEF1 MIER1 DNAI4 TCTEX1D1 SERBP1 MN308949 SLC35D1
GH01J066929 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 610.2 +7.6 7576 6.9 PRDM10 ZNF629 ZNF512 IKZF1 KDM1A POLR2A BACH1 LARP7 PRDM1 ZNF143 MIER1 DNAI4 TCTEX1D1 SLC35D1 MN308949
GH01J067681 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 24.2 +761.2 761152 8.3 SP1 HNRNPL GATAD2A PRDM10 ZNF629 REST TFE3 LEF1 IKZF1 ZNF692 GADD45A NONHSAG001763.2 MIER1 SERBP1 DNAI4 LOC105378781 GNG12
GH01J066329 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 -590.8 -590758 9.3 SP1 PRDM10 ZNF629 POLR2A BACH1 FOXA1 LARP7 STAT3 PRDM1 ZNF143 PDE4B MIER1 SLC35D1 HSALNG0004217 piR-61289-003 SGIP1
GH01J067701 Enhancer 0.8 Ensembl 29.2 +774.4 774406 0.2 ZNF629 ZNF331 ZNF501 ZNF341 RBAK ZNF140 ZNF639 KLF7 ZXDB ZEB1 MIER1 GNG12 DNAI4 SERBP1 NONHSAG001763.2 GADD45A LOC105378781
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIER1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MIER1

Top Transcription factor binding sites by QIAGEN in the MIER1 gene promoter:
  • AML1a
  • FOXF2
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Ik-2
  • STAT5A

Genomic Locations for MIER1 Gene

Genomic Locations for MIER1 Gene
chr1:66,924,895-66,988,619
(GRCh38/hg38)
Size:
63,725 bases
Orientation:
Plus strand
chr1:67,390,578-67,454,302
(GRCh37/hg19)
Size:
63,725 bases
Orientation:
Plus strand

Genomic View for MIER1 Gene

Genes around MIER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER1 Gene

Proteins for MIER1 Gene

  • Protein details for MIER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N108-MIER1_HUMAN
    Recommended name:
    Mesoderm induction early response protein 1
    Protein Accession:
    Q8N108
    Secondary Accessions:
    • C9JFD4
    • Q08AE0
    • Q32NC4
    • Q5T104
    • Q5TAD1
    • Q5TAD2
    • Q5TAD4
    • Q5TAD5
    • Q6AHY8
    • Q86TB4
    • Q8N156
    • Q8N161
    • Q8NC37
    • Q8NES4
    • Q8NES5
    • Q8NES6
    • Q8WWG2
    • Q9HCG2

    Protein attributes for MIER1 Gene

    Size:
    512 amino acids
    Molecular mass:
    57983 Da
    Quaternary structure:
    • Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=AAH17423.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS. Probable cloning artifact due to reverse transcription from RNA internal poly-A tracts.; Evidence={ECO:0000305}; Sequence=AAM76041.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAM97500.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAM97503.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAM97506.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC11339.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. C-terminal is identical to the product of the WLS gene.; Evidence={ECO:0000305}; Sequence=CAD89921.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: It is uncertain whether Met-1 or Met-55 is the initiator.
    • [Isoform 5]: It is uncertain whether Met-1 or Met-55 is the initiator.

    Alternative splice isoforms for MIER1 Gene

neXtProt entry for MIER1 Gene

Post-translational modifications for MIER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER1 Gene

Domains & Families for MIER1 Gene

Gene Families for MIER1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MIER1 Gene

Suggested Antigen Peptide Sequences for MIER1 Gene

GenScript: Design optimal peptide antigens:
  • Mesoderm induction early response protein 1 (MIER1_HUMAN)
  • cDNA FLJ60095, highly similar to Mesoderm induction early response protein 1 (Q5TAD5_HUMAN)
  • MIER1 protein (Q6NXT7_HUMAN)
genes like me logo Genes that share domains with MIER1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIER1 Gene

Function for MIER1 Gene

Molecular function for MIER1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Phenotypes From GWAS Catalog for MIER1 Gene

Gene Ontology (GO) - Molecular Function for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001103 RNA polymerase II repressing transcription factor binding IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IBA 21873635
GO:0004407 contributes_to histone deacetylase activity IDA 28046085
genes like me logo Genes that share ontologies with MIER1: view

Phenotypes for MIER1 Gene

genes like me logo Genes that share phenotypes with MIER1: view

Animal Models for MIER1 Gene

MGI Knock Outs for MIER1:
  • Mier1 Mier1<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIER1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIER1 Gene

Localization for MIER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER1 Gene

[Isoform 1]: Nucleus.
[Isoform 2]: Nucleus.
[Isoform 3]: Nucleus.
[Isoform 4]: Cytoplasm.
[Isoform 5]: Cytoplasm.
[Isoform 6]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIER1 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 28046085
GO:0005654 nucleoplasm IBA,IDA --
GO:0005737 cytoplasm IEA --
GO:0017053 transcriptional repressor complex IDA 12482978
GO:0032991 protein-containing complex IDA 28046085
genes like me logo Genes that share ontologies with MIER1: view

Pathways & Interactions for MIER1 Gene

PathCards logo

SuperPathways for MIER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016575 histone deacetylation IDA 28046085
GO:0031937 positive regulation of chromatin silencing IDA 12482978
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP 12761501
genes like me logo Genes that share ontologies with MIER1: view

No data available for Pathways by source and SIGNOR curated interactions for MIER1 Gene

Drugs & Compounds for MIER1 Gene

No Compound Related Data Available

Transcripts for MIER1 Gene

mRNA/cDNA for MIER1 Gene

12 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIER1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIER1 Gene

No ASD Table

Relevant External Links for MIER1 Gene

GeneLoc Exon Structure for
MIER1

Expression for MIER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MIER1 Gene

This gene is overexpressed in Plasma (21.1), Peripheral blood mononuclear cells (15.0), and Blymphocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MIER1 Gene



Protein tissue co-expression partners for MIER1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIER1

SOURCE GeneReport for Unigene cluster for MIER1 Gene:

Hs.605432

mRNA Expression by UniProt/SwissProt for MIER1 Gene:

Q8N108-MIER1_HUMAN
Tissue specificity: Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.

Evidence on tissue expression from TISSUES for MIER1 Gene

  • Liver(4.5)
  • Lung(4.5)
  • Muscle(4.5)
  • Eye(4.3)
  • Nervous system(2.8)
  • Skin(2.5)
  • Kidney(2.5)
  • Spleen(2.4)
  • Heart(2.4)
  • Intestine(2.4)
  • Bone marrow(2.3)
  • Blood(2.3)
  • Lymph node(2.2)
  • Stomach(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with MIER1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIER1 Gene

Orthologs for MIER1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MIER1 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MIER1 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MIER1 31
  • 96 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mier1 30
  • 91.7 (n)
Mouse
(Mus musculus)
Mammalia Mier1 30 17 31
  • 90.59 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MIER1 31
  • 70 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MIER1 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MIER1 31
  • 83 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MIER1 31
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mi-er1-prov 30
Zebrafish
(Danio rerio)
Actinopterygii mier1a 30
  • 62.95 (n)
mier1b 31
  • 59 (a)
OneToOne
wufb30a02 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG1620 31
  • 21 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T07F8.4 31
  • 26 (a)
ManyToMany
F10E7.11 31
  • 26 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToOne
Species where no ortholog for MIER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for MIER1 Gene

ENSEMBL:
Gene Tree for MIER1 (if available)
TreeFam:
Gene Tree for MIER1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MIER1: view image

Paralogs for MIER1 Gene

Paralogs for MIER1 Gene

(2) SIMAP similar genes for MIER1 Gene using alignment to 4 proteins:

  • MIER1_HUMAN
  • L8EC72_HUMAN
  • Q5TAD1_HUMAN
  • Q6NXT7_HUMAN
genes like me logo Genes that share paralogs with MIER1: view

Variants for MIER1 Gene

Additional dbSNP identifiers (rs#s) for MIER1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIER1 Gene

Variant ID Type Subtype PubMed ID
esv3309013 CNV mobile element insertion 20981092
esv3398423 CNV insertion 20981092
nsv1078294 OTHER inversion 25765185

Variation tolerance for MIER1 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIER1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIER1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIER1 Gene

Disorders for MIER1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MIER1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
amelogenesis imperfecta, type ig
  • ai1g
hairy tongue
  • overgrowth of filiform papillae
frozen shoulder
  • adhesions-capsulitis,shoulder
teeth hard tissue disease
amelogenesis imperfecta
  • ai
- elite association - COSMIC cancer census association via MalaCards
Search MIER1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MIER1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIER1 Gene

Publications for MIER1 Gene

  1. Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization. (PMID: 12242014) Paterno GD … Gillespie LL (Gene 2002) 2 3 4 23
  2. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. (PMID: 12482978) Ding Z … Paterno GD (Molecular and cellular biology 2003) 2 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for MIER1 Gene

  • Signalway ELISA kits for MIER1

Sources for MIER1 Gene